| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypersensitivity | D006967 | 22 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Urination Disorders | D014555 | 9 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Anemia, Hemolytic | D000743 | 4 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Vision Disorders | D014786 | 10 associated lipids |
| Multiple Myeloma | D009101 | 13 associated lipids |
| Osteochondrodysplasias | D010009 | 3 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Misra DP et al. | Pulmonary co-infection with Nocardia and Aspergillus in a patient with adult-onset Still's disease receiving steroids and tacrolimus. | 2014 | BMJ Case Rep | pmid:25398925 |
| Kamburova EG et al. | Longitudinal analysis of T and B cell phenotype and function in renal transplant recipients with or without rituximab induction therapy. | 2014 | PLoS ONE | pmid:25393622 |
| Wu MJ et al. | Reduced variability of tacrolimus trough level in once-daily tacrolimus-based Taiwanese kidney transplant recipients with high-expressive genotype of cytochrome P450 3A5. | 2014 | Transplant. Proc. | pmid:24655974 |
| Filler G and Smith N | The need for tacrolimus assay standardization. | 2014 | Ther Drug Monit | pmid:25390282 |
| Jun H et al. | Experiences on conversion to once-daily Advagraf and sirolimus combination in stable kidney recipients. | 2014 | Transplant. Proc. | pmid:24655973 |
| Sachewsky N et al. | Cyclosporin A enhances neural precursor cell survival in mice through a calcineurin-independent pathway. | 2014 | Dis Model Mech | pmid:25056698 |
| Masutani K et al. | Protocol biopsy findings in living donor kidney transplant patients treated with once-daily or twice-daily tacrolimus formulation. | 2014 | Transplant. Proc. | pmid:24655972 |
| Erdinest N and Solomon A | Topical immunomodulators in the management of allergic eye diseases. | 2014 | Curr Opin Allergy Clin Immunol | pmid:25054831 |
| Mo D et al. | In vitro interactions of calcineurin inhibitors with conventional antifungal agents against the yeast form of Penicillium marneffei. | 2014 | Mycopathologia | pmid:25052248 |
| Tian SY et al. | Immunosuppressive therapies for the induction treatment of proliferative lupus nephritis: a systematic review and network metaanalysis. | 2014 | J. Rheumatol. | pmid:25225281 |
| Liu Y et al. | Role of retrograde trafficking in stress response, host cell interactions, and virulence of Candida albicans. | 2014 | Eukaryotic Cell | pmid:24363364 |
| Wei TQ et al. | Sandwich assay for tacrolimus using 2 antitacrolimus antibodies. | 2014 | Clin. Chem. | pmid:24381229 |
| Hamzah S et al. | Pharmacogenotyping of CYP3A5 in predicting dose-adjusted trough levels of tacrolimus among Malaysian kidney-transplant patients. | 2014 | Can. J. Physiol. Pharmacol. | pmid:24383873 |
| Amorim J et al. | Tacrolimus-induced neutropenia in a cardiac transplant patient. | 2014 | Pediatr Transplant | pmid:24384051 |
| Silva HT et al. | Long-term follow-up of a phase III clinical trial comparing tacrolimus extended-release/MMF, tacrolimus/MMF, and cyclosporine/MMF in de novo kidney transplant recipients. | 2014 | Transplantation | pmid:24521771 |
| Klawitter J et al. | Mycophenolate mofetil enhances the negative effects of sirolimus and tacrolimus on rat kidney cell metabolism. | 2014 | PLoS ONE | pmid:24497939 |
| Mori T et al. | Nephrotoxicity of concomitant use of tacrolimus and teicoplanin in allogeneic hematopoietic stem cell transplant recipients. | 2014 | Transpl Infect Dis | pmid:24494811 |
| Alloway RR et al. | Conversion from twice daily tacrolimus capsules to once daily extended-release tacrolimus (LCP-Tacro): phase 2 trial of stable liver transplant recipients. | 2014 | Liver Transpl. | pmid:24493215 |
| DU C et al. | [In vitro effects of tacrolimus on platelet function]. | 2014 | Zhonghua Xue Ye Xue Za Zhi | pmid:25339327 |
| Yin Z et al. | Topical pimecrolimus inhibits high-dose UVB irradiation-induced epidermal Langerhans cell migration, via regulation of TNF-α and E-cadherin. | 2014 | Drug Des Devel Ther | pmid:25336924 |
| Tsuchimoto A et al. | Urinary neutrophil gelatinase-associated lipocalin: a useful biomarker for tacrolimus-induced acute kidney injury in liver transplant patients. | 2014 | PLoS ONE | pmid:25329716 |
| Vavic N et al. | The influence of comedication on tacrolimus blood concentration in patients subjected to kidney transplantation: a retrospective study. | 2014 | Eur J Drug Metab Pharmacokinet | pmid:24356808 |
| Steinebrunner N et al. | Pharmacodynamic monitoring of nuclear factor of activated T cell-regulated gene expression in liver allograft recipients on immunosuppressive therapy with calcineurin inhibitors in the course of time and correlation with acute rejection episodes--a prospective study. | 2014 | Ann. Transplant. | pmid:24457606 |
| Chen D et al. | Association of hemoglobin levels, CYP3A5, and NR1I3 gene polymorphisms with tacrolimus pharmacokinetics in liver transplant patients. | 2014 | Drug Metab. Pharmacokinet. | pmid:24351870 |
| Müller GG et al. | Topical tacrolimus 0.03% as sole therapy in vernal keratoconjunctivitis: a randomized double-masked study. | 2014 | Eye Contact Lens | pmid:24418865 |
| Bruel A et al. | Early protocol biopsies in pediatric renal transplantation: interest for the adaptation of immunosuppression. | 2014 | Pediatr Transplant | pmid:24341571 |
| Hesselink DA et al. | The role of pharmacogenetics in the disposition of and response to tacrolimus in solid organ transplantation. | 2014 | Clin Pharmacokinet | pmid:24249597 |
| Ahmed S et al. | Photocleavable dimerizer for the rapid reversal of molecular trap antagonists. | 2014 | J. Biol. Chem. | pmid:24421317 |
| Sapir-Pichhadze R et al. | Time-dependent variability in tacrolimus trough blood levels is a risk factor for late kidney transplant failure. | 2014 | Kidney Int. | pmid:24336032 |
| Al-Amri AM | Long-term follow-up of tacrolimus ointment for treatment of atopic keratoconjunctivitis. | 2014 | Am. J. Ophthalmol. | pmid:24439439 |
| Danby SG et al. | The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis. | 2014 | Br. J. Dermatol. | pmid:24328907 |
| Kim JR et al. | 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol-fortified ginseng extract attenuates the development of atopic dermatitis-like symptoms in NC/Nga mice. | 2014 | J Ethnopharmacol | pmid:24269244 |
| Tavira B et al. | Mitochondrial DNA haplogroups and risk of new-onset diabetes among tacrolimus-treated renal transplanted patients. | 2014 | Gene | pmid:24445060 |
| Lin Y et al. | PERK activation preserves the viability and function of remyelinating oligodendrocytes in immune-mediated demyelinating diseases. | 2014 | Am. J. Pathol. | pmid:24269558 |
| Barreiro C and MartÃnez-Castro M | Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506). | 2014 | Appl. Microbiol. Biotechnol. | pmid:24272367 |
| Budde K et al. | Novel once-daily extended-release tacrolimus (LCPT) versus twice-daily tacrolimus in de novo kidney transplants: one-year results of Phase III, double-blind, randomized trial. | 2014 | Am. J. Transplant. | pmid:25278376 |
| Gomez-Moyano E et al. | Periorbital granuloma annulare successfully treated with tacrolimus 0.1% ointment. | 2014 | Int. J. Dermatol. | pmid:23432464 |
| Sugiyama K et al. | Immune monitoring with a lymphocyte adenosine triphosphate assay in kidney transplant recipients treated with a calcineurin inhibitor. | 2014 | Exp Clin Transplant | pmid:24907718 |
| Shlivko IL et al. | Morphological changes in skin of different phototypes under the action of topical corticosteroid therapy and tacrolimus. | 2014 | Skin Res Technol | pmid:23808907 |
| Jalil MH et al. | Population pharmacokinetic and pharmacogenetic analysis of tacrolimus in paediatric liver transplant patients. | 2014 | Br J Clin Pharmacol | pmid:23738951 |
| Deng Z et al. | [Early diagnosis and comprehensive treatments of post-transplantation lymphoproliferative disorder after pediatric liver transplantation]. | 2014 | Zhonghua Er Ke Za Zhi | pmid:25224233 |
| Peloso LJ et al. | The serum concentration of tacrolimus after ingesting omeprazole: a pilot study. | 2014 | Transplantation | pmid:25221905 |
| RodrÃguez-Serrano M et al. | Does the calcineurin inhibitor have influence on cytomegalovirus infection in heart transplantation? | 2014 | Clin Transplant | pmid:24325305 |
| Souza MC et al. | Tacrolimus-loaded PLGA implants: in vivo release and ocular toxicity. | 2014 | Curr. Eye Res. | pmid:24325382 |
| Talreja N et al. | Successful desensitization to agalsidase beta after anaphylaxis. | 2014 | Ann. Allergy Asthma Immunol. | pmid:24331397 |
| Chen Z et al. | Mutations adjacent to the end of transmembrane helices 6 and 7 independently affect drug efflux capacity of yeast ABC transporter Pdr5p. | 2014 | Biochim. Biophys. Acta | pmid:24333836 |
| Sæves I et al. | Tacrolimus exposure and mycophenolate pharmacokinetics and pharmacodynamics early after liver transplantation. | 2014 | Ther Drug Monit | pmid:24081206 |
| Ueda K et al. | Early corticosteroid withdrawal in the real world: a long-term analysis of kidney transplant recipients from the Mycophenolic Acid Observational Renal Transplant Registry. | 2014 | Ann. Transplant. | pmid:24535029 |
| Musuamba FT et al. | Population pharmacokinetic analysis of tacrolimus early after pediatric liver transplantation. | 2014 | Ther Drug Monit | pmid:24081207 |
| Tanaka H et al. | Efficacy of mizoribine-tacrolimus-based induction therapy for pediatric lupus nephritis. | 2014 | Lupus | pmid:24651669 |
| Taber DJ et al. | Significant racial differences in the key factors associated with early graft loss in kidney transplant recipients. | 2014 | Am. J. Nephrol. | pmid:24969370 |
| Jacobo-Cabral CO et al. | Limustin®, a non-innovator tacrolimus formulation, yields reduced drug exposure in pediatric renal transplant recipients. | 2014 | Pediatr Transplant | pmid:25156476 |
| Keniya MV et al. | Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5. | 2014 | Mol. Pharm. | pmid:25115303 |
| Shah NP et al. | Treatment of a Crohn's disease-related cutaneous facial lesion with topical tacrolimus. | 2014 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:25151593 |
| Størset E et al. | Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling. | 2014 | Br J Clin Pharmacol | pmid:25279405 |
| Choi SW et al. | Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: a phase 1/2 trial. | 2014 | Lancet Oncol. | pmid:24295572 |
| Görzer I et al. | Plasma DNA levels of Torque teno virus and immunosuppression after lung transplantation. | 2014 | J. Heart Lung Transplant. | pmid:24559947 |
| Barnieh L et al. | The cost of kidney transplant over time. | 2014 | Prog Transplant | pmid:25193726 |
| Tolar J and McGrath JA | Augmentation of cutaneous wound healing by pharmacologic mobilization of endogenous bone marrow stem cells. | 2014 | J. Invest. Dermatol. | pmid:25120149 |
| Pichler R et al. | De novo renal cell carcinoma in a kidney allograft with focus on contrast-enhanced ultrasound. | 2014 | Urol. Int. | pmid:25115614 |
| Bogan JS | Endocytic cycling of glucose transporters and insulin resistance due to immunosuppressive agents. | 2014 | J. Clin. Endocrinol. Metab. | pmid:25279573 |
| Tsuchida T et al. | The development of humanized liver with Rag1 knockout rats. | 2014 | Transplant. Proc. | pmid:24815157 |
| Li Q et al. | Proniosome-derived niosomes for tacrolimus topical ocular delivery: in vitro cornea permeation, ocular irritation, and in vivo anti-allograft rejection. | 2014 | Eur J Pharm Sci | pmid:24905830 |
| Oda K and Yamano K | Effect of telaprevir on the metabolism and hepatic uptake of tacrolimus (FK506). | 2014 | Biopharm Drug Dispos | pmid:25059890 |
| Lapteva M et al. | Polymeric micelle nanocarriers for the cutaneous delivery of tacrolimus: a targeted approach for the treatment of psoriasis. | 2014 | Mol. Pharm. | pmid:25057896 |
| Zwiech R | [The early C4d urinary excretion and long-term kidney graft survival in patients treated with tacrolimus and mycophenolate mophetil]. | 2014 | Pol. Merkur. Lekarski | pmid:24779215 |
| Matia I et al. | Immunosuppressive protocol with delayed use of low-dose tacrolimus after aortic transplantation suppresses donor-specific anti-MHC class I and class II antibody production in rats. | 2014 | Ann. Transplant. | pmid:24815872 |
| Harada N et al. | [Follow-up study on patients with vernal keratoconjunctivitis undergoing topical 0.1% tacrolimus treatment]. | 2014 | Nippon Ganka Gakkai Zasshi | pmid:24864437 |
| Piao SG et al. | Combined treatment of tacrolimus and everolimus increases oxidative stress by pharmacological interactions. | 2014 | Transplantation | pmid:24825522 |
| Navas-López VM et al. | Oral tacrolimus for pediatric steroid-resistant ulcerative colitis. | 2014 | J Crohns Colitis | pmid:23582736 |
| Carbajal R et al. | Case report: boldo (Peumus boldus) and tacrolimus interaction in a renal transplant patient. | 2014 | Transplant. Proc. | pmid:24981811 |
| Ohe M et al. | Successful treatment with tacrolimus of refractory adult-onset Still's disease. | 2014 | Korean J. Intern. Med. | pmid:24648814 |
| Kassir N et al. | Population pharmacokinetics and Bayesian estimation of tacrolimus exposure in paediatric liver transplant recipients. | 2014 | Br J Clin Pharmacol | pmid:24977292 |
| Wu Q et al. | Heterogeneity of radiological spectrum in tacrolimus-associated encephalopathy after lung transplantation. | 2014 | Behav Neurol | pmid:24970980 |
| Nath PR et al. | Immunophilins control T lymphocyte adhesion and migration by regulating CrkII binding to C3G. | 2014 | J. Immunol. | pmid:25225668 |
| Toniutto P et al. | Biliary strictures after liver transplantation: role of interleukin 28B genotypes in cyclosporine treated. | 2014 | Int J Surg | pmid:25219480 |
| Buechter M et al. | Tacrolimus as a reasonable alternative in a patient with steroid-dependent and thiopurine-refractory autoimmune pancreatitis with IgG4-associated cholangitis. | 2014 | Z Gastroenterol | pmid:24905108 |
| Wohlfahrtova M and Viklicky O | Recent trials in immunosuppression and their consequences for current therapy. | 2014 | Curr Opin Organ Transplant | pmid:24905020 |
| Boonyapredee M et al. | Increased BK viremia and progression to BK-virus nephropathy following high-dose intravenous immunoglobulin for acute cellular rejection. | 2014 | Mil Med | pmid:24902140 |
| Lebel MJ et al. | Increase in de novo food allergies after pediatric liver transplantation: tacrolimus vs. cyclosporine immunosuppression. | 2014 | Pediatr Transplant | pmid:25156571 |
| Fazal MA et al. | Dyslipidaemia among renal transplant recipients: cyclosporine versus tacrolimus. | 2014 | J Pak Med Assoc | pmid:25272531 |
| Taimur S et al. | Donor T-cell chimerism and early post-transplant cytomegalovirus viremia in patients treated with myeloablative allogeneic hematopoietic stem cell transplant. | 2014 | Transpl Infect Dis | pmid:24251680 |
| Kurbalija V et al. | Time-series analysis in the medical domain: a study of Tacrolimus administration and influence on kidney graft function. | 2014 | Comput. Biol. Med. | pmid:24813681 |
| Stewart JI et al. | Reverse halo sign on chest imaging in a renal transplant recipient. | 2014 | Transpl Infect Dis | pmid:24289813 |
| Reitamo S and Remitz A | An update on current pharmacotherapy options in atopic dermatitis. | 2014 | Expert Opin Pharmacother | pmid:24811606 |
| Stifft F et al. | Rectal and sublingual administration of tacrolimus: a single-dose pharmacokinetic study in healthy volunteers. | 2014 | Br J Clin Pharmacol | pmid:24809233 |
| Korbel L et al. | Clinically relevant pharmacogenomic testing in pediatric practice. | 2014 | Clin Pediatr (Phila) | pmid:24803633 |
| Dipchand AI et al. | Myocyte growth, repair, and oxidative stress following pediatric heart transplantation. | 2014 | Pediatr Transplant | pmid:25118092 |
| Hošková L et al. | Tacrolimus-induced hypertension and nephrotoxicity in Fawn-Hooded rats are attenuated by dual inhibition of renin-angiotensin system. | 2014 | Hypertens. Res. | pmid:24718302 |
| Lee SJ et al. | Functional interpretation of metabolomics data as a new method for predicting long-term side effects: treatment of atopic dermatitis in infants. | 2014 | Sci Rep | pmid:25491116 |
| Miller EC et al. | Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer-induced AMPA glutamate receptor signaling deficits. | 2014 | Eur. J. Neurosci. | pmid:24713000 |
| Fernandes MB et al. | Supplementation with omega-3 polyunsaturated fatty acids and experimental tacrolimus-induced nephrotoxicity. | 2014 | Exp Clin Transplant | pmid:25489802 |
| Supe-Markovina K et al. | Alemtuzumab with corticosteroid minimization for pediatric deceased donor renal transplantation: a seven-yr experience. | 2014 | Pediatr Transplant | pmid:24712738 |
| Borda B et al. | Side effects of the calcineurin inhibitor, such as new-onset diabetes after kidney transplantation. | 2014 | Acta Physiol Hung | pmid:25183511 |
| Chung BH et al. | Decrease of immature B cell and interleukin-10 during early-post-transplant period in renal transplant recipients under tacrolimus based immunosuppression. | 2014 | Transpl. Immunol. | pmid:24709525 |
| Hodzic E et al. | Posterior reversible encephalopathy syndrome (PRES) as a complication of immunosuppressive therapy in renal transplantation in children. | 2014 | Med Arh | pmid:25195358 |
| Nishimoto K et al. | [Case of organizing pneumonia associated with sweet's syndrome]. | 2014 | Arerugi | pmid:25163580 |
| Hässig A et al. | Association of BK viremia with human leukocyte antigen mismatches and acute rejection, but not with type of calcineurin inhibitor. | 2014 | Transpl Infect Dis | pmid:24134704 |
| Larkins N and Matsell DG | Tacrolimus therapeutic drug monitoring and pediatric renal transplant graft outcomes. | 2014 | Pediatr Transplant | pmid:25284168 |
| Kharfan-Dabaja M et al. | Mycophenolate mofetil versus methotrexate for prevention of graft-versus-host disease in people receiving allogeneic hematopoietic stem cell transplantation. | 2014 | Cochrane Database Syst Rev | pmid:25061777 |