| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jain AB et al. | Comparative study of cyclosporine and FK 506 dosage requirements in adult and pediatric orthotopic liver transplant patients. | 1991 | Transplant. Proc. | pmid:1721270 |
| Abu-Elmagd KM et al. | Four-hour versus 24-hour intravenous infusion of FK 506 in liver transplantation. | 1991 | Transplant. Proc. | pmid:1721271 |
| DiLella AG and Craig RJ | Characterization of the human FKBP-12 gene and related pseudogenes. | 1991 | Transplant. Proc. | pmid:1721302 |
| Kar S and Carr B | Gene expression of FK 506-binding protein. | 1991 | Transplant. Proc. | pmid:1721303 |
| Winkler M et al. | Use of FK 506 for treatment of chronic rejection after liver transplantation. | 1991 | Transplant. Proc. | pmid:1721334 |
| D'Alessandro AM et al. | FK 506 rescue therapy for resistant rejection episodes in liver transplant recipients. | 1991 | Transplant. Proc. | pmid:1721335 |
| Nalesnik MA et al. | Lymphoproliferative disorders arising under immunosuppression with FK 506: initial observations in a large transplant population. | 1991 | Transplant. Proc. | pmid:1703335 |
| Armitage JM et al. | A clinical trial of FK 506 as primary and rescue immunosuppression in cardiac transplantation. | 1991 | Transplant. Proc. | pmid:1703336 |
| Offner G et al. | FK 506 in a 14-year-old renal allograft recipient with cyclosporine-related liver nephrotoxicity: 1-year follow-up. | 1991 | Transplant. Proc. | pmid:1721366 |
| Japanese study of FK 506 on kidney transplantation: the benefit of monitoring the whole blood FK 506 concentration. Japanese FK 506 Study Group. | 1991 | Transplant. Proc. | pmid:1721367 | |
| Sewing KF and Christians U | FK 506. | 1991 | Lancet | pmid:1704090 |
| Wiederrecht G et al. | FKB1 encodes a nonessential FK 506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1704127 |
| Ogasa N et al. | Effect of FK 506 on growth of transplanted newborn rat intestine. | 1991 | Transplant. Proc. | pmid:1721428 |
| de Bruin RW et al. | Fulminant graft-versus-host disease after FK 506 treatment in fully allogeneic small bowel transplantation. | 1991 | Transplant. Proc. | pmid:1721429 |
| Langrehr JM et al. | FK 506 inhibits nitric oxide production by cells infiltrating sponge matrix allografts. | 1991 | Transplant. Proc. | pmid:1721430 |
| Halloran PF and Madrenas J | The mechanism of action of cyclosporine: a perspective for the 90's. | 1991 | Clin. Biochem. | pmid:1711939 |
| Palaszynski EW et al. | Purification and characterization of cyclosporine and FK-506 binding proteins from a human T-helper cell line. | 1991 | Clin. Biochem. | pmid:1711940 |
| Shiraki K et al. | Effect of FK-506 on replication of human cytomegalovirus in vitro. | 1991 | J. Antibiot. | pmid:1712008 |
| Deguchi K et al. | Effects of FK 506 on acute experimental allergic encephalomyelitis. | 1991 | Transplant. Proc. | pmid:1721461 |
| Bolton C | The ability of myelin basic protein-sensitised leukocytes to adoptively transfer experimental allergic encephalomyelitis following coculture with FK 506, cyclosporine, or prednisolone. | 1991 | Transplant. Proc. | pmid:1721462 |
| Morris RE | Rapamycin: FK506's fraternal twin or distant cousin? | 1991 | Immunol. Today | pmid:1715165 |
| Baumann G et al. | Cyclosporin A and FK-506 both affect DNA binding of regulatory nuclear proteins to the human interleukin-2 promoter. | 1991 | New Biol. | pmid:1715185 |
| Fujino Y et al. | FK506 treatment of S-antigen induced uveitis in primates. | 1991 | Curr. Eye Res. | pmid:1717199 |
| Ryu S and Yasunami Y | The necessity of differential immunosuppression for prevention of immune rejection by FK506 in rat islet allografts transplanted into the liver or beneath the kidney capsule. | 1991 | Transplantation | pmid:1718064 |
| Kuroki H et al. | Morphological and immunological analysis of rats with long-term-surviving limb allografts induced by a short course of FK 506 or cyclosporine. | 1991 | Transplant. Proc. | pmid:1703697 |
| Starzl TE et al. | Hepatotrophic properties in dogs of human FKBP, the binding protein for FK506 and rapamycin. | 1991 | Transplantation | pmid:1718068 |
| Morris RE et al. | Use of rapamycin for the suppression of alloimmune reactions in vivo: schedule dependence, tolerance induction, synergy with cyclosporine and FK 506, and effect on host-versus-graft and graft-versus-host reactions. | 1991 | Transplant. Proc. | pmid:1703698 |
| Jordan ML et al. | Initial studies with FK506 in renal transplantation. | 1991 Sep-Oct | Cleve Clin J Med | pmid:1718631 |
| Kusne S et al. | Infections during a randomized trial comparing cyclosporine to FK 506 immunosuppression in liver transplantation. | 1992 | Transplant. Proc. | pmid:1371626 |
| Lee C et al. | FK-506 binding protein from Tolypocladium inflatum: resistance of FKBP/FK-506 complex against proteolysis. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1371677 |
| Edkins RD et al. | Comparison of cyclosporine and FK506 effects on glutathione levels in rat cochlea, brain, liver and kidney. | 1992 | Biochem. Pharmacol. | pmid:1371687 |
| Galat A et al. | A rapamycin-selective 25-kDa immunophilin. | 1992 | Biochemistry | pmid:1371698 |
| Metcalfe S et al. | FK506 and rapamycin: differential sensitivity of human, baboon, cynomolgus monkey, dog and pig lymphocytes. | 1992 | Transpl. Int. | pmid:14621863 |
| Hanawa H et al. | An immunosuppressant compound, FK-506, prevents the progression of autoimmune myocarditis in rats. | 1992 | Clin. Immunol. Immunopathol. | pmid:1371730 |
| Japanese study of kidney transplantation: 1. Results of early phase II study. | 1992 | Transpl. Int. | pmid:14621866 | |
| Hiraoka Y et al. | The effects of FK-506, a novel and potent immunosuppressant, upon murine Coxsackievirus B3 myocarditis. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1372051 |
| Japanese study of FK 506 on kidney transplantation: 2. Follow-up study of FK 506-treated patients. | 1992 | Transpl. Int. | pmid:14621874 | |
| Chen TS et al. | Microbial transformation of immunosuppressive compounds. I. Desmethylation of FK506 and immunomycin (FR 900520) by Actinoplanes sp. ATCC 53771. | 1992 | J. Antibiot. | pmid:1372307 |
| Walpoth B et al. | Prevention of cardiac allograft rejection by FK506 and rapamycin: assessment by histology and nuclear magnetic resonance. | 1992 | Transpl. Int. | pmid:14621877 |
| Morisaki M and Arai T | Identity of immunosuppressant FR-900520 with ascomycin. | 1992 | J. Antibiot. | pmid:1372308 |
| Doi R et al. | Effects of FK506 on exocrine pancreas in rats. | 1992 | Pancreas | pmid:1372739 |
| Kawano K et al. | FK 506 ameliorates normothermic liver ischemia in rats by suppressing production of tumor necrosis factor. | 1992 | Transpl. Int. | pmid:14621904 |
| Furukawa H et al. | The effect of bile duct ligation and bile diversion on FK506 pharmacokinetics in dogs. | 1992 | Transplantation | pmid:1373531 |
| Sakr M et al. | The protective effect of FK506 pretreatment against renal ischemia/reperfusion injury in rats. | 1992 | Transplantation | pmid:1374948 |
| Lepre CA et al. | Solution structure of FK506 bound to FKBP-12. | 1992 | FEBS Lett. | pmid:1375171 |
| Ruff VA et al. | FKBP-12 is not an inhibitor of protein kinase C. | 1992 | Immunol. Invest. | pmid:1375189 |
| Kawaguchi S | [Effects of FK506 on aminonucleoside-induced nephrotic rats]. | 1992 | Nihon Jinzo Gakkai Shi | pmid:1375300 |
| Sigal NH and Dumont FJ | Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction. | 1992 | Annu. Rev. Immunol. | pmid:1375473 |
| Chen TS et al. | Microbial transformation of immunosuppressive compounds. II. Specific desmethylation of 13-methoxy group of FK 506 and FR 900520 by an unidentified Actinomycete ATCC 53828 [corrected]. | 1992 | J. Antibiot. | pmid:1375593 |
| Meingassner JG and Stütz A | Immunosuppressive macrolides of the type FK 506: a novel class of topical agents for treatment of skin diseases? | 1992 | J. Invest. Dermatol. | pmid:1375617 |
| Schneck FX et al. | Pediatric renal transplantation under FK-506 immunosuppression. | 1992 | J. Urol. | pmid:1375663 |
| Yagihashi A et al. | Changes in cell surface markers in human small bowel transplantation with FK 506. | 1992 | Transplant. Proc. | pmid:1376522 |
| Abu-Elmagd K et al. | Management of intestinal transplantation in humans. | 1992 | Transplant. Proc. | pmid:1376523 |
| Takaori K et al. | Basic study on immunologic effects of cyclosporine and FK 506 for application to pancreatic transplantation. | 1992 | Transplant. Proc. | pmid:1376531 |
| Ohtsuka S et al. | The effect of short-term FK 506 therapy on pancreas transplantation using the cuff technique in rats. | 1992 | Transplant. Proc. | pmid:1376532 |
| Demetris AJ et al. | Donor dendritic cells after liver and heart allotransplantation under short-term immunosuppression. | 1992 | Lancet | pmid:1376851 |
| Ichihashi T et al. | Haemolytic uraemic syndrome during FK506 therapy. | 1992 | Lancet | pmid:1376852 |
| O'Keefe SJ et al. | FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. | 1992 | Nature | pmid:1377361 |
| Clipstone NA and Crabtree GR | Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. | 1992 | Nature | pmid:1377362 |
| Hasegawa S et al. | Combination use of suboptimal dose of FK 506 and cyclosporine in canine lung transplantation. | 1992 | J. Thorac. Cardiovasc. Surg. | pmid:1279319 |
| Peattie DA et al. | Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1279700 |
| Souza ER et al. | Acute effects of FK 506 on glomerular hemodynamics. | 1992 | Transplant. Proc. | pmid:1281585 |
| Hanke JH et al. | FK506 and rapamycin selectively enhance degradation of IL-2 and GM-CSF mRNA. | 1992 | Lymphokine Cytokine Res. | pmid:1281674 |
| Logan TM et al. | Side chain and backbone assignments in isotopically labeled proteins from two heteronuclear triple resonance experiments. | 1992 | FEBS Lett. | pmid:1281793 |
| Bergstrand H et al. | Modulation of neutrophil superoxide generation by inhibitors of protein kinase C, calmodulin, diacylglycerol and myosin light chain kinases, and peptidyl prolyl cis-trans isomerase. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1281879 |
| DiLella AG et al. | Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1281998 |
| Sawada M et al. | Down regulation of CD4 expression in cultured microglia by immunosuppressants and lipopolysaccharide. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1282000 |
| Minoda M et al. | Effects of gamma-interferon and FK506 on resting B cell proliferation of New Zealand black/white F1 mice. | 1992 | Microbiol. Immunol. | pmid:1282197 |
| Min DI et al. | Visual compatibility of tacrolimus with commonly used drugs during simulated Y-site injection. | 1992 | Am J Hosp Pharm | pmid:1282779 |
| Mochizuki M | [Immunotherapy in ocular diseases]. | 1992 | Nippon Ganka Gakkai Zasshi | pmid:1283052 |
| Kumano K et al. | [Functional and morphological changes in rat kidney induced by FK506 and its reversal by various vasodilators]. | 1992 | Nippon Hinyokika Gakkai Zasshi | pmid:1379657 |
| Woodle ES et al. | FK506: inhibition of humoral mechanisms of hepatic allograft rejection. | 1992 | Transplantation | pmid:1379749 |
| Sato K et al. | Effectiveness of triple drug immunosuppression for pancreaticoduodenal allotransplantation in dogs. | 1992 | Transplant. Proc. | pmid:1379753 |
| Kobayashi N et al. | Abdominal organ cluster transplantation in pigs receiving FK 506. | 1992 | Transplant. Proc. | pmid:1379754 |
| Yoshimura R et al. | A comparative study of cyclosporine vs FK 506: role of kidney microsomal cytochrome P-450. | 1992 | Transplant. Proc. | pmid:1379755 |
| Yamada K et al. | FK 506-induced juxtaglomerular apparatus hyperplasia and tubular damage in rat kidney--morphologic and biologic analysis. | 1992 | Transplant. Proc. | pmid:1379756 |
| Fukuse T et al. | Optimal dose of FK 506 in canine lung allotransplantation. | 1992 | Transplant. Proc. | pmid:1379757 |
| Wada H et al. | Combination use of suboptimal doses of FK 506 and cyclosporine in canine lung transplantation. | 1992 | Transplant. Proc. | pmid:1379758 |
| Cai X et al. | Low-dose of FK 506 and associated blood levels in allotransplantation of rat liver, heart, and skin. | 1992 | Transplant. Proc. | pmid:1379759 |
| Taki J et al. | DNA analysis of peripheral blood mononuclear cells for early detection of hepatic graft rejection. | 1992 | Transplant. Proc. | pmid:1379760 |
| Friccius H et al. | The effects of the antifungal azoles itraconazole, fluconazole, ketoconazole and miconazole on cytokine gene expression in human lymphoid cells. | 1992 | Int. J. Immunopharmacol. | pmid:1380951 |
| Dumont FJ et al. | The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin. | 1992 | J. Exp. Med. | pmid:1380976 |
| Norris AA et al. | Protective effects of cyclophosphamide, cyclosporin A and FK506 against antigen-induced lung eosinophilia in guinea-pigs. | 1992 | Clin. Exp. Immunol. | pmid:1381297 |
| Karpas A et al. | Inhibition of human immunodeficiency virus and growth of infected T cells by the immunosuppressive drugs cyclosporin A and FK 506. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1381509 |
| Yatscoff RW and Shaw LM | Therapeutic monitoring of cyclosporine, FK-506, and rapamycin. | 1992 | Ther Drug Monit | pmid:1381530 |
| Arceci RJ et al. | Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype. | 1992 | Blood | pmid:1381629 |
| Pahl A and Keller U | FK-506-binding proteins from streptomycetes producing immunosuppressive macrolactones of the FK-506 type. | 1992 | J. Bacteriol. | pmid:1381710 |
| Takahashi N | [Cyclophilin and FK506-binding protein]. | 1992 | Seikagaku | pmid:1381737 |
| Lee TK et al. | Mucosal glutamine utilization after small-bowel transplantation: an electrophysiologic study. | 1992 | J. Surg. Res. | pmid:1382152 |
| Kaye RE et al. | Effects of cyclosporin A and FK506 on Fc epsilon receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1382293 |
| Siekierka JJ and Sigal NH | FK-506 and cyclosporin A: immunosuppressive mechanism of action and beyond. | 1992 | Curr. Opin. Immunol. | pmid:1384551 |
| Hultsch T et al. | The effect of the immunophilin ligands rapamycin and FK506 on proliferation of mast cells and other hematopoietic cell lines. | 1992 | Mol. Biol. Cell | pmid:1384815 |
| Petros AM et al. | Identification of solvent-exposed regions of an FK-506 analog, ascomycin, bound to FKBP using a paramagnetic probe. | 1992 | J. Biomol. NMR | pmid:1384850 |
| Liu J et al. | The effects of FK-506 and cyclosporin A on the proliferation of PHA-stimulated T cells in response to IL-2, IL-4 or IL-6. | 1992 | Int. Arch. Allergy Immunol. | pmid:1384862 |
| Mochizuki M et al. | Preclinical and clinical study of FK506 in uveitis. | 1992 | Curr. Eye Res. | pmid:1385045 |
| Chung J et al. | Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. | 1992 | Cell | pmid:1377606 |
| Xu RX et al. | Stereospecific assignments and chi 1 rotamers for FKBP when bound to ascomycin from 3JH alpha,H beta and 3HN,H beta coupling constants. | 1992 | FEBS Lett. | pmid:1377648 |
| Petros AM et al. | NMR studies of an FK-506 analog, [U-13C]ascomycin, bound to FK-506-binding protein. | 1992 | J. Med. Chem. | pmid:1377749 |
| Strom TB | Molecular immunology and immunopharmacology of allograft rejection. | 1992 | Kidney Int. Suppl. | pmid:1383599 |
| Wang SC et al. | FK-506 inhibits proliferation and IL-4 messenger RNA production by a T-helper 2 cell line. | 1992 | J. Surg. Res. | pmid:1383612 |