| MeSH term | MeSH ID | Detail |
|---|---|---|
| Retrognathia | D063173 | 1 associated lipids |
| Drug-Related Side Effects and Adverse Reactions | D064420 | 3 associated lipids |
| Scorpion Stings | D065008 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hatanaka H and Shimomura K | [Immunosuppressive activity of a microbial product]. | 1997 | Nippon Yakurigaku Zasshi | pmid:9503409 |
| Devine SM et al. | The outcome of unrelated donor bone marrow transplantation in patients with hematologic malignancies using tacrolimus (FK506) and low dose methotrexate for graft-versus-host disease prophylaxis. | 1997 | Biol. Blood Marrow Transplant. | pmid:9209738 |
| Su Y et al. | Cyclosporin A but not FK506 inhibits thyroid hormone-induced apoptosis in tadpole intestinal epithelium. | 1997 | FASEB J. | pmid:9212079 |
| Maeda T | [Experimental study of the effectiveness of immunosuppression therapy using FK506 and 15-deoxyspergualin in concordant xenotransplantation]. | 1997 | Nihon Kyobu Geka Gakkai Zasshi | pmid:9217381 |
| duBell WH et al. | Effect of the immunosupressant FK506 on excitation-contraction coupling and outward K+ currents in rat ventricular myocytes. | 1997 | J. Physiol. (Lond.) | pmid:9218211 |
| de-la-Serna-Higuera C et al. | Tacrolimus-induced bone marrow suppression. | 1997 | Lancet | pmid:9291912 |
| Yoshikawa H et al. | Fc gammaRIII-mediated regulation of hematopoiesis in murine bone marrow cells by interleukin-3 and CD95 (Fas/Apo-1). | 1997 | Blood | pmid:9292524 |
| Jain A et al. | Pregnancy after liver transplantation under tacrolimus. | 1997 | Transplantation | pmid:9293865 |
| Garcia-Criado FJ et al. | Tacrolimus (FK506) down-regulates free radical tissue levels, serum cytokines, and neutrophil infiltration after severe liver ischemia. | 1997 | Transplantation | pmid:9293871 |
| Suzuki H et al. | Induction of transplantation tolerance in adult rats by vascularized spleen transplantation. | 1997 | Transplantation | pmid:9293881 |
| Alvaro D et al. | Role and mechanisms of action of acetylcholine in the regulation of rat cholangiocyte secretory functions. | 1997 | J. Clin. Invest. | pmid:9294100 |
| Ruzicka T et al. | A short-term trial of tacrolimus ointment for atopic dermatitis. European Tacrolimus Multicenter Atopic Dermatitis Study Group. | 1997 | N. Engl. J. Med. | pmid:9295241 |
| Birnbaum AH et al. | Recurrence of autoimmune hepatitis in children after liver transplantation. | 1997 | J. Pediatr. Gastroenterol. Nutr. | pmid:9226522 |
| Alarcón CM and Heitman J | FKBP12 physically and functionally interacts with aspartokinase in Saccharomyces cerevisiae. | 1997 | Mol. Cell. Biol. | pmid:9315655 |
| Scott JE et al. | Dynamic equilibrium between calcineurin and kinase activities regulates the phosphorylation state and localization of the nuclear factor of activated T-cells. | 1997 | Biochem. J. | pmid:9182723 |
| Goodyear N et al. | The 37 kDa immunophilin has uracil DNA glycosylase but not rotamase activity. | 1997 | Clin. Biochem. | pmid:9316745 |
| Suzuki N et al. | In vivo mechanisms for the inhibition of T lymphocyte activation by long-term therapy with tacrolimus (FK-506): experience in patients with Behçet's disease. | 1997 | Arthritis Rheum. | pmid:9182928 |
| Rudi J et al. | Prevalence of serum antibodies to Helicobacter pylori and to CagA protein in liver transplant recipients. | 1997 | Am. J. Gastroenterol. | pmid:9317070 |
| Odom A et al. | Calcineurin is required for virulence of Cryptococcus neoformans. | 1997 | EMBO J. | pmid:9184205 |
| Kesten S et al. | Tacrolimus as rescue therapy for bronchiolitis obliterans syndrome. | 1997 | J. Heart Lung Transplant. | pmid:9322139 |
| Nishinaka H et al. | Graft persistence effectively induces and maintains donor-specific unresponsiveness. | 1997 | J. Surg. Res. | pmid:9184673 |
| Cardoso CM et al. | Uncoupling of Ca2+ transport ATPase in muscle and blood platelets by diacylglycerol analogues and cyclosporin A antagonism. | 1997 | Biochem. J. | pmid:9581558 |
| Ko WJ et al. | Hypomagnesia and arrhythmia corrected by replacing cyclosporine with FK506 in a heart transplant recipient. | 1997 | J. Heart Lung Transplant. | pmid:9322151 |
| Miwa S et al. | Effect of anti-intercellular adhesion molecule-1 and anti-leukocyte function associated antigen-1 monoclonal antibodies on rat-to-mouse cardiac xenograft rejection. | 1997 | Surgery | pmid:9186469 |
| Arbustini E et al. | Acute rejection and heart infection rates in FK 506- versus cyclosporine A-treated heart transplant recipients: an endomyocardial biopsy pathologic study. | 1997 | J. Heart Lung Transplant. | pmid:9322152 |
| Fujino H et al. | Stimulatory roles of muscarinic acetylcholine receptors on T cell antigen receptor/CD3 complex-mediated interleukin-2 production in human peripheral blood lymphocytes. | 1997 | Mol. Pharmacol. | pmid:9187267 |
| Denecker G et al. | Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma. | 1997 | Cytokine | pmid:9325011 |
| Hausen B and Morris RE | Review of immunosuppression for lung transplantation. Novel drugs, new uses for conventional immunosuppressants, and alternative strategies. | 1997 | Clin. Chest Med. | pmid:9187827 |
| Fujita T et al. | Prolonged survival of rat skin allograft by treatment with FK506 ointment. | 1997 | Transplantation | pmid:9326422 |
| Pratschke J et al. | Treatment of cyclosporine-related adverse effects by conversion to tacrolimus after liver transplantation. | 1997 | Transplantation | pmid:9326428 |
| Raufman JP et al. | Regulation of calcium-induced exocytosis from gastric chief cells by protein phosphatase-2B (calcineurin). | 1997 | Biochim. Biophys. Acta | pmid:9202177 |
| McGhee B et al. | Therapeutic use of an extemporaneously prepared oral suspension of tacrolimus in pediatric patients. | 1997 | Transplantation | pmid:9326429 |
| Mochizuki M | Immunotherapy for Behçet's disease. | 1997 | Int. Rev. Immunol. | pmid:9203026 |
| Braun F et al. | Pitfalls in monitoring tacrolimus (FK 506). | 1997 | Ther Drug Monit | pmid:9421102 |
| Guckelberger O et al. | Cardiovascular risk factors in long-term follow-up after orthotopic liver transplantation. | 1997 | Clin Transplant | pmid:9067697 |
| Mueller AR et al. | Association between hepatitis and rejection: upregulation of cytokines and extracellular matrix parameters. | 1997 | Transplant. Proc. | pmid:9365585 |
| Singh N et al. | Clinical spectrum of invasive cryptococcosis in liver transplant recipients receiving tacrolimus. | 1997 | Clin Transplant | pmid:9067698 |
| Platz KP et al. | FK 506 and mycofenolate mofetil rescue for acute steroid-resistant and chronic rejection after liver transplantation. | 1997 | Transplant. Proc. | pmid:9365598 |
| Victor RG et al. | Mechanism of Ca(2+)-dependent inactivation of L-type Ca2+ channels in GH3 cells: direct evidence against dephosphorylation by calcineurin. | 1997 | J. Membr. Biol. | pmid:9070464 |
| Platz KP et al. | Indications for mycofenolate mofetil therapy after liver transplantation. | 1997 | Transplant. Proc. | pmid:9365601 |
| Demirbas A et al. | FK 506 in simultaneous pancreas/kidney transplantation: the University of Miami experience. | 1997 | Transplant. Proc. | pmid:9365608 |
| Ferron GM et al. | Population pharmacokinetics of sirolimus in kidney transplant patients. | 1997 | Clin. Pharmacol. Ther. | pmid:9129559 |
| Kliem V et al. | Long-term results after primary successful FK 506 treatment of steroid- and OKT3-resistant rejection in renal transplant recipients. | 1997 | Transplant. Proc. | pmid:9365627 |
| Weil SJ et al. | Chemotaxis of macrophages by a peritoneal fluid protein in women with endometriosis. | 1997 | Fertil. Steril. | pmid:9130891 |
| Xu M et al. | Effect of peritransplant FTY720 alone or in combination with posttransplant FK 506 in a rat model of cardiac allotransplantation. | 1997 | Transplant. Proc. | pmid:9365631 |
| Karlsson H et al. | Energy levels in resting and mitogen-stimulated human lymphocytes during treatment with FK506 or cyclosporin A in vitro. | 1997 | Biochim. Biophys. Acta | pmid:9131051 |
| Gavlik A et al. | Mycophenolate mofetil rescue therapy in liver transplant recipients: an extended follow-up. | 1997 | Transplant. Proc. | pmid:9365633 |
| Pratt WB | The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase. | 1997 | Annu. Rev. Pharmacol. Toxicol. | pmid:9131255 |
| Lee CM et al. | Outcomes in diabetic patients after simultaneous pancreas-kidney versus kidney alone transplantation. | 1997 | Transplantation | pmid:9371670 |
| Niederstadt C et al. | Effect of FK506 on magnesium homeostasis after renal transplantation. | 1997 | Transplant. Proc. | pmid:9365709 |
| Filler G et al. | Transient diabetes mellitus and peripheral insulin resistance following Tacrolimus intoxication in a child after renal transplantation. | 1997 | Nephrol. Dial. Transplant. | pmid:9132657 |
| Takao T et al. | [A case of recurrent IgA nephropathy following renal transplantation under tacrolimus (FK506)]. | 1997 | Hinyokika Kiyo | pmid:9365847 |
| Yap AS et al. | Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function. | 1997 | Curr. Biol. | pmid:9133345 |
| Aoyama S et al. | [The effect of FK 506, an immunosuppressant, on cerebral infarction volume in focal cerebral ischemia in rats]. | 1997 | Nippon Ika Daigaku Zasshi | pmid:9366145 |
| Ross DJ et al. | FK 506 'rescue' immunosuppression for obliterative bronchiolitis after lung transplantation. | 1997 | Chest | pmid:9367453 |
| Tomás ML | [Immunosuppressive agents: side effects]. | 1997 | An R Acad Nac Med (Madr) | pmid:9616947 |
| Singh N et al. | Bloodstream infections in liver transplant recipients receiving tacrolimus. | 1997 | Clin Transplant | pmid:9267715 |
| Guo Z et al. | In vivo effects of leflunomide on normal pancreatic islet and syngeneic islet graft function. | 1997 | Transplantation | pmid:9075844 |
| Gruessner RW | Tacrolimus in pancreas transplantation: a multicenter analysis. Tacrolimus Pancreas Transplant Study Group. | 1997 | Clin Transplant | pmid:9267719 |
| Ciancio G et al. | Use of intravenous FK506 to treat acute rejection in simultaneous pancreas-kidney transplant recipients on maintenance oral FK506. | 1997 | Transplantation | pmid:9075856 |
| Sherrington PD et al. | TLiSA1 (PTA1) activation antigen implicated in T cell differentiation and platelet activation is a member of the immunoglobulin superfamily exhibiting distinctive regulation of expression. | 1997 | J. Biol. Chem. | pmid:9268302 |
| Mirza DF et al. | Reduced acute rejection after liver transplantation with Neoral-based triple immunosuppression. | 1997 | Lancet | pmid:9078209 |
| Danovitch GM | Cyclosporin or tacrolimus: which agent to choose? | 1997 | Nephrol. Dial. Transplant. | pmid:9269630 |
| Yoshikawa H et al. | FK506 prevents induction of rat experimental autoimmune myasthenia gravis. | 1997 | J. Autoimmun. | pmid:9080295 |
| Filler G et al. | Pharmacokinetics of tacrolimus (FK 506) in children and adolescents with renal transplants. | 1997 | Nephrol. Dial. Transplant. | pmid:9269646 |
| Yokoyama I et al. | Fas antigen expression of hepatocytes and its modification by immunosuppressants. | 1997 | Dig. Dis. Sci. | pmid:9440622 |
| Sperr WR et al. | Inhibition of allergen-induced histamine release from human basophils by cyclosporine A and FK-506. | 1997 | Int. Arch. Allergy Immunol. | pmid:9303333 |
| Azuma H et al. | Atypical Epstein-Barr virus infection during and after intermittent FK506 therapy. | 1997 | Acta Paediatr Jpn | pmid:9141259 |
| Izuishi K et al. | Effects of an immunosuppressive agent, tacrolimus (FK-506), on the activities of cytochrome P-450-linked monooxygenase systems in rat liver microsomes. | 1997 | Int. J. Biochem. Cell Biol. | pmid:9304807 |
| Tsuchida Y et al. | Vascularized bone marrow allotransplantation in rats prolongs a simultaneous skin allograft. | 1997 | Transplant. Proc. | pmid:9142252 |
| Jonas S et al. | De novo malignancies after liver transplantation using tacrolimus-based protocols or cyclosporine-based quadruple immunosuppression with an interleukin-2 receptor antibody or antithymocyte globulin. | 1997 | Cancer | pmid:9305716 |
| Costa A et al. | Small bowel myoelectrical activity after transplantation in pigs: motility versus ACR score. | 1997 | Transplant. Proc. | pmid:9142281 |
| Tze WJ et al. | Prolongation of pig islet xenograft survival in rats immunosuppressed with FK506. | 1997 | Diabetes Res. Clin. Pract. | pmid:9306035 |
| Soin AS et al. | Complement activation during rejection in experimental intestinal transplantation. | 1997 | Transplant. Proc. | pmid:9142282 |
| Tanaka H et al. | [Discovery and development of a novel immunosuppressant, tacrolimus hydrate]. | 1997 | Yakugaku Zasshi | pmid:9306728 |
| Rossi G et al. | Small bowel transplantation under oral immunosuppression: experimental study in the pig. | 1997 | Transplant. Proc. | pmid:9142285 |
| Kamada H et al. | Immunopharmacological studies on collagen-induced arthritis in dark Agouti (DA) rats. | 1997 | Jpn. J. Pharmacol. | pmid:9307327 |
| Spada M et al. | Tacrolimus and mycophenolate mofetil in pig small bowel transplantation: different protocols and their outcome. | 1997 | Transplant. Proc. | pmid:9142286 |
| Ronchetti F et al. | Intestinal damage evaluation in swine allograft small bowel through hyaluronic acid quantification. | 1997 | Transplant. Proc. | pmid:9142293 |
| McKee M et al. | Initial experience with FK506 (tacrolimus) in pediatric renal transplant recipients. | 1997 | J. Pediatr. Surg. | pmid:9165452 |
| Uno T et al. | The pharmacokinetics of water-in-oil-in-water-type multiple emulsion of a new tacrolimus formulation. | 1997 | Lipids | pmid:9168461 |
| Gold BG | FK506 and the role of immunophilins in nerve regeneration. | 1997 | Mol. Neurobiol. | pmid:9457703 |
| Jiang H et al. | Distinct tissue and cellular distribution of two major isoforms of calcineurin. | 1997 | Mol. Immunol. | pmid:9393969 |
| Schweda F et al. | Tacrolimus treatment for steroid- and cyclosporin-resistant minimal-change nephrotic syndrome. | 1997 | Nephrol. Dial. Transplant. | pmid:9394341 |
| Sabatini DM et al. | Neural roles of immunophilins and their ligands. | 1997 | Mol. Neurobiol. | pmid:9396011 |
| Su Y et al. | Thyroid hormone induces apoptosis in primary cell cultures of tadpole intestine: cell type specificity and effects of extracellular matrix. | 1997 | J. Cell Biol. | pmid:9396758 |
| Yamaguchi Y et al. | Enhanced expression of cytokine-induced neutrophil chemoattractant in rat hepatic allografts during acute rejection. | 1997 | Hepatology | pmid:9397996 |
| Mollison KW et al. | Discovery of less nephrotoxic FK506 analogs and determining immunophilin dependence of immunosuppressant nephrotoxicity with a novel single-dose rat cisplatin potentiation assay. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9400028 |
| Mondragon A et al. | Overexpression and purification of human calcineurin alpha from Escherichia coli and assessment of catalytic functions of residues surrounding the binuclear metal center. | 1997 | Biochemistry | pmid:9125515 |
| Murthy JN et al. | Identification of a 37 kDa tacrolimus, sirolimus and cyclosporine binding immunophilin possessing glyceraldehyde 3-phosphate dehydrogenase activity isolated from the Jurkat T cell line. | 1997 | Clin. Biochem. | pmid:9127694 |
| Odom A et al. | The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. | 1997 | Antimicrob. Agents Chemother. | pmid:8980772 |
| High KP and Washburn RG | Invasive aspergillosis in mice immunosuppressed with cyclosporin A, tacrolimus (FK506), or sirolimus (rapamycin). | 1997 | J. Infect. Dis. | pmid:8985226 |
| Yoshikai Y et al. | Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS. | 1997 | J. Virol. | pmid:8985410 |
| Jordan ML et al. | Tacrolimus rescue therapy for renal allograft rejection--five-year experience. | 1997 | Transplantation | pmid:9020321 |
| Noguchi N et al. | Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes. | 1997 | J. Biol. Chem. | pmid:9013543 |
| Ishizuka T et al. | Rapamycin potentiates dexamethasone-induced apoptosis and inhibits JNK activity in lymphoblastoid cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9016789 |
| Bragado MJ et al. | p70s6k is activated by CCK in rat pancreatic acini. | 1997 | Am. J. Physiol. | pmid:9252447 |
| Lacaille F et al. | Life-threatening food allergy in a child treated with FK506. | 1997 | J. Pediatr. Gastroenterol. Nutr. | pmid:9252915 |
| Bagnis C et al. | Comparative acute nephrotoxicity of FK-506 and ciclosporin in an isolated in situ autoperfused rat kidney model. | 1997 | Am. J. Nephrol. | pmid:9057948 |
| Rühlmann A and Nordheim A | Effects of the immunosuppressive drugs CsA and FK506 on intracellular signalling and gene regulation. | 1997 | Immunobiology | pmid:9442391 |