MeSH term | MeSH ID | Detail |
---|---|---|
Retrognathia | D063173 | 1 associated lipids |
Drug-Related Side Effects and Adverse Reactions | D064420 | 3 associated lipids |
Scorpion Stings | D065008 | 1 associated lipids |
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Lee YH and Song GG | Relative efficacy and safety of tacrolimus, mycophenolate mofetil, and cyclophosphamide as induction therapy for lupus nephritis: a Bayesian network meta-analysis of randomized controlled trials. | 2015 | Lupus | pmid:26162684 |
Liao R et al. | Tacrolimus Protects Podocytes from Injury in Lupus Nephritis Partly by Stabilizing the Cytoskeleton and Inhibiting Podocyte Apoptosis. | 2015 | PLoS ONE | pmid:26161538 |
Kojima R et al. | Release mechanisms of tacrolimus-loaded PLGA and PLA microspheres and immunosuppressive effects of the microspheres in a rat heart transplantation model. | 2015 | Int J Pharm | pmid:26160668 |
Kanchongkittiphon W et al. | Child with atopic dermatitis. | 2015 | Ann. Allergy Asthma Immunol. | pmid:25528736 |
Meng QH et al. | Falsely elevated tacrolimus concentrations on the Dimension Xpand. | 2015 | Clin. Biochem. | pmid:26160209 |
Shamsudin N et al. | Objective assessment of vitiligo with a computerised digital imaging analysis system. | 2015 | Australas. J. Dermatol. | pmid:25367709 |
Velickovic-Radovanovic R et al. | Gender-dependent predictable pharmacokinetic method for tacrolimus exposure monitoring in kidney transplant patients. | 2015 | Eur J Drug Metab Pharmacokinet | pmid:24596067 |
Lee SC et al. | Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides. | 2015 | Mol. Microbiol. | pmid:26010100 |
Melilli E et al. | De novo use of a generic formulation of tacrolimus versus reference tacrolimus in kidney transplantation: evaluation of the clinical results, histology in protocol biopsies, and immunological monitoring. | 2015 | Transpl. Int. | pmid:26088437 |
Traitanon O et al. | Differential Effects of Tacrolimus versus Sirolimus on the Proliferation, Activation and Differentiation of Human B Cells. | 2015 | PLoS ONE | pmid:26087255 |
Kedzierska K et al. | The effect of immunosuppressive therapy on renal cell apoptosis in native rat kidneys. | 2015 | Histol. Histopathol. | pmid:25029518 |
Seo YG et al. | Solid self-nanoemulsifying drug delivery system (SNEDDS) for enhanced oral bioavailability of poorly water-soluble tacrolimus: physicochemical characterisation and pharmacokinetics. | 2015 | J Microencapsul | pmid:26079598 |
Menotta M et al. | Label-free quantification of Tacrolimus in biological samples by atomic force microscopy. | 2015 | Anal. Chim. Acta | pmid:26073814 |
Sato K et al. | Late onset of progressive speech impairment due to tacrolimus-associated leukoencephalopathy after kidney transplantation. | 2015 | Int Urol Nephrol | pmid:26071870 |
Hu WX et al. | Glucocorticoid with or without additional immunosuppressant therapy for patients with lupus podocytopathy: a retrospective single-center study. | 2015 | Lupus | pmid:25819933 |
Mabuchi M et al. | Improvement of solid material for affinity resins by application of long PEG spacers to capture the whole target complex of FK506. | 2015 | Bioorg. Med. Chem. Lett. | pmid:26025877 |
Zhang D et al. | Multifunctional Poly(methyl vinyl ether-co-maleic anhydride)-graft-hydroxypropyl-β-cyclodextrin Amphiphilic Copolymer as an Oral High-Performance Delivery Carrier of Tacrolimus. | 2015 | Mol. Pharm. | pmid:26024817 |
Considine A et al. | Performance of modified-release tacrolimus after conversion in liver transplant patients indicates potentially favorable outcomes in selected cohorts. | 2015 | Liver Transpl. | pmid:25312292 |
Huang G et al. | [Analysis on BK virus associated nephropathy related risk factors in renal transplant recipients]. | 2015 | Zhonghua Yi Xue Za Zhi | pmid:26814103 |
Taber DJ et al. | African-American race modifies the influence of tacrolimus concentrations on acute rejection and toxicity in kidney transplant recipients. | 2015 | Pharmacotherapy | pmid:26011276 |
Parody R et al. | GVHD prophylaxis with sirolimus-tacrolimus may overcome the deleterious effect on survival of HLA mismatch after reduced-intensity conditioning allo-SCT. | 2015 | Bone Marrow Transplant. | pmid:25310306 |
Hollis IB et al. | Medication management of cardiac allograft vasculopathy after heart transplantation. | 2015 | Pharmacotherapy | pmid:26011142 |
Grammatikopoulos T et al. | Anti-CD20 Monoclonal Antibody Therapy in Functional Bile Salt Export Pump Deficiency After Liver Transplantation. | 2015 | J. Pediatr. Gastroenterol. Nutr. | pmid:24231640 |
Shuker N et al. | Conversion from twice-daily to once-daily tacrolimus does not reduce intrapatient variability in tacrolimus exposure. | 2015 | Ther Drug Monit | pmid:25265255 |
Leyking S et al. | Calcineurin inhibitors differentially alter the circadian rhythm of T-cell functionality in transplant recipients. | 2015 | J Transl Med | pmid:25885792 |
Wang X et al. | Tacrolimus 0.03% ointment in labial discoid lupus erythematosus: A randomized, controlled clinical trial. | 2015 | J Clin Pharmacol | pmid:25951426 |
Ozbek OY and Ozcay F | Long-term outcome of food allergy after liver transplantation in children. | 2015 | Pediatr Transplant | pmid:25882294 |
Mistry NP et al. | Formulation and evaluation of tacrolimus-loaded galactosylated Poly(lactic-co-glycolic acid) nanoparticles for liver targeting. | 2015 | J. Pharm. Pharmacol. | pmid:25944126 |
Andreu F et al. | Development of a population PK model of tacrolimus for adaptive dosage control in stable kidney transplant patients. | 2015 | Ther Drug Monit | pmid:25254416 |
Banhara PB et al. | Tubular dysfunction in renal transplant patients using sirolimus or tacrolimus. | 2015 | Clin. Nephrol. | pmid:25943142 |
Bonanni A et al. | Low-dose ofatumumab for rituximab-resistant nephrotic syndrome. | 2015 | BMJ Case Rep | pmid:26376698 |
Ding L et al. | Clinical Immunosuppressants Inhibit Inflammatory, Proliferative, and Reprogramming Potential, But Not Angiogenesis of Human Pancreatic Duct Cells. | 2015 | Cell Transplant | pmid:25198311 |
Zhou X et al. | Effect of immunosuppression on the human mesangial cell cycle. | 2015 | Mol Med Rep | pmid:25370945 |
Rojanathammanee L et al. | Attenuation of microglial activation in a mouse model of Alzheimer's disease via NFAT inhibition. | 2015 | J Neuroinflammation | pmid:25889879 |
Ikitimur B et al. | Long-Term Impact of Different Immunosuppressive Drugs on QT and PR Intervals in Renal Transplant Patients. | 2015 | Ann Noninvasive Electrocardiol | pmid:25367596 |
Peccerillo F et al. | Eosinophilic cellulitis. | 2015 | G Ital Dermatol Venereol | pmid:25946678 |
Størset E et al. | Improved Tacrolimus Target Concentration Achievement Using Computerized Dosing in Renal Transplant Recipients--A Prospective, Randomized Study. | 2015 | Transplantation | pmid:25886918 |
Ganetsky A et al. | Lack of a significant pharmacokinetic interaction between maraviroc and tacrolimus in allogeneic HSCT recipients. | 2015 | J. Antimicrob. Chemother. | pmid:25881619 |
Liang GB et al. | Impact of immunosuppressive agents on the expression of indoleamine 2,3-dioxygenase, heme oxygenase-1 and interleukin-7 in mesangial cells. | 2015 | Mol Med Rep | pmid:25936769 |
Montero N and Pascual J | Immunosuppression and Post-transplant Hyperglycemia. | 2015 | Curr Diabetes Rev | pmid:25824238 |
Seo YG et al. | Preparation and pharmaceutical evaluation of new tacrolimus-loaded solid self-emulsifying drug delivery system. | 2015 | Arch. Pharm. Res. | pmid:25134927 |
Ott M et al. | Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway. | 2015 | Glia | pmid:25132599 |
Abudou M et al. | Immunosuppressants for the prophylaxis of corneal graft rejection after penetrating keratoplasty. | 2015 | Cochrane Database Syst Rev | pmid:26313245 |
Zegarska J et al. | Mycophenolic Acid Metabolites Acyl-Glucuronide and Glucoside Affect the Occurrence of Infectious Complications and Bone Marrow Dysfunction in Liver Transplant Recipients. | 2015 | Ann. Transplant. | pmid:26313036 |
Li Z et al. | Tacrolimus Induces Insulin Resistance and Increases the Glucose Absorption in the Jejunum: A Potential Mechanism of the Diabetogenic Effects. | 2015 | PLoS ONE | pmid:26599323 |
Madariaga ML et al. | Kidney-induced cardiac allograft tolerance in miniature swine is dependent on MHC-matching of donor cardiac and renal parenchyma. | 2015 | Am. J. Transplant. | pmid:25824550 |
Naito T et al. | ABCB1 genetic variant and its associated tacrolimus pharmacokinetics affect renal function in patients with rheumatoid arthritis. | 2015 | Clin. Chim. Acta | pmid:25817604 |
Lee JR et al. | Gut microbiota and tacrolimus dosing in kidney transplantation. | 2015 | PLoS ONE | pmid:25815766 |
Honda Y et al. | Disseminated Mycobacterium mantenii infection with multiple purulent cutaneous lesions. | 2015 | Acta Derm. Venereol. | pmid:25881714 |
Stevens RB et al. | A randomized 2×2 factorial trial, part 1: single-dose rabbit antithymocyte globulin induction may improve renal transplantation outcomes. | 2015 | Transplantation | pmid:25083614 |
Chhatrala R et al. | Evolution of serum atherogenic risk in liver transplant recipients: Role of lipoproteins and metabolic and inflammatory markers. | 2015 | Liver Transpl. | pmid:25762084 |
Soylu H et al. | Survival of renal transplant patients: data from a tertiary care center in Turkey. | 2015 | Transplant. Proc. | pmid:25769571 |
Helmschrott M et al. | Advantageous effects of immunosuppression with tacrolimus in comparison with cyclosporine A regarding renal function in patients after heart transplantation. | 2015 | Drug Des Devel Ther | pmid:25759566 |
Mlih M et al. | Na(+)/H (+) exchanger isoform 1 induced osteopontin expression in cardiomyocytes involves NFAT3/Gata4. | 2015 | Mol. Cell. Biochem. | pmid:25758355 |
Ravaioli M et al. | Immunosuppression Modifications Based on an Immune Response Assay: Results of a Randomized, Controlled Trial. | 2015 | Transplantation | pmid:25757214 |
Ohe M and Bohgaki T | A Case of Adult-Onset Still's Disease Treated with Monitoring of Serum Tacrolimus Levels. | 2015 | Bull Hosp Jt Dis (2013) | pmid:26535602 |
Xiao A et al. | H2S, a novel gasotransmitter, involves in gastric accommodation. | 2015 | Sci Rep | pmid:26531221 |
Devine SM et al. | Phase II Study of Allogeneic Transplantation for Older Patients With Acute Myeloid Leukemia in First Complete Remission Using a Reduced-Intensity Conditioning Regimen: Results From Cancer and Leukemia Group B 100103 (Alliance for Clinical Trials in Oncology)/Blood and Marrow Transplant Clinical Trial Network 0502. | 2015 | J. Clin. Oncol. | pmid:26527780 |
Abdel-Azim H et al. | Unrelated donor hematopoietic stem cell transplantation for the treatment of non-malignant genetic diseases: An alemtuzumab based regimen is associated with cure of clinical disease; earlier clearance of alemtuzumab may be associated with graft rejection. | 2015 | Am. J. Hematol. | pmid:26242764 |
Liu X et al. | Associations of HSD11B1 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients with prednisone combined therapy. | 2015 | Drug Metab. Dispos. | pmid:25587129 |
Staatz CE et al. | Tacrolimus pharmacokinetics after kidney transplantation--Influence of changes in haematocrit and steroid dose. | 2015 | Br J Clin Pharmacol | pmid:26235203 |
Vanhove T et al. | Response to 'Tacrolimus pharmacokinetics after kidney transplantation--Influence of changes in haematocrit and steroid dose'. | 2015 | Br J Clin Pharmacol | pmid:26235051 |
Pensi D et al. | An UPLC-MS/MS method coupled with automated on-line SPE for quantification of tacrolimus in peripheral blood mononuclear cells. | 2015 | J Pharm Biomed Anal | pmid:25698619 |
Ceulemans LJ et al. | Nonsteroidal anti-inflammatory drug-induced intestinal graft loss 12 years after transplantation. | 2015 | Transplantation | pmid:25695790 |
Vardas PN et al. | Identification and management of atypical hemolytic uremic syndrome immediately post-heart transplantation. | 2015 | J Card Surg | pmid:25693626 |
Hanifin JM | A Reassuring Rejoinder Against Malignant Influences of Topical Calcineurin Use in Children. | 2015 | JAMA Dermatol | pmid:25692944 |
Margolis DJ et al. | Association Between Malignancy and Topical Use of Pimecrolimus. | 2015 | JAMA Dermatol | pmid:25692459 |
Roche NA et al. | Long-Term Multifunctional Outcome and Risks of Face Vascularized Composite Allotransplantation. | 2015 | J Craniofac Surg | pmid:26468783 |
BlažiÄ M et al. | Roles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis. | 2015 | Microb. Cell Fact. | pmid:26466669 |
Stevens RB et al. | A Randomized 2x2 Factorial Clinical Trial of Renal Transplantation: Steroid-Free Maintenance Immunosuppression with Calcineurin Inhibitor Withdrawal after Six Months Associates with Improved Renal Function and Reduced Chronic Histopathology. | 2015 | PLoS ONE | pmid:26465152 |
Cai W et al. | Limited sampling strategy for predicting area under the concentration-time curve for mycophenolic Acid in Chinese adults receiving mycophenolate mofetil and tacrolimus early after renal transplantation. | 2015 | Ther Drug Monit | pmid:25525761 |
Wang JY and Fan H | P70S6 kinase phosphorylation: a new site to assess pharmacodynamy of sirolimus. | 2015 | Chin. Med. J. | pmid:25698201 |
Van Driest SL and Webber SA | Pharmacogenomics: personalizing pediatric heart transplantation. | 2015 | Circulation | pmid:25645611 |
Detroyer D et al. | Resolution of diffuse skin and systemic Kaposi's sarcoma in a renal transplant recipient after introduction of everolimus: a case report. | 2015 | Transpl Infect Dis | pmid:25645490 |
Chow SP et al. | Long-Term Outcomes of High-Risk Keratoplasty in Patients Receiving Systemic Immunosuppression. | 2015 | Cornea | pmid:26382894 |
Chen QJ et al. | Tacrolimus decreases insulin sensitivity without reducing fasting insulin concentration: a 2-year follow-up study in kidney transplant recipients. | 2015 | Ren Fail | pmid:25644968 |
Lin NC et al. | Minimization or withdrawal of immunosuppressants in pediatric liver transplant recipients. | 2015 | J. Pediatr. Surg. | pmid:26377868 |
Garcia MF et al. | Behavioral measures to reduce non-adherence in renal transplant recipients: a prospective randomized controlled trial. | 2015 | Int Urol Nephrol | pmid:26377496 |
Ogul H et al. | Severe toxic leukoencephalopathy associated with tacrolimus after living donor liver transplantation. | 2015 | Acta Neurol Belg | pmid:24854146 |
Tsujiwaki M et al. | Warty intralymphatic histiocytosis successfully treated with topical tacrolimus. | 2015 | J Eur Acad Dermatol Venereol | pmid:24851952 |
Fukushima D et al. | Epstein-Barr virus--associated posttransplantation lymphoproliferative disorder with tacrolimus metabolism deterioration in infants after living-donor liver transplantation. | 2015 | Transplantation | pmid:24846306 |
Pallet N et al. | Kidney transplant recipients carrying the CYP3A4*22 allelic variant have reduced tacrolimus clearance and often reach supratherapeutic tacrolimus concentrations. | 2015 | Am. J. Transplant. | pmid:25588704 |
Elbadri A et al. | Factors affecting eGFR 5-year post-deceased donor renal transplant: analysis and predictive model. | 2015 | Ren Fail | pmid:25585951 |
Tohme FA et al. | Conversion to a sirolimus-based regimen is associated with lower incidence of BK viremia in low-risk kidney transplant recipients. | 2015 | Transpl Infect Dis | pmid:25582442 |
Dagher M et al. | Overweight, central obesity, and cardiometabolic risk factors in pediatric liver transplantation. | 2015 | Pediatr Transplant | pmid:25581506 |
Krystel-Whittemore M et al. | Polyomavirus nephropathy of the native kidney in a patient with rheumatoid arthritis and pulmonary fibrosis. | 2015 | BMJ Case Rep | pmid:26318171 |
Saint-Marcoux F et al. | How to handle missed or delayed doses of tacrolimus in renal transplant recipients? A pharmacokinetic investigation. | 2015 | Pharmacol. Res. | pmid:26316426 |
Karam S and Wali RK | Current State of Immunosuppression: Past, Present, and Future. | 2015 | Crit. Rev. Eukaryot. Gene Expr. | pmid:26080606 |
Kurita T et al. | The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis. | 2015 | Rheumatology (Oxford) | pmid:24764266 |
Ãœnal CM and Steinert M | FKBPs in bacterial infections. | 2015 | Biochim. Biophys. Acta | pmid:25529296 |
Higa M et al. | Spatial control of calcineurin in response to heat shock in fission yeast. | 2015 | Genes Cells | pmid:25529221 |
Joshi S et al. | Phosphatase inhibition prevents the activity-dependent trafficking of GABAA receptors during status epilepticus in the young animal. | 2015 | Epilepsia | pmid:26248944 |
Cavalié M et al. | Maintenance therapy of adult vitiligo with 0.1% tacrolimus ointment: a randomized, double blind, placebo-controlled study. | 2015 | J. Invest. Dermatol. | pmid:25521460 |
Lim SW et al. | Inhibition of dipeptidyl peptidase IV protects tacrolimus-induced kidney injury. | 2015 | Lab. Invest. | pmid:26237274 |
Vaeth M et al. | Selective NFAT targeting in T cells ameliorates GvHD while maintaining antitumor activity. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25583478 |
Hoerning A et al. | Pharmacodynamic monitoring of mammalian target of rapamycin inhibition by phosphoflow cytometric determination of p70S6 kinase activity. | 2015 | Transplantation | pmid:25099702 |
Wu B et al. | Triple immunosuppressive therapy in steroid-resistant nephrotic syndrome children with tacrolimus resistance or tacrolimus sensitivity but frequently relapsing. | 2015 | Nephrology (Carlton) | pmid:25312783 |
Namvaran F et al. | The Effect of Tacrolimus on Reactive Oxygen Species and Total Antioxidant Status in Pancreatic Beta Cell Line. | 2015 | Exp Clin Transplant | pmid:25431882 |
Li YX and Dijkers PF | Specific calcineurin isoforms are involved in Drosophila toll immune signaling. | 2015 | J. Immunol. | pmid:25429067 |
Vives R et al. | Safety and Activity of UR-1505 in Atopic Dermatitis: A Randomized, Double-blind Phase II Exploratory Trial. | 2015 | Clin Ther | pmid:26163200 |