| MeSH term | MeSH ID | Detail |
|---|---|---|
| Heart Failure | D006333 | 36 associated lipids |
| Angioedema | D000799 | 6 associated lipids |
| Fractures, Spontaneous | D005598 | 4 associated lipids |
| Hydronephrosis | D006869 | 4 associated lipids |
| Trypanosomiasis | D014352 | 5 associated lipids |
| Alopecia | D000505 | 14 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Corneal Diseases | D003316 | 13 associated lipids |
| Testicular Diseases | D013733 | 15 associated lipids |
| Facial Dermatoses | D005148 | 7 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Uslu Gokceoglu A et al. | Hyperuricemia in pediatric renal transplant recipients. | 2013 | Exp Clin Transplant | pmid:24344940 |
| Peddi VR et al. | Review of combination therapy with mTOR inhibitors and tacrolimus minimization after transplantation. | 2013 | Transplant Rev (Orlando) | pmid:23932018 |
| Gulleroglu K et al. | Sudden hearing loss associated with tacrolimus after pediatric renal transplant. | 2013 | Exp Clin Transplant | pmid:24344948 |
| Ormaechea-Pérez N et al. | Superficial granulomatous pyoderma. Report of 2 cases treated with topical tacrolimus. | 2013 | Actas Dermosifiliogr | pmid:23933249 |
| Posadas Salas MA et al. | Critical analysis of valganciclovir dosing and renal function on the development of cytomegalovirus infection in kidney transplantation. | 2013 | Transpl Infect Dis | pmid:24010993 |
| Garg V et al. | Topical tacrolimus nanoemulsion, a promising therapeutic approach for uveitis. | 2013 | Med. Hypotheses | pmid:24018283 |
| Bock ME et al. | Treatment of childhood nephrotic syndrome with long-term, low-dose tacrolimus. | 2013 | Clin. Nephrol. | pmid:23380387 |
| Gökceoğlu AU et al. | Circulating endothelial cells in pediatric renal transplant recipients. | 2013 | Pediatr. Nephrol. | pmid:24018796 |
| Andrades KM et al. | Modulation of Candida albicans virulence by antirejection immunosuppressant drugs. | 2013 | Transplantation | pmid:23380869 |
| Adams PS et al. | Postoperative cardiac tamponade after kidney transplantation: a possible consequence of alemtuzumab-induced cytokine release syndrome. | 2013 | Transplantation | pmid:23380870 |
| Danielsen AA et al. | Splice cassette II of Na+,HCO3(-) cotransporter NBCn1 (slc4a7) interacts with calcineurin A: implications for transporter activity and intracellular pH control during rat artery contractions. | 2013 | J. Biol. Chem. | pmid:23382378 |
| Cardona M et al. | [Association of everolimus with tacrolimus during the first year after heart transplantation: initial experience]. | 2013 | Med Clin (Barc) | pmid:23384432 |
| Yildirim R et al. | Treatment of pure red-cell aplasia with cyclosporine in a renal transplant patient. | 2013 | Exp Clin Transplant | pmid:22891934 |
| Chen W et al. | Outcomes of tacrolimus therapy in adults with refractory membranous nephrotic syndrome: a prospective, multicenter clinical trial. | 2013 | Am. J. Med. Sci. | pmid:22627258 |
| Saeki H | [Brief commentary on guidelines for the management of atopic dermatitis 2012 -the point of drug treatment]. | 2013 | Arerugi | pmid:24608647 |
| Ali MN et al. | Case series: hemolytic uremic syndrome--another cause of transplant dysfunction. | 2013 | Transplant. Proc. | pmid:24182801 |
| Mizuno S et al. | Immunological aspects in late phase of living donor liver transplant patients: usefulness of monitoring peripheral blood CD4+ adenosine triphosphate activity. | 2013 | Clin. Dev. Immunol. | pmid:24187567 |
| Uesugi M et al. | Influence of cytochrome P450 (CYP) 3A4*1G polymorphism on the pharmacokinetics of tacrolimus, probability of acute cellular rejection, and mRNA expression level of CYP3A5 rather than CYP3A4 in living-donor liver transplant patients. | 2013 | Biol. Pharm. Bull. | pmid:24189425 |
| Nakase H | [Tacrolimus therapy for patients with ulcerative colitis]. | 2013 | Nihon Shokakibyo Gakkai Zasshi | pmid:24189819 |
| Tsukamoto H et al. | Infliximab salvage therapy for patients with ulcerative colitis who failed to respond to tacrolimus. | 2013 | Eur J Gastroenterol Hepatol | pmid:23411870 |
| Kaczmarek I et al. | Tacrolimus with mycophenolate mofetil or sirolimus compared with calcineurin inhibitor-free immunosuppression (sirolimus/mycophenolate mofetil) after heart transplantation: 5-year results. | 2013 | J. Heart Lung Transplant. | pmid:23415313 |
| Beckebaum S et al. | Calcineurin inhibitors in liver transplantation - still champions or threatened by serious competitors? | 2013 | Liver Int. | pmid:23442173 |
| Kovacs D et al. | Follow up of lung transplant recipients using an electronic nose. | 2013 | J Breath Res | pmid:23445553 |
| Li H et al. | Immunosuppressant-related hip pain after orthotopic liver transplant. | 2013 | Exp Clin Transplant | pmid:22813534 |
| Zhang J et al. | Helminth protein vaccine induced follicular T helper cell for enhancement of humoral immunity against Schistosoma japonicum. | 2013 | Biomed Res Int | pmid:24308005 |
| Wu G et al. | Tacrolimus-induced encephalopathy and polyneuropathy in a renal transplant recipient. | 2013 | BMJ Case Rep | pmid:24311415 |
| Masri M et al. | Prograf five milligrams versus Tacrolimus medis in healthy volunteers: a bioequivalence study. | 2013 | Transplant. Proc. | pmid:24314930 |
| Laftavi MR et al. | African American renal transplant recipients (RTR) require higher tacrolimus doses to achieve target levels compared to white RTR: does clotrimazole help? | 2013 | Transplant. Proc. | pmid:24314941 |
| Gordon S et al. | Success using tacrolimus in patients with proliferative and membranous lupus nephritis and refractory proteinuria. | 2013 | Hawaii J Med Public Health | pmid:24052913 |
| Marente VC et al. | Modigraf administration through jejunostomy in liver transplant recipient: case report. | 2013 | Transplant. Proc. | pmid:24314992 |
| Koster RA et al. | Fast LC-MS/MS analysis of tacrolimus, sirolimus, everolimus and cyclosporin A in dried blood spots and the influence of the hematocrit and immunosuppressant concentration on recovery. | 2013 | Talanta | pmid:24054560 |
| Welberry Smith MP et al. | Alemtuzumab induction in renal transplantation permits safe steroid avoidance with tacrolimus monotherapy: a randomized controlled trial. | 2013 | Transplantation | pmid:24056618 |
| König S et al. | Inhibition of Orai1-mediated Ca(2+) entry is a key mechanism of the antiproliferative action of sirolimus in human arterial smooth muscle. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:24056904 |
| Sun JY et al. | [Association of CYP3A5 and MDR1 genetic polymorphisms with the blood concentration of tacrolimus in Chinese liver and renal transplant recipients]. | 2013 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:24059111 |
| Pereira-Lopes O et al. | Periodontal inflammation in renal transplant recipients receiving everolimus or tacrolimus - preliminary results. | 2013 | Oral Dis | pmid:23448098 |
| Bouamar R et al. | Tacrolimus predose concentrations do not predict the risk of acute rejection after renal transplantation: a pooled analysis from three randomized-controlled clinical trials(†). | 2013 | Am. J. Transplant. | pmid:23480233 |
| Nirmal J et al. | Development of potential orphan drug therapy of intravesical liposomal tacrolimus for hemorrhagic cystitis due to increased local drug exposure. | 2013 | J. Urol. | pmid:23127767 |
| Choe JY et al. | Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes. | 2013 | Arthritis Res. Ther. | pmid:23406906 |
| Okada K et al. | Vialinin A is a ubiquitin-specific peptidase inhibitor. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23791076 |
| Orange DE et al. | Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo. | 2013 | Elife | pmid:23390586 |
| Roan JN et al. | Dose-normalization for exposure to mycophenolic acid and the early clinical outcome in patients taking tacrolimus after heart transplantation. | 2013 | Ann. Transplant. | pmid:23792500 |
| Kanzaki T et al. | Long-term therapeutic effects and safety of tacrolimus added to methotrexate in patients with rheumatoid arthritis. | 2013 | Rheumatol. Int. | pmid:22806421 |
| Tanaka T et al. | Evaluation of immune function under conversion from Prograf to Advagraf in living donor liver transplantation. | 2013 | Ann. Transplant. | pmid:23792533 |
| Watanabe M et al. | Efficacy of DHMEQ, a NF-κB inhibitor, in islet transplantation: II. Induction DHMEQ treatment ameliorates subsequent alloimmune responses and permits long-term islet allograft acceptance. | 2013 | Transplantation | pmid:23860082 |
| Kim YC et al. | Tacrolimus decreases albuminuria in patients with IgA nephropathy and normal blood pressure: a double-blind randomized controlled trial of efficacy of tacrolimus on IgA nephropathy. | 2013 | PLoS ONE | pmid:23977072 |
| Bumbacea RS and Ghiordanescu I | Atopic dermatitis induced by systemic immunosupression with tacrolimus--case report. | 2013 | Eur Ann Allergy Clin Immunol | pmid:23862401 |
| Zhang JJ et al. | Effect of the P450 oxidoreductase 28 polymorphism on the pharmacokinetics of tacrolimus in Chinese healthy male volunteers. | 2013 | Eur. J. Clin. Pharmacol. | pmid:23097010 |
| Spiekerkoetter E et al. | FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. | 2013 | J. Clin. Invest. | pmid:23867624 |
| Ceresa CD et al. | Mesenchymal stromal cells promote bowel regeneration after intestinal transplantation: myth to mucosa. | 2013 | Transpl. Int. | pmid:23869998 |
| Pitarch G and Giner F | Periorbital necrobiosis lipoidica. | 2013 | Actas Dermosifiliogr | pmid:23871211 |
| Wang NK et al. | Origin of fundus hyperautofluorescent spots and their role in retinal degeneration in a mouse model of Goldmann-Favre syndrome. | 2013 | Dis Model Mech | pmid:23828046 |
| Li X et al. | Tacrolimus as rescue therapy for adult-onset refractory minimal change nephrotic syndrome with reversible acute renal failure. | 2013 | Nephrol. Dial. Transplant. | pmid:23787554 |
| Shirazi F and Kontoyiannis DP | The calcineurin pathway inhibitor tacrolimus enhances the in vitro activity of azoles against Mucorales via apoptosis. | 2013 | Eukaryotic Cell | pmid:23851337 |
| Prud'homme GJ et al. | GABA protects human islet cells against the deleterious effects of immunosuppressive drugs and exerts immunoinhibitory effects alone. | 2013 | Transplantation | pmid:23851932 |
| Hilbrands R et al. | Predictive factors of allosensitization after immunosuppressant withdrawal in recipients of long-term cultured islet cell grafts. | 2013 | Transplantation | pmid:23857001 |
| Zahn A et al. | Mycophenolate mofetil combination therapy improves survival after liver transplantation. A single-center retrospective analysis. | 2013 | Ann. Transplant. | pmid:24088725 |
| Sánchez M et al. | Membranous glomerulonephritis in a patient with Hodgkin's lymphoma in remission. | 2013 | Nefrologia | pmid:24089174 |
| Baradaran-Rafii A et al. | Complications of keratolimbal allograft surgery. | 2013 | Cornea | pmid:23073489 |
| Rajan S et al. | C-H…O hydrogen bonds in FK506-binding protein-ligand interactions. | 2013 | J. Mol. Recognit. | pmid:24089362 |
| Sung J et al. | Alemtuzumab induction with tacrolimus monotherapy in 25 pediatric renal transplant recipients. | 2013 | Pediatr Transplant | pmid:24164824 |
| Rodriguez-Rodriguez AE et al. | The higher diabetogenic risk of tacrolimus depends on pre-existing insulin resistance. A study in obese and lean Zucker rats. | 2013 | Am. J. Transplant. | pmid:23651473 |
| Im MS et al. | Diabetic ketoacidosis associated with acute pancreatitis in a heart transplant recipient treated with tacrolimus. | 2013 | Exp Clin Transplant | pmid:23075084 |
| Briem-Richter A et al. | Peripheral blood biomarkers for the characterization of alloimmune reactivity after pediatric liver transplantation. | 2013 | Pediatr Transplant | pmid:24164827 |
| Yuan H et al. | Effect of prolonged tacrolimus treatment in idiopathic membranous nephropathy with nephrotic syndrome. | 2013 | Pharmacology | pmid:23652322 |
| Shayani S et al. | Thrombotic microangiopathy associated with sirolimus level after allogeneic hematopoietic cell transplantation with tacrolimus/sirolimus-based graft-versus-host disease prophylaxis. | 2013 | Biol. Blood Marrow Transplant. | pmid:23078784 |
| Xu J et al. | Tacrolimus combined with corticosteroids in idiopathic membranous nephropathy: a randomized, prospective, controlled trial. | 2013 | Contrib Nephrol | pmid:23689577 |
| Li J et al. | Evaluation of mycophenolic acid exposure using a limited sampling strategy in renal transplant recipients. | 2013 | Am. J. Nephrol. | pmid:23689735 |
| Lower DR et al. | Comparison of CEDIA FK506 assay with HPLC/MS/MS in a large cohort of pediatric patients. | 2013 | Am. J. Clin. Pathol. | pmid:23690122 |
| Dai Y et al. | Liposomes containing bile salts as novel ocular delivery systems for tacrolimus (FK506): in vitro characterization and improved corneal permeation. | 2013 | Int J Nanomedicine | pmid:23690687 |
| Rerknimitr P et al. | Topical tacrolimus significantly promotes repigmentation in idiopathic guttate hypomelanosis: a double-blind, randomized, placebo-controlled study. | 2013 | J Eur Acad Dermatol Venereol | pmid:22324720 |
| Barequet IS et al. | Topical tacrolimus for the management of acute allergic conjunctivitis in a mouse model. | 2013 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:23553288 |
| Lin W et al. | Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis. | 2013 | J. Neurosci. | pmid:23554479 |
| Niioka T et al. | A limited sampling strategy to estimate the area under the concentration-time curve of tacrolimus modified-release once-daily preparation in renal transplant recipients. | 2013 | Ther Drug Monit | pmid:23296097 |
| Li DY et al. | CYP3A4/5 polymorphisms affect the blood level of cyclosporine and tacrolimus in Chinese renal transplant recipients. | 2013 | Int J Clin Pharmacol Ther | pmid:23557867 |
| Walsh C et al. | Anti-CD25 monoclonal antibody replacement therapy for chronic kidney disease in liver transplant recipients. | 2013 | Transplantation | pmid:23296149 |
| Matsumoto A et al. | [A case of tacrolimus plus intensive LCAP therapy combination for refractory ulcerative colitis]. | 2013 | Nihon Shokakibyo Gakkai Zasshi | pmid:23558127 |
| Muramatsu H and Nagai K | Streptomyces tsukubensis sp. nov., a producer of the immunosuppressant tacrolimus. | 2013 | J. Antibiot. | pmid:23299187 |
| Yamaguchi K et al. | Limited sampling strategy for the estimation of mycophenolic acid area under the concentration-time curve treated in Japanese living-related renal transplant recipients with concomitant extended-release tacrolimus. | 2013 | Biol. Pharm. Bull. | pmid:23558676 |
| van Maarseveen E and van Zuilen AD | Pretransplantation pharmacokinetic assessments to predict posttransplantation dosing requirements in renal transplant recipients: what is known? | 2013 | Clin. Pharmacol. Ther. | pmid:23299646 |
| Kita J et al. | Significant improvement in MRI-proven bone edema is associated with protection from structural damage in very early RA patients managed using the tight control approach. | 2013 | Mod Rheumatol | pmid:22669596 |
| Ayer J and Young HS | Pimecrolimus for psoriasis. | 2013 | Expert Opin Pharmacother | pmid:23461536 |
| Ramos E et al. | Post-transplant lymphoproliferative disorders and other malignancies after pediatric intestinal transplantation: incidence, clinical features and outcome. | 2013 | Pediatr Transplant | pmid:23730927 |
| Schneeberger S et al. | Upper-extremity transplantation using a cell-based protocol to minimize immunosuppression. | 2013 | Ann. Surg. | pmid:23001085 |
| Zhao W et al. | Limited sampling strategy using Bayesian estimation for estimating individual exposure of the once-daily prolonged-release formulation of tacrolimus in kidney transplant children. | 2013 | Eur. J. Clin. Pharmacol. | pmid:23208323 |
| Tavira B et al. | A search for new CYP3A4 variants as determinants of tacrolimus dose requirements in renal-transplanted patients. | 2013 | Pharmacogenet. Genomics | pmid:23778326 |
| Pinelli NR et al. | Coadministration of liraglutide with tacrolimus in kidney transplant recipients: a case series. | 2013 | Diabetes Care | pmid:24065848 |
| Borni-Duval C et al. | Risk factors for BK virus infection in the era of therapeutic drug monitoring. | 2013 | Transplantation | pmid:23778568 |
| Huang D et al. | Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies. | 2013 | J. Ind. Microbiol. Biotechnol. | pmid:23779221 |
| Broeders EN et al. | Large decrease of anti-tetanus anatoxin and anti-pneumococcal antibodies at one year after renal transplantation. | 2013 | Clin. Nephrol. | pmid:23211343 |
| McNeil C | Preventing graft-versus-host disease: transplanters glimpse hope beyond immunosuppressants. | 2013 | J. Natl. Cancer Inst. | pmid:23781000 |
| Ramser EM et al. | Amyloid-β oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons. | 2013 | Mol. Biol. Cell | pmid:23783030 |
| Bien CG et al. | Rasmussen encephalitis: incidence and course under randomized therapy with tacrolimus or intravenous immunoglobulins. | 2013 | Epilepsia | pmid:23216622 |
| Tanaka Y et al. | Prevention of joint destruction by tacrolimus in patients with early rheumatoid arthritis: a post hoc analysis of a double-blind, randomized, placebo-controlled study. | 2013 | Mod Rheumatol | pmid:23271170 |
| Borrego-Utiel FJ et al. | Painful gynaecomastia secondary to cyclosporine A and tacrolimus in a patient with focal segmental glomerulosclerosis. | 2013 | Nefrologia | pmid:24241383 |
| Lieber SR and Volk ML | Non-adherence and graft failure in adult liver transplant recipients. | 2013 | Dig. Dis. Sci. | pmid:23053889 |
| de Sandes-Freitas TV et al. | Basiliximab induction in patients receiving tacrolimus-based immunosuppressive regimens. | 2013 | Int Urol Nephrol | pmid:23054318 |
| Tatar E et al. | Pre-transplant HbA1c level as an early marker for new-onset diabetes after renal transplantation. | 2013 | Int Urol Nephrol | pmid:23054321 |
| Kim DH et al. | Mutational biosynthesis of tacrolimus analogues by fkbO deletion mutant of Streptomyces sp. KCTC 11604BP. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23392766 |
| Lee YJ et al. | Application for tacrolimus ointment in treating refractory inflammatory ocular surface diseases. | 2013 | Am. J. Ophthalmol. | pmid:23394907 |
| Boyer NL et al. | Tacrolimus-associated thrombotic microangiopathy in a lung transplant recipient. | 2013 | BMJ Case Rep | pmid:23396921 |