| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Del Poeta M et al. | Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans. | 2000 | Antimicrob. Agents Chemother. | pmid:10681348 |
| Katiyar SK et al. | Fks1 and Fks2 are functionally redundant but differentially regulated in Candida glabrata: implications for echinocandin resistance. | 2012 | Antimicrob. Agents Chemother. | pmid:23027185 |
| Vaes M et al. | Therapeutic drug monitoring of posaconazole in patients with acute myeloid leukemia or myelodysplastic syndrome. | 2012 | Antimicrob. Agents Chemother. | pmid:23027198 |
| Zhuang D et al. | Effect of calcineurin inhibitors on posaconazole blood levels as measured by the MVista microbiological assay. | 2008 | Antimicrob. Agents Chemother. | pmid:18025114 |
| Coilly A et al. | Practical management of boceprevir and immunosuppressive therapy in liver transplant recipients with hepatitis C virus recurrence. | 2012 | Antimicrob. Agents Chemother. | pmid:22908172 |
| Gao L and Sun Y | In vitro interactions of antifungal agents and tacrolimus against Aspergillus biofilms. | 2015 | Antimicrob. Agents Chemother. | pmid:26303797 |
| Uppuluri P et al. | Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms. | 2008 | Antimicrob. Agents Chemother. | pmid:18180354 |
| Rosenwirth B et al. | Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog. | 1994 | Antimicrob. Agents Chemother. | pmid:7527198 |
| Pea F et al. | Drop in trough blood concentrations of tacrolimus after switching from nelfinavir to fosamprenavir in four HIV-infected liver transplant patients. | 2008 | Antivir. Ther. (Lond.) | pmid:18771060 |
| Ginestà MM et al. | Acute xenograft rejection, late xenograft rejection and long term survival xenografts in the hamster-to-rat heart transplantation model: histological characterisation under low-dose of FK506. | 2002 | APMIS | pmid:12583441 |
| Kuo WW et al. | Cardiomyoblast apoptosis induced by insulin-like growth factor (IGF)-I resistance is IGF-II dependent and synergistically enhanced by angiotensin II. | 2006 | Apoptosis | pmid:16699953 |
| Rapak A et al. | Apoptosis of lymphoma cells is abolished due to blockade of cytochrome c release despite Nur77 mitochondrial targeting. | 2007 | Apoptosis | pmid:17701362 |
| Kabat-Koperska J et al. | The influence of exposure to immunosuppressive treatment during pregnancy on renal function and rate of apoptosis in native kidneys of female Wistar rats. | 2016 | Apoptosis | pmid:27586504 |
| Kemper K et al. | Targeting colorectal cancer stem cells with inducible caspase-9. | 2012 | Apoptosis | pmid:22223359 |
| Chen D et al. | Improvement of FK506 production in Streptomyces tsukubaensis by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems. | 2012 | Appl. Environ. Microbiol. | pmid:22582065 |
| Mo S et al. | Roles of fkbN in positive regulation and tcs7 in negative regulation of FK506 biosynthesis in Streptomyces sp. strain KCTC 11604BP. | 2012 | Appl. Environ. Microbiol. | pmid:22267670 |
| Kallscheuer N et al. | Single-Domain Peptidyl-Prolyl cis/trans Isomerase FkpA from Corynebacterium glutamicum Improves the Biomass Yield at Increased Growth Temperatures. | 2015 | Appl. Environ. Microbiol. | pmid:26341203 |
| Barreiro C and MartÃnez-Castro M | Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506). | 2014 | Appl. Microbiol. Biotechnol. | pmid:24272367 |
| Salehi-Najafabadi Z et al. | The gamma-butyrolactone receptors BulR1 and BulR2 of Streptomyces tsukubaensis: tacrolimus (FK506) and butyrolactone synthetases production control. | 2014 | Appl. Microbiol. Biotechnol. | pmid:24562179 |
| Kimura T et al. | N-glycosylation is involved in the sensitivity of Saccharomyces cerevisiae to HM-1 killer toxin secreted from Hansenula mrakii IFO 0895. | 1999 | Appl. Microbiol. Biotechnol. | pmid:10091323 |
| Song K et al. | Engineering of the LysR family transcriptional regulator FkbR1 and its target gene to improve ascomycin production. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28349163 |
| Mo S et al. | Application of a combined approach involving classical random mutagenesis and metabolic engineering to enhance FK506 production in Streptomyces sp. RM7011. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23053074 |
| Wang J et al. | Comparative proteomic and metabolomic analysis of Streptomyces tsukubaensis reveals the metabolic mechanism of FK506 overproduction by feeding soybean oil. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28175948 |
| Ordóñez-Robles M et al. | Target genes of the Streptomyces tsukubaensis FkbN regulator include most of the tacrolimus biosynthesis genes, a phosphopantetheinyl transferase and other PKS genes. | 2016 | Appl. Microbiol. Biotechnol. | pmid:27357227 |
| Salehi-Najafabadi Z et al. | Characterisation of a γ-butyrolactone receptor of Streptomyces tacrolimicus: effect on sporulation and tacrolimus biosynthesis. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21792593 |
| Ma D et al. | Manipulating the expression of SARP family regulator BulZ and its target gene product to increase tacrolimus production. | 2018 | Appl. Microbiol. Biotechnol. | pmid:29666890 |
| Ordóñez-Robles M et al. | Streptomyces tsukubaensis as a new model for carbon repression: transcriptomic response to tacrolimus repressing carbon sources. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28983826 |
| Kim DH et al. | Mutational biosynthesis of tacrolimus analogues by fkbO deletion mutant of Streptomyces sp. KCTC 11604BP. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23392766 |
| MartÃnez-Castro M et al. | Taxonomy and chemically semi-defined media for the analysis of the tacrolimus producer 'Streptomyces tsukubaensis'. | 2013 | Appl. Microbiol. Biotechnol. | pmid:22990582 |
| Pavan M et al. | Polyomavirus associated nephropathy presenting five years after kidney transplantation. | 2011 | Arab J Nephrol Transplant | pmid:21999857 |
| Okudaira H et al. | Control of allergic diseases by regulation of cytokine gene transcription. | 1997 | Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A M | pmid:9383912 |
| Laffitte E et al. | Erosive pustular dermatosis of the scalp: treatment with topical tacrolimus. | 2003 | Arch Dermatol | pmid:12810500 |
| Chu J et al. | Topical tacrolimus is a useful adjunctive therapy for bullous pemphigoid. | 2003 | Arch Dermatol | pmid:12810523 |
| Thiers BH | Topical tacrolimus: treatment failure in a patient with alopecia areata. | 2000 | Arch Dermatol | pmid:10632221 |
| Laffitte E and Panizzon RG | Is topical tacrolimus really an effective therapy for Hailey-Hailey disease? | 2004 | Arch Dermatol | pmid:15492199 |
| Choi CJ and Nghiem P | Tacrolimus ointment in the treatment of chronic cutaneous graft-vs-host disease: a case series of 18 patients. | 2001 | Arch Dermatol | pmid:11559218 |
| Neill SM and Lewis FM | Vulvovaginal lichen planus: a disease in need of a unified approach. | 2008 | Arch Dermatol | pmid:19015426 |
| Cooper SM et al. | Vulvovaginal lichen planus treatment: a survey of current practices. | 2008 | Arch Dermatol | pmid:19015433 |
| Lally A et al. | Penile pyoderma gangrenosum treated with topical tacrolimus. | 2005 | Arch Dermatol | pmid:16172330 |
| Le Cleach L et al. | Is topical monotherapy effective for localized pyoderma gangrenosum? | 2011 | Arch Dermatol | pmid:21242400 |
| Ng W and Ikeda S | Mount Tsukuba and the origin of tacrolimus. | 2009 | Arch Dermatol | pmid:19289758 |
| Ostovari N et al. | Lack of efficacy of tacrolimus in the treatment of vitiligo in the absence of UV-B exposure. | 2006 | Arch Dermatol | pmid:16490866 |
| Olivier V et al. | Treatment of chronic erosive oral lichen planus with low concentrations of topical tacrolimus: an open prospective study. | 2002 | Arch Dermatol | pmid:12374539 |
| Shah KN and Yan AC | Low but detectable serum levels of tacrolimus seen with the use of very dilute, extemporaneously compounded formulations of tacrolimus ointment in the treatment of patients with netherton syndrome. | 2006 | Arch Dermatol | pmid:17043199 |
| Antille C et al. | Induction of rosaceiform dermatitis during treatment of facial inflammatory dermatoses with tacrolimus ointment. | 2004 | Arch Dermatol | pmid:15096374 |
| Banky JP et al. | Successful treatment of epidermolysis bullosa pruriginosa with topical tacrolimus. | 2004 | Arch Dermatol | pmid:15262686 |
| Qureshi A and Fischer MA | Topical calcineurin inhibitors revisited. | 2007 | Arch Dermatol | pmid:17438195 |
| Cheng A and Mann C | Oral erosive lichen planus treated with efalizumab. | 2006 | Arch Dermatol | pmid:16785369 |
| Sniezek PJ et al. | Annular atrophic plaques on the arms of a 57-year-old woman. | 2006 | Arch Dermatol | pmid:16785386 |
| Hall VC et al. | Ocular mucous membrane pemphigoid and ocular pemphigus vulgaris treated topically with tacrolimus ointment. | 2003 | Arch Dermatol | pmid:12925404 |