Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Rosborough SL et al. | Identification of FKBP-related proteins with antibodies of predetermined specificity and isolation by FK 506 affinity chromatography. | 1991 | Transplant. Proc. | pmid:1721306 |
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Moffatt SD et al. | Comparative efficacy of liposomal FK 506 with FK 506 (tacrolimus) with and without anti-CD4/CD8 monoclonal antibodies. | 1999 | Transplant. Proc. | pmid:10578277 |
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Zeevi A et al. | In vitro assessment of FK 506 immunosuppressive activity in transplant patients. | 1991 | Transplant. Proc. | pmid:1721307 |
Woo J et al. | Flow cytometric analysis of lymphocyte populations and activation antigen expression in blood and lymphoid tissues of FK 506-treated rats. | 1990 | Transplant. Proc. | pmid:1697112 |
Woo J et al. | Effects of FK 506 and low concentration cyclosporine on human lymphocyte activation antigen expression: a flow cytometric analysis. | 1990 | Transplant. Proc. | pmid:1697113 |
Bachetoni A et al. | Preliminary evaluation of the new TACR flex method versus MEIA method in the therapeutic monitoring of tacrolimus in organ transplantation. | 2007 Jul-Aug | Transplant. Proc. | pmid:17692678 |
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Ohtsuka S et al. | The effect of short-term FK 506 therapy on pancreas transplantation using the cuff technique in rats. | 1992 | Transplant. Proc. | pmid:1376532 |
Ko S et al. | Significance of newly developed liposomal FK 506 in canine liver transplantation. | 1995 | Transplant. Proc. | pmid:7533406 |
McDiarmid SV et al. | FK 506 rescue therapy in liver transplantation: outcome and complications. | 1991 | Transplant. Proc. | pmid:1721339 |
Tzakis AG et al. | Campath-1H in intestinal and multivisceral transplantation: preliminary data. | 2002 | Transplant. Proc. | pmid:12034248 |
Allers C et al. | Tacrolimus, daclizumab, sirolimus, and budesonide after small bowel transplantation in order to reduce nephrotoxicity. | 2002 | Transplant. Proc. | pmid:12034251 |
Böttiger Y et al. | Effect of bile flow on the absorption of tacrolimus in liver allograft transplantation. | 2002 | Transplant. Proc. | pmid:12176476 |
Hodge EE et al. | Use of mycophenolate mofetil in liver transplant recipients experiencing renal dysfunction on cyclosporine or tacrolimus-randomized, prospective, multicenter study results. | 2002 | Transplant. Proc. | pmid:12176477 |
Yuan-Xin L et al. | Preliminary experience with alemtuzumab induction therapy combined with maintenance low-dose tacrolimus monotherapy in small-bowel transplantation in China. | 2010 Jan-Feb | Transplant. Proc. | pmid:20172275 |
Kilian K et al. | FK-506 (tacrolimus) therapy for an unusual SLE-like disease. | 1998 | Transplant. Proc. | pmid:9865322 |
Schorlemmer HU and Kurrle R | Combination therapy of malononitrilamides and tacrolimus (FK 506) induced long-term xenograft survival. | 1998 | Transplant. Proc. | pmid:9865337 |
Sánchez-Pérez B et al. | Influence of immunosuppression and effect of hepatitis C virus on new onset of diabetes mellitus in liver transplant recipients. | 2008 | Transplant. Proc. | pmid:19010171 |
Alessiani M et al. | Combined FK 506 and mycophenolate mofetil immunosuppression prolongs survival after small bowel transplantation in pigs. | 1996 | Transplant. Proc. | pmid:8907922 |
Chamienia A et al. | One-year observation of kidney allograft recipients converted from cyclosporine microemulsion to tacrolimus. | 2006 Jan-Feb | Transplant. Proc. | pmid:16504670 |
Bartlomiejczyk I et al. | Therapeutic monitoring of tacrolimus concentrations in blood of renal and liver transplant recipients: comparison of microparticle enzyme immunoassay and enzyme multiplied immunoassay methods. | 2006 Jan-Feb | Transplant. Proc. | pmid:16504673 |
Yoshimura R et al. | Study of the effect of immunosuppressive agents on renal cytochrome P-450 system in the rat. | 1994 | Transplant. Proc. | pmid:7520610 |
Wijnen RM et al. | Toxicity of FK 506 in the cynomolgus monkey: noncorrelation with FK 506 serum levels. | 1991 | Transplant. Proc. | pmid:1721371 |
Venkataramanan R et al. | Pharmacokinetics of FK 506 following oral administration: a comparison of FK 506 and cyclosporine. | 1991 | Transplant. Proc. | pmid:1703355 |
Herrero JI et al. | Conversion from calcineurin inhibitors to mycophenolate mofetil in liver transplant recipients with diabetes mellitus. | 2003 | Transplant. Proc. | pmid:12962832 |
Youseff N and Small S | A retrospective analysis of a sirolimus/prograf regimen for the prevention of acute rejection in recipients of primary mismatched renal allografts. | 2002 | Transplant. Proc. | pmid:12176522 |
Sanada O et al. | Establishment of chimerism in donors by intraportal injection of recipient-type bone marrow cells with concomitant administration of FK 506 before liver transplantation prolongs liver allograft survival in rats. | 1998 | Transplant. Proc. | pmid:9838689 |
Kandaswamy R et al. | Vascular graft thrombosis after pancreas transplantation: comparison of the FK 506 and cyclosporine eras. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083254 |
Akutsu N et al. | Two cases of calcineurin inhibitor-associated reversible posterior leukoencephalopathy syndrome in renal transplant recipients. | 2008 | Transplant. Proc. | pmid:18790253 |
Tashiro H et al. | Correlation of high-level microchimerism with graft acceptance in rat liver transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123287 |
Guckelberger O et al. | Does the choice of primary immunosuppression influence the prevalence of cardiovascular risk factors after liver transplantation? | 1996 | Transplant. Proc. | pmid:8962230 |
Aono T et al. | Minimal threshold of FK 506 for enhancing liver regeneration in thymectomized rats. | 1995 | Transplant. Proc. | pmid:7536981 |
Balbontin FG et al. | Tacrolimus monitoring by simplified sparse sampling under the concentration time curve. | 2003 | Transplant. Proc. | pmid:14611982 |
Morrisett JD et al. | Effect of FK 506 and cyclosporine on plasma cholesterol levels in rabbits. | 1991 | Transplant. Proc. | pmid:1721402 |
Kobayashi N et al. | Abdominal organ cluster transplantation in pigs receiving FK 506. | 1992 | Transplant. Proc. | pmid:1379754 |
Jordan ML et al. | Tacrolimus rescue therapy for renal transplant rejection. | 1996 | Transplant. Proc. | pmid:8769174 |
Jacobs TW et al. | The effect of FK 506, cyclosporine A, and cyclosporine G on serum 1,25-dihydroxyvitamin D levels. | 1991 | Transplant. Proc. | pmid:1721403 |
Yoshimura R et al. | A comparative study of cyclosporine vs FK 506: role of kidney microsomal cytochrome P-450. | 1992 | Transplant. Proc. | pmid:1379755 |
Baruch Y et al. | Anasarca and hypertrophic cardiomyopathy in a liver transplant patient on FK506: relieved after a switch to Neoral. | 1996 | Transplant. Proc. | pmid:8769215 |
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Langrehr JM et al. | Chronic rejection after orthotopic liver transplantation is increased under induction therapy with interleukin-2 receptor antibody BT563. | 2001 | Transplant. Proc. | pmid:11377531 |
Saber LT et al. | Posttransplantation conversion to sirolimus-based immunosuppression: a single center experience. | 2007 | Transplant. Proc. | pmid:18089330 |
Tanabe K et al. | Prospective analysis of thrombotic microangiopathy after renal transplantation: comparison between cyclosporine and tacrolimus immunosuppression. | 2002 | Transplant. Proc. | pmid:12176590 |
Erickson LM et al. | Gene expression profiles of rat heart allografts with immunosuppression. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266960 |
Chung YW et al. | Tacrolimus-Induced Apoptosis is Mediated by Endoplasmic Reticulum-derived Calcium-dependent Caspases-3,-12 in Jurkat Cells. | 2018 | Transplant. Proc. | pmid:29731088 |
Lee KH et al. | Distribution of Anti-ABO Immunoglobulin G Subclass and C1q Antibody in ABO-incompatible Kidney Transplantation. | 2018 | Transplant. Proc. | pmid:29731066 |
Dopazo C et al. | Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin with rapamycin plus tacrolimus in liver transplant patient. | 2009 | Transplant. Proc. | pmid:19376416 |
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Kobayashi N et al. | Effect of FK 506 on abdominal organ cluster transplantation in pigs. | 1991 | Transplant. Proc. | pmid:1721434 |
Liu W et al. | Transfusion of endothelial cells with lentivirus-mediated expression of fas ligand prolonged survival of rat liver allograft. | 2012 | Transplant. Proc. | pmid:22664023 |
Collier DS et al. | Kidney transplantation in the dog receiving FK-506. | 1987 | Transplant. Proc. | pmid:2445077 |
Ishida S et al. | Calcineurin Inhibitor-Induced Pain Syndrome in ABO-Incompatible Living Kidney Transplantation: A Case Report. | Transplant. Proc. | pmid:28104127 | |
Matevossian E et al. | Nitric oxide inhibition and consecutive Aspisol application show a prolonged survival of orthotopic transplanted livers in a rat model. | 2008 | Transplant. Proc. | pmid:18555092 |
Jain A et al. | Prospective randomized trial of tacrolimus and prednisone versus tacrolimus, prednisone, and mycophenolate mofetil: complete report on 350 primary adult liver transplantations. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267319 |
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Morena M et al. | Low-density lipoprotein composition and oxidation are not influenced by calcineurin inhibitors in renal transplant patients. | 2000 | Transplant. Proc. | pmid:11134805 |
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Bresci S et al. | Case report: cystic fibrosis, lung transplantation, and the novel H1N1 flu. | 2010 Jul-Aug | Transplant. Proc. | pmid:20692461 |
White SA et al. | Effect of acute rejection on expression of fibrosis associated genes in renal transplant recipients. | 2000 | Transplant. Proc. | pmid:10700949 |
Braun F et al. | Living-related versus living-unrelated kidney transplantation using tacrolimus initial immunosuppression. | 2000 | Transplant. Proc. | pmid:10700989 |
Finni PE et al. | Is hepatitis C a risk factor to posttransplant diabetes mellitus after renal transplantation in patients using tacrolimus? | 2004 | Transplant. Proc. | pmid:15194303 |
Hariharan S et al. | Conversion from cyclosporine to tacrolimus after pancreas transplantation. | 1995 | Transplant. Proc. | pmid:8539799 |
White SA et al. | Influence of delayed graft function in renal transplants from cadaveric or non-heart-beating donors. | 2000 | Transplant. Proc. | pmid:10701018 |
Sens YA et al. | Posttransplant diabetes mellitus in renal transplant patients with hepatitis C virus. | 2004 | Transplant. Proc. | pmid:15194304 |
Nakamura A et al. | Effects of elevated tacrolimus trough levels in association with infectious enteritis on graft function in renal transplant recipients. | 2014 | Transplant. Proc. | pmid:24656020 |