| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hashimoto M et al. | Feasibility of cryopreserved tracheal xenotransplants with the use of short-course immunosuppression. | 2001 | J. Thorac. Cardiovasc. Surg. | pmid:11174729 |
| Paller AS | Use of nonsteroidal topical immunomodulators for the treatment of atopic dermatitis in the pediatric population. | 2001 | J. Pediatr. | pmid:11174611 |
| Hauk PJ and Leung DY | Tacrolimus (FK506): new treatment approach in superantigen-associated diseases like atopic dermatitis? | 2001 | J. Allergy Clin. Immunol. | pmid:11174211 |
| Panhans-Gross A et al. | Human epidermal Langerhans' cells are targets for the immunosuppressive macrolide tacrolimus (FK506). | 2001 | J. Allergy Clin. Immunol. | pmid:11174203 |
| Shibazaki Y et al. | Effect of the immunosuppressant drug FK506 on neonatal cerebral mitochondrial function and energy metabolism after transient intrauterine ischemia in rats. | 2001 | Brain Res. | pmid:11172783 |
| Manzarbeitia C et al. | Tacrolimus conversion improves hyperlipidemic states in stable liver transplant recipients. | 2001 | Liver Transpl. | pmid:11172391 |
| Bayguinov O et al. | Muscarinic stimulation increases basal Ca(2+) and inhibits spontaneous Ca(2+) transients in murine colonic myocytes. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11171588 |
| Jørgensen PF et al. | Sirolimus interferes with the innate response to bacterial products in human whole blood by attenuation of IL-10 production. | 2001 | Scand. J. Immunol. | pmid:11169223 |
| Boulad F et al. | Stem cell transplantation for the treatment of Fanconi anaemia using a fludarabine-based cytoreductive regimen and T-cell-depleted related HLA-mismatched peripheral blood stem cell grafts. | 2000 | Br. J. Haematol. | pmid:11167755 |
| Macleod MR et al. | Serum withdrawal causes apoptosis in SHSY 5Y cells. | 2001 | Brain Res. | pmid:11166724 |
| Tanaka K et al. | Immunosuppressive and non-immunosuppressive immunophilin ligands improve H(2)O(2)-induced cell damage by increasing glutathione levels in NG108-15 cells. | 2001 | Brain Res. | pmid:11166708 |
| Baran DA et al. | Tacrolimus monotherapy in adult cardiac transplant recipients: intermediate-term results. | 2001 | J. Heart Lung Transplant. | pmid:11166613 |
| Wakugawa M et al. | Evaluation of mite allergen-induced Th1 and Th2 cytokine secretion of peripheral blood mononuclear cells from atopic dermatitis patients: association between IL-13 and mite-specific IgE levels. | 2001 | J. Dermatol. Sci. | pmid:11164708 |
| Hofbauer LC et al. | Effects of immunosuppressants on receptor activator of NF-kappaB ligand and osteoprotegerin production by human osteoblastic and coronary artery smooth muscle cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11162519 |
| Peeling J et al. | Effect of FK-506 on inflammation and behavioral outcome following intracerebral hemorrhage in rat. | 2001 | Exp. Neurol. | pmid:11161622 |
| Rose N and Lever A | The rapamycin sensitivity of human T-cell leukaemia virus type I-induced T-cell proliferation is mediated independently of the polypyrimidine motifs in the 5' long terminal repeat. | 2001 | J. Gen. Virol. | pmid:11161283 |
| Hanauer SB and Dassopoulos T | Evolving treatment strategies for inflammatory bowel disease. | 2001 | Annu. Rev. Med. | pmid:11160781 |
| Coupes BM et al. | Plasma transforming growth factor beta(1) and platelet activation: implications for studies in transplant recipients. | 2001 | Nephrol. Dial. Transplant. | pmid:11158413 |
| Ligtenberg G et al. | Cardiovascular risk factors in renal transplant patients: cyclosporin A versus tacrolimus. | 2001 | J. Am. Soc. Nephrol. | pmid:11158228 |
| Prestle J et al. | Overexpression of FK506-binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca(2+) leak from the sarcoplasmic reticulum and increases contractility. | 2001 | Circ. Res. | pmid:11157671 |
| Mathis AS and Friedman GS | Coadministration of digoxin with itraconazole in renal transplant recipients. | 2001 | Am. J. Kidney Dis. | pmid:11157404 |
| Tolou-Ghamari Z et al. | In vitro pentamer formation as a biomarker of tacrolimus-related immunosuppressive activity after liver transplantation. | 2000 | Clin. Chem. Lab. Med. | pmid:11156362 |
| Cather JC et al. | Cyclosporine and tacrolimus in dermatology. | 2001 | Dermatol Clin | pmid:11155577 |
| MacDonald AS | Impact of immunosuppressive therapy on hypertension. | 2000 | Transplantation | pmid:11152235 |
| Kainz A et al. | Review of the course and outcome of 100 pregnancies in 84 women treated with tacrolimus. | 2000 | Transplantation | pmid:11152103 |
| König A et al. | Intravascular ultrasound for assessment of coronary allograft vasculopathy. | 2000 | Z Kardiol | pmid:11151792 |
| Gruber SA et al. | Local drug delivery to composite tissue allografts. | 2000 | Microsurgery | pmid:11150992 |
| Bain JR | Peripheral nerve and neuromuscular allotransplantation: current status. | 2000 | Microsurgery | pmid:11150988 |
| Hamar P et al. | Interleukin-2-dependent mechanisms are involved in the development of glomerulosclerosis after partial renal ablation in rats. | 2001 Mar-Apr | Exp. Nephrol. | pmid:11150862 |
| Nagatomo I et al. | Effects of MK-801, dantrolene, and FK506 on convulsive seizures and brain nitric oxide production in seizure-susceptible EL mice. | 2001 | Brain Res. | pmid:11150489 |
| Emre S et al. | Safety and risk of using pediatric donor livers in adult liver transplantation. | 2001 | Liver Transpl. | pmid:11150421 |
| Remitz A et al. | Tacrolimus ointment reduces staphylococcal colonization of atopic dermatitis lesions. | 2001 | J. Allergy Clin. Immunol. | pmid:11150013 |
| Gondo H et al. | Acquired Pelger-Huët anomaly in association with concomitant tacrolimus and fluconazole therapy following allogeneic bone marrow transplantation. | 2000 | Bone Marrow Transplant. | pmid:11149744 |
| Butani L and Makker SP | Conversion from tacrolimus to neoral for postrenal transplant diabetes. | 2000 | Pediatr. Nephrol. | pmid:11149106 |
| Nghiem P | "Topical immunomodulators?": introducing old friends and a new ally, tacrolimus. | 2001 | J. Am. Acad. Dermatol. | pmid:11148486 |
| Vallejo C et al. | Resolution of cyclosporine-induced gingival hyperplasia resistant to azithromycin by switching to tacrolimus. | 2001 | Haematologica | pmid:11146586 |
| Drake L et al. | The impact of tacrolimus ointment on health-related quality of life of adult and pediatric patients with atopic dermatitis. | 2001 | J. Am. Acad. Dermatol. | pmid:11145797 |
| Kang S et al. | Long-term safety and efficacy of tacrolimus ointment for the treatment of atopic dermatitis in children. | 2001 | J. Am. Acad. Dermatol. | pmid:11145796 |
| Paller A et al. | A 12-week study of tacrolimus ointment for the treatment of atopic dermatitis in pediatric patients. | 2001 | J. Am. Acad. Dermatol. | pmid:11145795 |
| Soter NA et al. | Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: part II, safety. | 2001 | J. Am. Acad. Dermatol. | pmid:11145794 |
| Hanifin JM et al. | Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: part I, efficacy. | 2001 | J. Am. Acad. Dermatol. | pmid:11145793 |
| Bekersky I et al. | Nonclinical and early clinical development of tacrolimus ointment for the treatment of atopic dermatitis. | 2001 | J. Am. Acad. Dermatol. | pmid:11145792 |
| Barone GW et al. | The tolerability of newer immunosuppressive medications in a patient with acute intermittent porphyria. | 2001 | J Clin Pharmacol | pmid:11144989 |
| Haas M et al. | Hypothyroidism as a cause of tacrolimus intoxication and acute renal failure: a case report. | 2000 | Wien. Klin. Wochenschr. | pmid:11144010 |
| Abraham KA et al. | Hemolytic-uremic syndrome in association with both cyclosporine and tacrolimus. | 2000 | Transpl. Int. | pmid:11140243 |
| Lopau K et al. | Tacrolimus in acute renal failure: does L-arginine-infusion prevent changes in renal hemodynamics? | 2000 | Transpl. Int. | pmid:11140242 |
| Michnick SW | Chemical biology beyond binary codes. | 2000 | Chem. Biol. | pmid:11137822 |
| Sestak K et al. | Tacrolimus-FK506 induced immunosuppression in gnotobiotic piglets. | 2000 | Vet. Immunol. Immunopathol. | pmid:11137126 |
| Sam WJ et al. | Population pharmacokinetics of tacrolimus in Asian paediatric liver transplant patients. | 2000 | Br J Clin Pharmacol | pmid:11136292 |
| Fischer S et al. | Initial experience of combined immunosuppressive induction therapy with polyclonal antithymocyte antibody, FK 506 (tacrolimus), and prednisolone in clinical liver transplantation. | 2000 | Transplant. Proc. | pmid:11134815 |
| Morena M et al. | Low-density lipoprotein composition and oxidation are not influenced by calcineurin inhibitors in renal transplant patients. | 2000 | Transplant. Proc. | pmid:11134805 |
| Tur MD et al. | Apolipoprotein CIII is upregulated by anticalcineurins and rapamycin: implications in transplantation-induced dyslipidemia. | 2000 | Transplant. Proc. | pmid:11134804 |
| Khoury N et al. | Posttransplant diabetes mellitus in kidney transplant recipients under tacrolimus immunosuppression. | 2000 | Transplant. Proc. | pmid:11134791 |
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| Tanaka K et al. | Immunophilin ligands prevent H2O2-induced apoptotic cell death by increasing glutathione levels in neuro 2A neuroblastoma cells. | 2000 | Acta Med. Okayama | pmid:11132921 |
| Morisaki T et al. | A combination of cyclosporin-A (CsA) and interferon-gamma (INF-gamma) induces apoptosis in human gastric carcinoma cells. | 2000 Sep- Oct | Anticancer Res. | pmid:11131636 |
| Jongen VH et al. | Vaginal delivery after lung transplantation. | 2000 | Acta Obstet Gynecol Scand | pmid:11130101 |
| Carnevale-Schianca F et al. | Changing from cyclosporine to tacrolimus as salvage therapy for chronic graft-versus-host disease. | 2000 | Biol. Blood Marrow Transplant. | pmid:11128811 |
| Becker DB et al. | Effects of FKBP-12 ligands following tibial nerve injury in rats. | 2000 | J Reconstr Microsurg | pmid:11127284 |
| Nowak JL | [Adverse effects of drug interactions of cyclosporin A and tacrolimus therapy]. | 2000 | Pol. Merkur. Lekarski | pmid:11126995 |
| Revell MP et al. | Conservation of small-airway function by tacrolimus/cyclosporine conversion in the management of bronchiolitis obliterans following lung transplantation. | 2000 | J. Heart Lung Transplant. | pmid:11124493 |
| Salm P et al. | Evaluation of microparticle enzyme immunoassay against HPLC-mass spectrometry for the determination of whole-blood tacrolimus in heart- and lung-transplant recipients. | 2000 | Clin. Biochem. | pmid:11124341 |
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| England K et al. | Signalling pathways regulating the dephosphorylation of Ser729 in the hydrophobic domain of protein kinase Cepsilon upon cell passage. | 2001 | J. Biol. Chem. | pmid:11121415 |
| Goto Y et al. | Suppressive effects of cyclosporin A and FK-506 on superoxide generation in human polymorphonuclear leukocytes primed by tumor necrosis factor alpha. | 2000 | J. Invest. Dermatol. | pmid:11121130 |
| Frey N and Olson EN | Making matters worse for a broken heart. | 2000 | J. Clin. Invest. | pmid:11120749 |
| Watanabe K et al. | Donor bone marrow cell infusion is effective in inducing tolerance in dogs treated with fractionated lymphoid irradiation and FK506. | 2000 | Transplant. Proc. | pmid:11120286 |
| Ringe B et al. | Replacement of corticosteroids by mycophenolate mofetil in liver graft recipients on initial tacrolimus immunosuppression. | 2000 | Transplant. Proc. | pmid:11120285 |
| Braun F et al. | An ex vivo model to study the intestinal biotransformation of immunosuppressives. | 2000 | Transplant. Proc. | pmid:11120282 |
| Braun F et al. | Primary tacrolimus immunosuppression in kidney recipients considered "higher immunologic risk". | 2000 | Transplant. Proc. | pmid:11120281 |
| Yoshida S et al. | Combination therapy with FK 506 and RS61443 for rejection following allogeneic small bowel transplantation in rats. | 2000 | Transplant. Proc. | pmid:11120262 |
| Yamaguchi M et al. | FK 506 significantly improves transferred insulin gene expression in total pancreatectomized dogs. | 2000 | Transplant. Proc. | pmid:11120255 |
| Jang HJ et al. | Comparison of pancreas transplantation outcome between the cyclosporine and tacrolimus eras. | 2000 | Transplant. Proc. | pmid:11120249 |
| Imamura M et al. | FK 506 inhibits severe graft-versus-host disease without mediating cytokine balance and/or cytotoxic molecules. | 2000 | Transplant. Proc. | pmid:11120238 |
| Tashiro H et al. | Donor bone marrow perioperatively administered via portal vein induced prolongation of skin allograft survival and microchimerism in liver-transplanted rats. | 2000 | Transplant. Proc. | pmid:11120201 |
| Moriuchi H et al. | Mechanisms of immunosuppressive effects of FK 506 in light of apoptosis of hepatocytes and infiltrating lymphocytes in rat allografted livers. | 2000 | Transplant. Proc. | pmid:11120182 |
| Lo CM et al. | More effective immunosuppression with the use of FK506 after liver transplantation. | 2000 | Transplant. Proc. | pmid:11120161 |
| Oishi M et al. | A case of hyperkalemic distal renal tubular acidosis secondary to tacrolimus in living donor liver transplantation. | 2000 | Transplant. Proc. | pmid:11120143 |
| Harihara Y et al. | Correlation between graft size and necessary tacrolimus dose after living-related liver transplantation. | 2000 | Transplant. Proc. | pmid:11120116 |
| Koyamada N et al. | Strategy for chronic rejection in recipient of living-related liver transplantation. | 2000 | Transplant. Proc. | pmid:11120102 |
| Sekido H et al. | Successful conversion from cyclosporine to tacrolimus for immunosuppression. | 2000 | Transplant. Proc. | pmid:11120096 |
| Hossain MA et al. | Effect of the immunosuppressants FK506 and D-allose on allogenic orthotopic liver transplantation in rats. | 2000 | Transplant. Proc. | pmid:11120048 |
| Fujikawa K et al. | Effects of tacrolimus on rat thymic epithelial cells. | 2000 | Transplant. Proc. | pmid:11120046 |
| Luk JM et al. | Immunosuppressive effects of Tripterygium wilfordii polysaccharide on LPS-stimulated human monocytes. | 2000 | Transplant. Proc. | pmid:11120045 |
| Nakao A et al. | Combined effect of donor-specific bone marrow transplantation via portal vein and FK506 on small bowel transplantation in the rat. | 2000 | Transplant. Proc. | pmid:11120044 |
| Braun F et al. | An ex vivo model to study the intestinal biotransformation of immunosuppressive drugs. | 2000 | Transplant. Proc. | pmid:11120037 |
| Vathsala A et al. | Inhibition of apoptosis in anti-CD3-treated peripheral blood lymphocytes by immunosuppressive drugs. | 2000 | Transplant. Proc. | pmid:11120034 |
| Chueh SC et al. | Drug fever caused by mycophenolate mofetil in a renal transplant recipient--a case report. | 2000 | Transplant. Proc. | pmid:11120003 |
| Shimizu T et al. | Risk factors of acute tacrolimus nephrotoxicity in renal allografts. | 2000 | Transplant. Proc. | pmid:11119998 |
| Kim HC and Park SB | Mycophenolate mofetil-induced ischemic colitis. | 2000 | Transplant. Proc. | pmid:11119990 |
| Shimada H et al. | Existence of serum p53 antibodies in cyclosporine A-treated transplant patients: possible detection of p53 protein over-expression. | 2000 | Transplant. Proc. | pmid:11119931 |
| Jang HJ et al. | Tacrolimus for rescue therapy in refractory renal allograft rejection. | 2000 | Transplant. Proc. | pmid:11119925 |
| Ichikawa Y et al. | Acute rejection and the therapeutic choice of drug. | 2000 | Transplant. Proc. | pmid:11119923 |
| Tsang WK et al. | Efficacy and safety of mycophenolate mofetil in different dosages in Asian renal allograft recipients. | 2000 | Transplant. Proc. | pmid:11119921 |
| Manu M et al. | Impact of tacrolimus on hyperlipidemia after renal transplantation: a Japanese single center experience. | 2000 | Transplant. Proc. | pmid:11119912 |
| Ichikura H et al. | Conversion of renal transplant immunosuppression from tacrolimus (FK 506) to cyclosporine: a single center experience. | 2000 | Transplant. Proc. | pmid:11119911 |
| Suzuki K et al. | Effect of tacrolimus in renal transplant recipients with immunoglobulin-A nephropathy. | 2000 | Transplant. Proc. | pmid:11119910 |
| Toda F et al. | Non-heart-beating donor kidney transplantation under tacrolimus immunosuppression. | 2000 | Transplant. Proc. | pmid:11119909 |
| Goto Y et al. | Outcome of tacrolimus-treated renal transplantation from elderly donors. | 2000 | Transplant. Proc. | pmid:11119908 |