| MeSH term | MeSH ID | Detail |
|---|---|---|
| Acne Vulgaris | D000152 | 35 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Metalidis C et al. | Expression of CYP3A5 and P-glycoprotein in renal allografts with histological signs of calcineurin inhibitor nephrotoxicity. | 2011 | Transplantation | pmid:21544031 |
| Ekberg H | Calcineurin inhibitor sparing in renal transplantation. | 2008 | Transplantation | pmid:18813097 |
| Gaynor JJ and Ciancio G | The Importance of Using Serially Measured Tacrolimus Clearance Values, Especially During the Early Posttransplantation Period. | 2018 | Transplantation | pmid:29271869 |
| Shivaswamy V et al. | Tacrolimus and sirolimus induce reproductive abnormalities in female rats. | 2011 | Transplantation | pmid:21508897 |
| Dumont FJ et al. | A tacrolimus-related immunosuppressant with reduced toxicity. | 1998 | Transplantation | pmid:9448138 |
| Fischer L et al. | Three-year Outcomes in De Novo Liver Transplant Patients Receiving Everolimus With Reduced Tacrolimus: Follow-Up Results From a Randomized, Multicenter Study. | 2015 | Transplantation | pmid:26151607 |
| Miyauchi T et al. | Effect of donor-specific splenocytes via portal vein and FK506 in rat small bowel transplantation. | 1998 | Transplantation | pmid:9448139 |
| Rosen HR et al. | Significance of early aminotransferase elevation after liver transplantation. | 1998 | Transplantation | pmid:9448146 |
| Mieles L et al. | Interaction between FK506 and clotrimazole in a liver transplant recipient. | 1991 | Transplantation | pmid:1721250 |
| Roth D et al. | A prospective study of hepatitis C virus infection in renal allograft recipients. | 1996 | Transplantation | pmid:8623154 |
| Koprak S et al. | Depletion of the mature CD4+8- thymocyte subset by FK506 analogs correlates with their immunosuppressive and calcineurin inhibitory activities. | 1996 | Transplantation | pmid:8623162 |
| Silva HT et al. | Long-term follow-up of a phase III clinical trial comparing tacrolimus extended-release/MMF, tacrolimus/MMF, and cyclosporine/MMF in de novo kidney transplant recipients. | 2014 | Transplantation | pmid:24521771 |
| Calmus Y et al. | Assessing renal function with daclizumab induction and delayed tacrolimus introduction in liver transplant recipients. | 2010 | Transplantation | pmid:20495510 |
| Ouyang J et al. | Effect of a novel inducible nitric oxide synthase inhibitor in prevention of rat chronic aortic rejections. | 2005 | Transplantation | pmid:15912108 |
| Egli A et al. | Inhibition of polyomavirus BK-specific T-Cell responses by immunosuppressive drugs. | 2009 | Transplantation | pmid:19935369 |
| Boyer O et al. | Improvement of renal function in pediatric heart transplant recipients treated with low-dose calcineurin inhibitor and mycophenolate mofetil. | 2005 | Transplantation | pmid:15912111 |
| Selzner N et al. | Antiviral treatment of recurrent hepatitis C after liver transplantation: predictors of response and long-term outcome. | 2009 | Transplantation | pmid:19935376 |
| Rush DN et al. | Factors associated with progression of interstitial fibrosis in renal transplant patients receiving tacrolimus and mycophenolate mofetil. | 2009 | Transplantation | pmid:19935461 |
| Villanueva G and Baldwin D | Rosiglitazone therapy of posttransplant diabetes mellitus. | 2005 | Transplantation | pmid:16340782 |
| Numakura K et al. | Clinical and genetic risk factors for posttransplant diabetes mellitus in adult renal transplant recipients treated with tacrolimus. | 2005 | Transplantation | pmid:16340785 |
| Cendales LC et al. | Composite tissue allotransplantation: development of a preclinical model in nonhuman primates. | 2005 | Transplantation | pmid:16340790 |
| Khanna A et al. | Donor bone marrow potentiates the effect of tacrolimus on nonvascularized heart allograft survival: association with microchimerism and growth of donor dendritic cell progenitors from recipient bone marrow. | 1998 | Transplantation | pmid:9500620 |
| Shihab FS et al. | Donor preconditioning with a calcineurin inhibitor improves outcome in rat syngeneic kidney transplantation. | 2009 | Transplantation | pmid:19202436 |
| Gayowski T et al. | Orthotopic liver transplantation in high-risk patients: risk factors associated with mortality and infectious morbidity. | 1998 | Transplantation | pmid:9500623 |
| Neylan JF | Racial differences in renal transplantation after immunosuppression with tacrolimus versus cyclosporine. FK506 Kidney Transplant Study Group. | 1998 | Transplantation | pmid:9500626 |
| Johnson MC et al. | QT prolongation and Torsades de Pointes after administration of FK506. | 1992 | Transplantation | pmid:1373538 |
| Kim YI et al. | Stimulation of liver regeneration by pretreatment with azathioprine as well as cyclosporine and FK506. | 1992 | Transplantation | pmid:1373539 |
| D'Antiga L et al. | Late cellular rejection in paediatric liver transplantation: aetiology and outcome. | 2002 | Transplantation | pmid:11792983 |
| Timmermann W et al. | Videomicroscopic imaging of graft mucosa for monitoring immunosuppressive therapy after small intestinal transplantation in rats. | 1999 | Transplantation | pmid:10401762 |
| Gupta A et al. | Elevated myeloid: plasmacytoid dendritic cell ratio associates with late, but not early, liver rejection in children induced with rabbit anti-human thymocyte globulin. | 2009 | Transplantation | pmid:19696644 |
| Gerlach UA et al. | Intragraft and Systemic Immune Parameters Discriminating Between Rejection and Long-Term Graft Function in a Preclinical Model of Intestinal Transplantation. | 2017 | Transplantation | pmid:27607529 |
| de Sandes-Freitas TV et al. | Subclinical Lesions and Donor-Specific Antibodies in Kidney Transplant Recipients Receiving Tacrolimus-Based Immunosuppressive Regimen Followed by Early Conversion to Sirolimus. | 2015 | Transplantation | pmid:25929604 |
| Ciancio G et al. | Daclizumab induction, tacrolimus, mycophenolate mofetil and steroids as an immunosuppression regimen for primary kidney transplant recipients. | 2002 | Transplantation | pmid:11965039 |
| Khanna A et al. | Tacrolimus induces increased expression of transforming growth factor-beta1 in mammalian lymphoid as well as nonlymphoid cells. | 1999 | Transplantation | pmid:10071036 |
| Kessler M et al. | A renal allograft recipient with late recurrence of focal and segmental glomerulosclerosis after switching from cyclosporine to tacrolimus. | 1999 | Transplantation | pmid:10071045 |
| Rostaing L et al. | Corticosteroid-free immunosuppression with tacrolimus, mycophenolate mofetil, and daclizumab induction in renal transplantation. | 2005 | Transplantation | pmid:15818323 |
| Bozorgzadeh A et al. | Impact of hepatitis C viral infection in primary cadaveric liver allograft versus primary living-donor allograft in 100 consecutive liver transplant recipients receiving tacrolimus. | 2004 | Transplantation | pmid:15087773 |
| Benigni A et al. | The acute effect of FK506 and cyclosporine on endothelial cell function and renal vascular resistance. | 1992 | Transplantation | pmid:1279848 |
| Mor E et al. | Late-onset acute rejection in orthotopic liver transplantation--associated risk factors and outcome. | 1992 | Transplantation | pmid:1279849 |
| Hirano Y et al. | The effects of FK506 and cyclosporine on the exocrine function of the rat pancreas. | 1992 | Transplantation | pmid:1279850 |
| Diem HV et al. | Pediatric liver transplantation for biliary atresia: results of primary grafts in 328 recipients. | 2003 | Transplantation | pmid:12777858 |
| Wasik M et al. | Effect of FK506 versus cyclosporine on human natural and antibody-dependent cytotoxicity reactions in vitro. | 1991 | Transplantation | pmid:1702910 |
| Smets F et al. | Ratio between Epstein-Barr viral load and anti-Epstein-Barr virus specific T-cell response as a predictive marker of posttransplant lymphoproliferative disease. | 2002 | Transplantation | pmid:12042647 |
| van Rijen MM et al. | CD154 is expressed during treatment with calcineurin inhibitors after organ transplantation. | 2002 | Transplantation | pmid:12042657 |
| Bellon H et al. | The Effect of Immunosuppression on Airway Integrity. | 2017 | Transplantation | pmid:28471870 |
| Horner BM et al. | Recipient damage after musculocutaneous transplant rejection. | 2008 | Transplantation | pmid:18946349 |
| di Francesco F et al. | One year follow-up of steroid-free immunosuppression plus everolimus in isolated pancreas transplantation. | 2008 | Transplantation | pmid:18946356 |
| Bäckman L et al. | FK506 trough levels in whole blood and plasma in liver transplant recipients. Correlation with clinical events and side effects. | 1994 | Transplantation | pmid:7509516 |
| Higgins RM et al. | Acute rejection after renal transplantation is reduced by approximately 50% by prior therapeutic blood transfusions, even in tacrolimus-treated patients. | 2004 | Transplantation | pmid:14966430 |
| Aulagnon F et al. | Diarrhea after kidney transplantation: a new look at a frequent symptom. | 2014 | Transplantation | pmid:25073040 |
| Mahé E et al. | Drug-induced hypersensitivity syndrome associated with primary Epstein-Barr virus and human herpesvirus 6 infections in a child intestinal transplant recipient. | 2004 | Transplantation | pmid:14966435 |
| Paramesh AS et al. | Thrombotic microangiopathy associated with combined sirolimus and tacrolimus immunosuppression after intestinal transplantation. | 2004 | Transplantation | pmid:14724447 |
| Boillot O et al. | Reversal of early acute rejection with increased doses of tacrolimus in liver transplantation: a pilot study. | 1998 | Transplantation | pmid:9825815 |
| Tanaka M et al. | Effect of anticomplement agent K76 COOH on hamster-to-rat and guinea pig-to-rat heart xenotransplantation. | 1996 | Transplantation | pmid:8830837 |
| Jain AB et al. | Comparative incidence of de novo nonlymphoid malignancies after liver transplantation under tacrolimus using surveillance epidemiologic end result data. | 1998 | Transplantation | pmid:9825817 |
| Opelz G | Comparison of FK506 and cyclosporine. | 1996 | Transplantation | pmid:8830844 |
| Yoshimura N et al. | Effect of a new immunosuppressive agent, FK506, on human lymphocyte responses in vitro. I. Inhibition of expression of alloantigen-activated suppressor cells, as well as induction of alloreactivity. | 1989 | Transplantation | pmid:2465592 |
| Gruessner RW and Sharp HL | Living-related intestinal transplantation: first report of a standardized surgical technique. | 1997 | Transplantation | pmid:9415566 |
| Yoshimura N et al. | Effect of a new immunosuppressive agent, FK506, on human lymphocyte responses in vitro. II. Inhibition of the production of IL-2 and gamma-IFN, but not B cell-stimulating factor 2. | 1989 | Transplantation | pmid:2465593 |
| Abadja F et al. | Impact of mycophenolic acid and tacrolimus on Th17-related immune response. | 2011 | Transplantation | pmid:21818055 |
| Piao SG et al. | Combined treatment of tacrolimus and everolimus increases oxidative stress by pharmacological interactions. | 2014 | Transplantation | pmid:24825522 |
| Gujadhur A et al. | CMV sinusitis in a HIV-negative renal transplant recipient. | 2014 | Transplantation | pmid:24827770 |
| Jain AB et al. | A prospective randomized trial of tacrolimus and prednisone versus tacrolimus, prednisone, and mycophenolate mofetil in primary adult liver transplant recipients: an interim report. | 1998 | Transplantation | pmid:9846530 |
| Takatsuki M et al. | Weaning of immunosuppression in living donor liver transplant recipients. | 2001 | Transplantation | pmid:11502975 |
| Riegersperger M et al. | Effect of conversion from ciclosporin to tacrolimus on endothelial progenitor cells in stable long-term kidney transplant recipients. | 2013 | Transplantation | pmid:23594858 |
| Poncelet AJ et al. | Inhibition of humoral response to allogeneic porcine mesenchymal stem cell with 12 days of tacrolimus. | 2008 | Transplantation | pmid:19077894 |
| Uchida N et al. | Mycophenolate and tacrolimus for graft-versus-host disease prophylaxis for elderly after cord blood transplantation: a matched pair comparison with tacrolimus alone. | 2011 | Transplantation | pmid:21677598 |
| Herzog D et al. | Normal glomerular filtration rate in long-term follow-up of children after orthotopic liver transplantation. | 2006 | Transplantation | pmid:16534467 |
| Mañez R et al. | Anomalous pattern of IgG antibody response to primary cytomegalovirus infection after solid organ retransplantation. | 1995 | Transplantation | pmid:7537400 |
| Josephson MA et al. | Treatment of renal allograft polyoma BK virus infection with leflunomide. | 2006 | Transplantation | pmid:16534472 |
| Ochiai T et al. | Optimal serum trough levels of FK506 in renal allotransplantation of the beagle dog. | 1989 | Transplantation | pmid:2474208 |
| Ochiai T et al. | Effects of combination treatment with FK506 and cyclosporine on survival time and vascular changes in renal-allograft-recipient dogs. | 1989 | Transplantation | pmid:2474209 |
| Hariharan S | Case 2: strategies to minimize the use of calcineurin inhibitors (CNIs). | 2002 | Transplantation | pmid:12357988 |
| Wu MJ et al. | Lower variability of tacrolimus trough concentration after conversion from prograf to advagraf in stable kidney transplant recipients. | 2011 | Transplantation | pmid:21912349 |
| Stempfle HU et al. | The role of tacrolimus (FK506)-based immunosuppression on bone mineral density and bone turnover after cardiac transplantation: a prospective, longitudinal, randomized, double-blind trial with calcitriol. | 2002 | Transplantation | pmid:11889427 |
| van Maarseveen EM et al. | Pretransplantation pharmacokinetic curves of tacrolimus in HIV-infected patients on ritonavir-containing cART: a pilot study. | 2013 | Transplantation | pmid:23250333 |
| Hanto DW and Chudzinski R | What does the CONVERT trial really tell us about conversion from calcineurin inhibitors to sirolimus? | 2009 | Transplantation | pmid:19155968 |
| Schena FP et al. | Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the CONVERT trial. | 2009 | Transplantation | pmid:19155978 |
| Gouraud A et al. | Follow-up of tacrolimus breastfed babies. | 2012 | Transplantation | pmid:22996303 |
| Muraki T et al. | Antithrombotic effect of FK506 versus prothrombotic effect of cyclosporine in vivo. | 1995 | Transplantation | pmid:7544038 |
| Boots JM et al. | Early steroid withdrawal in renal transplantation with tacrolimus dual therapy: a pilot study. | 2002 | Transplantation | pmid:12499885 |
| Fridell JA et al. | Causes of mortality beyond 1 year after primary pediatric liver transplant under tacrolimus. | 2002 | Transplantation | pmid:12499888 |
| Metcalfe S and Milner J | Evidence that FK506 and rapamycin block T cell activation at different sites relative to early reversible phosphorylation involving the protein phosphatases PP1 and PP2A. | 1991 | Transplantation | pmid:1710844 |
| Aw MM et al. | Basiliximab (Simulect) for the treatment of steroid-resistant rejection in pediatric liver transpland recipients: a preliminary experience. | 2003 | Transplantation | pmid:12660504 |
| Charpentier B et al. | A three-arm study comparing immediate tacrolimus therapy with antithymocyte globulin induction therapy followed by tacrolimus or cyclosporine A in adult renal transplant recipients. | 2003 | Transplantation | pmid:12660513 |
| Pape E et al. | Management of Tacrolimus-Telaprevir Drug-Drug Interaction in a Liver Transplant Patient With Hepatitis C Virus: Practical Considerations. | 2015 | Transplantation | pmid:26308424 |
| Kim SJ et al. | A comparison of the effects of C2-cyclosporine and C0-tacrolimus on renal function and cardiovascular risk factors in kidney transplant recipients. | 2006 | Transplantation | pmid:17038908 |
| Molmenti EP et al. | Kidney transplantation for end-stage renal failure in liver transplant recipients with hepatitis C viral infection. | 2001 | Transplantation | pmid:11213072 |
| Saad ER et al. | Successful treatment of BK viremia using reduction in immunosuppression without antiviral therapy. | 2008 | Transplantation | pmid:18360267 |
| Deuse T et al. | Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545. | 2012 | Transplantation | pmid:22971540 |
| Jain A et al. | One thousand consecutive primary liver transplants under tacrolimus immunosuppression: a 17- to 20-year longitudinal follow-up. | 2011 | Transplantation | pmid:21378604 |
| Jain AB et al. | Capillary blood versus arterial or venous blood for tacrolimus monitoring in liver transplantation. | 1995 | Transplantation | pmid:7545836 |
| Uchikoshi F et al. | Restoration of immune abnormalities in diabetic BB rats after pancreas transplantation. I. Macrochimerism of donor-graft-derived RT6+ T cells responsible for restoration of immune responsiveness and suppression of autoimmune reaction. | 1996 | Transplantation | pmid:8669109 |
| Gruessner RW et al. | Portal donor-specific blood transfusion and mycophenolate mofetil allow steroid avoidance and tacrolimus dose reduction with sustained levels of chimerism in a pig model of intestinal transplantation. | 2004 | Transplantation | pmid:15239611 |
| Bendahan J et al. | The effect of administration of FK506 on delayed regeneration in flushed partially hepatectomized livers. | 1994 | Transplantation | pmid:7511255 |
| Margreiter R et al. | A double-hand transplant can be worth the effort! | 2002 | Transplantation | pmid:12134104 |
| Burger CI et al. | Case report: drug interaction between tacrolimus and amiodarone with QT prolongation. | 2010 | Transplantation | pmid:20440199 |
| Wong W et al. | 2005 immunosuppressive strategies in kidney transplantation: which role for the calcineurin inhibitors? | 2005 | Transplantation | pmid:16082321 |
| Mendez R et al. | A prospective, randomized trial of tacrolimus in combination with sirolimus or mycophenolate mofetil in kidney transplantation: results at 1 year. | 2005 | Transplantation | pmid:16082323 |
| Oku M et al. | Hepatocyte growth factor sustains T regulatory cells and prolongs the survival of kidney allografts in major histocompatibility complex-inbred CLAWN-miniature swine. | 2012 | Transplantation | pmid:22158517 |