| MeSH term | MeSH ID | Detail |
|---|---|---|
| Denys-Drash Syndrome | D030321 | 1 associated lipids |
| Hypophosphatemia | D017674 | 1 associated lipids |
| Moyamoya Disease | D009072 | 1 associated lipids |
| Latent Tuberculosis | D055985 | 1 associated lipids |
| Leukoplakia | D007971 | 1 associated lipids |
| Oculomotor Nerve Diseases | D015840 | 1 associated lipids |
| Scorpion Stings | D065008 | 1 associated lipids |
| Esophageal Perforation | D004939 | 1 associated lipids |
| Mediastinitis | D008480 | 2 associated lipids |
| Coproporphyria, Hereditary | D046349 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Herz S et al. | Checkpoint inhibitors in chronic kidney failure and an organ transplant recipient. | 2016 | Eur. J. Cancer | pmid:27614165 |
| Nakajima A et al. | Effectiveness of tacrolimus in comparison with methotrexate or biologics in propensity score-matched patients with rheumatoid arthritis. | 2016 | Mod Rheumatol | pmid:26934454 |
| Pan GH et al. | Low-dose tacrolimus combined with donor-derived mesenchymal stem cells after renal transplantation: a prospective, non-randomized study. | 2016 | Oncotarget | pmid:26933811 |
| Dugast E et al. | Failure of Calcineurin Inhibitor (Tacrolimus) Weaning Randomized Trial in Long-Term Stable Kidney Transplant Recipients. | 2016 | Am. J. Transplant. | pmid:27367750 |
| Knight SR | Intrapatient variability in tacrolimus exposure - a useful tool for clinical practice? | 2016 | Transpl. Int. | pmid:27283231 |
| Shuker N et al. | A high intrapatient variability in tacrolimus exposure is associated with poor long-term outcome of kidney transplantation. | 2016 | Transpl. Int. | pmid:27188932 |
| Rodrigues-Diez R et al. | Calcineurin inhibitors cyclosporine A and tacrolimus induce vascular inflammation and endothelial activation through TLR4 signaling. | 2016 | Sci Rep | pmid:27295076 |
| Song JL et al. | Minimizing tacrolimus decreases the risk of new-onset diabetes mellitus after liver transplantation. | 2016 | World J. Gastroenterol. | pmid:26877618 |
| Viesselmann CW et al. | Clinically Significant Drug Interaction Between Clotrimazole and Tacrolimus in Pancreas Transplant Recipients and Associated Risk of Allograft Rejection. | 2016 | Pharmacotherapy | pmid:26877191 |
| Than NN et al. | Long-term follow-up of patients with difficult to treat type 1 autoimmune hepatitis on Tacrolimus therapy. | 2016 | Scand. J. Gastroenterol. | pmid:26458216 |
| Wang X et al. | Ureaplasma urealyticum Causes Hyperammonemia in an Experimental Immunocompromised Murine Model. | 2016 | PLoS ONE | pmid:27537683 |
| Malik N et al. | A simple office-based procedure for patients with extensive vitiligo. | 2016 | J. Am. Acad. Dermatol. | pmid:27745651 |
| Lee JH et al. | Stability of tacrolimus solutions in polyolefin containers. | 2016 | Am J Health Syst Pharm | pmid:26796907 |
| Cruzado JM et al. | Controlled randomized study comparing the cardiovascular profile of everolimus with tacrolimus in renal transplantation. | 2016 | Transpl. Int. | pmid:27648523 |
| Torrisi JS et al. | Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity. | 2016 | Sci Rep | pmid:26796537 |
| Ward I et al. | Digital Pulp Ulcerations and Inverse Gottron Papules in Melanoma Differentiation-Associated Gene 5-Related Dermatomyositis. | 2016 | J Clin Rheumatol | pmid:27464773 |
| EriÅŸ E et al. | Evaluation of Effect of Topical Tacrolimus Treatment on Herpetic Stromal Keratitis in a Rat Model. | 2016 | Eye Contact Lens | pmid:25996419 |
| Matsa E et al. | Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro. | 2016 | Cell Stem Cell | pmid:27545504 |
| Lee B et al. | Appropriate timing of tacrolimus concentration measurements in the emergency department. | 2016 | Am J Health Syst Pharm | pmid:27543574 |
| Komaki Y et al. | Efficacy and Safety of Tacrolimus Therapy for Active Ulcerative Colitis; A Systematic Review and Meta-analysis. | 2016 | J Crohns Colitis | pmid:26645641 |
| Vadcharavivad S et al. | Population pharmacokinetics of tacrolimus in Thai kidney transplant patients: comparison with similar data from other populations. | 2016 | J Clin Pharm Ther | pmid:27191538 |
| Thevissen K | How promising are combinatorial drug strategies in combating Candida albicans biofilms? | 2016 | Future Med Chem | pmid:27463947 |
| Ikeya K et al. | The Ulcerative Colitis Endoscopic Index of Severity More Accurately Reflects Clinical Outcomes and Long-term Prognosis than the Mayo Endoscopic Score. | 2016 | J Crohns Colitis | pmid:26581895 |
| Gala-Lopez BL et al. | Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice. | 2016 | Diabetes | pmid:26581595 |
| Shao K et al. | Different Effects of Tacrolimus on Innate and Adaptive Immune Cells in the Allograft Transplantation. | 2016 | Scand. J. Immunol. | pmid:26524694 |
| Moes DJ et al. | Population pharmacokinetics and pharmacogenetics of once daily tacrolimus formulation in stable liver transplant recipients. | 2016 | Eur. J. Clin. Pharmacol. | pmid:26521259 |
| Yeo L and Ormerod AD | Oral tacrolimus: a treatment option for recalcitrant erosive lichen planus. | 2016 | Clin. Exp. Dermatol. | pmid:27339859 |
| Gardiner KM et al. | Multinational Evaluation of Mycophenolic Acid, Tacrolimus, Cyclosporin, Sirolimus, and Everolimus Utilization. | 2016 | Ann. Transplant. | pmid:26729299 |
| Grześk E et al. | Cyclosporine-A, but not tacrolimus significantly increases reactivity of vascular smooth muscle cells. | 2016 | Pharmacol Rep | pmid:26721374 |
| Riegersperger M et al. | The Effect of ABCB1 Polymorphisms on Serial Tacrolimus Concentrations in Stable Austrian Long-Term Kidney Transplant Recipients. | 2016 | Clin. Lab. | pmid:28164520 |
| Levitsky J et al. | Immunoregulatory Effects of Everolimus on In Vitro Alloimmune Responses. | 2016 | PLoS ONE | pmid:27275747 |
| Schneider L et al. | Study of the Atopic March: Development of Atopic Comorbidities. | 2016 | Pediatr Dermatol | pmid:27273433 |
| Ramachandran R et al. | Cyclical cyclophosphamide and steroids is effective in resistant or relapsing nephrotic syndrome due to M-type phospholipase A2 receptor-related membranous nephropathy after tacrolimus therapy. | 2016 | Kidney Int. | pmid:27181781 |
| Chang HK et al. | Ten-Year Experience With Bowel Transplantation at Seoul St. Mary's Hospital. | 2016 | Transplant. Proc. | pmid:27109981 |
| Baraldo M | Meltdose Tacrolimus Pharmacokinetics. | 2016 | Transplant. Proc. | pmid:27109969 |
| Pretagostini R et al. | Delayed Introduction of Everolimus in De Novo Renal Transplanted Patients: A Single-Center Experience. | 2016 | Transplant. Proc. | pmid:27109947 |
| Vanhove T et al. | High Intrapatient Variability of Tacrolimus Concentrations Predicts Accelerated Progression of Chronic Histologic Lesions in Renal Recipients. | 2016 | Am. J. Transplant. | pmid:27013142 |
| Kanazawa H et al. | Chemotherapy-induced B-cell depletion in hepatoblastoma patients undergoing ABO-incompatible living donor liver transplantation. | 2016 | Pediatr Transplant | pmid:27012966 |
| Taşoğlu Ö et al. | Pregabalin: A New Adjunct in Calcineurin Inhibitor Pain Syndrome Treatment. | 2016 | Prog Transplant | pmid:27312682 |
| Dickerson JA et al. | Tacrolimus and sirolimus in capillary dried blood spots allows for remote monitoring. | 2015 | Pediatr Transplant | pmid:25414084 |
| Jahan A et al. | Clinical efficacy and pharmacokinetics of tacrolimus in children with steroid-resistant nephrotic syndrome. | 2015 | Pediatr. Nephrol. | pmid:26135137 |
| Marquezan MC et al. | Effect of Topical Tacrolimus in the Treatment of Thygeson's Superficial Punctate Keratitis. | 2015 | Am. J. Ophthalmol. | pmid:26133248 |
| Izumi Y et al. | Two cases of refractory polymyositis accompanied with steroid myopathy. | 2015 | Mod Rheumatol | pmid:24533547 |
| Li H et al. | Resistance reversal induced by a combination of fluconazole and tacrolimus (FK506) in Candida glabrata. | 2015 | J. Med. Microbiol. | pmid:25355935 |
| Gallon L et al. | Cellular and molecular immune profiles in renal transplant recipients after conversion from tacrolimus to sirolimus. | 2015 | Kidney Int. | pmid:25354238 |
| Pamuk F et al. | Evaluation of gingival alterations in rats medicated with cyclosporine A, tacrolimus and sirolimus: a stereological study. | 2015 | J. Periodont. Res. | pmid:25399832 |
| Huang X and Xu B | Efficacy and Safety of Tacrolimus versus Pimecrolimus for the Treatment of Atopic Dermatitis in Children: A Network Meta-Analysis. | 2015 | Dermatology (Basel) | pmid:26043855 |
| Zheng L et al. | Simultaneous determination of cortisol, cortisone, 6β-hydroxycortisol and 6β-hydroxycortisone by HPLC. | 2015 | J Chromatogr Sci | pmid:25628347 |
| Takahashi N et al. | Concomitant methotrexate and tacrolimus augment the clinical response to abatacept in patients with rheumatoid arthritis with a prior history of biological DMARD use. | 2015 | Rheumatol. Int. | pmid:25991396 |
| Gupta G et al. | Safe Conversion From Tacrolimus to Belatacept in High Immunologic Risk Kidney Transplant Recipients With Allograft Dysfunction. | 2015 | Am. J. Transplant. | pmid:25988397 |
| Brännström M et al. | Livebirth after uterus transplantation. | 2015 | Lancet | pmid:25301505 |
| de Weerd AE et al. | ABO-incompatible kidney transplant recipients have a higher bleeding risk after antigen-specific immunoadsorption. | 2015 | Transpl. Int. | pmid:25070762 |
| Yahng SA et al. | A well-tolerated regimen of 800 cGy TBI-fludarabine-busulfan-ATG for reliable engraftment after unmanipulated haploidentical peripheral blood stem cell transplantation in adult patients with acute myeloid leukemia. | 2015 | Biol. Blood Marrow Transplant. | pmid:25300871 |
| Lin YK et al. | Using Imiquimod-Induced Psoriasis-Like Skin as a Model to Measure the Skin Penetration of Anti-Psoriatic Drugs. | 2015 | PLoS ONE | pmid:26355594 |
| Andrews LM et al. | Dosing algorithms for initiation of immunosuppressive drugs in solid organ transplant recipients. | 2015 | Expert Opin Drug Metab Toxicol | pmid:25865963 |
| Matas AJ and Gaston RS | Moving Beyond Minimization Trials in Kidney Transplantation. | 2015 | J. Am. Soc. Nephrol. | pmid:25925686 |
| Bogéa TH et al. | Light Induces Ultrastructural Changes in Rod Outer and Inner Segments, Including Autophagy, in a Transgenic Xenopus laevis P23H Rhodopsin Model of Retinitis Pigmentosa. | 2015 | Invest. Ophthalmol. Vis. Sci. | pmid:26720441 |
| Hiraoka S et al. | The earliest trough concentration predicts the dose of tacrolimus required for remission induction therapy in ulcerative colitis patients. | 2015 | BMC Gastroenterol | pmid:25925267 |
| Cuervas-Mons V et al. | Impact of tacrolimus and mycophenolate mofetil regimen vs. a conventional therapy with steroids on cardiovascular risk in liver transplant patients. | 2015 | Clin Transplant | pmid:25924549 |
| Shahraki M et al. | Influence of Tacrolimus (FK506) on Nerve Regeneration Using Allografts: A Rat Sciatic Nerve Model. | 2015 | J. Oral Maxillofac. Surg. | pmid:25869987 |
| Zhu L et al. | Effects of CYP3A5 genotypes, ABCB1 C3435T and G2677T/A polymorphism on pharmacokinetics of Tacrolimus in Chinese adult liver transplant patients. | 2015 | Xenobiotica | pmid:25869250 |
| Jiang H et al. | An acyltransferase domain of FK506 polyketide synthase recognizing both an acyl carrier protein and coenzyme A as acyl donors to transfer allylmalonyl and ethylmalonyl units. | 2015 | FEBS J. | pmid:25865045 |
| Dastgheib L et al. | Assessment of the adjuvant effect of tacrolimus in the management of pemphigus vulgaris: A randomized controlled trial. | 2015 | J Dermatolog Treat | pmid:24552352 |
| RodrÃguez-RodrÃguez AE et al. | Glucose homeostasis changes and pancreatic β-cell proliferation after switching to cyclosporin in tacrolimus-induced diabetes mellitus. | 2015 | Nefrologia | pmid:26299169 |
| Halvorsen JA and Aasebø W | Oral tacrolimus treatment of pruritus in prurigo nodularis. | 2015 | Acta Derm. Venereol. | pmid:25804254 |
| Sigurgeirsson B et al. | Safety and efficacy of pimecrolimus in atopic dermatitis: a 5-year randomized trial. | 2015 | Pediatrics | pmid:25802354 |
| Kurita T et al. | The efficacy of calcineurin inhibitors for the treatment of interstitial lung disease associated with polymyositis/dermatomyositis. | 2015 | Lupus | pmid:25297551 |
| Birdwell KA et al. | Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing. | 2015 | Clin. Pharmacol. Ther. | pmid:25801146 |
| Shokati T et al. | Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS. | 2015 | J Vis Exp | pmid:26575262 |
| Jo GA et al. | Isolation and characterization of a 17-kDa FKBP-type peptidyl-prolyl cis/trans isomerase from Vibrio anguillarum. | 2015 | Protein Expr. Purif. | pmid:25747528 |
| Liu J et al. | Adherence to Immunosuppressive Medication in Renal Transplant Recipients From Follow-up Outpatient in China: Association of 2 Different Measurement Methods. | 2015 | Clin Ther | pmid:26519232 |
| Guerra Júnior AA et al. | Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil. | 2015 | Rev Saude Publica | pmid:25741648 |
| Youbin Z et al. | Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Gene Overexpression Prolongs the Survival of Rat Allogeneic Heart Allografts. | 2015 | Transplant. Proc. | pmid:26518962 |
| Schwarz C et al. | Tacrolimus, Mycophenolate Mofetil, and Low-Dose Steroids With or Without Interleukin-2 Receptor Antibody Induction Therapy: A Retrospective Cohort Analysis. | 2015 | Transplant. Proc. | pmid:26518948 |
| Ko MS et al. | Tacrolimus therapy causes hepatotoxicity in patients with a history of liver disease. | 2015 | Int J Clin Pharmacol Ther | pmid:25740263 |
| Cotton D | Celebrating the ACP centennial: from the Annals archive. | 2015 | Ann. Intern. Med. | pmid:25560715 |
| Ikeya K et al. | Tacrolimus for remission induction in ulcerative colitis: Mayo endoscopic subscore 0 and 1 predict long-term prognosis. | 2015 | Dig Liver Dis | pmid:25682993 |
| Zhao L et al. | Bovine serum albumin nanoparticles for delivery of tacrolimus to reduce its kidney uptake and functional nephrotoxicity. | 2015 | Int J Pharm | pmid:25681723 |
| Ramesh M et al. | A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells. | 2015 | J. Biol. Chem. | pmid:25681440 |
| Pascher A et al. | Protein kinase C inhibitor sotrastaurin in de novo liver transplant recipients: a randomized phase II trial. | 2015 | Am. J. Transplant. | pmid:25677074 |
| Fukuta T et al. | Treatment of stroke with liposomal neuroprotective agents under cerebral ischemia conditions. | 2015 | Eur J Pharm Biopharm | pmid:26455340 |
| BuendÃa JA et al. | Combinational Effect of CYP3A5 and MDR-1 Polymorphisms on Tacrolimus Pharmacokinetics in Liver Transplant Patients. | 2015 | Exp Clin Transplant | pmid:26450467 |
| Ceberio I et al. | Sirolimus, tacrolimus and low-dose methotrexate based graft-versus-host disease prophylaxis after non-ablative or reduced intensity conditioning in related and unrelated donor allogeneic hematopoietic cell transplant. | 2015 | Leuk. Lymphoma | pmid:24913499 |
| Chung H et al. | Renal transplantation: better fat than thin. | 2015 | J. Surg. Res. | pmid:25634827 |
| Pennington CA and Park JM | Sublingual tacrolimus as an alternative to oral administration for solid organ transplant recipients. | 2015 | Am J Health Syst Pharm | pmid:25631834 |
| Satake K et al. | Olopatadine hydrochloride suppresses hot flashes induced by topical treatment with tacrolimus ointment in rats. | 2015 | Eur. J. Pharmacol. | pmid:26362749 |
| Farhangian ME et al. | Treatment of Alopecia Areata in the United States: A Retrospective Cross-Sectional Study. | 2015 | J Drugs Dermatol | pmid:26355621 |
| Kawahara T et al. | The role of NFATc1 in prostate cancer progression: cyclosporine A and tacrolimus inhibit cell proliferation, migration, and invasion. | 2015 | Prostate | pmid:25631176 |
| Yao X et al. | Limited Sampling Strategy for Mycophenolic Acid in Chinese Kidney Transplant Recipients Receiving Enteric-Coated Mycophenolate Sodium and Tacrolimus During the Early Posttransplantation Phase. | 2015 | Ther Drug Monit | pmid:25565669 |
| Lemaitre F et al. | Pharmacokinetics and pharmacodynamics of tacrolimus in liver transplant recipients: inside the white blood cells. | 2015 | Clin. Biochem. | pmid:25562187 |
| Palanisamy AP et al. | Induction therapy: clinical and quality of life outcomes in aged renal transplant recipients. | 2015 | Clin Transplant | pmid:25557762 |
| Tedesco-Silva H et al. | Reduced Incidence of Cytomegalovirus Infection in Kidney Transplant Recipients Receiving Everolimus and Reduced Tacrolimus Doses. | 2015 | Am. J. Transplant. | pmid:25988935 |
| Lu YX et al. | A population pharmacokinetic study of tacrolimus in healthy Chinese volunteers and liver transplant patients. | 2015 | Acta Pharmacol. Sin. | pmid:25500866 |
| Jung JW et al. | Long-term result of maintenance treatment with tacrolimus ointment in chronic ocular graft-versus-host disease. | 2015 | Am. J. Ophthalmol. | pmid:25498356 |
| Roberts WK et al. | A destructive feedback loop mediated by CXCL10 in central nervous system inflammatory disease. | 2015 | Ann. Neurol. | pmid:26224283 |
| Denardi LB et al. | Synergistic effects of tacrolimus and azole antifungal compounds in fluconazole-susceptible and fluconazole-resistant Candida glabrata isolates. | 2015 | Braz. J. Microbiol. | pmid:26221097 |
| Kloster-Jensen K et al. | Intracellular sirolimus concentration is reduced by tacrolimus in human pancreatic islets in vitro. | 2015 | Transpl. Int. | pmid:26046470 |
| Koster RA et al. | The performance of five different dried blood spot cards for the analysis of six immunosuppressants. | 2015 | Bioanalysis | pmid:26045003 |
| Georgakopoulou EA and Scully C | Systemic use of non-biologic agents in orofacial diseases: other immunomodulatory agents. | 2015 | Oral Dis | pmid:24028818 |
| Lancia P et al. | Choosing the right dose of tacrolimus. | 2015 | Arch. Dis. Child. | pmid:25416736 |