tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- J. Pharmacol. Exp. Ther. (1)
- Am. J. Physiol. Renal Physiol. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nakagawa K et al. | Immunosuppression with tacrolimus improved reproductive outcome of women with repeated implantation failure and elevated peripheral blood TH1/TH2 cell ratios. | 2015 | Am. J. Reprod. Immunol. | pmid:25394810 |
| Farnik H et al. | Telaprevir drug monitoring during antiviral therapy of hepatitis C graft infection after liver transplantation. | 2015 | Liver Int. | pmid:24649882 |
| Cantaluppi V et al. | Neutrophil Gelatinase Associated Lipocalin Is an Early and Accurate Biomarker of Graft Function and Tissue Regeneration in Kidney Transplantation from Extended Criteria Donors. | 2015 | PLoS ONE | pmid:26125566 |
| Fukahori H et al. | Effect of novel PKCθ selective inhibitor AS2521780 on acute rejection in rat and non-human primate models of transplantation. | 2015 | Int. Immunopharmacol. | pmid:26122135 |
| Langone A et al. | Switching STudy of Kidney TRansplant PAtients with Tremor to LCP-TacrO (STRATO): an open-label, multicenter, prospective phase 3b study. | 2015 | Clin Transplant | pmid:26113208 |
| Eidens M et al. | Development and validation of a rapid and reliable real-time PCR method for CYP3A5 genotyping. | 2015 | Clin. Lab. | pmid:25975003 |
| Castaneda J and Matzuk MM | DEVELOPMENTAL BIOLOGY. Toward a rapid and reversible male pill. | 2015 | Science | pmid:26494747 |
| Safa K et al. | Eculizumab for drug-induced de novo posttransplantation thrombotic microangiopathy: A case report. | 2015 | Clin. Nephrol. | pmid:24495904 |
| Staatz CE and Tett SE | Clinical Pharmacokinetics of Once-Daily Tacrolimus in Solid-Organ Transplant Patients. | 2015 | Clin Pharmacokinet | pmid:26038096 |
| Migita K et al. | Pneumococcal polysaccharide vaccination in rheumatoid arthritis patients receiving tacrolimus. | 2015 | Arthritis Res. Ther. | pmid:26036592 |
| Miyata H et al. | Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive. | 2015 | Science | pmid:26429887 |
| Wiseman AC | Induction Therapy in Renal Transplantation: Why? What Agent? What Dose? We May Never Know. | 2015 | Clin J Am Soc Nephrol | pmid:25979977 |
| Tanriover B et al. | Induction Therapies in Live Donor Kidney Transplantation on Tacrolimus and Mycophenolate With or Without Steroid Maintenance. | 2015 | Clin J Am Soc Nephrol | pmid:25979971 |
| Meyer C et al. | Impact of irradiation and immunosuppressive agents on immune system homeostasis in rhesus macaques. | 2015 | Clin. Exp. Immunol. | pmid:25902927 |
| Sassi MB et al. | Involvement of CYP 3A5 In the Interaction Between Tacrolimus and Nicardipine: A Case Report. | 2015 | Curr Drug Saf | pmid:25968921 |
| Wang CY et al. | Analysis of tacrolimus blood concentrations in renal transplant patients. | 2015 | Genet. Mol. Res. | pmid:25966149 |
| Bedi M and Taylor AL | Recalcitrant Hailey-Hailey disease responds to oral tacrolimus and botulinum toxin type A. | 2015 | Cutis | pmid:26761940 |
| Nagaya M et al. | A new system to evaluate the influence of immunosuppressive drugs on pancreatic islets using epigenetic analysis in a 3-dimensional culture. | 2015 | Pancreas | pmid:25906448 |
| Wang M et al. | Enteric polymer based on pH-responsive aliphatic polycarbonate functionalized with vitamin E to facilitate oral delivery of tacrolimus. | 2015 | Biomacromolecules | pmid:25714622 |
| Gallon L et al. | Differential Effects of Calcineurin and Mammalian Target of Rapamycin Inhibitors on Alloreactive Th1, Th17, and Regulatory T Cells. | 2015 | Transplantation | pmid:25905982 |
| Gajzlerska W et al. | Use of three-carbon chain compounds as biosynthesis precursors to enhance tacrolimus production in Streptomyces tsukubaensis. | 2015 | N Biotechnol | pmid:25152525 |
| Yu Z et al. | IL-15 is decreased upon CsA and FK506 treatment of acute rejection following heart transplantation in mice. | 2015 | Mol Med Rep | pmid:25333459 |
| Selk A | A Survey of Experts Regarding the Treatment of Adult Vulvar Lichen Sclerosus. | 2015 | J Low Genit Tract Dis | pmid:25853633 |
| Hurst AL et al. | Supra-therapeutic tacrolimus concentrations associated with concomitant nicardipine in pediatric liver transplant recipients. | 2015 | Pediatr Transplant | pmid:25850753 |
| Tajdaran K et al. | A novel polymeric drug delivery system for localized and sustained release of tacrolimus (FK506). | 2015 | Biotechnol. Bioeng. | pmid:25850693 |
| Jacobo-Cabral CO et al. | Population pharmacokinetic analysis of tacrolimus in Mexican paediatric renal transplant patients: role of CYP3A5 genotype and formulation. | 2015 | Br J Clin Pharmacol | pmid:25846845 |
| Bowman LJ et al. | Tacrolimus-Induced Cardiomyopathy in an Adult Renal Transplant Recipient. | 2015 | Pharmacotherapy | pmid:26616582 |
| Miguel-Gómez L et al. | [Peristomal pyoderma gangrenosum associated with colon cancer]. | 2015 | Med Clin (Barc) | pmid:25659860 |
| Romanowski M et al. | Adiponectin and leptin gene polymorphisms in patients with post-transplant diabetes mellitus. | 2015 | Pharmacogenomics | pmid:26282401 |
| Girdlestone J et al. | Enhancement of the immunoregulatory potency of mesenchymal stromal cells by treatment with immunosuppressive drugs. | 2015 | Cytotherapy | pmid:26276002 |
| Dedinská I et al. | Waist circumference as an independent risk factor for NODAT. | 2015 | Ann. Transplant. | pmid:25791039 |
| Suzuki N et al. | In vivo regulation of erythropoiesis by chemically inducible dimerization of the erythropoietin receptor intracellular domain. | 2015 | PLoS ONE | pmid:25790231 |
| Ross A and Kirsner RS | JID VisualDx Quiz: April 2015. | 2015 | J. Invest. Dermatol. | pmid:25785952 |
| Heneberg P et al. | Pimecrolimus Is a Potent Inhibitor of Allergic Reactions to Hymenopteran Venom Extracts and Birch Pollen Allergen In Vitro. | 2015 | PLoS ONE | pmid:26562153 |
| Yang CJ et al. | Differential Large-Amplitude Breathing Motions in the Interface of FKBP12-Drug Complexes. | 2015 | Biochemistry | pmid:26561008 |
| Fan J et al. | Donor IL-18 rs5744247 polymorphism as a new biomarker of tacrolimus elimination in Chinese liver transplant patients during the early post-transplantation period: results from two cohort studies. | 2015 | Pharmacogenomics | pmid:25712187 |
| Duong SQ et al. | Transition from brand to generic tacrolimus is associated with a decrease in trough blood concentration in pediatric heart transplant recipients. | 2015 | Pediatr Transplant | pmid:26497983 |
| Jóźwiak-Bębenista M et al. | The cyclic AMP effects and neuroprotective activities of PACAP and VIP in cultured astrocytes and neurons exposed to oxygen-glucose deprivation. | 2015 | Pharmacol Rep | pmid:25712659 |
| Kadlub N et al. | The calcineurin inhibitor tacrolimus as a new therapy in severe cherubism. | 2015 | J. Bone Miner. Res. | pmid:25491283 |
| Pucci N et al. | Tacrolimus vs. cyclosporine eyedrops in severe cyclosporine-resistant vernal keratoconjunctivitis: A randomized, comparative, double-blind, crossover study. | 2015 | Pediatr Allergy Immunol | pmid:25712437 |
| Katayama K et al. | Inhibition of radiographic joint damage in rheumatoid arthritis patients in DAS28 remission using single- or combined with methotrexate non biological disease-modifying antirheumatic drug therapy in routine clinical practice. | 2015 | Mod Rheumatol | pmid:24983407 |
| Kim KW et al. | The effect of mammalian target of rapamycin inhibition on T helper type 17 and regulatory T cell differentiation in vitro and in vivo in kidney transplant recipients. | 2015 | Immunology | pmid:24974886 |
| Yessayan L et al. | Race, Calcineurin Inhibitor Exposure, and Renal Function After Solid Organ Transplantation. | 2015 | Transplant. Proc. | pmid:26707323 |
| Yoon NY et al. | Topical glucocorticoid or pimecrolimus treatment suppresses thymic stromal lymphopoietin-related allergic inflammatory mechanism in an oxazolone-induced atopic dermatitis murine model. | 2015 | Arch. Dermatol. Res. | pmid:25786383 |
| Tanaka M et al. | Corticosteroid and tacrolimus treatment in neuromyelitis optica related disorders. | 2015 | Mult. Scler. | pmid:25662352 |
| Van der Perren A et al. | FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease. | 2015 | Neurobiol. Aging | pmid:25660193 |
| Wu SC et al. | Identification of Circulating miRNAs in a Mouse Model of Nerve Allograft Transplantation under FK506 Immunosuppression by Illumina Small RNA Deep Sequencing. | 2015 | Dis. Markers | pmid:26435568 |
| Okechuku G et al. | Anorexia nervosa in a pediatric renal transplant recipient and its reversal with cyclosporine. | 2015 | Pediatr Transplant | pmid:25661468 |
| Kume K et al. | Screening for a gene deletion mutant whose temperature sensitivity is suppressed by FK506 in budding yeast and its application for a positive screening for drugs inhibiting calcineurin. | 2015 | Biosci. Biotechnol. Biochem. | pmid:25614218 |
| Garnock-Jones KP | Tacrolimus prolonged release (Envarsus®): a review of its use in kidney and liver transplant recipients. | 2015 | Drugs | pmid:25613762 |
| Li CJ and Li L | Tacrolimus in preventing transplant rejection in Chinese patients--optimizing use. | 2015 | Drug Des Devel Ther | pmid:25609922 |
| Uemoto S et al. | Early coupled up-regulation of interleukin-12 receptor beta-1 in CD8+ central memory and effector T cells for better clinical outcomes in liver transplant recipients. | 2015 | Clin. Exp. Immunol. | pmid:25603847 |
| Dave CN et al. | Innovative use of intravesical tacrolimus for hemorrhagic radiation cystitis. | 2015 | Int Urol Nephrol | pmid:26347076 |
| Wu J et al. | MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes. | 2015 | J. Clin. Invest. | pmid:26436650 |
| Overk CR et al. | Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506. | 2015 | Neuroscience | pmid:26341908 |
| de Jonge H et al. | Progressive decline in tacrolimus clearance after renal transplantation is partially explained by decreasing CYP3A4 activity and increasing haematocrit. | 2015 | Br J Clin Pharmacol | pmid:26114223 |
| Kallscheuer N et al. | Single-Domain Peptidyl-Prolyl cis/trans Isomerase FkpA from Corynebacterium glutamicum Improves the Biomass Yield at Increased Growth Temperatures. | 2015 | Appl. Environ. Microbiol. | pmid:26341203 |
| Schnitzbauer AA et al. | Delayed bottom-up and amended simple method of dosing with once-daily tacrolimus application to achieve stable trough levels in liver transplantation. | 2015 | Ann. Transplant. | pmid:25553853 |
| Aruch DB and Renteria A | Simultaneous PRES and TMA secondary to tacrolimus after allogeneic bone marrow transplant. | 2015 | Blood | pmid:26287041 |
| Pagliarello C et al. | Calcipotriol/betamethasone dipropionate ointment compared with tacrolimus ointment for the treatment of erosive pustular dermatosis of the scalp: a split-lesion comparison. | 2015 | Eur J Dermatol | pmid:25786341 |
| Gong N et al. | Immunoregulatory effects of sirolimus vs. tacrolimus treatment in kidney allograft recipients. | 2015 | Cell. Immunol. | pmid:26205091 |
| Chamani G et al. | Efficacy of tacrolimus and clobetasol in the treatment of oral lichen planus: a systematic review and meta-analysis. | 2015 | Int. J. Dermatol. | pmid:26204904 |
| Muduma G et al. | Evaluating the economic implications of non-adherence and antibody-mediated rejection in renal transplant recipients: the role of once-daily tacrolimus in the UK. | 2015 | J Med Econ | pmid:26201252 |
| Mizuno K et al. | Dexamethasone but not tacrolimus suppresses TNF-α-induced thymic stromal lymphopoietin expression in lesional keratinocytes of atopic dermatitis model. | 2015 | J. Dermatol. Sci. | pmid:26198442 |
| Rathi M et al. | Conversion from tacrolimus to cyclosporine in patients with new-onset diabetes after renal transplant: an open-label randomized prospective pilot study. | 2015 | Transplant. Proc. | pmid:26036543 |
| Mohsin N et al. | Pharmacokinetics of mycophenolate mofetil in Omani patients on cyclosporine or tacrolimus. | 2015 | Transplant. Proc. | pmid:26036534 |
| Rivinius R et al. | Analysis of malignancies in patients after heart transplantation with subsequent immunosuppressive therapy. | 2015 | Drug Des Devel Ther | pmid:25552900 |
| Kabrine M and Laraba-Djebari F | Immunomodulatory and protective properties of tacrolimus in experimental scorpion envenomation. | 2014 Jan-Mar | Int J Immunopathol Pharmacol | pmid:24674680 |
| Wang C and Lin A | Efficacy of topical calcineurin inhibitors in psoriasis. | 2014 Jan-Feb | J Cutan Med Surg | pmid:24377467 |
| Feito-RodrÃguez M et al. | Bacterial vaginosis in the context of lichen sclerosus in a prepubertal girl. | 2014 Jan-Feb | Pediatr Dermatol | pmid:24125016 |
| Veisa G et al. | The importance of renal biopsy in the management of renal transplantation. | 2014 Apr-Jun | Rev Med Chir Soc Med Nat Iasi | pmid:25076703 |
| Mo D et al. | In vitro interactions of calcineurin inhibitors with conventional antifungal agents against the yeast form of Penicillium marneffei. | 2014 | Mycopathologia | pmid:25052248 |
| Silva HT et al. | Long-term follow-up of a phase III clinical trial comparing tacrolimus extended-release/MMF, tacrolimus/MMF, and cyclosporine/MMF in de novo kidney transplant recipients. | 2014 | Transplantation | pmid:24521771 |
| Alloway RR et al. | Conversion from twice daily tacrolimus capsules to once daily extended-release tacrolimus (LCP-Tacro): phase 2 trial of stable liver transplant recipients. | 2014 | Liver Transpl. | pmid:24493215 |
| Tsuchimoto A et al. | Urinary neutrophil gelatinase-associated lipocalin: a useful biomarker for tacrolimus-induced acute kidney injury in liver transplant patients. | 2014 | PLoS ONE | pmid:25329716 |
| Danby SG et al. | The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis. | 2014 | Br. J. Dermatol. | pmid:24328907 |
| Tavira B et al. | Mitochondrial DNA haplogroups and risk of new-onset diabetes among tacrolimus-treated renal transplanted patients. | 2014 | Gene | pmid:24445060 |
| Kato H et al. | Significant improvement of Takayasu arteritis after cord blood transplantation in a patient with myelodysplastic syndrome. | 2014 | Bone Marrow Transplant. | pmid:24317130 |
| Barreiro C and MartÃnez-Castro M | Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506). | 2014 | Appl. Microbiol. Biotechnol. | pmid:24272367 |
| Budde K et al. | Novel once-daily extended-release tacrolimus (LCPT) versus twice-daily tacrolimus in de novo kidney transplants: one-year results of Phase III, double-blind, randomized trial. | 2014 | Am. J. Transplant. | pmid:25278376 |
| Xu W et al. | Toward immunosuppressive effects on liver transplantation in rat model: tacrolimus loaded poly(ethylene glycol)-poly(D,L-lactide) nanoparticle with longer survival time. | 2014 | Int J Pharm | pmid:24172796 |
| Gomez-Moyano E et al. | Periorbital granuloma annulare successfully treated with tacrolimus 0.1% ointment. | 2014 | Int. J. Dermatol. | pmid:23432464 |
| Posadas Salas MA and Srinivas TR | Update on the clinical utility of once-daily tacrolimus in the management of transplantation. | 2014 | Drug Des Devel Ther | pmid:25210441 |
| Nasu R et al. | Favorable outcomes of tacrolimus compared with cyclosporine A for GVHD prophylaxis in HSCT for standard-risk hematological diseases. | 2014 | Ann. Hematol. | pmid:24590535 |
| Taber DJ et al. | Significant racial differences in the key factors associated with early graft loss in kidney transplant recipients. | 2014 | Am. J. Nephrol. | pmid:24969370 |
| Keniya MV et al. | Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5. | 2014 | Mol. Pharm. | pmid:25115303 |
| Ko SF et al. | Therapeutic potential of tacrolimus on acute myocardial infarction in minipigs: analysis with serial cardiac magnetic resonance and changes at histological and protein levels. | 2014 | Biomed Res Int | pmid:25114905 |
| Oh CK et al. | Safety and efficacy of conversion from twice-daily tacrolimus to once-daily tacrolimus one month after transplantation: randomized controlled trial in adult renal transplantation. | 2014 | Yonsei Med. J. | pmid:25048494 |
| Piao SG et al. | Combined treatment of tacrolimus and everolimus increases oxidative stress by pharmacological interactions. | 2014 | Transplantation | pmid:24825522 |
| Gujadhur A et al. | CMV sinusitis in a HIV-negative renal transplant recipient. | 2014 | Transplantation | pmid:24827770 |
| Navas-López VM et al. | Oral tacrolimus for pediatric steroid-resistant ulcerative colitis. | 2014 | J Crohns Colitis | pmid:23582736 |
| Ohe M et al. | Successful treatment with tacrolimus of refractory adult-onset Still's disease. | 2014 | Korean J. Intern. Med. | pmid:24648814 |
| Toniutto P et al. | Biliary strictures after liver transplantation: role of interleukin 28B genotypes in cyclosporine treated. | 2014 | Int J Surg | pmid:25219480 |
| Langone A et al. | Long-term dosing patterns of enteric-coated mycophenolate sodium or mycophenolate mofetil with tacrolimus after renal transplantation. | 2014 | Clin Transplant | pmid:24893821 |
| Tümgör G et al. | A case of uneventful ABO-incompatible liver transplantation from a deceased donor managed with routine immunosuppressive treatment. | 2014 | Turk J Gastroenterol | pmid:25599790 |
| Korbel L et al. | Clinically relevant pharmacogenomic testing in pediatric practice. | 2014 | Clin Pediatr (Phila) | pmid:24803633 |
| Chung BH et al. | Decrease of immature B cell and interleukin-10 during early-post-transplant period in renal transplant recipients under tacrolimus based immunosuppression. | 2014 | Transpl. Immunol. | pmid:24709525 |
| Al-Kadhimi Z et al. | High incidence of severe acute graft-versus-host disease with tacrolimus and mycophenolate mofetil in a large cohort of related and unrelated allogeneic transplantation patients. | 2014 | Biol. Blood Marrow Transplant. | pmid:24709007 |
| Hässig A et al. | Association of BK viremia with human leukocyte antigen mismatches and acute rejection, but not with type of calcineurin inhibitor. | 2014 | Transpl Infect Dis | pmid:24134704 |
| Manousou P et al. | Reduced fibrosis in recurrent HCV with tacrolimus, azathioprine and steroids versus tacrolimus: randomised trial long term outcomes. | 2014 | Gut | pmid:24131637 |