MeSH term | MeSH ID | Detail |
---|---|---|
Ileus | D045823 | 3 associated lipids |
Rectal Diseases | D012002 | 1 associated lipids |
Angiolymphoid Hyperplasia with Eosinophilia | D000796 | 1 associated lipids |
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Celli S et al. | Long-term survival of heart and liver xenografts with splenectomy and FK 506. | 1993 | Transplant. Proc. | pmid:7679830 |
Japanese study of FK 506 on kidney transplantation: results of late phase II study. | 1993 | Transplant. Proc. | pmid:7679831 | |
Kobayashi M et al. | Production of monoclonal antibody against recombinant human FKBP-12 and subcellular localization of FKBP-12 in human mononuclear and polymorphonuclear cells. | 1993 | Transplant. Proc. | pmid:7679832 |
Kuroki H et al. | Effect of FK 506 and donor-specific blood transfusion on the rat composite tissue limb allograft and the mechanism of long-term graft survival. | 1993 | Transplant. Proc. | pmid:7679833 |
Azhderian EM et al. | Nucleus associated FK 506 binding proteins with potential relevance to FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7679834 |
Egan DA et al. | Equilibrium denaturation of recombinant human FK binding protein in urea. | 1993 | Biochemistry | pmid:7680574 |
Lionetti P et al. | Activation of mucosal V beta 3+ T cells and tissue damage in human small intestine by the bacterial superantigen, Staphylococcus aureus enterotoxin B. | 1993 | Eur. J. Immunol. | pmid:7680613 |
Nelson PA et al. | Immunosuppressive activity of [MeBm2t]1-, D-diaminobutyryl-8-, and D-diaminopropyl-8-cyclosporin analogues correlates with inhibition of calcineurin phosphatase activity. | 1993 | J. Immunol. | pmid:7680683 |
Piekoszewski W and Jusko WJ | Plasma protein binding of tacrolimus in humans. | 1993 | J Pharm Sci | pmid:7680714 |
Ning YM and Sánchez ER | Potentiation of glucocorticoid receptor-mediated gene expression by the immunophilin ligands FK506 and rapamycin. | 1993 | J. Biol. Chem. | pmid:7681058 |
Hytiroglou P et al. | FK506 versus cyclosporine as primary immunosuppressive agent for orthotopic liver allograft recipients. Histologic and immunopathologic observations. | 1993 | Transplantation | pmid:7506452 |
Ishizuka J et al. | Effects of FK506 and cyclosporine on dynamic insulin secretion from isolated dog pancreatic islets. | 1993 | Transplantation | pmid:7506454 |
Dhar DK et al. | Effective prevention of ischemic injury of the dearterialized canine liver by FK506 pretreatment. | 1993 | Transplantation | pmid:7506456 |
Fabrega AJ et al. | Enhancement of allograft survival by single intraoperative donor-specific blood transfusion combined with FK506. | 1993 | Transplantation | pmid:7506458 |
Jain A et al. | FK506 and pregnancy in liver transplant patients. | 1993 | Transplantation | pmid:7506459 |
Liu J | FK506 and cyclosporin, molecular probes for studying intracellular signal transduction. | 1993 | Immunol. Today | pmid:7691065 |
Mori T et al. | FK-506: a new immunosuppressive agent, failed to reduce cerebral vasospasm after experimental subarachnoid hemorrhage. | 1993 | J. Vet. Med. Sci. | pmid:7691190 |
Distant DA and Gonwa TA | The kidney in liver transplantation. | 1993 | J. Am. Soc. Nephrol. | pmid:7691205 |
Muthukkumar S et al. | Elevation of cytosolic calcium is sufficient to induce growth inhibition in a B cell lymphoma. | 1993 | Eur. J. Immunol. | pmid:7691606 |
Wesselborg S et al. | Triggering via the alternative CD2 pathway induces apoptosis in activated human T lymphocytes. | 1993 | Eur. J. Immunol. | pmid:7691614 |
Sperr WR et al. | [Effector cells in allergy: biological principles and new pharmacologic concepts]. | 1993 | Wien. Klin. Wochenschr. | pmid:7508662 |
Shutter LA et al. | Cortical blindness and white matter lesions in a patient receiving FK506 after liver transplantation. | 1993 | Neurology | pmid:7694189 |
Dawson TM et al. | Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7694293 |
Spencer DM et al. | Controlling signal transduction with synthetic ligands. | 1993 | Science | pmid:7694365 |
Travis J | Making molecular matches in the cell. | 1993 | Science | pmid:7694368 |
Jusko WJ and Kobayashi M | Therapeutic monitoring of tacrolimus (FK 506) | 1993 | Ther Drug Monit | pmid:7694395 |
Wagner JA et al. | Failure of FK 506 to suppress the T cell-mediated immunity of mice to Listeria monocytogenes. | 1993 | Clin. Exp. Immunol. | pmid:7685672 |
Pilot-Matias TJ et al. | High-level synthesis of the 12-kDa human FK506-binding protein in Escherichia coli using translational coupling. | 1993 | Gene | pmid:7685727 |
Akamine S et al. | [Effect of FK-506 on bronchial healing of canine lung allografts]. | 1993 | Nihon Kyobu Geka Gakkai Zasshi | pmid:7685803 |
Partaledis JA and Berlin V | The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7685904 |
Sykes K et al. | Proline isomerases function during heat shock. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7685914 |
Murase N et al. | Hamster-to-rat heart and liver xenotransplantation with FK506 plus antiproliferative drugs. | 1993 | Transplantation | pmid:7682735 |
Emond JC et al. | Improved results of living-related liver transplantation with routine application in a pediatric program. | 1993 | Transplantation | pmid:7682738 |
Kai N et al. | Prevention of insulitis and diabetes in nonobese diabetic mice by administration of FK506. | 1993 | Transplantation | pmid:7682740 |
Heitman J et al. | The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae. | 1993 | Mol. Cell. Biol. | pmid:7687745 |
Abu-Elmagd K et al. | Recent advances in hepatic transplantation at the University of Pittsburgh. | 1993 | Clin Transpl | pmid:7522528 |
Hirakawa K et al. | [The effect of perioperative portal venous inoculation with donor lymphocytes in combination with immunosuppressive agents on rat cardiac allograft survivals]. | 1993 | Nihon Geka Gakkai Zasshi | pmid:7688065 |
Entani C et al. | Effect of a novel immunosuppressant, FK506, on spontaneous lupus nephritis in MRL/MpJ-lpr/lpr mice. | 1993 | Nephron | pmid:7688103 |
Ueki M et al. | Diabetogenic effects of FK506 on renal subcapsular islet isografts in rat. | 1993 | Diabetes Res. Clin. Pract. | pmid:7688276 |
Pleyer U et al. | Ocular absorption of topically applied FK506 from liposomal and oil formulations in the rabbit eye. | 1993 | Invest. Ophthalmol. Vis. Sci. | pmid:7688360 |
Abu-Elmagd K et al. | Resolution of severe pyoderma gangrenosum in a patient with streaking leukocyte factor disease after treatment with tacrolimus (FK 506). | 1993 | Ann. Intern. Med. | pmid:7689802 |
Christensen BG | FK-506: its role in immunosuppression. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689803 |
Kino T and Goto T | Discovery of FK-506 and update. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689804 |
Parsons WH et al. | FK-506--a novel immunosuppressant. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689805 |
Zenke G et al. | Molecular mechanisms of immunosuppression by cyclosporins. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689806 |
Kawai M et al. | Structure-activity profiles of macrolactam immunosuppressant FK-506 analogues. | 1993 | FEBS Lett. | pmid:7678400 |
Van Duyne GD et al. | Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin. | 1993 | J. Mol. Biol. | pmid:7678431 |
Meadows RP et al. | Three-dimensional structure of the FK506 binding protein/ascomycin complex in solution by heteronuclear three- and four-dimensional NMR. | 1993 | Biochemistry | pmid:7678499 |
Jiang H et al. | Anti-tumor-promoting action of FK506, a potent immunosuppressive agent. | 1993 | Carcinogenesis | pmid:7678785 |
Naito M et al. | Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance. | 1993 | J. Natl. Cancer Inst. | pmid:7678867 |