tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Hemolytic-Uremic Syndrome D006463 2 associated lipids
Pancytopenia D010198 6 associated lipids
Nervous System Diseases D009422 37 associated lipids
Ataxia D001259 20 associated lipids
Psoriasis D011565 47 associated lipids
Urinary Tract Infections D014552 11 associated lipids
Brain Edema D001929 20 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Respiratory Insufficiency D012131 10 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Gingivitis D005891 3 associated lipids
Periodontal Pocket D010514 9 associated lipids
Brain Infarction D020520 17 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Stroke D020521 32 associated lipids
Liver Cirrhosis, Biliary D008105 12 associated lipids
Hyperbilirubinemia D006932 11 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Nephritis, Interstitial D009395 10 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

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Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Hauser IA and Neumayer HN Tacrolimus and cyclosporine efficacy in high-risk kidney transplantation. European Multicentre Tacrolimus (FK506) Renal Study Group. 1998 Transpl. Int. pmid:9664948
Kokado Y et al. Low-dose tacrolimus (FK506)-based immunosuppressive protocol in living donor renal transplantation. 1998 Transpl. Int. pmid:9664945
Stockwell BR and Schreiber SL TGF-beta-signaling with small molecule FKBP12 antagonists that bind myristoylated FKBP12-TGF-beta type I receptor fusion proteins. 1998 Chem. Biol. pmid:9662508
Nagayasu T et al. Expression of proliferating cell nuclear antigen in bronchial epithelium after lung transplantation in the rat. 1998 J. Heart Lung Transplant. pmid:9662091
Lai MM et al. Cain, a novel physiologic protein inhibitor of calcineurin. 1998 J. Biol. Chem. pmid:9660798
Tsujikawa A et al. Tacrolimus (FK506) attenuates leukocyte accumulation after transient retinal ischemia. 1998 Stroke pmid:9660400
Bader G et al. Reduction of cyclosporine-induced gingival overgrowth following a change to tacrolimus. A case history involving a liver transplant patient. 1998 J. Periodontol. pmid:9660343
McBride WJ et al. Allogeneic fetal intestinal transplantation with FK506 immunosuppression. 1998 J. Pediatr. Surg. pmid:9660232
Fujino T et al. The immunosuppressive compound FK506 does not affect expulsion of Echinostoma trivolvis in C3H mice. 1998 Parasitol. Res. pmid:9660146
Le Bihan S et al. Calcium/calmodulin kinase inhibitors and immunosuppressant macrolides rapamycin and FK506 inhibit progestin- and glucocorticosteroid receptor-mediated transcription in human breast cancer T47D cells. 1998 Mol. Endocrinol. pmid:9658403
Sasa H et al. Hepatic extraction of tacrolimus in rats with experimental liver diseases. 1998 Biol. Pharm. Bull. pmid:9657047
Nishioka T et al. [Is tacrolimus effective for ongoing renal allograft rejection?]. 1998 Hinyokika Kiyo pmid:9656112
Morozumi K et al. [Current topics of the rejection pathology in human renal allografts]. 1998 Hinyokika Kiyo pmid:9656109
Tamura K [Multiple actions of tacrolimus and cyclosporin A as specific inhibitors of calcineurin]. 1998 Tanpakushitsu Kakusan Koso pmid:9655970
Matsui H et al. [Physiological role of calcineurin in central nervous system]. 1998 Tanpakushitsu Kakusan Koso pmid:9655961
Cetinkale O et al. Involvement of neutrophils in ischemia-reperfusion injury of inguinal island skin flaps in rats. 1998 Plast. Reconstr. Surg. pmid:9655420
Kommers T et al. Regulation of the phosphorylation of glial fibrillary acidic protein (GFAP) by glutamate and calcium ions in slices of immature rat spinal cord: comparison with immature hippocampus. 1998 Neurosci. Lett. pmid:9654363
Tarumi K et al. The plasma FK506-binding protein 12 level is related to acute cellular rejection in small bowel transplantation. 1998 Immunopharmacol Immunotoxicol pmid:9653668
Friberg H et al. Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death. 1998 J. Neurosci. pmid:9651198
Canzanello VJ et al. Late hypertension after liver transplantation: a comparison of cyclosporine and tacrolimus (FK 506). 1998 Liver Transpl Surg pmid:9649648