MeSH term | MeSH ID | Detail |
---|---|---|
Acne Vulgaris | D000152 | 35 associated lipids |
Abortion, Spontaneous | D000022 | 12 associated lipids |
Abnormalities, Multiple | D000015 | 13 associated lipids |
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Boswell GW et al. | Tacrolimus pharmacokinetics in BMT patients. | 1998 | Bone Marrow Transplant. | pmid:9486490 |
Tezcan H et al. | Severe cerebellar swelling and thrombotic thrombocytopenic purpura associated with FK506. | 1998 | Bone Marrow Transplant. | pmid:9486505 |
Ali H et al. | Mycophenolate mofetil-based salvage as acute GVHD prophylaxis after early discontinuation of tacrolimus and/or sirolimus. | 2015 | Bone Marrow Transplant. | pmid:25365064 |
Labrador J et al. | Risk factors for thrombotic microangiopathy in allogeneic hematopoietic stem cell recipients receiving GVHD prophylaxis with tacrolimus plus MTX or sirolimus. | 2014 | Bone Marrow Transplant. | pmid:24566710 |
Gharpure VS et al. | Thrombotic thrombocytopenic purpura associated with FK506 following bone marrow transplantation. | 1995 | Bone Marrow Transplant. | pmid:8547871 |
Jacobson P et al. | Factors affecting the pharmacokinetics of tacrolimus (FK506) in hematopoietic cell transplant (HCT) patients. | 2001 | Bone Marrow Transplant. | pmid:11781626 |
Menillo SA et al. | Intraoral psoralen ultraviolet A irradiation (PUVA) treatment of refractory oral chronic graft-versus-host disease following allogeneic stem cell transplantation. | 2001 | Bone Marrow Transplant. | pmid:11781637 |
Mori T et al. | Drug interaction between voriconazole and calcineurin inhibitors in allogeneic hematopoietic stem cell transplant recipients. | 2009 | Bone Marrow Transplant. | pmid:19270729 |
Takamatsu Y et al. | Intravenous cyclosporine and tacrolimus caused anaphylaxis but oral cyclosporine capsules were tolerated in an allogeneic bone marrow transplant recipient. | 2001 | Bone Marrow Transplant. | pmid:11571519 |
Przepiorka D et al. | Practical considerations in the use of tacrolimus for allogeneic marrow transplantation. | 1999 | Bone Marrow Transplant. | pmid:10578154 |
Ram R et al. | Prophylaxis regimens for GVHD: systematic review and meta-analysis. | 2009 | Bone Marrow Transplant. | pmid:18997826 |
Messina C et al. | Prevention and treatment of acute GvHD. | 2008 | Bone Marrow Transplant. | pmid:18545247 |
Eagle DA et al. | Gastroparesis following bone marrow transplantation. | 2001 | Bone Marrow Transplant. | pmid:11498745 |
Seropian S et al. | Allogeneic peripheral blood stem cell transplantation for high-risk non-Hodgkin's lymphoma. | 2003 | Bone Marrow Transplant. | pmid:14520419 |
Przepiorka D et al. | Bronchiolitis obliterans organizing pneumonia in a BMT patient receiving FK506. | 1993 | Bone Marrow Transplant. | pmid:7687503 |
Trifilio SM et al. | Tacrolimus use in adult allogeneic stem cell transplant recipients receiving voriconazole: preemptive dose modification and therapeutic drug monitoring. | 2010 | Bone Marrow Transplant. | pmid:19966844 |
Ochiai N et al. | Successful non-T cell-depleted HLA haplo-identical three-loci mismatched hematopoietic stem cell transplantation from mother to son based on the feto-maternal microchimerism in chronic myelogenous leukemia. | 2002 | Bone Marrow Transplant. | pmid:12439703 |
Suehiro A et al. | Enhancement by cyclosporine A and tacrolimus of serotonin-induced formation of small platelet aggregation. | 2002 | Bone Marrow Transplant. | pmid:11850703 |
Nelson R et al. | Sirolimus, tacrolimus and antithymocyte globulin as GVHD prophylaxis in HLA-mismatched unrelated donor hematopoietic cell transplantation: a single institution experience. | 2015 | Bone Marrow Transplant. | pmid:26301969 |
Elefante A et al. | Long-term stability of a patient-convenient 1 mg/ml suspension of tacrolimus for accurate maintenance of stable therapeutic levels. | 2006 | Bone Marrow Transplant. | pmid:16518428 |
Terakura S et al. | Exploratory research for optimal GvHD prophylaxis after single unit CBT in adults: short-term methotrexate reduced the incidence of severe GvHD more than mycophenolate mofetil. | 2017 | Bone Marrow Transplant. | pmid:27941766 |
Perez LE et al. | Visilizumab with tacrolimus and methotrexate for GvHD prevention after allogeneic hematopoietic cell transplantation from mismatched unrelated donors. | 2017 | Bone Marrow Transplant. | pmid:27991896 |
Nieto Y et al. | Acute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantation. | 2000 | Bone Marrow Transplant. | pmid:10918414 |
Yanik G et al. | Tacrolimus (FK506) and methotrexate as prophylaxis for acute graft-versus-host disease in pediatric allogeneic stem cell transplantation. | 2000 | Bone Marrow Transplant. | pmid:10918426 |
Mawardi H et al. | Combined topical dexamethasone/tacrolimus therapy for management of oral chronic GVHD. | 2010 | Bone Marrow Transplant. | pmid:19881552 |
Kanda J et al. | Pre-engraftment syndrome after myeloablative dual umbilical cord blood transplantation: risk factors and response to treatment. | 2013 | Bone Marrow Transplant. | pmid:23334274 |
Boughton O et al. | A published pharmacogenetic algorithm was poorly predictive of tacrolimus clearance in an independent cohort of renal transplant recipients. | 2013 | Br J Clin Pharmacol | pmid:23305195 |
Antignac M et al. | Population pharmacokinetics and bioavailability of tacrolimus in kidney transplant patients. | 2007 | Br J Clin Pharmacol | pmid:17425625 |
Nishimoto M et al. | Drug interactions and safety profiles with concomitant use of caspofungin and calcineurin inhibitors in allogeneic haematopoietic cell transplantation. | 2017 | Br J Clin Pharmacol | pmid:28407449 |
Böttiger Y et al. | Tacrolimus whole blood concentrations correlate closely to side-effects in renal transplant recipients. | 1999 | Br J Clin Pharmacol | pmid:10510159 |
Cusinato DA et al. | Relationship of CYP3A5 genotype and ABCB1 diplotype to tacrolimus disposition in Brazilian kidney transplant patients. | 2014 | Br J Clin Pharmacol | pmid:24528196 |
Mai I et al. | MDR1 haplotypes derived from exons 21 and 26 do not affect the steady-state pharmacokinetics of tacrolimus in renal transplant patients. | 2004 | Br J Clin Pharmacol | pmid:15521904 |
Woillard JB et al. | Risk of diarrhoea in a long-term cohort of renal transplant patients given mycophenolate mofetil: the significant role of the UGT1A8 2 variant allele. | 2010 | Br J Clin Pharmacol | pmid:20565459 |
Tang JT et al. | The pharmacokinetics and pharmacodynamics of mycophenolate mofetil in younger and elderly renal transplant recipients. | 2017 | Br J Clin Pharmacol | pmid:27753146 |
Hawwa AF et al. | Influence of ABCB1 polymorphisms and haplotypes on tacrolimus nephrotoxicity and dosage requirements in children with liver transplant. | 2009 | Br J Clin Pharmacol | pmid:19740399 |
Zahir H et al. | Factors affecting variability in distribution of tacrolimus in liver transplant recipients. | 2004 | Br J Clin Pharmacol | pmid:14998426 |
Atcheson BA et al. | Mycophenolic acid pharmacokinetics and related outcomes early after renal transplant. | 2005 | Br J Clin Pharmacol | pmid:15752372 |
Jalil MH et al. | Population pharmacokinetic and pharmacogenetic analysis of tacrolimus in paediatric liver transplant patients. | 2014 | Br J Clin Pharmacol | pmid:23738951 |
Johnston A and Holt DW | Therapeutic drug monitoring of immunosuppressant drugs. | 1999 | Br J Clin Pharmacol | pmid:10233195 |
Billaud EM et al. | Evidence for a pharmacokinetic interaction between itraconazole and tacrolimus in organ transplant patients. | 1998 | Br J Clin Pharmacol | pmid:9764970 |
Horigome A et al. | Lymphocyte-sensitivity to glucocorticoid correlates with the sensitivity to cyclosporin A and tacrolimus in chronic renal failure patients. | 1999 | Br J Clin Pharmacol | pmid:10583028 |
Øzbay LA et al. | Calcineurin inhibitors acutely improve insulin sensitivity without affecting insulin secretion in healthy human volunteers. | 2012 | Br J Clin Pharmacol | pmid:21988494 |
Størset E et al. | Response to: 'Response to: Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance'. | 2017 | Br J Clin Pharmacol | pmid:28374426 |
Jacobo-Cabral CO et al. | Population pharmacokinetic analysis of tacrolimus in Mexican paediatric renal transplant patients: role of CYP3A5 genotype and formulation. | 2015 | Br J Clin Pharmacol | pmid:25846845 |
Størset E et al. | Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling. | 2014 | Br J Clin Pharmacol | pmid:25279405 |
Suzuki Y et al. | Impact of CYP3A5 genetic polymorphism on pharmacokinetics of tacrolimus in healthy Japanese subjects. | 2008 | Br J Clin Pharmacol | pmid:18341670 |
Pham VV et al. | Graft rejection: pharmacogenetic analysis or drug anamnesis? | 2008 | Br J Clin Pharmacol | pmid:18341681 |
Gonschior AK et al. | Measurement of blood concentrations of FK506 (tacrolimus) and its metabolites in seven liver graft patients after the first dose by h.p.l.c.-MS and microparticle enzyme immunoassay (MEIA). | 1994 | Br J Clin Pharmacol | pmid:7534100 |
Zhao CY et al. | External evaluation of published population pharmacokinetic models of tacrolimus in adult renal transplant recipients. | 2016 | Br J Clin Pharmacol | pmid:26574188 |
Barraclough KA et al. | Evaluation of limited sampling methods for estimation of tacrolimus exposure in adult kidney transplant recipients. | 2011 | Br J Clin Pharmacol | pmid:21219401 |
Cremers S et al. | Characterizing the role of enterohepatic recycling in the interactions between mycophenolate mofetil and calcineurin inhibitors in renal transplant patients by pharmacokinetic modelling. | 2005 | Br J Clin Pharmacol | pmid:16120063 |
Barau C et al. | Population pharmacokinetics of mycophenolic acid and dose optimization with limited sampling strategy in liver transplant children. | 2012 | Br J Clin Pharmacol | pmid:22329639 |
Choi JH et al. | Influence of the CYP3A5 and MDR1 genetic polymorphisms on the pharmacokinetics of tacrolimus in healthy Korean subjects. | 2007 | Br J Clin Pharmacol | pmid:17391324 |
Musuamba FT et al. | Statistical tools for dose individualization of mycophenolic acid and tacrolimus co-administered during the first month after renal transplantation. | 2013 | Br J Clin Pharmacol | pmid:23072565 |
Vanhove T et al. | Comparative performance of oral midazolam clearance and plasma 4β-hydroxycholesterol to explain interindividual variability in tacrolimus clearance. | 2016 | Br J Clin Pharmacol | pmid:27501475 |
Woillard JB et al. | Population pharmacokinetic model and Bayesian estimator for two tacrolimus formulations--twice daily Prograf and once daily Advagraf. | 2011 | Br J Clin Pharmacol | pmid:21284698 |
Staatz CE et al. | Tacrolimus pharmacokinetics after kidney transplantation--Influence of changes in haematocrit and steroid dose. | 2015 | Br J Clin Pharmacol | pmid:26235203 |
Vanhove T et al. | Response to 'Tacrolimus pharmacokinetics after kidney transplantation--Influence of changes in haematocrit and steroid dose'. | 2015 | Br J Clin Pharmacol | pmid:26235051 |
Vanhove T et al. | Response to: 'Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance'. | 2017 | Br J Clin Pharmacol | pmid:28168728 |
Størset E et al. | The CYP3A biomarker 4β-hydroxycholesterol does not improve tacrolimus dose predictions early after kidney transplantation. | 2017 | Br J Clin Pharmacol | pmid:28146606 |
Mück W et al. | Tacrolimus/cerivastatin interaction study in liver transplant recipients. | 2001 | Br J Clin Pharmacol | pmid:11488782 |
Kassir N et al. | Population pharmacokinetics and Bayesian estimation of tacrolimus exposure in paediatric liver transplant recipients. | 2014 | Br J Clin Pharmacol | pmid:24977292 |
Passey C et al. | Dosing equation for tacrolimus using genetic variants and clinical factors. | 2011 | Br J Clin Pharmacol | pmid:21671989 |
Zheng S et al. | Tacrolimus placental transfer at delivery and neonatal exposure through breast milk. | 2013 | Br J Clin Pharmacol | pmid:23528073 |
Satoh S et al. | Lack of tacrolimus circadian pharmacokinetics and CYP3A5 pharmacogenetics in the early and maintenance stages in Japanese renal transplant recipients. | 2008 | Br J Clin Pharmacol | pmid:18429967 |
de Jonge H et al. | Progressive decline in tacrolimus clearance after renal transplantation is partially explained by decreasing CYP3A4 activity and increasing haematocrit. | 2015 | Br J Clin Pharmacol | pmid:26114223 |
Xin HW et al. | Effects of Schisandra sphenanthera extract on the pharmacokinetics of tacrolimus in healthy volunteers. | 2007 | Br J Clin Pharmacol | pmid:17506780 |
Mathew BS et al. | A limited sampling strategy for tacrolimus in renal transplant patients. | 2008 | Br J Clin Pharmacol | pmid:18662286 |
Christians U et al. | Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes. | 1996 | Br J Clin Pharmacol | pmid:8866917 |
Sam WJ et al. | Population pharmacokinetics of tacrolimus in Asian paediatric liver transplant patients. | 2000 | Br J Clin Pharmacol | pmid:11136292 |
Calvo PL et al. | Donor CYP3A5 genotype influences tacrolimus disposition on the first day after paediatric liver transplantation. | 2017 | Br J Clin Pharmacol | pmid:28044353 |
Stifft F et al. | Rectal and sublingual administration of tacrolimus: a single-dose pharmacokinetic study in healthy volunteers. | 2014 | Br J Clin Pharmacol | pmid:24809233 |
Størset E et al. | Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance. | 2017 | Br J Clin Pharmacol | pmid:28008657 |
Renders L et al. | Tacrolimus and cerivastatin pharmacokinetics and adverse effects after single and multiple dosing with cerivastatin in renal transplant recipients. | 2003 | Br J Clin Pharmacol | pmid:12895195 |
Knops N et al. | Tacrolimus dose requirements in paediatric renal allograft recipients are characterized by a biphasic course determined by age and bone maturation. | 2017 | Br J Clin Pharmacol | pmid:27966227 |
Elens L et al. | The CYP3A4*22 allele affects the predictive value of a pharmacogenetic algorithm predicting tacrolimus predose concentrations. | 2013 | Br J Clin Pharmacol | pmid:23163400 |
Bremer S et al. | NFAT-regulated cytokine gene expression during tacrolimus therapy early after renal transplantation. | 2017 | Br J Clin Pharmacol | pmid:28686294 |
Elens L et al. | Clinical implementation of pharmacogenetics in kidney transplantation: calcineurin inhibitors in the starting blocks. | 2014 | Br J Clin Pharmacol | pmid:24118098 |
Hesselink DA et al. | Tacrolimus dose requirement in renal transplant recipients is significantly higher when used in combination with corticosteroids. | 2003 | Br J Clin Pharmacol | pmid:12919182 |
Vanhove T et al. | Pretransplant 4β-hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation. | 2017 | Br J Clin Pharmacol | pmid:28603840 |
James DG | Which immunomodulator? | 1991 | Br J Clin Pract | pmid:1718384 |
Bowman H and Lennard TW | Immunosuppressive drugs. | 1992 Nov 4-17 | Br J Hosp Med | pmid:1282440 |
Shahid S et al. | Chronic hepatitis in the transplant patient. | 2017 | Br J Hosp Med (Lond) | pmid:28692371 |
Murphy CC et al. | Validity of using vision-related quality of life as a treatment end point in intermediate and posterior uveitis. | 2007 | Br J Ophthalmol | pmid:16973657 |
Oh-i K et al. | Intravitreal injection of Tacrolimus (FK506) suppresses ongoing experimental autoimmune uveoretinitis in Rats. | 2007 | Br J Ophthalmol | pmid:16987901 |
Tam PM et al. | Topical tacrolimus 0.03% monotherapy for vernal keratoconjunctivitis--case series. | 2010 | Br J Ophthalmol | pmid:20558422 |
Young AL et al. | Allo-limbal transplantation in patients with limbal stem cell deficiency. | 1999 | Br J Ophthalmol | pmid:10574823 |
Rao SK et al. | Limbal allografting using FK-506. | 1999 | Br J Ophthalmol | pmid:10574824 |
Oh-i K et al. | Upregulation of neurotrophic factor-related gene expression in retina with experimental autoimmune uveoretinitis by intravitreal injection of tacrolimus (FK506). | 2007 | Br J Ophthalmol | pmid:17940132 |
Fukushima A et al. | Therapeutic effects of 0.1% tacrolimus eye drops for refractory allergic ocular diseases with proliferative lesion or corneal involvement. | 2014 | Br J Ophthalmol | pmid:24695688 |
Joseph A et al. | Tacrolimus immunosuppression in high-risk corneal grafts. | 2007 | Br J Ophthalmol | pmid:16956911 |
Hogan A et al. | Outcomes after combination photodynamic therapy and immunosuppression for inflammatory subfoveal choroidal neovascularisation. | 2005 | Br J Ophthalmol | pmid:16113360 |
Lake DB and Poole TR | Tacrolimus. | 2003 | Br J Ophthalmol | pmid:12488279 |
Magalhaes OA et al. | Topical 0.03% tacrolimus preventing rejection in high-risk corneal transplantation: a cohort study. | 2013 | Br J Ophthalmol | pmid:24008822 |
Shoughy SS and Tabbara KF | Topical tacrolimus solution in autoimmune polyglandular syndrome-1-associated keratitis. | 2017 | Br J Ophthalmol | pmid:28137823 |
Leder HA et al. | Disappearance of classic birdshot spots after immunosuppression with tacrolimus and mycophenolate mofetil. | 2008 | Br J Ophthalmol | pmid:18227210 |
Aoki S et al. | Systemic FK506 improved tear secretion in dry eye associated with chronic graft versus host disease. | 2005 | Br J Ophthalmol | pmid:15665364 |
Ortega KL et al. | Oral ulcers after a transplant. | 2010 | Br J Oral Maxillofac Surg | pmid:19231045 |
Cetinkale O et al. | The use of FK506 and skin allografting for the treatment of severe burns in an animal model. | 1993 | Br J Plast Surg | pmid:7690295 |
Anoopkumar-Dukie S et al. | Mitochondrial modulation of oxygen-dependent radiosensitivity in some human tumour cell lines. | 2009 | Br J Radiol | pmid:19366737 |