| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hara Y et al. | Unresponsiveness to rat cardiac allografts induced by intrathymic injection of donor bone marrow cells and short course of immunosuppression. | 1994 | Transplant. Proc. | pmid:7527955 |
| Tzakis AG et al. | Two-year experience with FK 506 in pediatric patients. | 1993 | Transplant. Proc. | pmid:7679822 |
| Iwata H et al. | Suppression of allograft responses by combining alloantigen-specific i.v. presensitization with suboptimal doses of FK 506 or rapamycin. | 1994 | Transplant. Proc. | pmid:7513476 |
| Tanabe K et al. | Prospective analysis and successful treatment of thrombotic microangiopathy in renal allografts under tacrolimus immunosuppression. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750571 |
| Ochiai T et al. | Effective and safe use of FK 506: combination treatment with rapamycin or RS-61443 in experimental organ transplantation. | 1991 | Transplant. Proc. | pmid:1721255 |
| Tanabe K et al. | Japanese single-center experience of kidney transplantation under tacrolimus immunosuppression. | 2000 | Transplant. Proc. | pmid:11119897 |
| Pham SM et al. | Tacrolimus (FK 506) in clinical cardiac transplantation: a five-year experience. | 1996 | Transplant. Proc. | pmid:8623208 |
| Claesson K et al. | Lipoprotein patterns in renal transplant patients: a comparison between FK 506 and cyclosporine A patients. | 1998 | Transplant. Proc. | pmid:9636524 |
| Bruce DS et al. | Effects of tacrolimus, mycophenolate mofetil, and cyclosporine microemulsion on rejection incidence in synchronous pancreas-kidney transplantation. | 1998 | Transplant. Proc. | pmid:9532150 |
| Peddi VR et al. | Tacrolimus eliminates acute rejection as a major complication following simultaneous kidney and pancreas transplantation. | 1998 | Transplant. Proc. | pmid:9532151 |
| Gutiérrez Sánchez MJ et al. | Optimization of immunosuppression by switching from azathioprine to enteric-coated mycophenolate sodium in stable kidney transplant patients. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715907 |
| Rafecas A et al. | Immunosuppression with calcineurin inhibitors and polyclonal antibodies in liver transplantation. | 2002 | Transplant. Proc. | pmid:11959209 |
| Diez Ojea B et al. | Three-month experience with tacrolimus once-daily regimen in stable renal allografts. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715908 |
| Aptaramanov B et al. | A comparison of mycophenolate mofetil with mycophenolate sodium in renal transplant recipients on tacrolimus-based treatment. | 2011 | Transplant. Proc. | pmid:21486609 |
| Ma A et al. | Immunological evaluation of combination therapy with tacrolimus and sirolimus on long-term allograft survival in nonhuman primates. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808578 |
| Dheir H et al. | Intensive polyoma virus nephropathy treatment as a preferable approach for graft surveillance. | 2011 | Transplant. Proc. | pmid:21486617 |
| Waller JR et al. | Mycophenolate mofetil inhibits intimal hyperplasia and attenuates the expression of genes favouring smooth muscle cell proliferation and migration. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808582 |
| Ohara K et al. | Toxicologic evaluation of FK 506. | 1990 | Transplant. Proc. | pmid:1689910 |
| Nalesnik MA et al. | The effect of FK 506 and CyA on the Lewis rat renal ischemia model. | 1990 | Transplant. Proc. | pmid:1689911 |
| Faivre L et al. | FK 506 dose in transplantation: from theory to practice. | 2001 | Transplant. Proc. | pmid:11406256 |
| Woan MC et al. | Characterization of the biopsy growth assay in monitoring cardiac transplant patients for rejection. | 1993 | Transplant. Proc. | pmid:7680171 |
| Francavilla A et al. | The effects of FK 506, cyclosporine, and rapamycin on liver growth in vitro and in vivo. | 1991 | Transplant. Proc. | pmid:1721287 |
| Carobbi A et al. | Synergism of splenectomy and immunosuppressive drugs in prolongation of cardiac xenograft survival. | 1992 | Transplant. Proc. | pmid:1373543 |
| Kyo M et al. | Results with histological diagnosis in kidney transplant rejections treated with 15-deoxyspergualin. | 1996 | Transplant. Proc. | pmid:8623457 |
| Lang M et al. | Impact of immunosuppression in liver transplantation across a positive crossmatch. | 1998 | Transplant. Proc. | pmid:9636595 |
| Lo CM et al. | More effective immunosuppression with the use of FK506 after liver transplantation. | 2000 | Transplant. Proc. | pmid:11120161 |
| van Hooff JP et al. | Dosing and management guidelines for tacrolimus in renal transplant patients. | 1999 | Transplant. Proc. | pmid:10576046 |
| DÃaz-Molina B et al. | Effect of CYP3A5, CYP3A4, and ABCB1 genotypes as determinants of tacrolimus dose and clinical outcomes after heart transplantation. | 2012 | Transplant. Proc. | pmid:23146479 |
| Hatori M et al. | Clinicopathologic examination of no-episode biopsies in well-functioning renal allografts. | 1998 | Transplant. Proc. | pmid:9474971 |
| Watarai Y et al. | Effect of tacrolimus and cyclosporine on renal microcirculation and nitric oxide production. | 2004 | Transplant. Proc. | pmid:15518773 |
| Woo J et al. | Effects of FK 506 and low concentration cyclosporine on human lymphocyte activation antigen expression: a flow cytometric analysis. | 1990 | Transplant. Proc. | pmid:1697113 |
| Hayashi S et al. | Synergistic effect of donor pretreatment using FK 506 in hamster-to-rat cardiac xenotransplantation. | 1994 | Transplant. Proc. | pmid:7518126 |
| Woodle ES et al. | Recurrent rejection following FK 506 rescue therapy for acute hepatic allograft rejection. | 1993 | Transplant. Proc. | pmid:7682358 |
| Senninger N et al. | Glucose metabolism following liver transplantation and immunosuppression with cyclosporine A or FK 506. | 1995 | Transplant. Proc. | pmid:7533364 |
| Telkes G et al. | Kidney transplantation in hereditary coproporphyria using tacrolimus and mycophenolate mofetil: a case report. | 2013 | Transplant. Proc. | pmid:24315002 |
| Woodle ES et al. | FK 506 rescue therapy: early conversion improves efficacy. | 1993 | Transplant. Proc. | pmid:7682359 |
| Yagihashi A et al. | The effect of FK 506 on peripheral blood T-lymphocyte subsets in orthotopic liver transplant patients. | 1991 | Transplant. Proc. | pmid:1721318 |
| Ziolkowski J et al. | Effect of immunosuppressive regimen on acute rejection and liver graft function. | 2003 | Transplant. Proc. | pmid:14529915 |
| Woo J et al. | Effects of FK 506, mycophenolic acid, and bredinin on OKT-3-, PMA-, and alloantigen-induced activation molecule expression on cultured CD4+ and CD8+ human lymphocytes. | 1991 | Transplant. Proc. | pmid:1721319 |
| Teisseyre J et al. | Elevated tacrolimus levels during diarrhea in children after liver transplantation. | 2003 | Transplant. Proc. | pmid:14529919 |
| Kato T et al. | FK506 may suppress liver injury during the early period following living-related liver transplantation. | 2003 | Transplant. Proc. | pmid:12591316 |
| Takai K et al. | Delayed graft function after renal transplantation from a non-heart-beating donors. | 2003 | Transplant. Proc. | pmid:12591320 |
| González-Pinto IM et al. | Five-year follow-up of a trial comparing Tacrolimus and cyclosporine microemulsion in liver transplantation. | 2005 | Transplant. Proc. | pmid:15919441 |
| Hesselink DA et al. | The use of cyclosporine in renal transplantation. | 2004 | Transplant. Proc. | pmid:15041316 |
| Ã…berg F et al. | Asymptomatic De Novo Inflammatory Bowel Disease Late After Liver Transplantation for Primary Sclerosing Cholangitis: A Case Report. | 2015 | Transplant. Proc. | pmid:26680092 |
| Jain AK et al. | Interaction between tacrolimus and antiretroviral agents in human immunodeficiency virus-positive liver and kidney transplantation patients. | 2002 | Transplant. Proc. | pmid:12176474 |
| Shirakata Y et al. | The minimum graft size for successful orthotopic partial liver transplantation in the canine model. | 1995 | Transplant. Proc. | pmid:7533422 |
| Esposito C et al. | Effect of calcineurin inhibitors on extracellular matrix turnover in isolated human glomeruli. | 2004 | Transplant. Proc. | pmid:15110634 |
| Metcalfe SM et al. | In vitro transcription and translation of the tumour suppressor protein P53: qualitative and quantitative effects of FK506 and rapamycin. | 1998 | Transplant. Proc. | pmid:9865315 |
| Alessiani M et al. | CMV infection in liver transplantation under cyclosporine or FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721351 |
| Dierickx D et al. | Thrombotic microangiopathy following intestinal transplantation: a single center experience. | 2010 Jan-Feb | Transplant. Proc. | pmid:20172285 |
| Chmiel B et al. | Rheological properties of red blood cells in kidney transplant recipients: the role of lipid profile and type of immunosuppresion. | 2005 | Transplant. Proc. | pmid:15919493 |
| Pape L et al. | Long-term stable glomerular filtration rate achieved with tacrolimus in pediatric renal transplantation. | 2002 | Transplant. Proc. | pmid:12270367 |
| Miyagi M et al. | Comparison of the therapeutic effects between CsA and FK506 on chronic renal allograft injury and TGF-beta expression. | 2002 | Transplant. Proc. | pmid:12176497 |
| Nüssler NC et al. | CD8+ host cells infiltrate the intestinal mucosa after allogeneic small bowel transplantation even in the absence of acute rejection. | 1996 | Transplant. Proc. | pmid:8907898 |
| van Hooff JP et al. | Benelux experience with a combination of tacrolimus and mycophenolate mofetil: 4-year results. | 2002 | Transplant. Proc. | pmid:12176498 |
| Malaise J et al. | Immunosuppressive drugs after simultaneous pancreas-kidney transplantation. | 2005 Jul-Aug | Transplant. Proc. | pmid:16182827 |
| Malaise J et al. | Tacrolimus compared with cyclosporine microemulsion in primary simultaneous pancreas-kidney transplantation: the EURO-SPK 3-year results. | 2005 Jul-Aug | Transplant. Proc. | pmid:16182828 |
| Oishi M et al. | Successful swine small bowel transplantation using FK506: effect on endotoxin translocation. | 1994 | Transplant. Proc. | pmid:7520629 |
| Zegarska J et al. | Evaluation of the Relationship Between Concentrations of Tacrolimus Metabolites, 13-O-Demethyl Tacrolimus and 15-O-Demethyl Tacrolimus, and Clinical and Biochemical Parameters in Kidney Transplant Recipients. | 2018 | Transplant. Proc. | pmid:30177142 |
| Jiang H et al. | FK 506 and deoxyspergualin: additive immunosuppressive effect on rat cardiac allograft rejection in vivo and mitogen-stimulated human lymphocyte responses in vitro. | 1994 | Transplant. Proc. | pmid:7520631 |
| Moutabarrik A et al. | In vitro FK 506 kidney tubular cell toxicity. | 1991 | Transplant. Proc. | pmid:1721383 |
| Fukushima N et al. | Prolonged survival of pig cardiac xenografts in baboons by sequential cardiac transplantation. | 1998 | Transplant. Proc. | pmid:9838671 |
| Schulz T et al. | Mycophenolate mofetil/prednisolone/single-shot ATG with tacrolimus or cyclosporine in pancreas/kidney transplantation: first results of an ongoing prospective randomized trial. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083251 |
| Burke GW et al. | Donor bone marrow infusion in simultaneous pancreas/kidney transplantation with OKT3 induction: evidence for augmentation of chimerism. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123275 |
| Becker G et al. | Tacrolimus (FK 506) therapy in simultaneous pancreas kidney transplantation. | 1996 | Transplant. Proc. | pmid:8962228 |
| Baran DA et al. | Tacrolimus and new onset diabetes mellitus: the effect of steroid weaning. | 2002 | Transplant. Proc. | pmid:12176547 |
| Tsuchiya T et al. | Effect of conversion from twice-daily to once-daily tacrolimus on glucose intolerance in stable kidney transplant recipients. | 2012 | Transplant. Proc. | pmid:22310593 |
| Wierzbicka A et al. | Lipid, carbohydrate metabolism, and antioxidant status in children after liver transplantation. | 2007 | Transplant. Proc. | pmid:17580179 |
| Jiang H et al. | IL-10: a tacrolimus-specific cytotoxic mediator in ongoing allograft rejection. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266931 |
| Ohtsuka S et al. | The effect of short-term FK 506 therapy on pancreas transplantation in rats. | 1991 | Transplant. Proc. | pmid:1721413 |
| Cirocco RE et al. | Kidney recipient CMV incidence in the gancyclovir era: monitoring viral DNA by a CMV-PCR assay. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083604 |
| Nakao A et al. | Cytokine mRNA expression on rat small bowel allograft treated with tacrolimus and simultaneous bone marrow transplantation via the portal vein. | 2000 | Transplant. Proc. | pmid:10995965 |
| Sugito K et al. | A comparative study of clinicopathologic characteristics of renal allografts under cyclosporine and FK506 immunosuppression. | 1996 | Transplant. Proc. | pmid:8658683 |
| Soltero L et al. | Coadministration of tacrolimus and ketoconazole in renal transplant recipients: cost analysis and review of metabolic effects. | 2003 | Transplant. Proc. | pmid:12826147 |
| Langer RM et al. | De novo tumors after kidney transplantation: the Budapest experience. | 2003 | Transplant. Proc. | pmid:12826170 |
| Levy GA | Neoral is superior to FK 506 in liver transplantation. | 1998 | Transplant. Proc. | pmid:9723293 |
| Glanemann M et al. | Higher immunosuppressive efficacy of mycophenolate mofetil in combination with FK 506 than in combination with cyclosporine A. | 2000 | Transplant. Proc. | pmid:10812095 |
| White SA et al. | Randomized trial comparing neoral and tacrolimus immunousuppression for recipients of renal transplants procured from different donor groups. | 2000 | Transplant. Proc. | pmid:10812132 |
| Calne RY | The development of immunosuppression: the rapamycin milestone. | 2003 | Transplant. Proc. | pmid:12742463 |
| Fábrega E et al. | Effect of immunosuppressant blood levels on serum concentration of interleukin-17 and -23 in stable liver transplant recipients. | 2009 | Transplant. Proc. | pmid:19376417 |
| Sánchez Pérez B et al. | Adverse effects on the lipid profile of immunosuppressive regimens: tacrolimus versus cyclosporin measured using C2 levels. | 2009 | Transplant. Proc. | pmid:19376418 |
| Burke GW et al. | Steroid-resistant acute rejection following SPK: importance of maintaining therapeutic dosing in a triple-drug regimen. | 2002 | Transplant. Proc. | pmid:12176628 |
| Woeste G et al. | Tacrolimus/mycophenolate mofetil vs cyclosporine A/Azathioprine after simultaneous pancreas and kidney transplantation: five-year results of a randomized study. | 2002 | Transplant. Proc. | pmid:12176629 |
| Kishikawa H et al. | Low-dose steroid maintenance for renal transplant recipients. | 2010 | Transplant. Proc. | pmid:21168618 |
| Ji SM et al. | Rescue therapy by immunoadsorption in combination with tacrolimus and mycophenolate mofetil for C4d-positive acute humoral renal allograft rejection. | 2006 | Transplant. Proc. | pmid:17175303 |
| López-Vilella R et al. | Incidence of development of obesity after heart transplantation according to the calcineurin inhibitor. | Transplant. Proc. | pmid:25645789 | |
| Peltekian K et al. | De novo use of low-dose tacrolimus and sirolimus in liver transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267318 |
| Ybarra J et al. | Reflex sympathetic dystrophy syndrome in renal transplanted patients under immunosuppression with tacrolimus. | 2003 | Transplant. Proc. | pmid:14697943 |
| Propper DJ et al. | Evidence that FK 506 may abrogate suppressor cell activity induced by blood transfusion. | 1991 | Transplant. Proc. | pmid:1721446 |
| Gómez G et al. | Acute tacrolimus nephrotoxicity in renal transplant patients treated with clarithromycin. | 1999 | Transplant. Proc. | pmid:10500563 |
| Winkler M et al. | Plasma level-guided low-dose FK 506 therapy in patients with early liver dysfunction after liver transplantation. | 1993 | Transplant. Proc. | pmid:7689277 |
| Khoury N et al. | Posttransplant diabetes mellitus in kidney transplant recipients under tacrolimus immunosuppression. | 2000 | Transplant. Proc. | pmid:11134791 |
| Chamienia A et al. | Open prospective study to evaluate cardiovascular risk factors and renal function in 2 dosage regimens of tacrolimus combined with mycophenolate mofetil and steroids in renal transplant patients: 5-year results. | 2014 | Transplant. Proc. | pmid:25380901 |
| Abou-Jaoude MM et al. | Tacrolimus (FK506) versus cyclosporine microemulsion (neoral) as maintenance immunosuppression therapy in kidney transplant recipients. | 2005 | Transplant. Proc. | pmid:16213293 |
| Mita A et al. | Optimal initial dose of orally administered once-daily extended-release tacrolimus following intravenous tacrolimus therapy after liver transplantation. | 2014 | Transplant. Proc. | pmid:24767351 |
| Reimer J et al. | Quality of life after kidney transplantation--the impact of tacrolimus. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267573 |
| Miura S et al. | Effect of tacrolimus on the outcome of renal transplantation with donor-specific blood transfusion. | 1998 | Transplant. Proc. | pmid:9636492 |
| Mehra MR et al. | Corticosteroid weaning in the tacrolimus and mycophenolate era in heart transplantation: clinical and neurohormonal benefits. | 2004 | Transplant. Proc. | pmid:15686716 |
| Dallos G et al. | Results and complications after living related kidney transplantation in Hungary: 30 years' experience. | 2010 Jul-Aug | Transplant. Proc. | pmid:20692470 |