MeSH term | MeSH ID | Detail |
---|---|---|
Acne Vulgaris | D000152 | 35 associated lipids |
Abortion, Spontaneous | D000022 | 12 associated lipids |
Abnormalities, Multiple | D000015 | 13 associated lipids |
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ryffel B et al. | Interleukin-2 receptor (CD25) upregulation on human T-lymphocytes: sensitivity to immunosuppressants is defined by the mode of T-lymphocyte activation. | 1995 | Immunopharmacology | pmid:8557519 |
Stillman IE et al. | FK506 nephrotoxicity: morphologic and physiologic characterization of a rat model. | 1995 | Lab. Invest. | pmid:8558840 |
Gjertson DW et al. | The relative effects of FK506 and cyclosporine on short- and long-term kidney graft survival. | 1995 | Transplantation | pmid:8545861 |
Shirakata Y et al. | Inhibitory effect of plasma FKBP12 on immunosuppressive activity of FK506. | 1995 | Transplantation | pmid:8545894 |
Aoyama H et al. | Successful treatment of resistant facial lesions of atopic dermatitis with 0.1% FK506 ointment. | 1995 | Br. J. Dermatol. | pmid:8547017 |
Gharpure VS et al. | Thrombotic thrombocytopenic purpura associated with FK506 following bone marrow transplantation. | 1995 | Bone Marrow Transplant. | pmid:8547871 |
Koch K et al. | CP-123,369: a potent, orally active immunosuppressive agent. | 1995 | Inflamm. Res. | pmid:8548388 |
Lionetti P et al. | Mucosal adaptation and destruction in response to lamina propria T cell activation in explants of human fetal intestine. | 1995 | Adv. Exp. Med. Biol. | pmid:8525974 |
Clardy J | The chemistry of signal transduction. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7529414 |
Braun W et al. | Three-dimensional structure and actions of immunosuppressants and their immunophilins. | 1995 | FASEB J. | pmid:7529736 |
Kawai M et al. | Pyrrolidine dithiocarbamate inhibits intercellular adhesion molecule-1 biosynthesis induced by cytokines in human fibroblasts. | 1995 | J. Immunol. | pmid:7532665 |
Venkataraman L et al. | FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells. | 1995 | J. Exp. Med. | pmid:7532676 |
Wang CR et al. | T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection. | 1995 | J. Exp. Med. | pmid:7532685 |
Grobecker HF et al. | Cyclosporine A-induced hypertension in SHR and WKY: role of the sympatho-adrenal system. | 1995 | Clin Exp Pharmacol Physiol Suppl | pmid:9072458 |
O'Rourke M et al. | Recovery of delayed-type hypersensitivity following liver transplantation. | 1995 | Transplant. Proc. | pmid:7533369 |
Goodall T et al. | FK506-induced endothelin release by cultured rat mesangial cells. | 1995 | J. Cardiovasc. Pharmacol. | pmid:8587453 |
Gaweco AS et al. | Common and sequential overexpression patterns of T-helper cytokines during acute (cellular) rejection, and correlation of proinflammatory cytokine expression with chronic (ductopenic) rejection of human liver allografts: a study under cyclosporine, FK 506, and quadruple BT 563 immunosuppression. | 1995 | Transplant. Proc. | pmid:7533370 |
Soldin SJ | Receptor (immunophilin-binding) assay for immunosuppressive drugs. | 1995 | Ther Drug Monit | pmid:8588223 |
Armstrong VW et al. | Metabolic liver function and lipoprotein metabolism after orthotopic liver transplantation in patients on immunosuppressive therapy with FK 506 or cyclosporine. | 1995 | Transplant. Proc. | pmid:7533371 |
Thomson AW et al. | Mode of action of tacrolimus (FK506): molecular and cellular mechanisms. | 1995 | Ther Drug Monit | pmid:8588225 |
Martinez OM et al. | Molecular markers of Epstein-Barr virus infection in the circulation of transplant recipients. | 1995 | Transplant. Proc. | pmid:7533372 |
Fung JJ and Starzl TE | FK506 in solid organ transplantation. | 1995 | Ther Drug Monit | pmid:8588226 |
Langrehr JM et al. | Liver transplantation in hepatitis B surface antigen positive patients with postoperative long-term immunoprophylaxis. | 1995 | Transplant. Proc. | pmid:7533373 |
Jusko WJ | Analysis of tacrolimus (FK 506) in relation to therapeutic drug monitoring. | 1995 | Ther Drug Monit | pmid:8588227 |
Vargas V et al. | Alpha-interferon for acute hepatitis C in liver transplant patients. | 1995 | Transplant. Proc. | pmid:7533374 |
McMaster P et al. | Therapeutic drug monitoring of tacrolimus in clinical transplantation. | 1995 | Ther Drug Monit | pmid:8588228 |
Barkholt LM et al. | New criteria for diagnosing cytomegalovirus hepatitis in liver transplant patients. | 1995 | Transplant. Proc. | pmid:7533375 |
Jusko WJ et al. | Consensus document: therapeutic monitoring of tacrolimus (FK-506). | 1995 | Ther Drug Monit | pmid:8588229 |
Teraoka S et al. | Effect of rescue therapy using FK 506 on relapsing rejection after combined pancreas and kidney transplantation. | 1995 | Transplant. Proc. | pmid:7533381 |
Lohse DL et al. | Insights derived from the structures of the Ser/Thr phosphatases calcineurin and protein phosphatase 1. | 1995 | Structure | pmid:8590008 |
Fay JW et al. | FK 506-based immunosuppression for prevention of graft versus host disease after unrelated donor marrow transplantation. | 1995 | Transplant. Proc. | pmid:7533383 |
Izutani H et al. | Graft coronary arteriosclerosis in rat heart transplant model with FK 506 short-term administration. | 1995 | Transplant. Proc. | pmid:7533425 |
Funayama Y et al. | Changes in cell adhesion molecules after small bowel transplantation in rats. | 1995 | Transplant. Proc. | pmid:7533426 |
Laskow DA et al. | Phase II FK 506 multicenter concentration control study: one-year follow-up. | 1995 | Transplant. Proc. | pmid:7533431 |
Shapiro R et al. | A prospective, randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone in renal transplant patients. | 1995 | Transplant. Proc. | pmid:7533432 |
Winkler M et al. | Comparison of plasma vs whole blood as matrix for FK 506 drug level monitoring. | 1995 | Transplant. Proc. | pmid:7533433 |
Sakamoto K et al. | Sodium-losing nephropathy and distal tubular damage of transplant kidneys with FK506 administration. | 1995 | Transplant. Proc. | pmid:7533434 |
Ochiai T et al. | Phase III study of FK 506 in kidney transplantation. Japanese FK 506 Study Group. | 1995 | Transplant. Proc. | pmid:7533435 |
Scantlebury VP et al. | Renal transplantation under cyclosporine and FK 506 for hemolytic uremic syndrome. | 1995 | Transplant. Proc. | pmid:7533436 |
Hanafusa T et al. | Long-term impact of hepatitis virus infection on kidney transplant recipients and a pilot study of the effects of interferon alpha on chronic hepatitis C. | 1995 | Transplant. Proc. | pmid:7533440 |
Bundick RV et al. | The effect of cyclosporin A, FK506, and rapamycin on the murine chronic graft-versus-host response--an in vivo model of Th2-like activity. | 1995 | Clin. Exp. Immunol. | pmid:7533681 |
Atkison P et al. | Hypertrophic cardiomyopathy associated with tacrolimus in paediatric transplant patients. | 1995 | Lancet | pmid:7535875 |
Shaffer D et al. | Normal pancreas allograft function following simultaneous pancreas kidney transplantation after rescue therapy with tacrolimus (FK506). | 1995 | Transplantation | pmid:7535958 |
Bronster DJ et al. | Demyelinating sensorimotor polyneuropathy after administration of FK506. | 1995 | Transplantation | pmid:7535959 |
Sheppard KE | Cyclosporin A and FK506 are potent activators of proopiomelanocortin-derived peptide secretion without affecting corticotrope glucocorticoid receptor function. | 1995 | J. Neuroendocrinol. | pmid:8748119 |
Iwasaki K et al. | Further metabolism of FK506 (tacrolimus). Identification and biological activities of the metabolites oxidized at multiple sites of FK506. | 1995 | Drug Metab. Dispos. | pmid:7536652 |
Tumlin JA et al. | Expression of calcineurin activity and alpha-subunit isoforms in specific segments of the rat nephron. | 1995 | Am. J. Physiol. | pmid:7485542 |
Furukawa F et al. | FK506: therapeutic effects on lupus dermatoses in autoimmune-prone MRL/Mp-lpr/lpr mice. | 1995 | Arch. Dermatol. Res. | pmid:7487142 |
Miranker A and Karplus M | An automated method for dynamic ligand design. | 1995 | Proteins | pmid:8749844 |
Marumo T et al. | Cyclosporin A inhibits nitric oxide synthase induction in vascular smooth muscle cells. | 1995 | Hypertension | pmid:7536714 |
Nowaczyk M et al. | 2-Chlorodeoxyadenosine: lack of synergism with cyclosporine A and tacrolimus (FK 506). | 1995 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:8744655 |
Schwaninger M et al. | Involvement of the Ca(2+)-dependent phosphatase calcineurin in gene transcription that is stimulated by cAMP through cAMP response elements. | 1995 | J. Biol. Chem. | pmid:7536740 |
Min Z and Jones NF | Limb transplantation in rats: immunosuppression with FK-506. | 1995 | J Hand Surg Am | pmid:7536766 |
Lyons WE et al. | Neuronal regeneration enhances the expression of the immunophilin FKBP-12. | 1995 | J. Neurosci. | pmid:7536825 |
David M et al. | [Occurrence of suspicious changes in cervix cytology in women after liver transplantation]. | 1995 | Geburtshilfe Frauenheilkd | pmid:7557217 |
[Experimental and clinical studies on the effectiveness of new immunosuppressive agents used in heart transplantation and transplantation-related complications]. | 1995 | Nihon Kyobu Geka Gakkai Zasshi | pmid:7561285 | |
Yamamoto S et al. | Cross-species transplantation of photoreceptors with tacrolimus hydrate (FK506) treatment. | 1995 | Jpn. J. Ophthalmol. | pmid:8926639 |
Asano K et al. | Generation of effector T cells in Hymenolepis nana-infected, FK-506-treated BALB/c mice. | 1995 | Immunol. Lett. | pmid:7590919 |
Lam E et al. | A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. | 1995 | J. Biol. Chem. | pmid:7592869 |
Galat A and Metcalfe SM | Peptidylproline cis/trans isomerases. | 1995 | Prog. Biophys. Mol. Biol. | pmid:7538221 |
Goldfeld AE et al. | Cyclosporin A and FK506 block induction of the Epstein-Barr virus lytic cycle by anti-immunoglobulin. | 1995 | Virology | pmid:7538254 |
Kanda T et al. | Synergistic effects of tacrolimus and human interferon-alpha A/D in murine viral myocarditis. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7542339 |
Jurim O et al. | Living-donor liver transplantation at UCLA. | 1995 | Am. J. Surg. | pmid:7538267 |
Canzanello VJ et al. | Renal sodium handling with cyclosporin A and FK506 after orthotopic liver transplantation. | 1995 | J. Am. Soc. Nephrol. | pmid:7542491 |
Conde M et al. | Inhibitory effect of cyclosporin A and FK506 on nitric oxide production by cultured macrophages. Evidence of a direct effect on nitric oxide synthase activity. | 1995 | Immunology | pmid:7538492 |
Garrett-Engele P et al. | Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase. | 1995 | Mol. Cell. Biol. | pmid:7542741 |
Skeen MJ and Ziegler HK | Activation of gamma delta T cells for production of IFN-gamma is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12. | 1995 | J. Immunol. | pmid:7538532 |
Baughman G et al. | FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition. | 1995 | Mol. Cell. Biol. | pmid:7542743 |
Columbo M et al. | Human skin mast cells express functional beta 1 integrins that mediate adhesion to extracellular matrix proteins. | 1995 | J. Immunol. | pmid:7538541 |
Pearlman DA and Connelly PR | Determination of the differential effects of hydrogen bonding and water release on the binding of FK506 to native and Tyr82-->Phe82 FKBP-12 proteins using free energy simulations. | 1995 | J. Mol. Biol. | pmid:7538591 |
Dumont FJ et al. | Dominant mutations confer resistance to the immunosuppressant, rapamycin, in variants of a T cell lymphoma. | 1995 | Cell. Immunol. | pmid:7538911 |
Rouvière-Fourmy N et al. | 1H and 15N assignment of NMR spectrum, secondary structure and global folding of the immunophilin-like domain of the 59-kDa FK506-binding protein. | 1995 | Eur. J. Biochem. | pmid:7544285 |
Sakamoto K et al. | A new assay method for immunosuppressants with a tacrolimus (FK506)-like mode of action. | 1995 | J. Antibiot. | pmid:7544337 |
Lee MJ et al. | Combined inhibition effects of tacrolimus and methylprednisolone on in vitro human lymphocyte proliferation. | 1995 | Immunopharmacol Immunotoxicol | pmid:7544367 |
Sauer P et al. | In patients with orthotopic liver transplantation, serum markers of cholestasis are unreliable indicators of biliary secretion. | 1995 | J. Hepatol. | pmid:7544368 |
Nielsen FT et al. | Nephrotoxicity of FK-506 in the rat. Studies on glomerular and tubular function, and on the relationship between efficacy and toxicity. | 1995 | Nephrol. Dial. Transplant. | pmid:7540737 |
Chang HY et al. | Asymmetric retraction of growth cone filopodia following focal inactivation of calcineurin. | 1995 | Nature | pmid:7544441 |
Reichenspurner H et al. | First experience with FK 506 for treatment of chronic pulmonary rejection. | 1995 | Transplant. Proc. | pmid:7540775 |
Murio JE et al. | Compassionate use of FK 506 in liver transplantation. | 1995 | Transplant. Proc. | pmid:7544501 |
Yumiba T et al. | Immunosuppressive and diabetogenic effect of FK 506 on pancreatic islet xenotransplantation. | 1995 | Transplant. Proc. | pmid:7540780 |
Llull R et al. | Multilineage amplification of graft-vs-host disease-resistant chimerism following rat vascularized bone marrow allotransplantation. | 1995 | Transplant. Proc. | pmid:7544504 |
Horne SM and Young KD | Escherichia coli and other species of the Enterobacteriaceae encode a protein similar to the family of Mip-like FK506-binding proteins. | 1995 | Arch. Microbiol. | pmid:7540828 |
Teutsch M et al. | Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and rapamycin. | 1995 | Int. Immunol. | pmid:7540861 |
Hoshino H et al. | Effects of FK506 on an experimental model of colitis in rats. | 1995 | Aliment. Pharmacol. Ther. | pmid:7544633 |
Mori A et al. | IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A. | 1995 | Int. Immunol. | pmid:7540862 |
Firdaous I et al. | HPLC-microparticle enzyme immunoassay specific for tacrolimus in whole blood of hepatic and renal transplant patients. | 1995 | Clin. Chem. | pmid:7544705 |
Tashiro H et al. | Monitoring for engraftment following rat orthotopic liver transplantation by in vitro amplification of Y-chromosome gene using polymerase chain reaction. | 1995 | Cell Transplant | pmid:7540919 |
Hikita N et al. | Effects of topical FK506 on endotoxin-induced uveitis (EIU) in the Lewis rat. | 1995 | Curr. Eye Res. | pmid:7540967 |
Cardenas ME et al. | Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A. | 1995 | EMBO J. | pmid:7540976 |
Madsen KL et al. | FK506 increases permeability in rat intestine by inhibiting mitochondrial function. | 1995 | Gastroenterology | pmid:7540994 |
Platz KP et al. | Toxicity versus rejection--or why conversions between cyclosporine A and FK506 were performed after liver transplantation. | 1995 | Clin Transplant | pmid:7549052 |
Mueller AR et al. | The optimal immunosuppressant after liver transplantation according to diagnosis: cyclosporine A or FK506? | 1995 | Clin Transplant | pmid:7549057 |
Nagai H et al. | Effect of some immunosuppressors on allergic bronchial inflammation and airway hyperresponsiveness in mice. | 1995 | Int. Arch. Allergy Immunol. | pmid:7549508 |
Jung-Testas I et al. | Cyclosporin A promotes nuclear transfer of a cytoplasmic progesterone receptor mutant. | 1995 | C. R. Acad. Sci. III, Sci. Vie | pmid:7583777 |
Kissinger CR et al. | Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. | 1995 | Nature | pmid:8524402 |
Lauerma AI | Immunomodulation of contact dermatitis. | 1995 | Curr. Probl. Dermatol. | pmid:7587333 |
Cardenas ME et al. | Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin. | 1995 | Curr. Opin. Nephrol. Hypertens. | pmid:8591053 |
Lake KD and Canafax DM | Important interactions of drugs with immunosuppressive agents used in transplant recipients. | 1995 | J. Antimicrob. Chemother. | pmid:8601538 |
Cameron AM et al. | Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux. | 1995 | Cell | pmid:8521476 |
Tamura K | FK506: mechanism of immunosuppression and adverse-effects. | 1995 | J Toxicol Sci | pmid:8531246 |