| MeSH term | MeSH ID | Detail |
|---|---|---|
| Heart Failure | D006333 | 36 associated lipids |
| Angioedema | D000799 | 6 associated lipids |
| Fractures, Spontaneous | D005598 | 4 associated lipids |
| Hydronephrosis | D006869 | 4 associated lipids |
| Trypanosomiasis | D014352 | 5 associated lipids |
| Alopecia | D000505 | 14 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Corneal Diseases | D003316 | 13 associated lipids |
| Testicular Diseases | D013733 | 15 associated lipids |
| Facial Dermatoses | D005148 | 7 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tanaka E and Yamanaka H | [DMARDs (disease-modifying antirheumatic drugs)]. | 2013 | Nippon Rinsho | pmid:23961667 |
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| Peddi VR et al. | Review of combination therapy with mTOR inhibitors and tacrolimus minimization after transplantation. | 2013 | Transplant Rev (Orlando) | pmid:23932018 |
| Ormaechea-Pérez N et al. | Superficial granulomatous pyoderma. Report of 2 cases treated with topical tacrolimus. | 2013 | Actas Dermosifiliogr | pmid:23933249 |
| Konofaos P and Terzis JK | FK506 and nerve regeneration: past, present, and future. | 2013 | J Reconstr Microsurg | pmid:23322540 |
| Payne SJ et al. | The efficacy of tacrolimus and sirolimus in heavily pre-treated unresectable thymic malignancies. | 2013 | Lung Cancer | pmid:23380223 |
| Bock ME et al. | Treatment of childhood nephrotic syndrome with long-term, low-dose tacrolimus. | 2013 | Clin. Nephrol. | pmid:23380387 |
| Andrades KM et al. | Modulation of Candida albicans virulence by antirejection immunosuppressant drugs. | 2013 | Transplantation | pmid:23380869 |
| Shilbayeh S et al. | The impact of CYP3A5 and MDR1 polymorphisms on tacrolimus dosage requirements and trough concentrations in pediatric renal transplant recipients. | 2013 | Saudi J Kidney Dis Transpl | pmid:24231473 |
| Legris T et al. | Humoral immunity after kidney transplantation: impact of two randomized immunosuppressive protocols. | 2013 | Ann. Transplant. | pmid:24231646 |
| Fan JY et al. | Noncanonical FK506-binding protein BDBT binds DBT to enhance its circadian function and forms foci at night. | 2013 | Neuron | pmid:24210908 |
| Saeki H | [Brief commentary on guidelines for the management of atopic dermatitis 2012 -the point of drug treatment]. | 2013 | Arerugi | pmid:24608647 |
| Herranz M et al. | Bioequivalence between generic tacrolimus products marketed in Spain by adjusted indirect comparison. | 2013 | Eur. J. Clin. Pharmacol. | pmid:23196824 |
| Ali MN et al. | Case series: hemolytic uremic syndrome--another cause of transplant dysfunction. | 2013 | Transplant. Proc. | pmid:24182801 |
| Michel M et al. | Protein phosphatase-dependent circadian regulation of intermediate-term associative memory. | 2013 | J. Neurosci. | pmid:23467376 |
| Grigoriu S et al. | The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin. | 2013 | PLoS Biol. | pmid:23468591 |
| Que J et al. | Effect of FK506 in reducing scar formation by inducing fibroblast apoptosis after sciatic nerve injury in rats. | 2013 | Cell Death Dis | pmid:23470533 |
| Chen YL et al. | Posaconazole exhibits in vitro and in vivo synergistic antifungal activity with caspofungin or FK506 against Candida albicans. | 2013 | PLoS ONE | pmid:23472097 |
| Tsukamoto H et al. | Infliximab salvage therapy for patients with ulcerative colitis who failed to respond to tacrolimus. | 2013 | Eur J Gastroenterol Hepatol | pmid:23411870 |
| Naniwa T et al. | Case report: successful use of short-term add-on tocilizumab for multirefractory systemic flare of adult-onset Still's disease. | 2013 | Clin. Rheumatol. | pmid:20842515 |
| Breckner A et al. | Effect of Calstabin1 depletion on calcium transients and energy utilization in muscle fibers and treatment opportunities with RyR1 stabilizers. | 2013 | PLoS ONE | pmid:24303040 |
| Zhang J et al. | Helminth protein vaccine induced follicular T helper cell for enhancement of humoral immunity against Schistosoma japonicum. | 2013 | Biomed Res Int | pmid:24308005 |
| Nakamura T et al. | Co-stimulation with bone morphogenetic protein-9 and FK506 induces remarkable osteoblastic differentiation in rat dedifferentiated fat cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:24064349 |
| Wu G et al. | Tacrolimus-induced encephalopathy and polyneuropathy in a renal transplant recipient. | 2013 | BMJ Case Rep | pmid:24311415 |
| Masri M et al. | Prograf five milligrams versus Tacrolimus medis in healthy volunteers: a bioequivalence study. | 2013 | Transplant. Proc. | pmid:24314930 |
| Elens L et al. | Impact of CYP3A4*22 allele on tacrolimus pharmacokinetics in early period after renal transplantation: toward updated genotype-based dosage guidelines. | 2013 | Ther Drug Monit | pmid:24052064 |
| Gordon S et al. | Success using tacrolimus in patients with proliferative and membranous lupus nephritis and refractory proteinuria. | 2013 | Hawaii J Med Public Health | pmid:24052913 |
| Lee SE et al. | Differential effects of topical corticosteroid and calcineurin inhibitor on the epidermal tight junction. | 2013 | Exp. Dermatol. | pmid:23174045 |
| Koster RA et al. | Fast LC-MS/MS analysis of tacrolimus, sirolimus, everolimus and cyclosporin A in dried blood spots and the influence of the hematocrit and immunosuppressant concentration on recovery. | 2013 | Talanta | pmid:24054560 |
| Sadilkova K et al. | Clinical validation and implementation of a multiplexed immunosuppressant assay in dried blood spots by LC-MS/MS. | 2013 | Clin. Chim. Acta | pmid:23473895 |
| Carassiti M and Antonelli S | PRES: clinical evidence or incidental finding? | 2013 | Minerva Anestesiol | pmid:23174927 |
| Welberry Smith MP et al. | Alemtuzumab induction in renal transplantation permits safe steroid avoidance with tacrolimus monotherapy: a randomized controlled trial. | 2013 | Transplantation | pmid:24056618 |
| Yarur A and Kane SV | Update on pregnancy and breastfeeding in the era of biologics. | 2013 | Dig Liver Dis | pmid:23474350 |
| Bosó V et al. | Increased hospital stay and allograft dysfunction in renal transplant recipients with Cyp2c19 AA variant in SNP rs4244285. | 2013 | Drug Metab. Dispos. | pmid:23175667 |
| Schnider JT et al. | Site-specific immunosuppression in vascularized composite allotransplantation: prospects and potential. | 2013 | Clin. Dev. Immunol. | pmid:23476677 |
| Pereira-Lopes O et al. | Periodontal inflammation in renal transplant recipients receiving everolimus or tacrolimus - preliminary results. | 2013 | Oral Dis | pmid:23448098 |
| Bouamar R et al. | Tacrolimus predose concentrations do not predict the risk of acute rejection after renal transplantation: a pooled analysis from three randomized-controlled clinical trials(†). | 2013 | Am. J. Transplant. | pmid:23480233 |
| Nirmal J et al. | Development of potential orphan drug therapy of intravesical liposomal tacrolimus for hemorrhagic cystitis due to increased local drug exposure. | 2013 | J. Urol. | pmid:23127767 |
| Okada K et al. | Vialinin A is a ubiquitin-specific peptidase inhibitor. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23791076 |
| Kanzaki T et al. | Long-term therapeutic effects and safety of tacrolimus added to methotrexate in patients with rheumatoid arthritis. | 2013 | Rheumatol. Int. | pmid:22806421 |
| Goldust M et al. | Treatment of seborrheic dermatitis: the efficiency of sertaconazole 2% cream vs. tacrolimus 0.03% cream. | 2013 | Ann Parasitol | pmid:24171300 |
| Kato M et al. | Pneumocystis pneumonia induced by treatment with low-dose tacrolimus and methylprednisolone in a patient with rheumatoid arthritis: a case report. | 2013 | BMC Res Notes | pmid:24289285 |
| Hillen U et al. | Tumor regression and sirolimus-based therapy in lung transplantation. | 2013 | J. Heart Lung Transplant. | pmid:23953823 |
| Watanabe M et al. | Efficacy of DHMEQ, a NF-κB inhibitor, in islet transplantation: II. Induction DHMEQ treatment ameliorates subsequent alloimmune responses and permits long-term islet allograft acceptance. | 2013 | Transplantation | pmid:23860082 |
| Annunziato RA et al. | Strangers headed to a strange land? A pilot study of using a transition coordinator to improve transfer from pediatric to adult services. | 2013 | J. Pediatr. | pmid:23993138 |
| Kim YC et al. | Tacrolimus decreases albuminuria in patients with IgA nephropathy and normal blood pressure: a double-blind randomized controlled trial of efficacy of tacrolimus on IgA nephropathy. | 2013 | PLoS ONE | pmid:23977072 |
| Mok CC et al. | Combined low-dose mycophenolate mofetil and tacrolimus for lupus nephritis with suboptimal response to standard therapy: a 12-month prospective study. | 2013 | Lupus | pmid:23995863 |
| Bumbacea RS and Ghiordanescu I | Atopic dermatitis induced by systemic immunosupression with tacrolimus--case report. | 2013 | Eur Ann Allergy Clin Immunol | pmid:23862401 |
| Sartori-Valinotti JC et al. | A 10-year review of otic lichen planus: the Mayo Clinic experience. | 2013 | JAMA Dermatol | pmid:23824252 |
| Zhang JJ et al. | Effect of the P450 oxidoreductase 28 polymorphism on the pharmacokinetics of tacrolimus in Chinese healthy male volunteers. | 2013 | Eur. J. Clin. Pharmacol. | pmid:23097010 |
| Stefos GC et al. | NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect. | 2013 | PLoS ONE | pmid:23825664 |
| Elfadawy N et al. | The impact of surveillance and rapid reduction in immunosuppression to control BK virus-related graft injury in kidney transplantation. | 2013 | Transpl. Int. | pmid:23763289 |
| Wang NK et al. | Origin of fundus hyperautofluorescent spots and their role in retinal degeneration in a mouse model of Goldmann-Favre syndrome. | 2013 | Dis Model Mech | pmid:23828046 |
| Li X et al. | Tacrolimus as rescue therapy for adult-onset refractory minimal change nephrotic syndrome with reversible acute renal failure. | 2013 | Nephrol. Dial. Transplant. | pmid:23787554 |
| Onumah N and Kircik L | Pimecrolimus cream and Tacrolimus ointment in the treatment of atopic dermatitis: a pilot study on patient preference. | 2013 | J Drugs Dermatol | pmid:24085050 |
| Willems MC et al. | Tacrolimus does not affect early wound healing in a rodent model of bowel anastomoses and abdominal wall closure. | 2013 | PLoS ONE | pmid:24086731 |
| Musuamba FT et al. | Statistical tools for dose individualization of mycophenolic acid and tacrolimus co-administered during the first month after renal transplantation. | 2013 | Br J Clin Pharmacol | pmid:23072565 |
| Zahn A et al. | Mycophenolate mofetil combination therapy improves survival after liver transplantation. A single-center retrospective analysis. | 2013 | Ann. Transplant. | pmid:24088725 |
| Wang Y et al. | Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control. | 2013 | J. Med. Chem. | pmid:23647266 |
| Sánchez M et al. | Membranous glomerulonephritis in a patient with Hodgkin's lymphoma in remission. | 2013 | Nefrologia | pmid:24089174 |
| Wong VW et al. | Tacrolimus fails to regulate collagen expression in dermal fibroblasts. | 2013 | J. Surg. Res. | pmid:23647800 |
| Baradaran-Rafii A et al. | Complications of keratolimbal allograft surgery. | 2013 | Cornea | pmid:23073489 |
| Kishi K et al. | [Successful effect of tacrolimus in a 5-year-old boy presenting with repeated episodes of non-herpetic acute limbic encephalitis]. | 2013 | No To Hattatsu | pmid:23650823 |
| Rodriguez-Rodriguez AE et al. | The higher diabetogenic risk of tacrolimus depends on pre-existing insulin resistance. A study in obese and lean Zucker rats. | 2013 | Am. J. Transplant. | pmid:23651473 |
| Yuan H et al. | Effect of prolonged tacrolimus treatment in idiopathic membranous nephropathy with nephrotic syndrome. | 2013 | Pharmacology | pmid:23652322 |
| Tirado-Sánchez A and Ponce-Olivera RM | Tacrolimus in confluent and reticulated papillomatosis of Gougerot Carteaud. | 2013 | Int. J. Dermatol. | pmid:22512695 |
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| Goyal RK et al. | Sirolimus pharmacokinetics in early postmyeloablative pediatric blood and marrow transplantation. | 2013 | Biol. Blood Marrow Transplant. | pmid:23266742 |
| Hickey MD et al. | Use of rifabutin for the treatment of a latent tuberculosis infection in a patient after solid organ transplantation. | 2013 | Liver Transpl. | pmid:23526600 |
| Lee WJ et al. | Penile lichen nitidus successfully treated with topical pimecrolimus 1% cream. | 2013 | J. Dermatol. | pmid:23551296 |
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| Cadou A et al. | The Kin1 kinase and the calcineurin phosphatase cooperate to link actin ring assembly and septum synthesis in fission yeast. | 2013 | Biol. Cell | pmid:23294323 |
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| Lin W et al. | Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis. | 2013 | J. Neurosci. | pmid:23554479 |
| Niioka T et al. | A limited sampling strategy to estimate the area under the concentration-time curve of tacrolimus modified-release once-daily preparation in renal transplant recipients. | 2013 | Ther Drug Monit | pmid:23296097 |
| Najera JE et al. | Akinetic mutism-a serious complication to tacrolimus-based GVHD prophylaxis. | 2013 | Bone Marrow Transplant. | pmid:22705799 |
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| Caplan AL | Ensuring the future of uterine transplantation. | 2013 | Fertil. Steril. | pmid:23200690 |
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| Acquazzino MA et al. | Refractory autoimmune hemolytic anemia after intestinal transplant responding to conversion from a calcineurin to mTOR inhibitor. | 2013 | Pediatr Transplant | pmid:23730873 |
| Kim HY et al. | The imbalance of T helper 17/regulatory T cells and memory B cells during the early post-transplantation period in peripheral blood of living donor liver transplantation recipients under calcineurin inhibitor-based immunosuppression. | 2013 | Immunology | pmid:23205589 |
| Ramos E et al. | Post-transplant lymphoproliferative disorders and other malignancies after pediatric intestinal transplantation: incidence, clinical features and outcome. | 2013 | Pediatr Transplant | pmid:23730927 |
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| Patsatsi A et al. | A therapeutic approach for female, relapsing genital lichen sclerosus: a single-center study. | 2013 | J Dermatolog Treat | pmid:23164046 |
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| Kim TW et al. | Proactive treatment of adult facial seborrhoeic dermatitis with 0.1% tacrolimus ointment: randomized, double-blind, vehicle-controlled, multi-centre trial. | 2013 | Acta Derm. Venereol. | pmid:23388687 |
| de Sandes-Freitas TV et al. | Basiliximab induction in patients receiving tacrolimus-based immunosuppressive regimens. | 2013 | Int Urol Nephrol | pmid:23054318 |
| Tatar E et al. | Pre-transplant HbA1c level as an early marker for new-onset diabetes after renal transplantation. | 2013 | Int Urol Nephrol | pmid:23054321 |
| Kim DH et al. | Mutational biosynthesis of tacrolimus analogues by fkbO deletion mutant of Streptomyces sp. KCTC 11604BP. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23392766 |
| Lee YJ et al. | Application for tacrolimus ointment in treating refractory inflammatory ocular surface diseases. | 2013 | Am. J. Ophthalmol. | pmid:23394907 |
| Boyer O et al. | Renal function and histology in children after small bowel transplantation. | 2013 | Pediatr Transplant | pmid:22882667 |