tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Body Weight D001835 333 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

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Authors Title Published Journal PubMed Link
Briffa N and Morris RE Immunosuppressive drugs after lung transplantation. 1998 BMJ pmid:9529396
Iheanacho I Definitely not acceptable: drug company sues journal over review. 2011 BMJ pmid:21285186
Allen BR and Luger TA Risk: benefit ratio is important in treating atopic dermatitis. 2002 BMJ pmid:12399360
Misra DP et al. Pulmonary co-infection with Nocardia and Aspergillus in a patient with adult-onset Still's disease receiving steroids and tacrolimus. 2014 BMJ Case Rep pmid:25398925
Slocum AMY A surgeon's nightmare: pyoderma gangrenosum with pathergy effect mimicking necrotising fasciitis. 2017 BMJ Case Rep pmid:29269363
Maus EA The importance of challenging your diagnosis even in straightforward cases. 2012 BMJ Case Rep pmid:22847565
Mallon DH et al. A spontaneous coronary arterial dissection associated with a calcineurin inhibitor. 2012 BMJ Case Rep pmid:22783013
Borges-Costa J et al. Kaposi's sarcoma presenting as violaceous macules on the chest of a kidney transplanted patient. 2016 BMJ Case Rep pmid:26759393
Bonanni A et al. Low-dose ofatumumab for rituximab-resistant nephrotic syndrome. 2015 BMJ Case Rep pmid:26376698
Wu G et al. Tacrolimus-induced encephalopathy and polyneuropathy in a renal transplant recipient. 2013 BMJ Case Rep pmid:24311415
Purani JM and Purani HJ Treatment of geographic tongue with topical tacrolimus. 2014 BMJ Case Rep pmid:25085945
Viecelli A et al. Diagnostic and management dilemma of a pancreas-kidney transplant recipient with aplastic anaemia. 2014 BMJ Case Rep pmid:25257886
Kirpalani A et al. Idiosyncratic drug reactions and membranous glomerulopathy. 2017 BMJ Case Rep pmid:28137906
Liu HY et al. Ribavirin-induced anaemia reduced tacrolimus level in a hepatitis C patient receiving haemodialysis. 2018 BMJ Case Rep pmid:29669765
Gupta M et al. Tacrolimus-induced unilateral ischaemic optic neuropathy in a non-transplant patient. 2012 BMJ Case Rep pmid:22914240
Krystel-Whittemore M et al. Polyomavirus nephropathy of the native kidney in a patient with rheumatoid arthritis and pulmonary fibrosis. 2015 BMJ Case Rep pmid:26318171
Boyer NL et al. Tacrolimus-associated thrombotic microangiopathy in a lung transplant recipient. 2013 BMJ Case Rep pmid:23396921
Undre N and Dickinson J Relative bioavailability of single doses of prolonged-release tacrolimus administered as a suspension, orally or via a nasogastric tube, compared with intact capsules: a phase 1 study in healthy participants. 2017 BMJ Open pmid:28377389
Goldsmith PM et al. Impact of intrapatient variability (IPV) in tacrolimus trough levels on long-term renal transplant function: multicentre collaborative retrospective cohort study protocol. 2017 BMJ Open pmid:28756385
Castillo Lugo JA Clinical and experimental immunosuppression. 1995 May-Jun Bol Asoc Med P R pmid:8573248
Varanasi SS and Datta HK Characterisation of cytosolic FK506 binding protein 12 and its role in modulating expression of Cbfa1 and osterix in ROS 17/2.8 cells. 2005 Bone pmid:15780950
Fukunaga J et al. Expression of osteoclast differentiation factor and osteoclastogenesis inhibitory factor in rat osteoporosis induced by immunosuppressant FK506. 2004 Bone pmid:15003790
Darcy A et al. A novel library screen identifies immunosuppressors that promote osteoblast differentiation. 2012 Bone pmid:22421346
Voggenreiter G et al. Immunosuppression with FK506 has no influence on fracture healing in the rat. 2005 Bone pmid:15963777
Igarashi K et al. Cyclosporine A and FK506 induce osteoclast apoptosis in mouse bone marrow cell cultures. 2004 Bone pmid:15207740
Kharfan-Dabaja MA et al. Tacrolimus plus sirolimus with or without ATG as GVHD prophylaxis in HLA-mismatched unrelated donor allogeneic stem cell transplantation. 2017 Bone Marrow Transplant. pmid:27819684
Cutler C et al. Double umbilical cord blood transplantation with reduced intensity conditioning and sirolimus-based GVHD prophylaxis. 2011 Bone Marrow Transplant. pmid:20697368
Parody R et al. GvHD prophylaxis with tacrolimus plus sirolimus after reduced intensity conditioning allogeneic transplantation: results of a multicenter study. 2016 Bone Marrow Transplant. pmid:27295268
Hale GA et al. Blood tacrolimus concentrations in bone marrow transplant patients undergoing plasmapheresis. 2000 Bone Marrow Transplant. pmid:10723590
Rotenstein L et al. Management of refractory autoimmune hemolytic anemia via allogeneic stem cell transplantation. 2016 Bone Marrow Transplant. pmid:27272445
Schmook T et al. Treatment of cutaneous chronic graft-versus-host disease with topical pimecrolimus. 2005 Bone Marrow Transplant. pmid:15895116
Boswell GW et al. Tacrolimus pharmacokinetics in BMT patients. 1998 Bone Marrow Transplant. pmid:9486490
Tezcan H et al. Severe cerebellar swelling and thrombotic thrombocytopenic purpura associated with FK506. 1998 Bone Marrow Transplant. pmid:9486505
Gharpure VS et al. Thrombotic thrombocytopenic purpura associated with FK506 following bone marrow transplantation. 1995 Bone Marrow Transplant. pmid:8547871
Jacobson P et al. Factors affecting the pharmacokinetics of tacrolimus (FK506) in hematopoietic cell transplant (HCT) patients. 2001 Bone Marrow Transplant. pmid:11781626
Menillo SA et al. Intraoral psoralen ultraviolet A irradiation (PUVA) treatment of refractory oral chronic graft-versus-host disease following allogeneic stem cell transplantation. 2001 Bone Marrow Transplant. pmid:11781637
Miceli M et al. Significant interaction of tacrolimus with ritonavir during allogeneic hematopoietic SCT in an HIV-infected patient. 2012 Bone Marrow Transplant. pmid:22120984
Yanada M et al. Tacrolimus instead of cyclosporine used for prophylaxis against graft-versus-host disease improves outcome after hematopoietic stem cell transplantation from unrelated donors, but not from HLA-identical sibling donors: a nationwide survey conducted in Japan. 2004 Bone Marrow Transplant. pmid:15220958
Steg RE et al. Cortical blindness and seizures in a patient receiving FK506 after bone marrow transplantation. 1999 Bone Marrow Transplant. pmid:10338054
Mori T et al. Drug interaction between voriconazole and calcineurin inhibitors in allogeneic hematopoietic stem cell transplant recipients. 2009 Bone Marrow Transplant. pmid:19270729
Misawa A et al. FK506-induced intractable leukoencephalopathy following allogeneic bone marrow transplantation. 2000 Bone Marrow Transplant. pmid:10673708
Przepiorka D et al. Tacrolimus for prevention of graft-versus-host disease after mismatched unrelated donor cord blood transplantation. 1999 Bone Marrow Transplant. pmid:10414918
Kanda Y et al. A randomized controlled trial of cyclosporine and tacrolimus with strict control of blood concentrations after unrelated bone marrow transplantation. 2016 Bone Marrow Transplant. pmid:26437063
Espino G et al. Assessment of myocardial hypertrophy by echocardiography in adult patients receiving tacrolimus or cyclosporine therapy for prevention of acute GVHD. 2001 Bone Marrow Transplant. pmid:11803349
Watanabe N et al. Relationship between tacrolimus blood concentrations and clinical outcome during the first 4 weeks after SCT in children. 2010 Bone Marrow Transplant. pmid:19915626
Ratanatharathorn V et al. Low-dose antithymocyte globulin enhanced the efficacy of tacrolimus and mycophenolate for GVHD prophylaxis in recipients of unrelated SCT. 2015 Bone Marrow Transplant. pmid:25285804
Kato H et al. Significant improvement of Takayasu arteritis after cord blood transplantation in a patient with myelodysplastic syndrome. 2014 Bone Marrow Transplant. pmid:24317130
Takamatsu Y et al. Intravenous cyclosporine and tacrolimus caused anaphylaxis but oral cyclosporine capsules were tolerated in an allogeneic bone marrow transplant recipient. 2001 Bone Marrow Transplant. pmid:11571519
Oshima K et al. Target blood concentrations of CYA and tacrolimus in randomized controlled trials for the prevention of acute GVHD after hematopoietic SCT. 2010 Bone Marrow Transplant. pmid:19701249
Furlong T et al. Clinical outcome after conversion to FK 506 (tacrolimus) therapy for acute graft-versus-host disease resistant to cyclosporine or for cyclosporine-associated toxicities. 2000 Bone Marrow Transplant. pmid:11100278
Narimatsu H et al. Short-term methotrexate could reduce early immune reactions and improve outcomes in umbilical cord blood transplantation for adults. 2007 Bone Marrow Transplant. pmid:17115066
Lekakis L et al. Phase II study of unrelated cord blood transplantation for adults with high-risk hematologic malignancies. 2006 Bone Marrow Transplant. pmid:16892072
Ikegame K et al. Successful treatment of bcr/abl-positive acute mixed lineage leukemia by unmanipulated bone marrow transplantation from an HLA-haploidentical (3-antigen-mismatched) cousin. 2003 Bone Marrow Transplant. pmid:12796797
Przepiorka D et al. Tacrolimus clearance is age-dependent within the pediatric population. 2000 Bone Marrow Transplant. pmid:11041564
Ganetsky A et al. Higher tacrolimus concentrations early after transplant reduce the risk of acute GvHD in reduced-intensity allogeneic stem cell transplantation. 2016 Bone Marrow Transplant. pmid:26691423
Jabbour E et al. Treatment of donor graft failure with nonmyeloablative conditioning of fludarabine, antithymocyte globulin and a second allogeneic hematopoietic transplantation. 2007 Bone Marrow Transplant. pmid:17603511
Honda A et al. Omission of day-11 MTX, in combination with tacrolimus, is not associated with increased risk of acute graft-versus-host disease after allo-BMT. 2013 Bone Marrow Transplant. pmid:22751000
Ram R et al. Prophylaxis regimens for GVHD: systematic review and meta-analysis. 2009 Bone Marrow Transplant. pmid:18997826
Neuman DL et al. Toxic absorption of tacrolimus [corrected] in a patient with severe acute graft-versus-host disease. 2005 Bone Marrow Transplant. pmid:16151424
Fuji S et al. Decreased insulin secretion in patients receiving tacrolimus as GVHD prophylaxis after allogeneic hematopoietic SCT. 2010 Bone Marrow Transplant. pmid:19648969
Onizuka M et al. Cytochrome P450 genetic polymorphisms influence the serum concentration of calcineurin inhibitors in allogeneic hematopoietic SCT recipients. 2011 Bone Marrow Transplant. pmid:21102498
Skeens M et al. Twice daily i.v. bolus tacrolimus infusion for GVHD prophylaxis in children undergoing stem cell transplantation. 2012 Bone Marrow Transplant. pmid:22484323
Hiraoka A et al. Phase III study comparing tacrolimus (FK506) with cyclosporine for graft-versus-host disease prophylaxis after allogeneic bone marrow transplantation. 2001 Bone Marrow Transplant. pmid:11509936
Fujino M et al. Intestinal thrombotic microangiopathy induced by FK506 in rats. 2007 Bone Marrow Transplant. pmid:17277791
Kakihana K et al. Clinical features of calcineurin inhibitor-induced pain syndrome after allo-SCT. 2012 Bone Marrow Transplant. pmid:21625227
Yoshida Y et al. FK506-associated limbic injury following umbilical cord blood transplantation. 2003 Bone Marrow Transplant. pmid:12942100
Gaziev D et al. Chronic graft-versus-host disease: is there an alternative to the conventional treatment? 2000 Bone Marrow Transplant. pmid:10745252
Mori T et al. Drug interaction between voriconazole and tacrolimus in allogeneic hematopoietic SCT recipients. 2011 Bone Marrow Transplant. pmid:20453893
Eagle DA et al. Gastroparesis following bone marrow transplantation. 2001 Bone Marrow Transplant. pmid:11498745
Kanamaru A et al. FK506 treatment of graft-versus-host disease developing or exacerbating during prophylaxis and therapy with cyclosporin and/or other immunosuppressants. Japanese FK506 BMT Study Group. 1995 Bone Marrow Transplant. pmid:7581086
Koehler MT et al. FK506 (tacrolimus) in the treatment of steroid-resistant acute graft-versus-host disease in children undergoing bone marrow transplantation. 1995 Bone Marrow Transplant. pmid:7581088
Riley L et al. Cross-sensitivity reaction between tacrolimus and macrolide antibiotics. 2000 Bone Marrow Transplant. pmid:10808214
Jacobson P et al. Tacrolimus: a new agent for the prevention of graft-versus-host disease in hematopoietic stem cell transplantation. 1998 Bone Marrow Transplant. pmid:9720734
Hsiao CC et al. Evaluation for synergistic suppression of T cell responses to minor histocompatibility antigens by chloroquine in combination with tacrolimus and a rapamycin derivative, SDZ-RAD. 2002 Bone Marrow Transplant. pmid:12476284
Najera JE et al. Akinetic mutism-a serious complication to tacrolimus-based GVHD prophylaxis. 2013 Bone Marrow Transplant. pmid:22705799
Devine SM et al. Tacrolimus (FK506)-induced cerebral blindness following bone marrow transplantation. 1996 Bone Marrow Transplant. pmid:8879619
Przepiorka D et al. Bronchiolitis obliterans organizing pneumonia in a BMT patient receiving FK506. 1993 Bone Marrow Transplant. pmid:7687503
Trifilio SM et al. Tacrolimus use in adult allogeneic stem cell transplant recipients receiving voriconazole: preemptive dose modification and therapeutic drug monitoring. 2010 Bone Marrow Transplant. pmid:19966844
Yumura-Yagi K et al. Unrelated donor bone marrow transplantation for 100 pediatric patients: a single institute's experience. 2005 Bone Marrow Transplant. pmid:15968285
Przepiorka D et al. Tacrolimus and minidose methotrexate for prevention of acute graft-versus-host disease after HLA-mismatched marrow or blood stem cell transplantation. 1999 Bone Marrow Transplant. pmid:10516680
Gondo H et al. Acquired Pelger-Huët anomaly in association with concomitant tacrolimus and fluconazole therapy following allogeneic bone marrow transplantation. 2000 Bone Marrow Transplant. pmid:11149744
Couriel DR et al. Chronic graft-versus-host disease manifesting as polymyositis: an uncommon presentation. 2002 Bone Marrow Transplant. pmid:12379897
Yu C et al. Tacrolimus (FK506) and methotrexate regimens to prevent graft-versus-host disease after unrelated dog leukocyte antigen (DLA) nonidentical marrow transplantation. 1996 Bone Marrow Transplant. pmid:8722370
Mori T et al. Cold agglutinin disease associated with adenovirus infection after allogeneic bone marrow transplantation. 2005 Bone Marrow Transplant. pmid:15937504
Suehiro A et al. Enhancement by cyclosporine A and tacrolimus of serotonin-induced formation of small platelet aggregation. 2002 Bone Marrow Transplant. pmid:11850703
Uberti JP et al. Tacrolimus as monotherapy or combined with minidose methotrexate for graft-versus-host disease prophylaxis after allogeneic peripheral blood stem cell transplantation: long-term outcomes. 2004 Bone Marrow Transplant. pmid:15273705
Elefante A et al. Long-term stability of a patient-convenient 1 mg/ml suspension of tacrolimus for accurate maintenance of stable therapeutic levels. 2006 Bone Marrow Transplant. pmid:16518428
Sastry J et al. Acute pancreatitis due to tacrolimus in a case of allogeneic bone marrow transplantation. 2004 Bone Marrow Transplant. pmid:14743193
Han CW et al. Differential effects of the immunosuppressants cyclosporin A, FK506 and KM2210 on cytokine gene expression. 1995 Bone Marrow Transplant. pmid:7545487
Castagna L et al. Tacrolimus compared with cyclosporine A after haploidentical T-cell replete transplantation with post-infusion cyclophosphamide. 2016 Bone Marrow Transplant. pmid:26595078
Prot-Labarthe S et al. Toxic serum levels of tacrolimus after topical administration in an infant with severe cutaneous graft-versus-host disease. 2007 Bone Marrow Transplant. pmid:17549052
Shayani S et al. Aprepitant (Emend) significantly increases sirolimus levels in patients undergoing allogeneic hematopoietic SCT. 2012 Bone Marrow Transplant. pmid:21383680
Zohren F et al. Tacrolimus and mycofenolate mofetil as GvHD prophylaxis following nonmyeloablative conditioning and unrelated hematopoietic SCT for adult patients with advanced hematologic diseases. 2011 Bone Marrow Transplant. pmid:20661230
Dvorak CC et al. Use of intravenous mycophenolate mofetil for graft-versus-host disease prophylaxis in an allogeneic hematopoietic stem cell transplant recipient with an allergic reaction to cyclosporine and tacrolimus. 2006 Bone Marrow Transplant. pmid:16785867
Khaled SK et al. A phase II study of sirolimus, tacrolimus and rabbit anti-thymocyte globulin as GVHD prophylaxis after unrelated-donor PBSC transplant. 2013 Bone Marrow Transplant. pmid:23000644
Nieto Y et al. Acute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantation. 2000 Bone Marrow Transplant. pmid:10918414
Mawardi H et al. Combined topical dexamethasone/tacrolimus therapy for management of oral chronic GVHD. 2010 Bone Marrow Transplant. pmid:19881552
Esquirol A et al. Single-agent GvHD prophylaxis with tacrolimus after post-transplant high-dose cyclophosphamide is a valid option for haploidentical transplantation in adults with hematological malignancies. 2017 Bone Marrow Transplant. pmid:28604667
Cooper MH et al. Short-term myeloid reconstitution following TBI is not adversely affected by doses of FK506 that abrogate lethal GVHD. 1994 Bone Marrow Transplant. pmid:7527689
Al-Kadhimi Z et al. Low incidence of severe cGvHD and late NRM in a phase II trial of thymoglobulin, tacrolimus and sirolimus for GvHD prevention. 2017 Bone Marrow Transplant. pmid:28581472