| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sampson BA and Gotschlich EC | Neisseria meningitidis encodes an FK506-inhibitable rotamase. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1371354 |
| Andersson J et al. | Effects of FK506 and cyclosporin A on cytokine production studied in vitro at a single-cell level. | 1992 | Immunology | pmid:1371491 |
| Strasser S et al. | Effect of FK506 on insulin secretion in normal dogs. | 1992 | Metab. Clin. Exp. | pmid:1371575 |
| Andersson J et al. | FK 506 and cyclosporine inhibit antigen- or mitogen-induced monokine and lymphokine production in vitro. | 1992 | Transplant. Proc. | pmid:1371621 |
| Matsuura T et al. | Blockade of interleukin-2 production from cloned T cells by cyclosporine and FK 506 assessed by proliferation assays in vitro. | 1992 | Transplant. Proc. | pmid:1371623 |
| Okamura N et al. | Enhanced liver regeneration by FK 506 can be blocked by interleukin-1 alpha and interleukin-2. | 1992 | Transplant. Proc. | pmid:1371624 |
| Sakr M et al. | Effect of renal ischemia on plasma levels of FK 506 in rats. | 1992 | Transplant. Proc. | pmid:1371625 |
| Kusne S et al. | Infections during a randomized trial comparing cyclosporine to FK 506 immunosuppression in liver transplantation. | 1992 | Transplant. Proc. | pmid:1371626 |
| Lee C et al. | FK-506 binding protein from Tolypocladium inflatum: resistance of FKBP/FK-506 complex against proteolysis. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1371677 |
| Edkins RD et al. | Comparison of cyclosporine and FK506 effects on glutathione levels in rat cochlea, brain, liver and kidney. | 1992 | Biochem. Pharmacol. | pmid:1371687 |
| Galat A et al. | A rapamycin-selective 25-kDa immunophilin. | 1992 | Biochemistry | pmid:1371698 |
| Hanawa H et al. | An immunosuppressant compound, FK-506, prevents the progression of autoimmune myocarditis in rats. | 1992 | Clin. Immunol. Immunopathol. | pmid:1371730 |
| Hiraoka Y et al. | The effects of FK-506, a novel and potent immunosuppressant, upon murine Coxsackievirus B3 myocarditis. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1372051 |
| Japanese study of FK 506 on kidney transplantation: 2. Follow-up study of FK 506-treated patients. | 1992 | Transpl. Int. | pmid:14621874 | |
| Chen TS et al. | Microbial transformation of immunosuppressive compounds. I. Desmethylation of FK506 and immunomycin (FR 900520) by Actinoplanes sp. ATCC 53771. | 1992 | J. Antibiot. | pmid:1372307 |
| Walpoth B et al. | Prevention of cardiac allograft rejection by FK506 and rapamycin: assessment by histology and nuclear magnetic resonance. | 1992 | Transpl. Int. | pmid:14621877 |
| Kawano K et al. | FK 506 ameliorates normothermic liver ischemia in rats by suppressing production of tumor necrosis factor. | 1992 | Transpl. Int. | pmid:14621904 |
| Ochiai T | [Advances in the fundamentals and therapeutic use of immunosuppressive agents]. | 1992 | Arerugi | pmid:1374229 |
| Hung DT and Schreiber SL | cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1374240 |
| Jayaraman T et al. | FK506 binding protein associated with the calcium release channel (ryanodine receptor). | 1992 | J. Biol. Chem. | pmid:1374404 |
| Höllsberg P et al. | Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells. | 1992 | J. Immunol. | pmid:1374452 |
| Schreiber SL and Crabtree GR | The mechanism of action of cyclosporin A and FK506. | 1992 | Immunol. Today | pmid:1374612 |
| Demetris AJ et al. | Conversion of liver allograft recipients from cyclosporine to FK506 immunosuppressive therapy--a clinicopathologic study of 96 patients. | 1992 | Transplantation | pmid:1374944 |
| Bundick RV et al. | FK506 as an agonist to induce inhibition of interleukin 2 production. | 1992 | Transplantation | pmid:1374947 |
| Sakr M et al. | The protective effect of FK506 pretreatment against renal ischemia/reperfusion injury in rats. | 1992 | Transplantation | pmid:1374948 |
| Lepre CA et al. | Solution structure of FK506 bound to FKBP-12. | 1992 | FEBS Lett. | pmid:1375171 |
| Ruff VA et al. | FKBP-12 is not an inhibitor of protein kinase C. | 1992 | Immunol. Invest. | pmid:1375189 |
| Kawaguchi S | [Effects of FK506 on aminonucleoside-induced nephrotic rats]. | 1992 | Nihon Jinzo Gakkai Shi | pmid:1375300 |
| Sigal NH and Dumont FJ | Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction. | 1992 | Annu. Rev. Immunol. | pmid:1375473 |
| Chen TS et al. | Microbial transformation of immunosuppressive compounds. II. Specific desmethylation of 13-methoxy group of FK 506 and FR 900520 by an unidentified Actinomycete ATCC 53828 [corrected]. | 1992 | J. Antibiot. | pmid:1375593 |
| Meingassner JG and Stütz A | Immunosuppressive macrolides of the type FK 506: a novel class of topical agents for treatment of skin diseases? | 1992 | J. Invest. Dermatol. | pmid:1375617 |
| Schneck FX et al. | Pediatric renal transplantation under FK-506 immunosuppression. | 1992 | J. Urol. | pmid:1375663 |
| Connelly PR and Thomson JA | Heat capacity changes and hydrophobic interactions in the binding of FK506 and rapamycin to the FK506 binding protein. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1375751 |
| Lancaster JR et al. | EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft. | 1992 | J. Biol. Chem. | pmid:1375934 |
| Hirai T et al. | The immunosuppressive effect of FK 506 on canine lung transplantation. | 1992 | J. Thorac. Cardiovasc. Surg. | pmid:1375967 |
| Tai PK et al. | Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex. | 1992 | Science | pmid:1376003 |
| Jegasothy BV et al. | Tacrolimus (FK 506)--a new therapeutic agent for severe recalcitrant psoriasis. | 1992 | Arch Dermatol | pmid:1376102 |
| Abu-Elmagd K et al. | Management of intestinal transplantation in humans. | 1992 | Transplant. Proc. | pmid:1376523 |
| Takaori K et al. | Basic study on immunologic effects of cyclosporine and FK 506 for application to pancreatic transplantation. | 1992 | Transplant. Proc. | pmid:1376531 |
| Ohtsuka S et al. | The effect of short-term FK 506 therapy on pancreas transplantation using the cuff technique in rats. | 1992 | Transplant. Proc. | pmid:1376532 |
| Demetris AJ et al. | Donor dendritic cells after liver and heart allotransplantation under short-term immunosuppression. | 1992 | Lancet | pmid:1376851 |
| Ichihashi T et al. | Haemolytic uraemic syndrome during FK506 therapy. | 1992 | Lancet | pmid:1376852 |
| O'Keefe SJ et al. | FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. | 1992 | Nature | pmid:1377361 |
| Clipstone NA and Crabtree GR | Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. | 1992 | Nature | pmid:1377362 |
| Hasegawa S et al. | Combination use of suboptimal dose of FK 506 and cyclosporine in canine lung transplantation. | 1992 | J. Thorac. Cardiovasc. Surg. | pmid:1279319 |
| Peattie DA et al. | Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1279700 |
| Lhoëst G et al. | Isolation and mass spectrometric identification of two metabolites of FK 506 from rat liver microsomal incubation media. | 1992 | Pharm Acta Helv | pmid:1279730 |
| Benigni A et al. | The acute effect of FK506 and cyclosporine on endothelial cell function and renal vascular resistance. | 1992 | Transplantation | pmid:1279848 |
| Mor E et al. | Late-onset acute rejection in orthotopic liver transplantation--associated risk factors and outcome. | 1992 | Transplantation | pmid:1279849 |
| Hirano Y et al. | The effects of FK506 and cyclosporine on the exocrine function of the rat pancreas. | 1992 | Transplantation | pmid:1279850 |
| Takaya S et al. | Liver transplantation in positive cytotoxic crossmatch cases using FK506, high-dose steroids, and prostaglandin E1. | 1992 | Transplantation | pmid:1279851 |
| Hanke JH et al. | FK506 and rapamycin selectively enhance degradation of IL-2 and GM-CSF mRNA. | 1992 | Lymphokine Cytokine Res. | pmid:1281674 |
| Logan TM et al. | Side chain and backbone assignments in isotopically labeled proteins from two heteronuclear triple resonance experiments. | 1992 | FEBS Lett. | pmid:1281793 |
| Bergstrand H et al. | Modulation of neutrophil superoxide generation by inhibitors of protein kinase C, calmodulin, diacylglycerol and myosin light chain kinases, and peptidyl prolyl cis-trans isomerase. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1281879 |
| DiLella AG et al. | Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1281998 |
| Sawada M et al. | Down regulation of CD4 expression in cultured microglia by immunosuppressants and lipopolysaccharide. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1282000 |
| Minoda M et al. | Effects of gamma-interferon and FK506 on resting B cell proliferation of New Zealand black/white F1 mice. | 1992 | Microbiol. Immunol. | pmid:1282197 |
| Min DI et al. | Visual compatibility of tacrolimus with commonly used drugs during simulated Y-site injection. | 1992 | Am J Hosp Pharm | pmid:1282779 |
| Mochizuki M | [Immunotherapy in ocular diseases]. | 1992 | Nippon Ganka Gakkai Zasshi | pmid:1283052 |
| Olejniczak ET et al. | A 4D HCCH-TOCSY experiment for assigning the side chain 1H and 13C resonances of proteins. | 1992 | J. Biomol. NMR | pmid:1283353 |
| Bauer S et al. | The effect of the new immunosuppressive drug FK506 on the formation of secondary metabolites of cyclosporin A. | 1992 | Int J Clin Pharmacol Ther Toxicol | pmid:1283385 |
| Renoir JM et al. | [Effect of immunosuppressants FK506 and rapamycin on the function of progesterone receptor: protein "p59-HBI", intersection between immunology and endocrinology?]. | 1992 | C. R. Acad. Sci. III, Sci. Vie | pmid:1284044 |
| Natazuka T | FK506 reverses adriamycin resistance in a multidrug-resistant human leukemia cell line. | 1992 | Kobe J Med Sci | pmid:1284834 |
| Tocci MJ and Sigal NH | Recent advances in the mechanism of action of cyclosporine and FK506. | 1992 | Curr. Opin. Nephrol. Hypertens. | pmid:1285380 |
| Woodle ES et al. | FK506: inhibition of humoral mechanisms of hepatic allograft rejection. | 1992 | Transplantation | pmid:1379749 |
| Sato K et al. | Effectiveness of triple drug immunosuppression for pancreaticoduodenal allotransplantation in dogs. | 1992 | Transplant. Proc. | pmid:1379753 |
| Kobayashi N et al. | Abdominal organ cluster transplantation in pigs receiving FK 506. | 1992 | Transplant. Proc. | pmid:1379754 |
| Yoshimura R et al. | A comparative study of cyclosporine vs FK 506: role of kidney microsomal cytochrome P-450. | 1992 | Transplant. Proc. | pmid:1379755 |
| Yamada K et al. | FK 506-induced juxtaglomerular apparatus hyperplasia and tubular damage in rat kidney--morphologic and biologic analysis. | 1992 | Transplant. Proc. | pmid:1379756 |
| Fukuse T et al. | Optimal dose of FK 506 in canine lung allotransplantation. | 1992 | Transplant. Proc. | pmid:1379757 |
| Wada H et al. | Combination use of suboptimal doses of FK 506 and cyclosporine in canine lung transplantation. | 1992 | Transplant. Proc. | pmid:1379758 |
| Cai X et al. | Low-dose of FK 506 and associated blood levels in allotransplantation of rat liver, heart, and skin. | 1992 | Transplant. Proc. | pmid:1379759 |
| Taki J et al. | DNA analysis of peripheral blood mononuclear cells for early detection of hepatic graft rejection. | 1992 | Transplant. Proc. | pmid:1379760 |
| Sato Y et al. | FK 506 suppresses class II antigen expression in regenerating livers following partial hepatectomy in the rat. | 1992 | Transplant. Proc. | pmid:1379761 |
| Stütz A | Immunosuppressive macrolides. | 1992 | Transplant. Proc. | pmid:1379762 |
| Leiva MC and Lyttle CR | Leukocyte chemotactic activity of FKBP and inhibition by FK506. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1379802 |
| Iwasaki K et al. | Effect of repeated oral doses of a novel immunosuppressive macrolide lactone on hepatic mixed-function oxidase system in the rat. Comparative study with ciclosporin. | 1992 | Arzneimittelforschung | pmid:1379812 |
| Takada K et al. | Distribution kinetics of FK-506, a novel immunosuppressant, after intravenous administration to rats in comparison with cyclosporin A. | 1992 | Biopharm Drug Dispos | pmid:1379839 |
| Dumont FJ et al. | The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin. | 1992 | J. Exp. Med. | pmid:1380976 |
| Norris AA et al. | Protective effects of cyclophosphamide, cyclosporin A and FK506 against antigen-induced lung eosinophilia in guinea-pigs. | 1992 | Clin. Exp. Immunol. | pmid:1381297 |
| Karpas A et al. | Inhibition of human immunodeficiency virus and growth of infected T cells by the immunosuppressive drugs cyclosporin A and FK 506. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1381509 |
| Yatscoff RW and Shaw LM | Therapeutic monitoring of cyclosporine, FK-506, and rapamycin. | 1992 | Ther Drug Monit | pmid:1381530 |
| Arceci RJ et al. | Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype. | 1992 | Blood | pmid:1381629 |
| Pahl A and Keller U | FK-506-binding proteins from streptomycetes producing immunosuppressive macrolactones of the FK-506 type. | 1992 | J. Bacteriol. | pmid:1381710 |
| Takahashi N | [Cyclophilin and FK506-binding protein]. | 1992 | Seikagaku | pmid:1381737 |
| Lee TK et al. | Mucosal glutamine utilization after small-bowel transplantation: an electrophysiologic study. | 1992 | J. Surg. Res. | pmid:1382152 |
| Kaye RE et al. | Effects of cyclosporin A and FK506 on Fc epsilon receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1382293 |
| Edalji R et al. | High-level expression of recombinant human FK-binding protein from a fusion precursor. | 1992 | J. Protein Chem. | pmid:1382438 |
| Thomson AW and Starzl TE | FK 506 and autoimmune disease: perspective and prospects. | 1992 | Autoimmunity | pmid:1382646 |
| Christians U et al. | Specific and sensitive measurement of FK506 and its metabolites in blood and urine of liver-graft recipients. | 1992 | Clin. Chem. | pmid:1382896 |
| Fruman DA et al. | Correlation of calcineurin phosphatase activity and programmed cell death in murine T cell hybridomas. | 1992 | Eur. J. Immunol. | pmid:1382988 |
| Hultsch T et al. | The effect of the immunophilin ligands rapamycin and FK506 on proliferation of mast cells and other hematopoietic cell lines. | 1992 | Mol. Biol. Cell | pmid:1384815 |
| Petros AM et al. | Identification of solvent-exposed regions of an FK-506 analog, ascomycin, bound to FKBP using a paramagnetic probe. | 1992 | J. Biomol. NMR | pmid:1384850 |
| Liu J et al. | The effects of FK-506 and cyclosporin A on the proliferation of PHA-stimulated T cells in response to IL-2, IL-4 or IL-6. | 1992 | Int. Arch. Allergy Immunol. | pmid:1384862 |
| Mochizuki M et al. | Preclinical and clinical study of FK506 in uveitis. | 1992 | Curr. Eye Res. | pmid:1385045 |
| Chung J et al. | Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. | 1992 | Cell | pmid:1377606 |
| Xu RX et al. | Stereospecific assignments and chi 1 rotamers for FKBP when bound to ascomycin from 3JH alpha,H beta and 3HN,H beta coupling constants. | 1992 | FEBS Lett. | pmid:1377648 |
| Petros AM et al. | NMR studies of an FK-506 analog, [U-13C]ascomycin, bound to FK-506-binding protein. | 1992 | J. Med. Chem. | pmid:1377749 |
| Strom TB | Molecular immunology and immunopharmacology of allograft rejection. | 1992 | Kidney Int. Suppl. | pmid:1383599 |
| Wang SC et al. | FK-506 inhibits proliferation and IL-4 messenger RNA production by a T-helper 2 cell line. | 1992 | J. Surg. Res. | pmid:1383612 |