| MeSH term | MeSH ID | Detail |
|---|---|---|
| Heart Failure | D006333 | 36 associated lipids |
| Angioedema | D000799 | 6 associated lipids |
| Fractures, Spontaneous | D005598 | 4 associated lipids |
| Hydronephrosis | D006869 | 4 associated lipids |
| Trypanosomiasis | D014352 | 5 associated lipids |
| Alopecia | D000505 | 14 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Corneal Diseases | D003316 | 13 associated lipids |
| Testicular Diseases | D013733 | 15 associated lipids |
| Facial Dermatoses | D005148 | 7 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Swanson C et al. | FK 506-based immunosuppression in clinical pancreas transplantation. | 1995 | Transplant. Proc. | pmid:8539827 |
| Tesi RJ et al. | Conversion of pancreas transplants to FK 506 from CsA. | 1995 | Transplant. Proc. | pmid:8539828 |
| Burke GW et al. | Use of FK 506 in simultaneous pancreas/kidney transplantation: lack of impairment of glycemic or lipid metabolism. | 1995 | Transplant. Proc. | pmid:8539872 |
| Burke GW et al. | The use of FK506 in simultaneous pancreas/kidney transplantation: rescue, induction, and maintenance immunosuppression. | 1995 | Transplant. Proc. | pmid:8539874 |
| Wennberg L et al. | Immunosuppression with leflunomide and cyclosporine prevents pig-to-rat islet xenograft rejection. | 1995 | Transplant. Proc. | pmid:8539967 |
| Klintmalm GB and Gonwa TA | Nephrotoxicity associated with cyclosporine and FK506. | 1995 | Liver Transpl Surg | pmid:9346596 |
| Wong PY et al. | FK506 in liver transplantation for chronic hepatitis B: in vitro studies on lymphocyte activation and virus replication. | 1995 | Liver Transpl Surg | pmid:9346613 |
| Todo S et al. | Abdominal multivisceral transplantation. | 1995 | Transplantation | pmid:7530873 |
| Monfar M et al. | Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP. | 1995 | Mol. Cell. Biol. | pmid:7528328 |
| Fukuzaki T et al. | A protocol with FK 506 for inducing unresponsiveness to murine islet allografts. | 1995 | Surgery | pmid:7531371 |
| Lemster BH et al. | IL-8/IL-8 receptor expression in psoriasis and the response to systemic tacrolimus (FK506) therapy. | 1995 | Clin. Exp. Immunol. | pmid:7531627 |
| Timerman AP et al. | Characterization of an exchange reaction between soluble FKBP-12 and the FKBP.ryanodine receptor complex. Modulation by FKBP mutants deficient in peptidyl-prolyl isomerase activity. | 1995 | J. Biol. Chem. | pmid:7531689 |
| Hamasaki Y et al. | Inhibition of leukotriene production by FK506 in rat basophilic leukemia-1 cells. | 1995 | Pharmacology | pmid:7538218 |
| Jain AB et al. | One thousand consecutive primary orthotopic liver transplants under FK 506: survival and adverse events. | 1995 | Transplant. Proc. | pmid:7533353 |
| Rucay P et al. | FK 506 as treatment of late acute rejection in liver transplant patients. | 1995 | Transplant. Proc. | pmid:7533354 |
| Schwartz M et al. | FK 506 in liver transplantation: correlation of whole blood levels with efficacy and toxicity. The US Multicenter FK 506 Dose Optimization. | 1995 | Transplant. Proc. | pmid:7533355 |
| Yasuhara M et al. | Pharmacokinetics and pharmacodynamics of FK 506 in pediatric patients receiving living-related donor liver transplantations. | 1995 | Transplant. Proc. | pmid:7533356 |
| Platz KP et al. | OKT3 vs FK 506 rescue management of acute steroid-resistant and chronic rejection. | 1995 | Transplant. Proc. | pmid:7533357 |
| Bierer BE | Mechanisms of action of immunosuppressive agents: cyclosporin A, FK506, and rapamycin. | 1995 | Proc. Assoc. Am. Physicians | pmid:8630742 |
| Porayko MK et al. | Comparing nephrotoxicity of FK 506 and cyclosporine regimens after liver transplantation: preliminary results from US Multicenter trial. U.S. Multicenter Liver Study Group. | 1995 | Transplant. Proc. | pmid:7533358 |
| Mueller AR et al. | The superior immunosuppressant according to diagnosis: FK 506 or cyclosporine A. | 1995 | Transplant. Proc. | pmid:7533359 |
| Abouljoud MS et al. | Hyperlipidemia after liver transplantation: long-term results of the FK506/cyclosporine A US Multicenter Trial. US Multicenter Study Group. | 1995 | Transplant. Proc. | pmid:7533360 |
| Chakraborty TK et al. | Design and synthesis of a rapamycin-based high affinity binding FKBP12 ligand. | 1995 | Chem. Biol. | pmid:9383417 |
| Kuroki H and Ikuta Y | Nerve regeneration of vascularized rat limb allograft and functional recovery of long-term graft survivals treated by short course of FK 506 or cyclosporine. | 1995 | Transplant. Proc. | pmid:7533405 |
| Ko S et al. | Significance of newly developed liposomal FK 506 in canine liver transplantation. | 1995 | Transplant. Proc. | pmid:7533406 |
| Fukuzaki T et al. | Induction of unresponsiveness to islet allografts with donor spleen cell inoculation followed by a single injection of FK 506. | 1995 | Transplant. Proc. | pmid:7533407 |
| Grochowicz PM et al. | Synergism of castanospermine and FK 506. | 1995 | Transplant. Proc. | pmid:7533408 |
| Itoh S and Navia MA | Structure comparison of native and mutant human recombinant FKBP12 complexes with the immunosuppressant drug FK506 (tacrolimus). | 1995 | Protein Sci. | pmid:8563622 |
| Tamura K et al. | Inhibition of insulin production by FK 506 is caused at the transcriptional level in pancreatic beta cell when FK BP-12 content is relatively high. | 1995 | Transplant. Proc. | pmid:7533409 |
| Kawano K et al. | Protective effect of FK 506 on hepatic injury following cold ischemic preservation and transplantation: influence on hepatic microcirculation. | 1995 | Transplant. Proc. | pmid:7533410 |
| Charters AR et al. | Developmental expression of FK506 binding proteins and calcineurin in rat brain. | 1995 | Biochem. Soc. Trans. | pmid:8566310 |
| Tanabe M et al. | Therapeutic synergism between low-dose FK 506 and antimetabolites in rat allogeneic heart transplantation. | 1995 | Transplant. Proc. | pmid:7533411 |
| Abu-Elmagd K et al. | The current status of hepatic transplantation at the University of Pittsburgh. | 1995 | Clin Transpl | pmid:8794262 |
| Masri MA | Comparative study of toxicity and efficacy of cyclosporine, cyclosporine G (OG37), FK 506, and rapamycin in BALB/c mice with fitted skin grafts. | 1995 | Transplant. Proc. | pmid:7533412 |
| Shapiro R et al. | The superiority of tacrolimus in renal transplant recipients -- the Pittsburgh experience. | 1995 | Clin Transpl | pmid:8794266 |
| Jiang H et al. | Immunosuppressive effects of FK 506 on rat renal allograft survival, in comparison with cyclosporine. | 1995 | Transplant. Proc. | pmid:7533413 |
| Sen J et al. | Expression and induction of nuclear factor-kappa B-related proteins in thymocytes. | 1995 | J. Immunol. | pmid:7534792 |
| Hodgkiss JP and Kelly JS | Only 'de novo' long-term depression (LTD) in the rat hippocampus in vitro is blocked by the same low concentration of FK506 that blocks LTD in the visual cortex. | 1995 | Brain Res. | pmid:8821755 |
| Komori T | [The change of lymphocyte subset and effect of FK506 in experimental small bowel transplantation of rats]. | 1995 | Nihon Geka Gakkai Zasshi | pmid:7534867 |
| Woo J et al. | Combined effects of FK506 (tacrolimus) and cyclophosphamide on atypical B220+ T cells, cytokine gene expression and disease activity in MRL/MpJ-lpr/lpr mice. | 1995 | Clin. Exp. Immunol. | pmid:7535208 |
| Jusko WJ et al. | Pharmacokinetics of tacrolimus in liver transplant patients. | 1995 | Clin. Pharmacol. Ther. | pmid:7535213 |
| Ockenfels HM et al. | Cyclosporin A, FK506 and dithranol after tyrosine-specific protein phosphorylation in HaCaT keratinocytes. | 1995 | Arch. Dermatol. Res. | pmid:7541191 |
| Victor RG et al. | Presynaptic modulation of cortical synaptic activity by calcineurin. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7541535 |
| Mehta BA et al. | Two pathways of exocytosis of cytoplasmic granule contents and target cell killing by cytokine-induced CD3+ CD56+ killer cells. | 1995 | Blood | pmid:7579455 |
| Kaufman DB et al. | The successful use of tacrolimus (FK506) in a pancreas/kidney transplant recipient with recurrent cyclosporine-associated hemolytic uremic syndrome. | 1995 | Transplantation | pmid:7541579 |
| Hemenway C | FK506 in bone marrow transplantation. | 1995 | Blood | pmid:7579473 |
| McDiarmid SV et al. | The treatment of intractable rejection with tacrolimus (FK506) in pediatric liver transplant recipients. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:7541834 |
| Yamamoto M et al. | Cyclosporin A and FK506 reverse anthracycline resistance by altering the cell cycle. | 1995 | Anticancer Drugs | pmid:7579561 |
| Zhao Y and Iwata M | Cross-linking of the TCR-CD3 complex with CD4, CD8 or LFA-1 induces an anti-apoptotic signal in thymocytes: the signal is canceled by FK506. | 1995 | Int. Immunol. | pmid:7495746 |
| O'Gorman MA et al. | Proximal renal tubular acidosis secondary to FK506 in pediatric liver transplant patients. | 1995 | Clin Transplant | pmid:7579739 |
| Aono T et al. | Minimal threshold of FK 506 for enhancing liver regeneration in thymectomized rats. | 1995 | Transplant. Proc. | pmid:7536981 |
| Saito T et al. | In situ dephosphorylation of tau by protein phosphatase 2A and 2B in fetal rat primary cultured neurons. | 1995 | FEBS Lett. | pmid:7498550 |
| Kanamaru A et al. | FK506 treatment of graft-versus-host disease developing or exacerbating during prophylaxis and therapy with cyclosporin and/or other immunosuppressants. Japanese FK506 BMT Study Group. | 1995 | Bone Marrow Transplant. | pmid:7581086 |
| Iwabuchi T et al. | Effects of immunosuppressive peptidyl-prolyl cis-trans isomerase (PPIase) inhibitors, cyclosporin A, FK506, ascomycin and rapamycin, on hair growth initiation in mouse: immunosuppression is not required for new hair growth. | 1995 | J. Dermatol. Sci. | pmid:7537082 |
| Antoni FA et al. | Calcineurin feedback inhibition of agonist-evoked cAMP formation. | 1995 | J. Biol. Chem. | pmid:7499291 |
| Koehler MT et al. | FK506 (tacrolimus) in the treatment of steroid-resistant acute graft-versus-host disease in children undergoing bone marrow transplantation. | 1995 | Bone Marrow Transplant. | pmid:7581088 |
| Arnold JC and Theilmann L | [Comparison between tacrolimus (FK 506) and cyclosporin in immunosuppressive therapy after liver transplantation]. | 1995 | Z Gastroenterol | pmid:7502559 |
| Reisman L et al. | Modulation of interleukin-1 secretion by immunosuppressive drugs, alone and in combination. | 1995 | Transpl. Immunol. | pmid:7551978 |
| Osman A et al. | Schistosoma mansoni: characterization of p50, an immunophilin. | 1995 | Exp. Parasitol. | pmid:7537219 |
| Woo J et al. | Effects of FK 506 on chimerism and the induction of donor-specific unresponsiveness following fully allogeneic bone marrow transplantation in mice. | 1995 | Transpl. Immunol. | pmid:7551985 |
| Tanida I et al. | Cooperation of calcineurin and vacuolar H(+)-ATPase in intracellular Ca2+ homeostasis of yeast cells. | 1995 | J. Biol. Chem. | pmid:7537264 |
| Koch K et al. | The C-32 triacetyl-L-rhamnose derivative of ascomycin: a potent, orally active macrolactone immunosuppressant. | 1995 | J. Med. Chem. | pmid:7537331 |
| Torii N et al. | An inhibitor for calcineurin, FK506, blocks induction of long-term depression in rat visual cortex. | 1995 | Neurosci. Lett. | pmid:7537357 |
| Miyazawa H et al. | Hamster to rat kidney xenotransplantation. Effects of FK 506, cyclophosphamide, organ perfusion, and complement inhibition. | 1995 | Transplantation | pmid:7537396 |
| Pockley AG et al. | Effect of cyclosporin A, FK506 and rapamycin on proliferation and soluble IL-2 receptor release from mitogenically stimulated rat spleen cells. | 1995 | Biochem. Soc. Trans. | pmid:8654800 |
| Prud'homme GJ et al. | Effects of cyclosporin A, rapamycin, and FK520 on peripheral T-cell deletion and anergy. | 1995 | Cell. Immunol. | pmid:7543371 |
| Migita K et al. | FK506 augments activation-induced programmed cell death of T lymphocytes in vivo. | 1995 | J. Clin. Invest. | pmid:7543492 |
| Lhoëst G et al. | The in vitro immunosuppressive activity of the C15-demethylated metabolite of FK-506 is governed by ring- and open-chain tautomerism effects. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7543569 |
| Textor SC et al. | Urinary endothelin and renal vasoconstriction with cyclosporine or FK506 after liver transplantation. | 1995 | Kidney Int. | pmid:7543625 |
| Ko S et al. | The enhanced immunosuppressive efficacy of newly developed liposomal FK506 in canine liver transplantation. | 1995 | Transplantation | pmid:7539553 |
| Dollinger MM et al. | Tacrolimus and cardiotoxicity in adult liver transplant recipients. | 1995 | Lancet | pmid:7543645 |
| Fealy MJ et al. | Association of down-regulation of cytokine activity with rat hind limb allograft survival. | 1995 | Transplantation | pmid:7539555 |
| Romero DF et al. | Rapamycin: a bone sparing immunosuppressant? | 1995 | J. Bone Miner. Res. | pmid:7543725 |
| Rebollo A et al. | Differential effect of rapamycin and cyclosporin A in proliferation in a murine T cell line expressing either intermediate or high affinity receptor for IL-2. | 1995 | Cytokine | pmid:7543780 |
| Lam E et al. | Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs. | 1995 | Gene | pmid:7543869 |
| Hisatomi K et al. | Changes in the mononuclear cell subpopulations of rat cardiac transplant recipients administered FK506 for the treatment of ongoing rejection. | 1995 | Surg. Today | pmid:7539647 |
| Minamoto A et al. | Suppression of corneal graft rejection by subconjunctival injection of FK-506 in a rat model of penetrating keratoplasty. | 1995 | Jpn. J. Ophthalmol. | pmid:7543958 |
| Tamura K et al. | Transcriptional inhibition of insulin by FK506 and possible involvement of FK506 binding protein-12 in pancreatic beta-cell. | 1995 | Transplantation | pmid:7539960 |
| Fisher A et al. | FK506 hepatotoxicity in liver allograft recipients. | 1995 | Transplantation | pmid:7539961 |
| Nash RA et al. | Tacrolimus (FK506) alone or in combination with methotrexate or methylprednisolone for the prevention of acute graft-versus-host disease after marrow transplantation from HLA-matched siblings: a single-center study. | 1995 | Blood | pmid:7540071 |
| Taler SJ et al. | Loss of nocturnal blood pressure fall after liver transplantation during immunosuppressive therapy. | 1995 | Am. J. Hypertens. | pmid:7544983 |
| Teague S | Lessons from molecular matchmakers. | 1995 | Nat. Struct. Biol. | pmid:7545076 |
| Ito T et al. | Immunosuppressive agents induce the reduction of local pancreatic blood flow. | 1995 | Pancreas | pmid:7545292 |
| Zhang J and Steiner JP | Nitric oxide synthase, immunophilins and poly(ADP-ribose) synthetase: novel targets for the development of neuroprotective drugs. | 1995 | Neurol. Res. | pmid:7477744 |
| Han CW et al. | Differential effects of the immunosuppressants cyclosporin A, FK506 and KM2210 on cytokine gene expression. | 1995 | Bone Marrow Transplant. | pmid:7545487 |
| Jindal RM and Popescu I | Renal dysfunction associated with liver transplantation. | 1995 | Postgrad Med J | pmid:7479462 |
| Hattori Y and Nakanishi N | Effects of cyclosporin A and FK506 on nitric oxide and tetrahydrobiopterin synthesis in bacterial lipopolysaccharide-treated J774 macrophages. | 1995 | Cell. Immunol. | pmid:7545550 |
| Yeh WC et al. | Identification and characterization of an immunophilin expressed during the clonal expansion phase of adipocyte differentiation. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7479941 |
| Han JW et al. | Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites. | 1995 | J. Biol. Chem. | pmid:7545671 |
| Yeh WC et al. | Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7479942 |
| Ruff VA and Leach KL | Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody. | 1995 | J. Biol. Chem. | pmid:7545680 |
| Shaw KT et al. | Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7479966 |
| Annesley TM et al. | Stability of tacrolimus (FK 506) and cyclosporin G in whole blood. | 1995 | Ther Drug Monit | pmid:7482690 |
| Lampen A et al. | Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability. | 1995 | Drug Metab. Dispos. | pmid:8689938 |
| Lake JR et al. | The impact of immunosuppressive regimens on the cost of liver transplantation--results from the U.S. FK506 multicenter trial. | 1995 | Transplantation | pmid:7482713 |
| Mathew A et al. | Reversal of steroid-resistant rejection in renal allograft recipients using FK506. | 1995 | Transplantation | pmid:7482730 |
| Zhu D et al. | Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae. | 1995 | J. Biol. Chem. | pmid:7559604 |
| Hariharan S et al. | Conversion from cyclosporine to tacrolimus after pancreas transplantation. | 1995 | Transplant. Proc. | pmid:8539799 |
| Henley SE et al. | Lipids following pancreas transplantation in recipients receiving FK 506. | 1995 | Transplant. Proc. | pmid:8539809 |
| Stratta RJ et al. | Preliminary experience with FK 506 in pancreas transplant recipients. | 1995 | Transplant. Proc. | pmid:8539823 |