| MeSH term | MeSH ID | Detail |
|---|---|---|
| Insulin Resistance | D007333 | 99 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Galat A | A note on circular-dichroic-constrained prediction of protein secondary structure. | 1996 | Eur. J. Biochem. | pmid:8612612 |
| Márquez JA and Serrano R | Multiple transduction pathways regulate the sodium-extrusion gene PMR2/ENA1 during salt stress in yeast. | 1996 | FEBS Lett. | pmid:8612770 |
| Stoller G et al. | An 11.8 kDa proteolytic fragment of the E. coli trigger factor represents the domain carrying the peptidyl-prolyl cis/trans isomerase activity. | 1996 | FEBS Lett. | pmid:8612805 |
| Kogi M et al. | Effects of calyculin A and FK506 on the O2- generation of rat peritoneal macrophages. | 1996 | Tokai J. Exp. Clin. Med. | pmid:9239803 |
| Nakai T et al. | Immunosuppressive mechanism and immune tolerance of FK 506 in rat small bowel transplantation. | 1996 | Transplant. Proc. | pmid:8623237 |
| Jin MB et al. | Protective effect of FK 506 on hepatic energy metabolism in warm ischemic canine livers induced by total hepatic vascular exclusion. | 1996 | Transplant. Proc. | pmid:8623243 |
| Smit JA et al. | Induction of primate TH2 lymphokines to suppress TH1 cells. | 1996 | Transplant. Proc. | pmid:8623334 |
| Tanaka M et al. | Tacrolimus (FK 506)-dependent tolerance after liver and heart xenotransplantation: inhibition of humoral response and acceptance of donor organs. | 1996 | Transplant. Proc. | pmid:8623341 |
| Ye Q et al. | Functional analysis of hamster kidney xenografts in the rat: possible functional incompatibility and adaptation of hamster kidney grafts in a xenogenic rat environment. | 1996 | Transplant. Proc. | pmid:8623350 |
| Namii Y et al. | Tetrahydropyranyladriamycin with FK 506 combination therapy for hamster-to-rat-concordant xenotransplantation. | 1996 | Transplant. Proc. | pmid:8623358 |
| Valdivia LA et al. | Prolonged survival of hearts obtained from chimeric donors in a mouse to rat xenotransplant model. | 1996 | Transplant. Proc. | pmid:8623371 |
| Wakizaka Y et al. | Xenotransplantation of hamster liver into Gunn rats reserves congenital hyperbilirubinemia. | 1996 | Transplant. Proc. | pmid:8623372 |
| Appignani BA et al. | Neuroimaging findings in patients on immunosuppressive therapy: experience with tacrolimus toxicity. | 1996 | AJR Am J Roentgenol | pmid:8623651 |
| Asfar S et al. | Small bowel transplantation. A life-saving option for selected patients with intestinal failure. | 1996 | Dig. Dis. Sci. | pmid:8625758 |
| Fehr T et al. | Antascomicins A, B, C, D and E. Novel FKBP12 binding compounds from a Micromonospora strain. | 1996 | J. Antibiot. | pmid:8626235 |
| Zhang BW et al. | T cell responses in calcineurin A alpha-deficient mice. | 1996 | J. Exp. Med. | pmid:8627154 |
| Dragovich PS et al. | Structure-based design of novel, urea-containing FKBP12 inhibitors. | 1996 | J. Med. Chem. | pmid:8627611 |
| Eberhard OK et al. | How best to use tacrolimus (FK506) for treatment of steroid- and OKT3-resistant rejection after renal transplantation. | 1996 | Transplantation | pmid:8629294 |
| Millis JM et al. | Tacrolimus for primary treatment of steroid-resistant hepatic allograft rejection. | 1996 | Transplantation | pmid:8629298 |
| Systemic tacrolimus (FK 506) is effective for the treatment of psoriasis in a double-blind, placebo-controlled study. The European FK 506 Multicentre Psoriasis Study Group. | 1996 | Arch Dermatol | pmid:8629845 | |
| Busuttil RW et al. | General guidelines for the use of tacrolimus in adult liver transplant patients. | 1996 | Transplantation | pmid:8607197 |
| Esquivel CO et al. | Suggested guidelines for the use of tacrolimus in pediatric liver transplant patients. | 1996 | Transplantation | pmid:8607198 |
| Peters KP et al. | The automatic search for ligand binding sites in proteins of known three-dimensional structure using only geometric criteria. | 1996 | J. Mol. Biol. | pmid:8609611 |
| Singh N et al. | Pulmonary infections in liver transplant recipients receiving tacrolimus. Changing pattern of microbial etiologies. | 1996 | Transplantation | pmid:8610349 |
| Yanchar NL et al. | Tacrolimus (FK506)--its effects on intestinal glucose transport. | 1996 | Transplantation | pmid:8610392 |
| Hariharan S et al. | Rescue therapy with tacrolimus after combined kidney/pancreas and isolated pancreas transplantation in patients with severe cyclosporine nephrotoxicity. | 1996 | Transplantation | pmid:8610411 |
| Cacciarelli TV et al. | Oral tacrolimus (FK506) induction therapy in pediatric orthotopic liver transplantation. | 1996 | Transplantation | pmid:8610416 |
| Osowski CL et al. | Evaluation of the drug interaction between intravenous high-dose fluconazole and cyclosporine or tacrolimus in bone marrow transplant patients. | 1996 | Transplantation | pmid:8610430 |
| Yocum DE | Cyclosporine, FK-506, rapamycin, and other immunomodulators. | 1996 | Rheum. Dis. Clin. North Am. | pmid:8907069 |
| Lu YF et al. | FK506, a Ca2+/calmodulin-dependent phosphatase inhibitor, inhibits the induction of long-term potentiation in the rat hippocampus. | 1996 | Neurosci. Lett. | pmid:8907327 |
| Ye Q et al. | Persistence of donor cells and incidence of graft-versus-host disease after simultaneous small bowel and bone marrow transplantation. | 1996 | Transplant. Proc. | pmid:8907895 |
| Walgenbach KJ et al. | Increased presence of mast cells and interleukin-4 during chronic rejection of rat intestinal allografts. | 1996 | Transplant. Proc. | pmid:8907896 |
| Nüssler NC et al. | CD8+ host cells infiltrate the intestinal mucosa after allogeneic small bowel transplantation even in the absence of acute rejection. | 1996 | Transplant. Proc. | pmid:8907898 |
| Wu J et al. | Reversal of multidrug resistance by tacrolimus hydrate. | 1996 | Methods Find Exp Clin Pharmacol | pmid:9121220 |
| Perego C et al. | Orthotopic liver-small bowel transplantation in pigs: study of immunologic parameters during therapy with FK 506-based immunosuppressive regimens. | 1996 | Transplant. Proc. | pmid:8907908 |
| Alessiani M et al. | Combined FK 506 and mycophenolate mofetil immunosuppression prolongs survival after small bowel transplantation in pigs. | 1996 | Transplant. Proc. | pmid:8907922 |
| Tomono M et al. | Calcineurin is essential for DNA synthesis in Swiss 3T3 fibroblasts. | 1996 | Biochem. J. | pmid:8760349 |
| Cohen DS et al. | Porcine small bowel transplantation with rapamycin-based induction immunosuppression and short-course cyclosporine or FK 506 therapy. | 1996 | Transplant. Proc. | pmid:8907923 |
| Becker G et al. | Diltiazem minimizes tubular damage due to FK506-mediated nephrotoxicity following ischemia and reperfusion in rats. | 1996 | Transpl. Immunol. | pmid:8762016 |
| Toyama Y et al. | Prolonged small bowel graft survival using photochemotherapy and low-dose FK 506. | 1996 | Transplant. Proc. | pmid:8907924 |
| Paus R et al. | Hair growth control by immunosuppression. | 1996 | Arch. Dermatol. Res. | pmid:8818191 |
| Michel G et al. | FK506 in the treatment of inflammatory skin disease: promises and perspectives. | 1996 | Immunol. Today | pmid:8820265 |
| Boeve BF et al. | Dysarthria and apraxia of speech associated with FK-506 (tacrolimus). | 1996 | Mayo Clin. Proc. | pmid:8820772 |
| Komatsu K et al. | Prolonged survival of hamster-to-rat pulmonary xenografts by tacrolimus (FK506) and cyclophosphamide. | 1996 | J. Heart Lung Transplant. | pmid:8820789 |
| Hayashi K et al. | Suppression of experimental crescentic-type anti-glomerular basement membrane (GBM) nephritis by FK506 (tacrolimus hydrate) in rats. | 1996 | Jpn. J. Pharmacol. | pmid:8822088 |
| Weppler D et al. | Status of liver and gastrointestinal transplantation at the University of Miami. | 1996 | Clin Transpl | pmid:9286568 |
| Schumacher G et al. | Neurologic symptoms improve in patients with Wilson's disease despite immunosuppression. | 1996 | Transplant. Proc. | pmid:8962200 |
| Woodle ES et al. | Tacrolimus therapy for refractory acute renal allograft rejection: a prospective multicenter trial. Tacrolimus Kidney Transplantation Rescue Study Group. | 1996 | Transplant. Proc. | pmid:8962225 |
| Scott-Douglas N et al. | Treatment of acute renal transplant rejection with FK 506 in patients on cyclosporine after failure of standard antirejection therapy. | 1996 | Transplant. Proc. | pmid:8962226 |
| Kliem V et al. | FK 506 in the treatment of steroid- and OKT3-resistant rejection in renal transplant recipients: reduced dosage and anti-infective prophylaxis. | 1996 | Transplant. Proc. | pmid:8962227 |
| Becker G et al. | Tacrolimus (FK 506) therapy in simultaneous pancreas kidney transplantation. | 1996 | Transplant. Proc. | pmid:8962228 |
| Kiuchi T et al. | Experience of tacrolimus-based immunosuppression in living-related liver transplantation complicated with graft tuberculosis: interaction with rifampicin and side effects. | 1996 | Transplant. Proc. | pmid:8962229 |
| Guckelberger O et al. | Does the choice of primary immunosuppression influence the prevalence of cardiovascular risk factors after liver transplantation? | 1996 | Transplant. Proc. | pmid:8962230 |
| Dumont FJ et al. | Mixed agonist/antagonist activity of an FK-506-related immunosuppressant: biological and biochemical characterization. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8786538 |
| Braun F et al. | Clinical relevance of monitoring tacrolimus: comparison of microparticle enzyme immunoassay, enzyme-linked immunosorbent assay, and liquid chromatography mass spectrometry in renal transplant recipients converted from cyclosporine to tacrolimus. | 1996 | Transplant. Proc. | pmid:8962231 |
| Michel G et al. | Antioncogene P53 and mitogenic cytokine interleukin-8 aberrantly expressed in psoriatic skin are inversely regulated by the antipsoriatic drug tacrolimus (FK506). | 1996 | Biochem. Pharmacol. | pmid:8787547 |
| Wilczek HE et al. | Renal transplant histopathologic changes during the first year in patients with tacrolimus (FK 506). | 1996 | Transplant. Proc. | pmid:8962232 |
| Gonschior AK et al. | Tacrolimus (FK506) metabolite patterns in blood from liver and kidney transplant patients. | 1996 | Clin. Chem. | pmid:8787699 |
| Ikebe S et al. | Immunosuppressive effect of tacrolimus (FK-506). Bone xenografts in rabbits. | 1996 | Acta Orthop Scand | pmid:8792745 |
| Masaki Y et al. | Microchimerism and rat small bowel transplantation combined with donor-type bone marrow cells. | 1996 | Transplant. Proc. | pmid:8769154 |
| Jordan ML et al. | Tacrolimus rescue therapy for renal transplant rejection. | 1996 | Transplant. Proc. | pmid:8769174 |
| Baruch Y et al. | Anasarca and hypertrophic cardiomyopathy in a liver transplant patient on FK506: relieved after a switch to Neoral. | 1996 | Transplant. Proc. | pmid:8769215 |
| Melter M et al. | Successful reconversion from tacrolimus to cyclosporine A Neoral in pediatric liver recipients. | 1996 | Transplant. Proc. | pmid:8769224 |
| Woodle ES et al. | FK 506 therapy for refractory renal allograft rejection: lessons from liver transplantation. | 1996 | Clin Transplant | pmid:8884103 |
| Karashima T et al. | FK506 and cyclosporin A inhibit growth factor-stimulated human keratinocyte proliferation by blocking cells in the G0/G1 phases of the cell cycle. | 1996 | J. Dermatol. Sci. | pmid:8884530 |
| Monfar M and Blenis J | Inhibition of p70/p85 S6 kinase activities in T cells by dexamethasone. | 1996 | Mol. Endocrinol. | pmid:8885245 |
| Andoh TF et al. | Comparison of acute rapamycin nephrotoxicity with cyclosporine and FK506. | 1996 | Kidney Int. | pmid:8887267 |
| Shapiro R et al. | "Suboptimal" kidney donors: the experience with tacrolimus-based immunosuppression. | 1996 | Transplantation | pmid:8932264 |
| Mysliwiec J et al. | The effect of tacrolimus (FK506) and cyclosporin A (CyA) on peripheral serotonergic mechanisms in uremic rats. | 1996 | Thromb. Res. | pmid:8837316 |
| Devlin J and Williams R | Transplantation for fulminant hepatic failure: comparing tacrolimus versus cyclosporine for immunosuppression and the outcome in elective transplants. European FK506 Liver Study Group. | 1996 | Transplantation | pmid:8932266 |
| Lamb GD and Stephenson DG | Effects of FK506 and rapamycin on excitation-contraction coupling in skeletal muscle fibres of the rat. | 1996 | J. Physiol. (Lond.) | pmid:8842013 |
| Curran CF et al. | Acute overdoses of tacrolimus. | 1996 | Transplantation | pmid:8932293 |
| Kakefuda T et al. | Detection of nitrosylhemoglobin in liver allograft in rats by using near-infrared spectroscopy. | 1996 | Transplant. Proc. | pmid:8658885 |
| Kawabe A et al. | Anti-adhesion (anti-ICAM-1 and anti-LFA-1) therapy in a rat pancreas transplantation model. | 1996 | Transplant. Proc. | pmid:8658893 |
| Hayakawa K et al. | Maintenance of unresponsiveness by short-term pulse therapy with FK 506 in rat transplantation. | 1996 | Transplant. Proc. | pmid:8658904 |
| Ishikawa M et al. | Acetaminophen absorption test as a useful indicator of small intestinal rejection in rats. | 1996 | Transplant. Proc. | pmid:8658911 |
| Kawano K et al. | FK506 reduces oxidative hepatic injury following cold ischemic preservation and transplantation. | 1996 | Transplant. Proc. | pmid:8658938 |
| Kanzler S et al. | Complete reversal of FK 506 induced diabetes in a liver transplant recipient by change of immunosuppression to cyclosporine A. | 1996 | Z Gastroenterol | pmid:8659188 |
| Schaefer A et al. | Ca2+/calmodulin-dependent and -independent down-regulation of c-myb mRNA levels in erythropoietin-responsive murine erythroleukemia cells. The role of calcineurin. | 1996 | J. Biol. Chem. | pmid:8662717 |
| Owens-Grillo JK et al. | A model of protein targeting mediated by immunophilins and other proteins that bind to hsp90 via tetratricopeptide repeat domains. | 1996 | J. Biol. Chem. | pmid:8662874 |
| Cox KL and Freese DK | Tacrolimus (FK506): the pros and cons of its use as an immunosuppressant in pediatric liver transplantation. | 1996 | Clin Invest Med | pmid:8889279 |
| Bridges ND et al. | Lung transplantation in infancy and early childhood. | 1996 | J. Heart Lung Transplant. | pmid:8889985 |
| Iwasaki K et al. | Binding of tacrolimus (FK506) with human plasma proteins re-evaluation and effect of mycophenolic acid. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9029671 |
| Bousvaros A et al. | Tacrolimus (FK-506) treatment of fulminant colitis in a child. | 1996 | J. Pediatr. Gastroenterol. Nutr. | pmid:8890089 |
| De Rie MA et al. | Soluble interleukin-2 receptor (sIL-2R) is a marker of disease activity in psoriasis: a comparison of sIL-2R, sCD27, sCD4, sCD8 and sICAM-1. | 1996 | Acta Derm. Venereol. | pmid:8891007 |
| Timmerman LA et al. | Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. | 1996 | Nature | pmid:8893011 |
| Inutsuka K et al. | Reconstruction of trachea and carina with immediate or cryopreserved allografts in dogs. | 1996 | Ann. Thorac. Surg. | pmid:8893587 |
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| Ezeamuzie CI | Anti-allergic activity of cyclosporin-A metabolites and their interaction with the parent compound and FK 506. | 1996 | Int. J. Immunopharmacol. | pmid:8894806 |
| Hemenway CS and Heitman J | Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast. | 1996 | J. Biol. Chem. | pmid:8702500 |
| Tyedmers J et al. | Efficient folding of firefly luciferase after transport into mammalian microsomes in the absence of luminal chaperones and folding catalysts. | 1996 | J. Biol. Chem. | pmid:8702642 |
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| Timerman AP et al. | Selective binding of FKBP12.6 by the cardiac ryanodine receptor. | 1996 | J. Biol. Chem. | pmid:8702774 |
| Shih M and Malbon CC | Protein kinase C deficiency blocks recovery from agonist-induced desensitization. | 1996 | J. Biol. Chem. | pmid:8702931 |
| Okadome T et al. | Characterization of the interaction of FKBP12 with the transforming growth factor-beta type I receptor in vivo. | 1996 | J. Biol. Chem. | pmid:8702959 |
| Rahfeld JU et al. | Isolation and amino acid sequence of a new 22-kDa FKBP-like peptidyl-prolyl cis/trans-isomerase of Escherichia coli. Similarity to Mip-like proteins of pathogenic bacteria. | 1996 | J. Biol. Chem. | pmid:8703024 |
| Eckert B et al. | Calcium-mobilizing insulin secretagogues stimulate transcription that is directed by the cyclic adenosine 3',5'-monophosphate/calcium response element in a pancreatic islet beta-cell line. | 1996 | Endocrinology | pmid:8536617 |
| Wesselborg S et al. | Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp). | 1996 | J. Biol. Chem. | pmid:8576111 |
| Furth S et al. | Diabetes as a complication of tacrolimus (FK506) in pediatric renal transplant patients. | 1996 | Pediatr. Nephrol. | pmid:8611359 |
| Brousse N and Goulet O | Small bowel transplantation. | 1996 | BMJ | pmid:8611766 |