| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kanda J et al. | Effects of the calcineurin inhibitors cyclosporine and tacrolimus on bone metabolism in rats. | 2018 | Biomed. Res. | pmid:29899188 |
| De Lemos-Bonotto M et al. | A systematic review and meta-analysis of second-line immunosuppressants for autoimmune hepatitis treatment. | 2018 | Eur J Gastroenterol Hepatol | pmid:29227329 |
| Huo T et al. | Preparation and comparison of tacrolimus-loaded solid dispersion and self-microemulsifying drug delivery system by in vitro/in vivo evaluation. | 2018 | Eur J Pharm Sci | pmid:29222025 |
| Gao CJ et al. | Oxymatrine Sensitizes the HaCaT Cells to the IFN-γ Pathway and Downregulates MDC, ICAM-1, and SOCS1 by Activating p38, JNK, and Akt. | 2018 | Inflammation | pmid:29218605 |
| Nakahara T et al. | Mechanistic insights into topical tacrolimus for the treatment of atopic dermatitis. | 2018 | Pediatr Allergy Immunol | pmid:29205511 |
| Watanabe N et al. | The possible clinical impact of risperidone on P-glycoprotein-mediated transport of tacrolimus: A case report and in vitro study. | 2018 | Biopharm Drug Dispos | pmid:29055041 |
| Gupta PC and Ram J | Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. | 2018 | Cornea | pmid:29040120 |
| Banovic F et al. | Tacrolimus therapy for dermal arteritis of the nasal philtrum refractory to surgery and anti-inflammatory therapy (doxycycline/niacinamide and topical fluocinolone) in a dog. | 2018 | Vet. Dermatol. | pmid:28990239 |
| Nakamura K et al. | Prevention of chronic renal allograft rejection by AS2553627, a novel JAK inhibitor, in a rat transplantation model. | 2018 | Transpl. Immunol. | pmid:28988984 |
| Ixtlapale-Carmona X et al. | Graft immunologic events in deceased donor kidney transplant recipients with preformed HLA-donor specific antibodies. | 2018 | Transpl. Immunol. | pmid:28974434 |
| Sakai R et al. | Efficacy and safety of multitarget therapy with cyclophosphamide and tacrolimus for lupus nephritis: a prospective, single-arm, single-centre, open label pilot study in Japan. | 2018 | Lupus | pmid:28683654 |
| Guan XF et al. | Population Pharmacokinetic Modeling of Diltiazem in Chinese Renal Transplant Recipients. | 2018 | Eur J Drug Metab Pharmacokinet | pmid:28646274 |
| Almeida-Paulo GN et al. | Weight of ABCB1 and POR genes on oral tacrolimus exposure in CYP3A5 nonexpressor pediatric patients with stable kidney transplant. | 2018 | Pharmacogenomics J. | pmid:28094348 |
| Liu Y et al. | Delayed Initiation of Tacrolimus Is Safe and Effective in Renal Transplant Recipients With Delayed and Slow Graft Function. | 2018 | Transplant. Proc. | pmid:30316359 |
| Nordheim E et al. | Preserved insulin secretion and kidney function in recipients with functional pancreas grafts 1 year after transplantation: a single-center prospective observational study | 2018 | Eur. J. Endocrinol. | pmid:30299895 |
| Kandula P et al. | Plantar ulcerative lichen planus: rapid improvement with a novel triple-therapy approach. | 2018 | Cutis | pmid:30235362 |
| Jiang JW et al. | Optimal immunosuppressor induces stable gut microbiota after liver transplantation. | 2018 | World J. Gastroenterol. | pmid:30228781 |
| Park S et al. | Reduced Tacrolimus Trough Level Is Reflected by Estimated Glomerular Filtration Rate (eGFR) Changes in Stable Renal Transplantation Recipients: Results of the OPTIMUM Phase 3 Randomized Controlled Study. | 2018 | Ann. Transplant. | pmid:29891834 |
| Gu B et al. | Exploration of Fecal Microbiota Transplantation in the Treatment of Refractory Diarrhea After Renal Transplantation. | 2018 | Transplant. Proc. | pmid:29880353 |
| Lee H et al. | Thymoglobulin Versus Basiliximab Induction Therapy in Low-Risk Kidney Transplant Recipients: A Single-Center Experience. | 2018 | Transplant. Proc. | pmid:29880348 |
| Majeed A et al. | A 20-year experience with nocardiosis in solid organ transplant (SOT) recipients in the Southwestern United States: A single-center study. | 2018 | Transpl Infect Dis | pmid:29668074 |
| Mah A et al. | Graft loss attributed to possible transfusion-transmitted ehrlichiosis following cord blood stem cell transplant. | 2018 | Transpl Infect Dis | pmid:29668040 |
| Ma D et al. | Manipulating the expression of SARP family regulator BulZ and its target gene product to increase tacrolimus production. | 2018 | Appl. Microbiol. Biotechnol. | pmid:29666890 |
| Ichinose K et al. | The efficacy of adjunct tacrolimus treatment in pregnancy outcomes in patients with systemic lupus erythematosus. | 2018 | Lupus | pmid:29665758 |
| Ishikawa S et al. | Management of Juvenile Idiopathic Arthritis in ABO-incompatible Kidney Transplantation: A Case Report. | 2018 | Transplant. Proc. | pmid:29661455 |
| Hu T et al. | Tacrolimus decreases proteinuria in patients with refractory IgA nephropathy. | 2018 | Medicine (Baltimore) | pmid:29718866 |
| Mei S et al. | Simultaneous determination of cyclosporine and tacrolimus in human whole blood by ultra-high performance liquid chromatography tandem mass spectrometry and comparison with a chemiluminescence microparticle immunoassay. | 2018 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29704799 |
| Stanton BZ et al. | Chemically induced proximity in biology and medicine. | 2018 | Science | pmid:29590011 |
| Shi D et al. | CYP3A4 and GCK genetic polymorphisms are the risk factors of tacrolimus-induced new-onset diabetes after transplantation in renal transplant recipients. | 2018 | Eur. J. Clin. Pharmacol. | pmid:29546446 |
| Mina M et al. | Comparison between the efficacy of microneedling combined with 5-fluorouracil vs microneedling with tacrolimus in the treatment of vitiligo. | 2018 | J Cosmet Dermatol | pmid:29532621 |
| Zhong J et al. | Tacrolimus interacts with voriconazole to reduce the severity of fungal keratitis by suppressing IFN-related inflammatory responses and concomitant FK506 and voriconazole treatment suppresses fungal keratitis. | 2018 | Mol. Vis. | pmid:29527115 |
| Okada K et al. | EBV-positive PEL-like lymphoma that developed in the course of antisynthetase syndrome treated with tacrolimus. | 2018 | Int. J. Hematol. | pmid:29516290 |
| Sano H et al. | T-cell-replete haploidentical stem cell transplantation using low-dose antithymocyte globulin in children with relapsed or refractory acute leukemia. | 2018 | Int. J. Hematol. | pmid:29508228 |
| Wan Q et al. | Therapeutic Effect of 0.1% Tacrolimus Eye Drops in the Tarsal Form of Vernal Keratoconjunctivitis. | 2018 | Ophthalmic Res. | pmid:28803239 |
| Takeuchi T et al. | Post-marketing surveillance study of the long-term use of mizoribine for the treatment of lupus nephritis: 2-Year results. | 2018 | Mod Rheumatol | pmid:28722500 |
| Vosough M and Tehrani SM | Development of a fast HPLC-DAD method for simultaneous quantitation of three immunosuppressant drugs in whole blood samples using intelligent chemometrics resolving of coeluting peaks in the presence of blood interferences. | 2018 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29241087 |
| Hashemian MN et al. | Topical Tacrolimus as Adjuvant Therapy to Corticosteroids in Acute Endothelial Graft Rejection After Penetrating Keratoplasty: A Randomized Controlled Trial. | 2018 | Cornea | pmid:29215395 |
| Charnaya O et al. | Results of early treatment for de novo donor-specific antibodies in pediatric kidney transplant recipients in a cross-sectional and longitudinal cohort. | 2018 | Pediatr Transplant | pmid:29356221 |
| Yamada K et al. | Correlation between disease activity and serum ferritin in clinically amyopathic dermatomyositis with rapidly-progressive interstitial lung disease: a case report. | 2018 | BMC Res Notes | pmid:29338781 |
| Jin L et al. | Effect of Conversion to CTLA4Ig on Tacrolimus-Induced Diabetic Rats. | 2018 | Transplantation | pmid:29319618 |
| Oetting WS et al. | Attempted validation of 44 reported SNPs associated with tacrolimus troughs in a cohort of kidney allograft recipients. | 2018 | Pharmacogenomics | pmid:29318894 |
| Rayar M et al. | High Intrapatient Variability of Tacrolimus Exposure in the Early Period After Liver Transplantation Is Associated With Poorer Outcomes. | 2018 | Transplantation | pmid:29315140 |
| Miyake M et al. | Ligand-induced rapid skeletal muscle atrophy in HSA-Fv2E-PERK transgenic mice. | 2017 | PLoS ONE | pmid:28644884 |
| Zhang HJ et al. | Tacrolimus population pharmacokinetics according to CYP3A5 genotype and clinical factors in Chinese adult kidney transplant recipients. | 2017 | J Clin Pharm Ther | pmid:28401703 |
| Dhakal P et al. | Eculizumab in Transplant-Associated Thrombotic Microangiopathy. | 2017 | Clin. Appl. Thromb. Hemost. | pmid:26259912 |
| Chapman WC et al. | Effect of Early Everolimus-Facilitated Reduction of Tacrolimus on Efficacy and Renal Function in De Novo Liver Transplant Recipients: 24-Month Results for the North American Subpopulation. | 2017 | Transplantation | pmid:28121741 |
| Zhao YT et al. | Sensitized signalling between L-type Ca2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes. | 2017 | Cardiovasc. Res. | pmid:28077437 |
| Ishida R et al. | The Tissue-Reconstructing Ability of Colon CSCs Is Enhanced by FK506 and Suppressed by GSK3 Inhibition. | 2017 | Mol. Cancer Res. | pmid:28710230 |
| Parrow NL and Fleming RE | Releasing the FKBP12 brake on hepcidin. | 2017 | Blood | pmid:29122771 |
| Barau C et al. | Pharmacokinetics of Mycophenolic Acid and Dose Optimization in Children After Intestinal Transplantation. | 2017 | Ther Drug Monit | pmid:27898598 |