MeSH term | MeSH ID | Detail |
---|---|---|
Pruritus Vulvae | D011539 | 1 associated lipids |
Central Serous Chorioretinopathy | D056833 | 1 associated lipids |
Feline Acquired Immunodeficiency Syndrome | D016181 | 1 associated lipids |
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Sugden PH | Signalling pathways in cardiac myocyte hypertrophy. | 2001 | Ann. Med. | pmid:11817656 |
Sun L et al. | Cellular and molecular consequences of calcineurin A alpha gene deletion. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17872390 |
Shipston MJ et al. | Glucocorticoid negative feedback in pituitary corticotropes. Pivotal role for calcineurin inhibition of adenylyl cyclase. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7529975 |
Iwanaga Y et al. | Living donor islet transplantation, the alternative approach to overcome the obstacles limiting transplant. | 2006 | Ann. N. Y. Acad. Sci. | pmid:17130575 |
Xu L et al. | Potential for pharmacology of ryanodine receptor/calcium release channels. | 1998 | Ann. N. Y. Acad. Sci. | pmid:10603942 |
Bers DM et al. | Factors that control sarcoplasmic reticulum calcium release in intact ventricular myocytes. | 1998 | Ann. N. Y. Acad. Sci. | pmid:10603944 |
Engelbrecht ME et al. | The effect of immunosuppressants on human leukocyte NADPH oxidase. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7518204 |
Zuany-Amorim C et al. | Modulation by rm interferon-gamma and CD4+ T-lymphocytes of allergic eosinophil accumulation in the mice peritoneal cavity. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7518212 |
Nagai H et al. | The role of interleukin-5 (IL-5) in allergic airway hyperresponsiveness in mice. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8906215 |
Clipstone NA and Crabtree GR | Calcineurin is a key signaling enzyme in T lymphocyte activation and the target of the immunosuppressive drugs cyclosporin A and FK506. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509131 |
Takahara S | Efficacy of FK506 in renal transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509132 |
Thomson AW et al. | Incidence of CD4+ IL-2R alpha+ and CD4+ CD45RA+ T-cells in progressive multiple sclerosis and the influence of short-term (3 months) FK 506 therapy. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509133 |
Lemster B et al. | FK 506 inhibits cytokine gene and adhesion molecule expression in psoriatic skin lesions. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509134 |
Tamura K et al. | Inhibitory effect of FK 506 on autoimmune thyroid disease in the PVG rat. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509135 |
Ochiai T et al. | Combination of immunosuppressive drugs for organ transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509136 |
Wiederrecht G et al. | The mechanism of action of FK-506 and cyclosporin A. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509138 |
Lee RK and Wurtman RJ | Regulation of APP synthesis and secretion by neuroimmunophilin ligands and cyclooxygenase inhibitors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:11193162 |
Christensen BG | FK-506: its role in immunosuppression. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689803 |
Kino T and Goto T | Discovery of FK-506 and update. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689804 |
Parsons WH et al. | FK-506--a novel immunosuppressant. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689805 |
Zenke G et al. | Molecular mechanisms of immunosuppression by cyclosporins. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689806 |
Clardy J | Structural studies of complexed FK-506 binding protein. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689808 |
Starzl TE et al. | Allograft and xenograft acceptance under FK-506 and other immunosuppressant treatment. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689809 |
Reem GH et al. | FK-506 inhibits the IL-2-independent induction of the activation antigen CD 69. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689811 |
Mollison KW et al. | Comparison of FK-506, rapamycin, ascomycin, and cyclosporine in mouse models of host-versus-graft disease and heterotopic heart transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689812 |
Ponseti JM et al. | Tacrolimus for myasthenia gravis: a clinical study of 212 patients. | 2008 | Ann. N. Y. Acad. Sci. | pmid:18096852 |
Paterson DL et al. | Could a herpesvirus mimic tacrolimus-induced leukoencephalopathy? | 1997 | Ann. Neurol. | pmid:9266742 |
Caprariello AV et al. | Apoptosis of oligodendrocytes in the central nervous system results in rapid focal demyelination. | 2012 | Ann. Neurol. | pmid:23034912 |
Keswani SC et al. | FK506 is neuroprotective in a model of antiretroviral toxic neuropathy. | 2003 | Ann. Neurol. | pmid:12509848 |
Dawson TM | Immunosuppressants, immunophilins, and the nervous system. | 1996 | Ann. Neurol. | pmid:8871573 |
Small SL et al. | Immunosuppression-induced leukoencephalopathy from tacrolimus (FK506) | 1996 | Ann. Neurol. | pmid:8871576 |
Roberts WK et al. | A destructive feedback loop mediated by CXCL10 in central nervous system inflammatory disease. | 2015 | Ann. Neurol. | pmid:26224283 |
Wijdicks EF et al. | FK506-induced neurotoxicity in liver transplantation. | 1994 | Ann. Neurol. | pmid:7512320 |
Nelson M et al. | Direct revascularization is superior for rat parathyroid allotransplantation with FK506. | 2005 | Ann. Otol. Rhinol. Laryngol. | pmid:15825570 |
Gerster JC et al. | Gout in liver transplant patients receiving tacrolimus. | 2004 | Ann. Rheum. Dis. | pmid:15194597 |
Igarashi T et al. | Central nervous system toxicity related to FK506 in patients with Behçet's disease. | 1994 | Ann. Rheum. Dis. | pmid:7517134 |
Villaverde V et al. | Leg bone pain syndrome in a kidney transplant patient treated with tacrolimus (FK506) | 1999 | Ann. Rheum. Dis. | pmid:10577370 |
Duddridge M and Powell RJ | Treatment of severe and difficult cases of systemic lupus erythematosus with tacrolimus. A report of three cases. | 1997 | Ann. Rheum. Dis. | pmid:9462174 |
Lightman S et al. | Pegylated interferon-α-2b reduces corticosteroid requirement in patients with Behçet's disease with upregulation of circulating regulatory T cells and reduction of Th17. | 2015 | Ann. Rheum. Dis. | pmid:25269831 |
Lampropoulos CE and D' Cruz DP | Topical tacrolimus treatment in a patient with dermatomyositis. | 2005 | Ann. Rheum. Dis. | pmid:16100347 |
Mok CC et al. | Tacrolimus versus mycophenolate mofetil for induction therapy of lupus nephritis: a randomised controlled trial and long-term follow-up. | 2016 | Ann. Rheum. Dis. | pmid:25550339 |
Lerut JP et al. | Is minimal, [almost] steroid-free immunosuppression a safe approach in adult liver transplantation? Long-term outcome of a prospective, double blind, placebo-controlled, randomized, investigator-driven study. | 2014 | Ann. Surg. | pmid:25379858 |
Colombani PM et al. | Liver transplantation in infants younger than 1 year of age. | 1996 | Ann. Surg. | pmid:8645039 |
Todo S et al. | Liver, kidney, and thoracic organ transplantation under FK 506. | 1990 | Ann. Surg. | pmid:1697743 |
Stratta RJ et al. | Evolution in pancreas transplantation techniques: simultaneous kidney-pancreas transplantation using portal-enteric drainage without antilymphocyte induction. | 1999 | Ann. Surg. | pmid:10235529 |
Fealy MJ et al. | Efficacy of rapamycin and FK 506 in prolonging rat hind limb allograft survival. | 1994 | Ann. Surg. | pmid:7507657 |
Ozawa K et al. | An appraisal of pediatric liver transplantation from living relatives. Initial clinical experiences in 20 pediatric liver transplantations from living relatives as donors. | 1992 | Ann. Surg. | pmid:1280074 |
Jain A et al. | What have we learned about primary liver transplantation under tacrolimus immunosuppression? Long-term follow-up of the first 1000 patients. | 1999 | Ann. Surg. | pmid:10493490 |
Schneeberger S et al. | Upper-extremity transplantation using a cell-based protocol to minimize immunosuppression. | 2013 | Ann. Surg. | pmid:23001085 |
Sho M et al. | New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs. | 2002 | Ann. Surg. | pmid:12409674 |