tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brazis PW et al. | A case of bilateral optic neuropathy in a patient on tacrolimus (FK506) therapy after liver transplantation. | 2000 | Am. J. Ophthalmol. | pmid:10764869 |
| Klein BC et al. | Influence of mycophenolic acid and FK-506 on human platelet activation in vitro. | 2000 | Kidney Blood Press. Res. | pmid:10765114 |
| Fernández-Miranda C et al. | Plasma homocysteine levels in renal transplanted patients on cyclosporine or tacrolimus therapy: effect of treatment with folic acid. | 2000 | Clin Transplant | pmid:10770414 |
| Outeda MacÃas M et al. | Tacrolimus-itraconazole interaction in a kidney transplant patient. | 2000 | Ann Pharmacother | pmid:10772445 |
| pmid:10773614 | ||||
| Kraiss LW et al. | Fluid flow activates a regulator of translation, p70/p85 S6 kinase, in human endothelial cells. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10775131 |
| Yamani MH et al. | Efficacy of tacrolimus in patients with steroid-resistant cardiac allograft cellular rejection. | 2000 | J. Heart Lung Transplant. | pmid:10775813 |
| Attur MG et al. | Differential anti-inflammatory effects of immunosuppressive drugs: cyclosporin, rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and PGE2 production. | 2000 | Inflamm. Res. | pmid:10778917 |
| Peters D et al. | Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506. | 2000 | Blood | pmid:10779414 |
| Chini EN and Walker H | FK506 (tacrolimus) increases halothane-induced Ca2+ release from skeletal muscle sarcoplasmic reticulum. | 2000 | Anesthesiology | pmid:10781282 |
| Vestergaard C et al. | The NC/Nga mouse: a model for atopic dermatitis. | 2000 | Mol Med Today | pmid:10782068 |
| Gonin JM | Maintenance immunosuppression: new agents and persistent dilemmas. | 2000 | Adv Ren Replace Ther | pmid:10782729 |
| Kataoka T and Nagai K | Involvement of FK506-sensitive and insensitive granule exocytosis pathways in perforin-dependent target cell lysis mediated by a CD8+ CTL clone. | 2000 | Immunol. Lett. | pmid:10789681 |
| Katayama Y et al. | [Studies on brain pyruvate dehydrogenase (PDH) activity and energy metabolites during ischemia and reperfusion]. | 1999 | Rinsho Shinkeigaku | pmid:10791103 |
| Neckermann G et al. | Atopic dermatitis-like symptoms in hypomagnesaemic hairless rats are prevented and inhibited by systemic or topical SDZ ASM 981. | 2000 | Br. J. Dermatol. | pmid:10792216 |
| Ramsay HM and Harden PN | Cyclosporin-induced flushing in a renal transplant recipient resolving after substitution with tacrolimus. | 2000 | Br. J. Dermatol. | pmid:10792253 |
| Yoshizawa K et al. | Time-specific occurrence of alopecia in neonatal C57BL mice treated with N-methyl-N-nitrosourea and the therapeutic efficacy of tacrolimus hydrate. | 2000 | Pathol. Int. | pmid:10792780 |
| Kiani A et al. | Manipulating immune responses with immunosuppressive agents that target NFAT. | 2000 | Immunity | pmid:10795734 |
| Gaweco AS et al. | Intragraft localization of activated nuclear factor kappaB in recurrent hepatitis C virus disease following liver transplantation. | 2000 | Hepatology | pmid:10796896 |
| Lu YM et al. | Calcineurin-mediated LTD of GABAergic inhibition underlies the increased excitability of CA1 neurons associated with LTP. | 2000 | Neuron | pmid:10798404 |
| Qi S et al. | Effect of tacrolimus (FK506) and sirolimus (rapamycin) mono- and combination therapy in prolongation of renal allograft survival in the monkey. | 2000 | Transplantation | pmid:10798741 |
| Borger P et al. | Cyclosporine, FK506, mycophenolate mofetil, and prednisolone differentially modulate cytokine gene expression in human airway-derived epithelial cells. | 2000 | Transplantation | pmid:10798763 |
| Moffatt SD et al. | STAT 6 up-regulation by FK506 in the presence of interleukin-4. | 2000 | Transplantation | pmid:10798785 |
| Adachi S et al. | Successive expression and activation of NFAT family members during thymocyte differentiation. | 2000 | J. Biol. Chem. | pmid:10799559 |
| Biggar SR and Crabtree GR | Chemically regulated transcription factors reveal the persistence of repressor-resistant transcription after disrupting activator function. | 2000 | J. Biol. Chem. | pmid:10801867 |
| Pirsch J et al. | Coadministration of tacrolimus and mycophenolate mofetil in stable kidney transplant patients: pharmacokinetics and tolerability. | 2000 | J Clin Pharmacol | pmid:10806606 |
| Riley L et al. | Cross-sensitivity reaction between tacrolimus and macrolide antibiotics. | 2000 | Bone Marrow Transplant. | pmid:10808214 |
| Chen XJ et al. | Positive and negative control of multidrug resistance by the Sit4 protein phosphatase in Kluyveromyces lactis. | 2000 | J. Biol. Chem. | pmid:10809730 |
| Glanemann M et al. | Higher immunosuppressive efficacy of mycophenolate mofetil in combination with FK 506 than in combination with cyclosporine A. | 2000 | Transplant. Proc. | pmid:10812095 |
| White SA et al. | Randomized trial comparing neoral and tacrolimus immunousuppression for recipients of renal transplants procured from different donor groups. | 2000 | Transplant. Proc. | pmid:10812132 |
| Taber DJ et al. | Drug-drug interaction between chloramphenicol and tacrolimus in a liver transplant recipient. | 2000 | Transplant. Proc. | pmid:10812156 |
| Soran A et al. | Renal retransplantation in elderly recipients under tacrolimus-based immunosuppression. | 2000 | Transplant. Proc. | pmid:10812157 |
| McLaughlin GE et al. | Use of phenobarbital in the management of acute tacrolimus toxicity: a case report. | 2000 | Transplant. Proc. | pmid:10812158 |
| Levy GA | Neoral use in the liver transplant recipient. | 2000 | Transplant. Proc. | pmid:10814745 |
| Przepiorka D et al. | Tacrolimus does not abrogate the increased risk of acute graft-versus-host disease after unrelated-donor marrow transplantation with allelic mismatching at HLA-DRB1 and HLA-DQB1. | 2000 | Biol. Blood Marrow Transplant. | pmid:10816027 |
| Küsters E et al. | Purification of an ascomycin derivative with simulated moving bed chromatography. A case study. | 2000 | J Chromatogr A | pmid:10817355 |
| Wang JJ et al. | Dimerization-dependent block of the proapoptotic effect of p75(NTR). | 2000 | J. Neurosci. Res. | pmid:10820429 |
| Ortega-Pérez I and Redondo JM | [The NFAT transcription factor family as immunosuppression target]. | 2000 | Nefrologia | pmid:10822734 |
| Bang H et al. | Prolyl isomerases in a minimal cell. Catalysis of protein folding by trigger factor from Mycoplasma genitalium. | 2000 | Eur. J. Biochem. | pmid:10824113 |
| Otley CC and Pittelkow MR | Skin cancer in liver transplant recipients. | 2000 | Liver Transpl. | pmid:10827224 |
| Eckhoff DE et al. | The safety and efficacy of a two-dose daclizumab (zenapax) induction therapy in liver transplant recipients. | 2000 | Transplantation | pmid:10830224 |
| Nakata Y et al. | Tacrolimus and myocardial hypertrophy. | 2000 | Transplantation | pmid:10830241 |
| Blaheta RA et al. | Mycophenolate mofetil decreases endothelial prostaglandin E2 in response to allogeneic T cells or cytokines. | 2000 | Transplantation | pmid:10830246 |
| Jindal RM and Dubernard JM | Towards a specific immunosuppression for pancreas and islet grafts. | 2000 | Clin Transplant | pmid:10831083 |
| Rerolle JP et al. | Tacrolimus-induced hemolytic uremic syndrome and end-stage renal failure after liver transplantation. | 2000 | Clin Transplant | pmid:10831087 |
| Filler G et al. | Tacrolimus reversibly reduces insulin secretion in paediatric renal transplant recipients. | 2000 | Nephrol. Dial. Transplant. | pmid:10831643 |
| Gallagher H et al. | Post-transplantation lymphoproliferative disorder: an unusual presentation in a patient receiving tacrolimus. | 2000 | Nephrol. Dial. Transplant. | pmid:10831670 |
| Chen H et al. | Compromised kidney graft rejection response in Vervet monkeys after withdrawal of immunosuppressants tacrolimus and sirolimus. | 2000 | Transplantation | pmid:10836361 |
| Moffatt SD and Metcalfe SM | Comparison between tacrolimus and cyclosporine as immunosuppressive agents compatible with tolerance induction by CD4/CD8 blockade. | 2000 | Transplantation | pmid:10836388 |
| Higgins RM et al. | Conversion from tacrolimus to cyclosporine in stable renal transplant patients: safety, metabolic changes, and pharmacokinetic comparison. | 2000 | Transplantation | pmid:10836393 |