tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Hemolytic-Uremic Syndrome D006463 2 associated lipids
Pancytopenia D010198 6 associated lipids
Nervous System Diseases D009422 37 associated lipids
Ataxia D001259 20 associated lipids
Psoriasis D011565 47 associated lipids
Urinary Tract Infections D014552 11 associated lipids
Brain Edema D001929 20 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Respiratory Insufficiency D012131 10 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Gingivitis D005891 3 associated lipids
Periodontal Pocket D010514 9 associated lipids
Brain Infarction D020520 17 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Stroke D020521 32 associated lipids
Liver Cirrhosis, Biliary D008105 12 associated lipids
Hyperbilirubinemia D006932 11 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Nephritis, Interstitial D009395 10 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Holtbäck U and Eklöf AC Mechanism of FK 506/520 action on rat renal proximal tubular Na+, K+-ATPase activity. 1999 Kidney Int. pmid:10469369
MacFarlane GD et al. Analytical validation of the PRO-Trac II ELISA for the determination of tacrolimus (FK506) in whole blood. 1999 Clin. Chem. pmid:10471647
Hohl CM and Altschuld RA FK506 alters sarcoplasmic reticulum calcium release in neonatal piglet cardiac myocytes. 1999 Pediatr. Res. pmid:10473047
Medina J et al. Cytokine profile of human bronchoalveolar macrophages and bronchial epithelial cells in response to inhalation particles of the cyclosporine derivative IMM 125. 1999 Inhal Toxicol pmid:10477442
Herrero JI et al. Conversion of liver transplant recipients on cyclosporine with renal impairment to mycophenolate mofetil. 1999 Liver Transpl Surg pmid:10477843
Perry SS et al. Direct effects of cyclosporin A on proliferation of hematopoietic stem and progenitor cells. 1999 Jul-Aug Cell Transplant pmid:10478713
Christner C et al. Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties. 1999 J. Med. Chem. pmid:10479292
Chan MA et al. Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506. 1999 Phytother Res pmid:10479754
Fredericks S and Holt DW TGF-beta quantitation can be tricky. 1999 Transplantation pmid:10480399
Hughes JR et al. Blood levels of TGFbeta1 in liver transplant recipients receiving either tacrolimus or micro-emulsified cyclosporine. 1999 Transplantation pmid:10480422
Hodge S et al. Postinoculation PMPA treatment, but not preinoculation immunomodulatory therapy, protects against development of acute disease induced by the unique simian immunodeficiency virus SIVsmmPBj. 1999 J. Virol. pmid:10482616
Fleischer AB Treatment of atopic dermatitis: role of tacrolimus ointment as a topical noncorticosteroidal therapy. 1999 J. Allergy Clin. Immunol. pmid:10482864
Mookerjee B et al. Salvage therapy for refractory chronic graft-versus-host disease with mycophenolate mofetil and tacrolimus. 1999 Bone Marrow Transplant. pmid:10482936
Otsu S et al. [T cell non-depleted bone marrow transplantation for primary refractory erythroleukemia using a partially HLA-mismatched related donor]. 1999 Rinsho Ketsueki pmid:10483142
Tsuji-Takayama K et al. Interleukin-18 induces interferon-gamma production through NF-kappaB and NFAT activation in murine T helper type 1 cells. 1999 Cell. Immunol. pmid:10486154
Pinna AD et al. Unusual presentation of graft-versus-host disease in pediatric liver transplant recipients: evidence of late and recurrent disease. 1999 Pediatr Transplant pmid:10487286
Muthuswamy SK et al. Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers. 1999 Mol. Cell. Biol. pmid:10490623
Ahlers C et al. Cyclosporin A inhibits Ca2+-mediated upregulation of the DNA repair enzyme DNA polymerase beta in human peripheral blood mononuclear cells. 1999 Eur. J. Biochem. pmid:10491144
Sata M and Walsh K Cyclosporine downregulates Fas ligand expression on vascular endothelial cells: implication for accelerated vasculopathy by immunosuppressive therapy. 1999 Biochem. Biophys. Res. Commun. pmid:10491310
Yeh CN et al. Acute overdoses of tacrolimus (FK 506). 1999 Dig. Dis. Sci. pmid:10492148