| MeSH term | MeSH ID | Detail |
|---|---|---|
| Denys-Drash Syndrome | D030321 | 1 associated lipids |
| Hypophosphatemia | D017674 | 1 associated lipids |
| Moyamoya Disease | D009072 | 1 associated lipids |
| Latent Tuberculosis | D055985 | 1 associated lipids |
| Leukoplakia | D007971 | 1 associated lipids |
| Oculomotor Nerve Diseases | D015840 | 1 associated lipids |
| Scorpion Stings | D065008 | 1 associated lipids |
| Esophageal Perforation | D004939 | 1 associated lipids |
| Mediastinitis | D008480 | 2 associated lipids |
| Coproporphyria, Hereditary | D046349 | 1 associated lipids |
| Ileus | D045823 | 3 associated lipids |
| Rectal Diseases | D012002 | 1 associated lipids |
| Angiolymphoid Hyperplasia with Eosinophilia | D000796 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hattori Y et al. | Influence of cytochrome P450 3A5 polymorphisms on viral infection incidence in kidney transplant patients treated with tacrolimus. | 2014 | Transplant. Proc. | pmid:24656015 |
| Gibbs JF et al. | Outcome analysis of FK 506 therapy for acute and chronic rejection. | 1993 | Transplant. Proc. | pmid:7679823 |
| Siekierka JJ et al. | Potential roles of other FK 506-binding proteins in mediating the effects of FK 506. | 1991 | Transplant. Proc. | pmid:1721256 |
| Furian L et al. | Everolimus associated with low-dose calcineurin inhibitors, an option in kidney transplant recipients of very old donors. | 2014 | Transplant. Proc. | pmid:25498057 |
| Morris RE | In vivo immunopharmacology of the macrolides FK 506 and rapamycin: toward the era of rational immunosuppressive drug discovery, development, and use. | 1991 | Transplant. Proc. | pmid:1721257 |
| Satomura K et al. | Pharmacokinetics of FK 506 in living-related liver transplantation. | 1996 | Transplant. Proc. | pmid:8623209 |
| Shapiro R et al. | The side effects of FK 506 in humans. | 1990 | Transplant. Proc. | pmid:1689892 |
| Van Thiel DH et al. | Gastrointestinal and metabolic problems associated with immunosuppression with either CyA or FK 506 in liver transplantation. | 1990 | Transplant. Proc. | pmid:1689893 |
| Kumar MS et al. | ATGAM versus OKT3 induction therapy in cadaveric kidney transplantation: patient and graft survival, CD3 subset, infection, and cost analysis. | 1998 | Transplant. Proc. | pmid:9636549 |
| Gutiérrez Sánchez MJ et al. | Optimization of immunosuppression by switching from azathioprine to enteric-coated mycophenolate sodium in stable kidney transplant patients. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715907 |
| Diez Ojea B et al. | Three-month experience with tacrolimus once-daily regimen in stable renal allografts. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715908 |
| Aptaramanov B et al. | A comparison of mycophenolate mofetil with mycophenolate sodium in renal transplant recipients on tacrolimus-based treatment. | 2011 | Transplant. Proc. | pmid:21486609 |
| Corry RJ et al. | Tacrolimus without antilymphocyte induction therapy prevents pancreas loss from rejection in 123 consecutive patients. | 1998 | Transplant. Proc. | pmid:9532157 |
| Dheir H et al. | Intensive polyoma virus nephropathy treatment as a preferable approach for graft surveillance. | 2011 | Transplant. Proc. | pmid:21486617 |
| Hayashi S et al. | Adenovirus-mediated gene transfer to the xenogeneic liver in liver xenotransplantation: the transduction of complement regulatory factor genes (DAF and HRF20). | 1997 | Transplant. Proc. | pmid:9193595 |
| Weiler N et al. | Tacrolimus effects and side effects after liver transplantation: is there a difference between immediate and extended release? | 2013 Jul-Aug | Transplant. Proc. | pmid:23953543 |
| Jang HJ et al. | Tacrolimus for rescue therapy in refractory renal allograft rejection. | 2000 | Transplant. Proc. | pmid:11119925 |
| Morita H et al. | Acceptance of skin xenografts (from guinea pig to mice) by portal venous and intravenous injections of donor hematolymphoid cells. | 2000 | Transplant. Proc. | pmid:10715422 |
| Shimada H et al. | Existence of serum p53 antibodies in cyclosporine A-treated transplant patients: possible detection of p53 protein over-expression. | 2000 | Transplant. Proc. | pmid:11119931 |
| Vela CG et al. | Prospective study of lipid disorders in FK506-versus cyclosporine-treated renal transplant patients. | 2000 | Transplant. Proc. | pmid:10715453 |
| Pascual J et al. | Updated metaanalysis of steroid withdrawal in renal transplant patients on calcineurin inhibitor and mycophenolate mofetil. | 2005 | Transplant. Proc. | pmid:16386525 |
| Weir MR | Methods and outcomes of calcineurin inhibitor reduction or withdrawal in patients with chronic allograft nephropathy after the first year posttransplantation. | 2001 | Transplant. Proc. | pmid:11406264 |
| Land W et al. | Mycophenolate mofetil monotherapy: an optimal, safe, and efficacious immunosuppressive maintenance regimen in kidney transplant patients. | 2001 | Transplant. Proc. | pmid:11406265 |
| Fukuzaki T et al. | Induction of unresponsiveness to islet allograft by preoperative donor spleen cell injection and FK 506 treatment. | 1993 | Transplant. Proc. | pmid:7680173 |
| Loréal O et al. | FK 506 is less cytotoxic than cyclosporine to human and rat hepatocytes in vitro. | 1991 | Transplant. Proc. | pmid:1721289 |
| Matsuzaki T et al. | Liver transplantation for diethylnitrosamine-induced hepatocellular carcinoma in rats. | 1992 | Transplant. Proc. | pmid:1373547 |
| Pirenne J et al. | Bone marrow augmentation of kidney allografts can cause graft-versus-host disease in immunosuppressed recipients. | 1996 | Transplant. Proc. | pmid:8623472 |
| Nakamura M et al. | Clinical and radiological features of two cases of tacrolimus-related posterior leukoencephalopathy in living related liver transplantation. | 1998 | Transplant. Proc. | pmid:9636600 |
| Charco R et al. | Hypercholesterolemia in long-term survivors of liver transplantation: a comparison between cyclosporine and FK 506. | 1998 | Transplant. Proc. | pmid:9636605 |
| Furlan V et al. | Interaction between tacrolimus and itraconazole in a heart-lung transplant recipient. | 1998 | Transplant. Proc. | pmid:9474996 |
| Amada N et al. | Deoxyspergualin prophylaxis with tacrolimus further improves long-term graft survival in living-related renal-transplant recipients transfused with donor-specific blood. | 2005 | Transplant. Proc. | pmid:15848577 |
| Oberholzer J et al. | Immediate conversion from tacrolimus to cyclosporine in the treatment of posttransplantation diabetes mellitus. | 2005 | Transplant. Proc. | pmid:15848603 |
| Hampel G et al. | Different effects of cyclosporine and tacrolimus on the activation of mesangial metalloproteinases and their inhibitors. | 1999 | Transplant. Proc. | pmid:10578279 |
| YaÄŸmurdur MC et al. | Tacrolimus conversion in kidney transplant recipients: analysis of 107 patients. | 2004 Jan-Feb | Transplant. Proc. | pmid:15013327 |
| Akbas SH et al. | Plasma homocysteine levels in renal transplant patients on tacrolimus therapy. | 2004 Jan-Feb | Transplant. Proc. | pmid:15013332 |
| Spagnoletti G et al. | Conversion from Prograf to Advagraf in stable kidney transplant recipients: better renal function after 3-year follow-up. | 2014 | Transplant. Proc. | pmid:25242756 |
| Woodle ES et al. | FK 506 rescue therapy: the rapidity of rejection reversal is related to the subsequent development of CMV disease. | 1993 | Transplant. Proc. | pmid:7682360 |
| Lang T et al. | Distinct patterns of Th2 cytokine production during immune activation in pediatric liver allograft recipients. | 1995 | Transplant. Proc. | pmid:7533367 |
| Meiser BM et al. | Simvastatin decreases accelerated graft vessel disease after heart transplantation in an animal model. | 1993 | Transplant. Proc. | pmid:7682363 |
| O'Rourke M et al. | Recovery of delayed-type hypersensitivity following liver transplantation. | 1995 | Transplant. Proc. | pmid:7533369 |
| Chen-Woan M et al. | Diminished lymphocyte growth from endomyocardial biopsies from cardiac transplant patients on FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721320 |
| Fukuzawa M et al. | Effect of FK 506 on CD4+ and CD8+ T-cell function in vivo. | 1991 | Transplant. Proc. | pmid:1721321 |
| Costa JS et al. | Polyomavirus Nephropathy: Ten-Year Experience. | 2017 | Transplant. Proc. | pmid:28457399 |
| Hasegawa A et al. | Successful treatment of 115 pediatric renal transplant recipients with tacrolimus-based immunosuppressive therapy: a 7-year multicenter study in Japan. | 2005 | Transplant. Proc. | pmid:15919460 |
| Ishikawa T et al. | Intestinal function and morphology after ex vivo irradiated small bowel transplantation. | 2002 | Transplant. Proc. | pmid:12034274 |
| Charco R et al. | Changes in renal function in long-term survivors of liver transplantation: a comparison between cyclosporine microemulsion and tacrolimus therapy. | 2002 | Transplant. Proc. | pmid:12176478 |
| Cakir U et al. | Role of Everolimus on Cardiac Functions in Kidney Transplant Recipients. | 2017 | Transplant. Proc. | pmid:28340820 |
| Kumano K et al. | Role of endothelin in FK 506-induced renal hypoperfusion in rats. | 1995 | Transplant. Proc. | pmid:7533423 |
| Chiereghin A et al. | Monitoring cytomegalovirus T-cell immunity in small bowel/multivisceral transplant recipients. | 2010 Jan-Feb | Transplant. Proc. | pmid:20172283 |
| Green M et al. | Infectious complications of pediatric liver transplantation under FK 506. | 1991 | Transplant. Proc. | pmid:1721352 |
| Yokoyama I et al. | Immunosuppressant effect on Fas antigen expression and p53 of an experimental tumor. | 1998 | Transplant. Proc. | pmid:9865346 |
| Miller J et al. | FK 506 in kidney transplantation: results of the U.S.A. randomized comparative phase III study. The FK 506 Kidney Transplant Study Group. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123008 |
| Bartlomiejczyk I et al. | Therapeutic monitoring of tacrolimus concentrations in blood of renal and liver transplant recipients: comparison of microparticle enzyme immunoassay and enzyme multiplied immunoassay methods. | 2006 Jan-Feb | Transplant. Proc. | pmid:16504673 |
| Toyama Y et al. | Prolonged small bowel graft survival using photochemotherapy and low-dose FK 506. | 1996 | Transplant. Proc. | pmid:8907924 |
| Falkiewicz K et al. | Renal function and tubular phosphate handling in long-term cyclosporine- and tacrolimus-based immunosuppression in kidney transplantation. | 2006 Jan-Feb | Transplant. Proc. | pmid:16504680 |
| Chen CL et al. | FK 506 used as rescue therapy for refractory liver allograft rejection. | 1994 | Transplant. Proc. | pmid:7520612 |
| Lama R et al. | Lung transplants with tacrolimus and mycophenolate mofetil: a review. | 2003 | Transplant. Proc. | pmid:12962866 |
| Crespo-Leiro MG | Tacrolimus in heart transplantation. | 2003 | Transplant. Proc. | pmid:12962869 |
| Campos HH and Abbud Filho M | One-year follow-up of a Brazilian randomized multicenter study comparing tacrolimus versus cyclosporine in kidney transplantation. | 2002 | Transplant. Proc. | pmid:12176523 |
| Dietl KH | Oral dosing of tacrolimus and cyclosporine microemulsion--results from a large multicenter study in renal transplantation. | 2002 | Transplant. Proc. | pmid:12176524 |
| Morris RE et al. | Immunopharmacology of FK-506. | 1989 | Transplant. Proc. | pmid:2468201 |
| Tauxe WN et al. | A comparison of the renal effects (ERPF, GFR, and FF) of FK 506 and cyclosporine in patients with liver transplantation. | 1991 | Transplant. Proc. | pmid:1721386 |
| Sho M et al. | Simultaneous inoculation of donor lymphocyte subsets with transplantation in a rat cardiac allograft model. | 1998 | Transplant. Proc. | pmid:9838696 |
| Schwarz C et al. | Tacrolimus, Mycophenolate Mofetil, and Low-Dose Steroids With or Without Interleukin-2 Receptor Antibody Induction Therapy: A Retrospective Cohort Analysis. | 2015 | Transplant. Proc. | pmid:26518948 |
| Yamamoto T et al. | Efficacy of Eculizumab Therapy for Atypical Hemolytic Uremic Syndrome Recurrence and Antibody-Mediated Rejection Progress After Renal Transplantation With Preformed Donor-Specific Antibodies: Case Report. | Transplant. Proc. | pmid:28104125 | |
| Kramer MR et al. | Dose adjustment and cost of itraconazole prophylaxis in lung transplant recipients receiving cyclosporine and tacrolimus (FK 506). | 1997 | Transplant. Proc. | pmid:9290780 |
| Shapiro R et al. | Reversibility of tacrolimus-induced posttransplant diabetes: an illustrative case and review of the literature. | 1997 | Transplant. Proc. | pmid:9290809 |
| Wijnen RM et al. | Thymus atrophy in the nonhuman primate by FK506: an immunohistochemical study. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123292 |
| Kumano K et al. | Role of the transforming growth factor and monocyte chemoattractant protein in FK506-induced nephropathy in the rat. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123293 |
| Braun F et al. | Clinical relevance of monitoring tacrolimus: comparison of microparticle enzyme immunoassay, enzyme-linked immunosorbent assay, and liquid chromatography mass spectrometry in renal transplant recipients converted from cyclosporine to tacrolimus. | 1996 | Transplant. Proc. | pmid:8962231 |
| Wilczek HE et al. | Renal transplant histopathologic changes during the first year in patients with tacrolimus (FK 506). | 1996 | Transplant. Proc. | pmid:8962232 |
| Chang HR et al. | Predictors of renal function improvement following tacrolimus conversion in cyclosporine-treated kidney transplant recipients. | 2007 | Transplant. Proc. | pmid:18089339 |
| Nakache R et al. | Management of massive proteinuria following renal transplantation with mycophenolate mofetil and blood pressure normalization. | 2001 | Transplant. Proc. | pmid:11377533 |
| Wilberg J et al. | Oral tacrolimus bioavailability is increased after right split liver transplantation. | 2007 | Transplant. Proc. | pmid:18089362 |
| Baran DA et al. | A novel tacrolimus dosing strategy in cardiac transplantation: drug levels, renal function, and biopsy results. | 2002 | Transplant. Proc. | pmid:12176595 |
| Reutzel-Selke A et al. | Donor pretreatment of grafts from marginal donors improves long-term graft outcome. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267150 |
| Fukuzaki T et al. | Induction of tolerance to islet allografts with preoperative donor spleen cell injection and a short course of FK 506 treatment. | 1991 | Transplant. Proc. | pmid:1721415 |
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| Ettenger R | The practical problems of prednisone in pediatric renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267159 |
| Lee KH et al. | Distribution of Anti-ABO Immunoglobulin G Subclass and C1q Antibody in ABO-incompatible Kidney Transplantation. | 2018 | Transplant. Proc. | pmid:29731066 |
| Tzakis AG et al. | FK 506 rescue in chronic graft-versus-host-disease after bone marrow transplantation. | 1991 | Transplant. Proc. | pmid:1721416 |
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| Dé P et al. | Early steroid-resistant rejection following orthotopic liver transplantation: new aspects of treatment with FK 506 instead of OKT3? | 1993 | Transplant. Proc. | pmid:7689279 |
| Cofan F et al. | Fatty acid composition in low-density lipoproteins from renal transplant recipients. | 1999 | Transplant. Proc. | pmid:10500603 |
| Back JH et al. | Antiproteinuric Effects of Green Tea Extract on Tacrolimus-Induced Nephrotoxicity in Mice. | Transplant. Proc. | pmid:26293093 | |
| Baskiran A et al. | Pregnancy After Liver Transplantation: Risks and Outcomes. | 2017 | Transplant. Proc. | pmid:28923640 |
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