MeSH term | MeSH ID | Detail |
---|---|---|
Hypophosphatemia | D017674 | 1 associated lipids |
Leukemia, Myeloid, Chronic-Phase | D015466 | 1 associated lipids |
Myelinolysis, Central Pontine | D017590 | 1 associated lipids |
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Omland SH and Gniadecki R | Psoriasis inversa: A separate identity or a variant of psoriasis vulgaris? | Clin. Dermatol. | pmid:26051061 | |
Chia BK and Tey HL | Systematic review on the efficacy, safety, and cost-effectiveness of topical calcineurin inhibitors in atopic dermatitis. | Dermatitis | pmid:25984688 | |
Jefferson J et al. | Follicular Mucinosis in a Male Adolescent with a History of Acute Myelogenous Leukemia and Graft-versus-Host Disease. | Pediatr Dermatol | pmid:26645410 | |
Borda B et al. | Early histopathological changes in new-onset diabetes after kidney transplantation. | Transplant. Proc. | pmid:25131129 | |
Porubsky M et al. | Excellent outcomes can be achieved in young pancreas transplant alone recipients by addition of sirolimus to maintenance immunosuppression regimen. | Transplant. Proc. | pmid:25131074 | |
Liu JY et al. | Tacrolimus Versus Cyclosporine as Primary Immunosuppressant After Renal Transplantation: A Meta-Analysis and Economics Evaluation. | Am J Ther | pmid:25299636 | |
pmid:9123014 | ||||
Haroon N et al. | Tacrolimus Toxicity With Minimal Clinical Manifestations: A Case Report and Literature Review. | Am J Ther | pmid:25730156 | |
Krzyżowska K et al. | No Significant Influence of Reduced Initial Tacrolimus Dose on Risk of Underdosing and Early Graft Function in Older and Overweight Kidney Transplant Recipients. | Transplant. Proc. | pmid:30056895 | |
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Zulim LFDC et al. | Comparison of the efficacy of 0.03% tacrolimus eye drops diluted in olive oil and linseed oil for the treatment of keratoconjunctivitis sicca in dogs. | Arq Bras Oftalmol | pmid:29995121 | |
Kim K et al. | Everolimus-Induced Systemic Serositis After Simultaneous Liver and Kidney Transplantation: A Case Report. | Transplant. Proc. | pmid:28104132 | |
Yamamoto T et al. | Efficacy of Eculizumab Therapy for Atypical Hemolytic Uremic Syndrome Recurrence and Antibody-Mediated Rejection Progress After Renal Transplantation With Preformed Donor-Specific Antibodies: Case Report. | Transplant. Proc. | pmid:28104125 | |
Ülkümen PK et al. | Annular lichenoid dermatitis of youth in a 15-year-old boy: Topical tacrolimus as a treatment option. | Indian J Dermatol Venereol Leprol | pmid:27279324 | |
Nayeri A et al. | Acute Calcineurin Inhibitor Nephrotoxicity Secondary to Turmeric Intake: A Case Report. | Transplant. Proc. | pmid:28104136 | |
Dedhia P et al. | Eculizumab and Belatacept for De Novo Atypical Hemolytic Uremic Syndrome Associated With CFHR3-CFHR1 Deletion in a Kidney Transplant Recipient: A Case Report. | Transplant. Proc. | pmid:28104134 | |
Zhang J et al. | Chemotherapy for De Novo Gastric Adenocarcinoma After Deceased Orthotopic Liver Transplantation: A Case Report. | Transplant. Proc. | pmid:28104131 | |
Britto-Williams P and Pansare M | Management of chronic idiopathic urticaria in childhood: are we on the same page? | J Allergy Clin Immunol Pract | pmid:24565627 | |
Ishida S et al. | Calcineurin Inhibitor-Induced Pain Syndrome in ABO-Incompatible Living Kidney Transplantation: A Case Report. | Transplant. Proc. | pmid:28104127 | |
Liu JY et al. | Sirolimus Versus Tacrolimus as Primary Immunosuppressant After Renal Transplantation: A Meta-Analysis and Economics Evaluation. | Am J Ther | pmid:25569597 | |
Norero B et al. | Â Conversion to mycophenolate mofetil monotherapy in liver recipients: Calcineurin inhibitor levels are key. | Ann Hepatol | pmid:28051798 | |
Back JH et al. | Antiproteinuric Effects of Green Tea Extract on Tacrolimus-Induced Nephrotoxicity in Mice. | Transplant. Proc. | pmid:26293093 | |
Dall'Agnol DJ et al. | Effects of immunosuppressive drugs on gastrointestinal transit of rats: effects of tacrolimus, cyclosporine, and prednisone. | Transplant. Proc. | pmid:25131057 | |
Collier DS et al. | FK-506 in experimental renal allografts. | 1987 | Transplant. Proc. | pmid:2445063 |
First International Workshop on FK-506. A potential breakthrough in immunosuppression. Proceedings. | 1987 | Transplant. Proc. | pmid:2445066 | |
Tanaka H et al. | Physicochemical properties of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis. | 1987 | Transplant. Proc. | pmid:2445067 |
Honbo T et al. | The oral dosage form of FK-506. | 1987 | Transplant. Proc. | pmid:2445068 |
Tamura K et al. | A highly sensitive method to assay FK-506 levels in plasma. | 1987 | Transplant. Proc. | pmid:2445069 |
Venkataramanan R et al. | Biopharmaceutical aspects of FK-506. | 1987 | Transplant. Proc. | pmid:2445070 |
Kino T et al. | Effect of FK-506 on human mixed lymphocyte reaction in vitro. | 1987 | Transplant. Proc. | pmid:2445071 |
Goto T et al. | Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis. | 1987 | Transplant. Proc. | pmid:2445072 |
Zeevi A et al. | Immunosuppressive effect of FK-506 on in vitro lymphocyte alloactivation: synergism with cyclosporine A. | 1987 | Transplant. Proc. | pmid:2445073 |
Sanghvi A et al. | FK-506 enhances cyclosporine uptake by peripheral blood lymphocytes. | 1987 | Transplant. Proc. | pmid:2445074 |
Ochiai T et al. | Prolongation of canine renal allograft survival by treatment with FK-506. | 1987 | Transplant. Proc. | pmid:2445075 |
Todo S et al. | Canine kidney transplantation with FK-506 alone or in combination with cyclosporine and steroids. | 1987 | Transplant. Proc. | pmid:2445076 |
Collier DS et al. | Kidney transplantation in the dog receiving FK-506. | 1987 | Transplant. Proc. | pmid:2445077 |
Calne R et al. | Observations about FK-506 in primates. | 1987 | Transplant. Proc. | pmid:2445078 |
Todo S et al. | Orthotopic liver transplantation in dogs receiving FK-506. | 1987 | Transplant. Proc. | pmid:2445079 |
Lim SM et al. | Heterotopic heart transplantation in the rat receiving FK-506. | 1987 | Transplant. Proc. | pmid:2445080 |
Murase N et al. | Heterotopic heart transplantation in the rat receiving FK-506 alone or with cyclosporine. | 1987 | Transplant. Proc. | pmid:2445081 |
Makowka L et al. | The effect of FK-506 on hyperacute rejection in presensitized rats. | 1987 | Transplant. Proc. | pmid:2445082 |
Ochiai T et al. | Effects of FK-506 on xenotransplantation of the heart and skin in a mouse-rat combination. | 1987 | Transplant. Proc. | pmid:2445083 |
Nalesnik MA et al. | Toxicology of FK-506 in the Lewis rat. | 1987 | Transplant. Proc. | pmid:2445084 |
Ochiai T et al. | Histopathologic studies in renal transplant recipient dogs receiving treatment with FK-506. | 1987 | Transplant. Proc. | pmid:2445085 |
Thiru S et al. | Pathological studies in canine and baboon renal allograft recipients immunosuppressed with FK-506. | 1987 | Transplant. Proc. | pmid:2445086 |
Kino T et al. | FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics. | 1987 | J. Antibiot. | pmid:2445721 |
Kino T et al. | FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro. | 1987 | J. Antibiot. | pmid:2445722 |
Ochiai T et al. | Studies of the effects of FK506 on renal allografting in the beagle dog. | 1987 | Transplantation | pmid:2447688 |
Ochiai T et al. | Studies of the induction and maintenance of long-term graft acceptance by treatment with FK506 in heterotopic cardiac allotransplantation in rats. | 1987 | Transplantation | pmid:2447689 |
Ochiai T et al. | Effect of a new immunosuppressive agent, FK 506, on heterotopic cardiac allotransplantation in the rat. | 1987 | Transplant. Proc. | pmid:2484094 |
Sawada S et al. | Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation. | 1987 | J. Immunol. | pmid:2442255 |
Inamura N et al. | Immunosuppressive effect of FK506 on collagen-induced arthritis in rats. | 1988 | Clin. Immunol. Immunopathol. | pmid:2446810 |
Inamura N et al. | Prolongation of skin allograft survival in rats by a novel immunosuppressive agent, FK506. | 1988 | Transplantation | pmid:2447690 |
Ochiai T et al. | Studies on FK506 in experimental organ transplantation. | 1988 | Transplant. Proc. | pmid:2450414 |
Immunosuppression: FK506. | 1988 | Transplant. Proc. | pmid:2450415 | |
Todo S et al. | Effect of FK506 in experimental organ transplantation. | 1988 | Transplant. Proc. | pmid:2450416 |
Tsuchimoto S et al. | [Orthotopic liver transplantation in the rat--immunosuppressive effect of FR100906 on the survival of liver allografts]. | 1988 | Nihon Geka Gakkai Zasshi | pmid:2452341 |
Nakajima K et al. | Prolongation of cardiac xenograft survival in rats treated with 15-deoxyspergualin alone and in combination with FK506. | 1988 | Transplantation | pmid:2454521 |
Todo S et al. | Immunosuppression of canine, monkey, and baboon allografts by FK 506: with special reference to synergism with other drugs and to tolerance induction. | 1988 | Surgery | pmid:2456627 |
Kawashima H et al. | Effects of a new immunosuppressive agent, FK506, on experimental autoimmune uveoretinitis in rats. | 1988 | Invest. Ophthalmol. Vis. Sci. | pmid:2458329 |
Warty V et al. | FK506: a novel immunosuppressive agent. Characteristics of binding and uptake by human lymphocytes. | 1988 | Transplantation | pmid:2458643 |
Hewitt CW and Black KS | Comparative studies of FK506 with cyclosporine. | 1988 | Transplantation | pmid:2458644 |
Woo J et al. | Spleen lymphocyte populations and expression of activation markers in rats treated with the potent new immunosuppressive agent FK-506. | 1988 | Immunology | pmid:2460401 |
Hatanaka H et al. | FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics. | 1988 | J. Antibiot. | pmid:2461926 |
Inamura N et al. | Immunosuppressive effect of FK506 on experimental allergic encephalomyelitis in rats. | 1988 | Int. J. Immunopharmacol. | pmid:2463974 |
Hatanaka H et al. | FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. I. Taxonomy of the producing strain. | 1988 | J. Antibiot. | pmid:3198493 |
Takabayashi K et al. | Effect of FK-506, a novel immunosuppressive drug on murine systemic lupus erythematosus. | 1989 | Clin. Immunol. Immunopathol. | pmid:2466594 |
Morris RE et al. | Immunopharmacology of FK-506. | 1989 | Transplant. Proc. | pmid:2468201 |
Yoshimura N et al. | A new immunosuppressive agent, FK506, inhibits the expression of alloantigen-activated suppressor cells as well as the induction of alloreactivity. | 1989 | Transplant. Proc. | pmid:2468202 |
Thomson AW et al. | Immunosuppressive activity, T-cell subset analysis, and acute toxicity of FK-506 in rats. | 1989 | Transplant. Proc. | pmid:2468203 |
Sanghvi A et al. | Increased cyclosporine uptake by cells pretreated with FK506 and evidence for binding of both drugs to a common intracellular protein. | 1989 | Transplant. Proc. | pmid:2468204 |
Takagishi K et al. | Effects of FK-506 on collagen arthritis in mice. | 1989 | Transplant. Proc. | pmid:2468205 |
Arita C et al. | Effect of FK 506 (FR 900506) on collagen arthritis in rats: a preliminary report. | 1989 | Transplant. Proc. | pmid:2468206 |
Morimoto T et al. | Blood levels of FK506 after intramuscular and intravenous administration in dogs. | 1989 | Transplant. Proc. | pmid:2468207 |
Tsuchimoto S et al. | Orthotopic liver transplantation in rats receiving FK506. | 1989 | Transplant. Proc. | pmid:2468208 |
Yokota K et al. | Comparative studies of FK506 and cyclosporine in canine orthotopic hepatic allograft survival. | 1989 | Transplant. Proc. | pmid:2468209 |
Inagaki K et al. | Effects of FK506 and 15-deoxyspergualin in rat orthotopic liver transplantation. | 1989 | Transplant. Proc. | pmid:2468210 |
Gudas VM et al. | Comparison of the immunosuppressive and toxic effects of FK506 and cyclosporine in xenograft recipients. | 1989 | Transplant. Proc. | pmid:2468211 |
Sato K et al. | Pancreaticoduodenal allotransplantation with cyclosporine and FK506. | 1989 | Transplant. Proc. | pmid:2468212 |
Watanabe K et al. | Prolongation effect of a small dose of FK506, cyclosporine, or azathioprine on renal allografts in dogs treated with fractionated lymphoid irradiation and donor bone marrow cell infusion. | 1989 | Transplant. Proc. | pmid:2468213 |
Sakamoto K et al. | Analysis of long-term acceptance of xenografts in rats induced by short-term administration of FK506. | 1989 | Transplant. Proc. | pmid:2468222 |
Nakajima K et al. | Effects of 15-deoxyspergualin and FK506 on the histology and survival of hamster-to-rat cardiac xenotransplantation. | 1989 | Transplant. Proc. | pmid:2468223 |
Ochiai T et al. | Comparative studies on the immunosuppressive activity of FK506, 15-deoxyspergualin, and cyclosporine. | 1989 | Transplant. Proc. | pmid:2468228 |
Yasunami Y et al. | Effects of a novel immunosuppressive agent, FK-506, on islet allograft survival in the rat. | 1989 | Transplant. Proc. | pmid:2468234 |
Kobayashi C et al. | Suppression of corneal graft rejection in rabbits by a new immunosuppressive agent, FK-506. | 1989 | Transplant. Proc. | pmid:2468254 |
Kuroki H et al. | Experimental studies of vascularized allogeneic limb transplantation in the rat using a new immunosuppressive agent, FK-506: morphological and immunological analysis. | 1989 | Transplant. Proc. | pmid:2468255 |
Thomson AW and Woo J | Immunosuppressive properties of FK-506 and rapamycin. | 1989 | Lancet | pmid:2474733 |
Todo S et al. | Renal transplantation in baboons under FK 506. | 1989 | Surgery | pmid:2474865 |
Kay JE et al. | Inhibition of T-lymphocyte activation by the immunosuppressive drug FK-506. | 1989 | Immunology | pmid:2475433 |
Moriyama S | [Experimental tracheal reconstruction by allotransplantation]. | 1989 | Nihon Kyobu Geka Gakkai Zasshi | pmid:2475555 |
Freedman RB | Immunosuppression. Convergence of drug action. | 1989 | Nature | pmid:2477712 |
Siekierka JJ et al. | A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. | 1989 | Nature | pmid:2477714 |
Harding MW et al. | A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. | 1989 | Nature | pmid:2477715 |
Kay JE et al. | The mechanism of action of the immunosuppressive drug FK-506. | 1989 | Cell. Immunol. | pmid:2478301 |
Starzl TE et al. | FK 506 for liver, kidney, and pancreas transplantation. | 1989 | Lancet | pmid:2478846 |
Arai K et al. | Limb allografts in rats immunosuppressed with FK506. I. Reversal of rejection and indefinite survival. | 1989 | Transplantation | pmid:2479130 |
Francavilla A et al. | Augmentation of rat liver regeneration by FK 506 compared with cyclosporin. | 1989 | Lancet | pmid:2479802 |
Walliser P et al. | Inhibition of murine B-lymphocyte proliferation by the novel immunosuppressive drug FK-506. | 1989 | Immunology | pmid:2480331 |
Aoki M et al. | [Histological observations of immunosuppressive effects of FK-506 in canine lung allotransplantation]. | 1989 | Bull Chest Dis Res Inst Kyoto Univ | pmid:2482787 |
Kay JE and Benzie CR | T lymphocyte activation through the C28 pathway is insensitive to inhibition by the immunosuppressive drug FK-506. | 1989 | Immunol. Lett. | pmid:2483716 |