Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Velasco-Guardado A et al. | Potential protective effect of Helicobacter pylori on the development of gastrointestinal GvHD. | 2016 | Bone Marrow Transplant. | pmid:26950379 |
Kloster-Jensen K et al. | Treatment with Tacrolimus and Sirolimus Reveals No Additional Adverse Effects on Human Islets In Vitro Compared to Each Drug Alone but They Are Reduced by Adding Glucocorticoids. | 2016 | J Diabetes Res | pmid:26885529 |
Shen X et al. | Calcineurin inhibitors cyclosporin A and tacrolimus protect against podocyte injury induced by puromycin aminonucleoside in rodent models. | 2016 | Sci Rep | pmid:27580845 |
Khan S et al. | Tacrolimus-loaded nanostructured lipid carriers for oral delivery-in vivo bioavailability enhancement. | 2016 | Eur J Pharm Biopharm | pmid:27793753 |
Andrews LM et al. | Consideration of the ethnic prevalence of genotypes in the clinical use of tacrolimus. | 2016 | Pharmacogenomics | pmid:27790923 |
Högerle BA et al. | Challenging immunosuppression treatment in lung transplant recipients with kidney failure. | 2016 | Transpl. Immunol. | pmid:26892232 |
Kimura H et al. | Has widespread use of biologic and immunosuppressant therapy for ulcerative colitis affected surgical trends? Results of a questionnaire survey of surgical institutions in Japan. | 2016 | Surg. Today | pmid:26467558 |
Brooks E et al. | Population Pharmacokinetic Modelling and Bayesian Estimation of Tacrolimus Exposure: Is this Clinically Useful for Dosage Prediction Yet? | 2016 | Clin Pharmacokinet | pmid:27138787 |
Rebora A | Tacrolimus and oral lichen planus. Possible absorption after mucosal application? | 2016 | J Eur Acad Dermatol Venereol | pmid:26372839 |
Ohe M et al. | A case of lupus nephritis treated with clarithromycin, tacrolimus, and glucocorticoids. | 2016 | Kaohsiung J. Med. Sci. | pmid:27638410 |
Wang N et al. | Paclitaxel and Tacrolimus Coencapsulated Polymeric Micelles That Enhance the Therapeutic Effect of Drug-Resistant Ovarian Cancer. | 2016 | ACS Appl Mater Interfaces | pmid:26809267 |
Gabriel D et al. | Improved topical delivery of tacrolimus: A novel composite hydrogel formulation for the treatment of psoriasis. | 2016 | J Control Release | pmid:27639683 |
Vasu S et al. | Granulocyte Colony-Stimulating Factor-Mobilized Allografts Contain Activated Immune Cell Subsets Associated with Risk of Acute and Chronic Graft-versus-Host Disease. | 2016 | Biol. Blood Marrow Transplant. | pmid:26743340 |
Yoo EC et al. | Developmental changes of MPA exposure in children. | 2016 | Pediatr. Nephrol. | pmid:26743220 |
Sommerer C et al. | Design and rationale of the ATHENA study--A 12-month, multicentre, prospective study evaluating the outcomes of a de novo everolimus-based regimen in combination with reduced cyclosporine or tacrolimus versus a standard regimen in kidney transplant patients: study protocol for a randomised controlled trial. | 2016 | Trials | pmid:26888217 |
Bapur Erduran F and Adışen E | Comparison of the efficacy of 308-nm excimer lamp monotherapy with topical tacrolimus or clobetasol 17-propionate combination therapies in localized vitiligo. | 2016 | Photodermatol Photoimmunol Photomed | pmid:27552312 |
Tsuji T et al. | Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 ointment (fingolimod) in NC/Nga mice. | 2016 | Allergol Int | pmid:26666476 |
Speckmann T et al. | Npas4 Transcription Factor Expression Is Regulated by Calcium Signaling Pathways and Prevents Tacrolimus-induced Cytotoxicity in Pancreatic Beta Cells. | 2016 | J. Biol. Chem. | pmid:26663079 |
Ren H et al. | Phosphatase inhibition increases AQP2 accumulation in the rat IMCD apical plasma membrane. | 2016 | Am. J. Physiol. Renal Physiol. | pmid:27488997 |
Woolner K and Sauder M | Periorbital erythema following alcohol ingestion during treatment with topical tacrolimus. | 2016 | CMAJ | pmid:26598374 |
Park JS et al. | A rapid and sensitive method to determine tacrolimus in rat whole blood using liquid-liquid extraction with mild temperature ultrasonication and LC-MS/MS. | 2016 | Arch. Pharm. Res. | pmid:26589688 |
Dabrowska-Zamojcin E et al. | CCL2 gene polymorphism is associated with post-transplant diabetes mellitus. | 2016 | Int. Immunopharmacol. | pmid:26802601 |
Tanriover B et al. | Acute Rejection Rates and Graft Outcomes According to Induction Regimen among Recipients of Kidneys from Deceased Donors Treated with Tacrolimus and Mycophenolate. | 2016 | Clin J Am Soc Nephrol | pmid:27364616 |
Ordóñez-Robles M et al. | Target genes of the Streptomyces tsukubaensis FkbN regulator include most of the tacrolimus biosynthesis genes, a phosphopantetheinyl transferase and other PKS genes. | 2016 | Appl. Microbiol. Biotechnol. | pmid:27357227 |
Handisurya A et al. | Conversion from Tacrolimus to Cyclosporine A Improves Glucose Tolerance in HCV-Positive Renal Transplant Recipients. | 2016 | PLoS ONE | pmid:26735686 |
Tsuji H et al. | Efficacy and Safety of Grapefruit Juice Intake Accompanying Tacrolimus Treatment in Connective Tissue Disease Patients. | 2016 | Intern. Med. | pmid:27301503 |
Menninga NJ et al. | Restless Legs Syndrome Following Lung Transplantation: Prevalence and Relationship With Tacrolimus Exposure. | 2016 | Prog Transplant | pmid:27207403 |
Jebabli N et al. | Consequences of erroneous phone transmission of tacrolimus blood concentration: A case report. | 2016 | Therapie | pmid:27203160 |
Reeves TM et al. | Targeting Kv1.3 channels to reduce white matter pathology after traumatic brain injury. | 2016 | Exp. Neurol. | pmid:27302680 |
Matsukawa T et al. | Reduced-dose methotrexate in combination with tacrolimus was associated with rapid engraftment and recovery from oral mucositis without affecting the incidence of GVHD. | 2016 | Int. J. Hematol. | pmid:27119977 |
Peng L et al. | Comparison of different therapies in high-risk patients with idiopathic membranous nephropathy. | 2016 | J. Formos. Med. Assoc. | pmid:26315481 |
Ruangkanchanasetr P et al. | Beta Cell Function and Insulin Resistance After Conversion from Tacrolimus Twice-Daily to Extended-Release Tacrolimus Once-Daily in Stable Renal Transplant Recipients. | 2016 | Ann. Transplant. | pmid:27980321 |
Castagna L et al. | Tacrolimus compared with cyclosporine A after haploidentical T-cell replete transplantation with post-infusion cyclophosphamide. | 2016 | Bone Marrow Transplant. | pmid:26595078 |
Yamamoto T et al. | Editorial: tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis--authors' reply. | 2016 | Aliment. Pharmacol. Ther. | pmid:27040167 |
Taylor KM and Sparrow MP | Editorial: tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis. | 2016 | Aliment. Pharmacol. Ther. | pmid:27040166 |
Imamura CK et al. | Impact of cytochrome P450 2C19 polymorphisms on the pharmacokinetics of tacrolimus when coadministered with voriconazole. | 2016 | J Clin Pharmacol | pmid:26239045 |
Lonowski S et al. | Vitiligo: a potential autoimmune sequela of DRESS syndrome. | 2016 | Br. J. Dermatol. | pmid:27038429 |
GarcÃa-Bello JA et al. | Effect of Immunosuppressive Therapy on Cardiovascular Risk Factor Prevalence in Kidney-Transplanted Children: Comparative Study. | 2016 | Transplant. Proc. | pmid:27110020 |
Gu C et al. | Triptolide Reduces the Required Dose of Tacrolimus by Attenuating Inflammation, Enhancing Immunosuppression, and Increasing Donor Chimerism in a Heterotopic Hindlimb Transplantation Model. | 2016 | Plast. Reconstr. Surg. | pmid:27879593 |
Meng QH et al. | Falsely elevated tacrolimus concentrations on the Dimension Xpand. | 2015 | Clin. Biochem. | pmid:26160209 |
Fischer L et al. | Three-year Outcomes in De Novo Liver Transplant Patients Receiving Everolimus With Reduced Tacrolimus: Follow-Up Results From a Randomized, Multicenter Study. | 2015 | Transplantation | pmid:26151607 |
Spolidorio LC et al. | The long-term administration of calcineurin inhibitors decreases antioxidant enzyme activity in the rat parotid and submandibular salivary glands. | 2015 | Life Sci. | pmid:26006038 |
Ali H et al. | Mycophenolate mofetil-based salvage as acute GVHD prophylaxis after early discontinuation of tacrolimus and/or sirolimus. | 2015 | Bone Marrow Transplant. | pmid:25365064 |
Lee SC et al. | Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides. | 2015 | Mol. Microbiol. | pmid:26010100 |
Sato K et al. | Late onset of progressive speech impairment due to tacrolimus-associated leukoencephalopathy after kidney transplantation. | 2015 | Int Urol Nephrol | pmid:26071870 |
Pulk RA et al. | Multigene predictors of tacrolimus exposure in kidney transplant recipients. | 2015 | Pharmacogenomics | pmid:26067485 |
Pardi C and Oltean M | An unusual case of red blood cell immunisation following liver transplantation. | 2015 | Blood Transfus | pmid:26057497 |
Chen YB et al. | Phase II Trial of Tandem High-Dose Chemotherapy with Autologous Stem Cell Transplantation Followed by Reduced-Intensity Allogeneic Stem Cell Transplantation for Patients with High-Risk Lymphoma. | 2015 | Biol. Blood Marrow Transplant. | pmid:26009261 |
Ribero S et al. | Efficacy of topical tacrolimus for oral lichen planus: real-life experience in a retrospective cohort of patients with a review of the literature. | 2015 | J Eur Acad Dermatol Venereol | pmid:25308924 |
Qasim W et al. | Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient. | 2015 | J. Hepatol. | pmid:25308176 |
Chan TM | Treatment of severe lupus nephritis: the new horizon. | 2015 | Nat Rev Nephrol | pmid:25421826 |
Andreu F et al. | Development of a population PK model of tacrolimus for adaptive dosage control in stable kidney transplant patients. | 2015 | Ther Drug Monit | pmid:25254416 |
Fussner LA et al. | Cardiovascular disease after liver transplantation: When, What, and Who Is at Risk. | 2015 | Liver Transpl. | pmid:25880971 |
Abuabara K et al. | Atopic dermatitis disease control and age: A cohort study. | 2015 | J. Allergy Clin. Immunol. | pmid:25935107 |
Clark SL et al. | Making every drop count for pediatric kidney transplant patients. | 2015 | Hosp Pediatr | pmid:25934814 |
de Sandes-Freitas TV et al. | Subclinical Lesions and Donor-Specific Antibodies in Kidney Transplant Recipients Receiving Tacrolimus-Based Immunosuppressive Regimen Followed by Early Conversion to Sirolimus. | 2015 | Transplantation | pmid:25929604 |
Ikitimur B et al. | Long-Term Impact of Different Immunosuppressive Drugs on QT and PR Intervals in Renal Transplant Patients. | 2015 | Ann Noninvasive Electrocardiol | pmid:25367596 |
Ganetsky A et al. | Lack of a significant pharmacokinetic interaction between maraviroc and tacrolimus in allogeneic HSCT recipients. | 2015 | J. Antimicrob. Chemother. | pmid:25881619 |
Goldthorpe H et al. | Occlusive lung arterial lesions in endothelial-targeted, fas-induced apoptosis transgenic mice. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25879383 |
Liang GB et al. | Impact of immunosuppressive agents on the expression of indoleamine 2,3-dioxygenase, heme oxygenase-1 and interleukin-7 in mesangial cells. | 2015 | Mol Med Rep | pmid:25936769 |
Chapron B et al. | Reversible, time-dependent inhibition of CYP3A-mediated metabolism of midazolam and tacrolimus by telaprevir in human liver microsomes. | 2015 | J Pharm Pharm Sci | pmid:25877445 |
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Söderlund C and Rådegran G | Immunosuppressive therapies after heart transplantation--The balance between under- and over-immunosuppression. | 2015 | Transplant Rev (Orlando) | pmid:25812489 |
Zegarska J et al. | Mycophenolic Acid Metabolites Acyl-Glucuronide and Glucoside Affect the Occurrence of Infectious Complications and Bone Marrow Dysfunction in Liver Transplant Recipients. | 2015 | Ann. Transplant. | pmid:26313036 |
Lee JR et al. | Gut microbiota and tacrolimus dosing in kidney transplantation. | 2015 | PLoS ONE | pmid:25815766 |
Stevens RB et al. | A randomized 2×2 factorial trial, part 1: single-dose rabbit antithymocyte globulin induction may improve renal transplantation outcomes. | 2015 | Transplantation | pmid:25083614 |
La Placa M et al. | Disfiguring papular sarcoidosis of the face: dramatic improvement with pimecrolimus. | 2015 | J Eur Acad Dermatol Venereol | pmid:25073484 |
Ravaioli M et al. | Immunosuppression Modifications Based on an Immune Response Assay: Results of a Randomized, Controlled Trial. | 2015 | Transplantation | pmid:25757214 |
Bis DM et al. | Characterization of the nocardiopsin biosynthetic gene cluster reveals similarities to and differences from the rapamycin and FK-506 pathways. | 2015 | Chembiochem | pmid:25755076 |
Rahman Z et al. | Comparison of X-ray powder diffraction and solid-state nuclear magnetic resonance in estimating crystalline fraction of tacrolimus in sustained-release amorphous solid dispersion and development of discriminating dissolution method. | 2015 | J Pharm Sci | pmid:25753829 |
Devine SM et al. | Phase II Study of Allogeneic Transplantation for Older Patients With Acute Myeloid Leukemia in First Complete Remission Using a Reduced-Intensity Conditioning Regimen: Results From Cancer and Leukemia Group B 100103 (Alliance for Clinical Trials in Oncology)/Blood and Marrow Transplant Clinical Trial Network 0502. | 2015 | J. Clin. Oncol. | pmid:26527780 |
Qian G et al. | Successful treatment of recalcitrant granulomatous rosacea with oral thalidomide and topical pimecrolimus. | 2015 | J. Dermatol. | pmid:25753523 |
Pennington CA et al. | Evaluation of a Weight-based Rabbit Anti-thymocyte Globulin Induction Dosing Regimen for Kidney Transplant Recipients. | 2015 | Pharmacotherapy | pmid:26234282 |
Zhu L et al. | Adrenergic stimulation sensitizes TRPV1 through upregulation of cystathionine β-synthetase in a rat model of visceral hypersensitivity. | 2015 | Sci Rep | pmid:26527188 |
Vanhove T et al. | Response to 'Tacrolimus pharmacokinetics after kidney transplantation--Influence of changes in haematocrit and steroid dose'. | 2015 | Br J Clin Pharmacol | pmid:26235051 |
Hanifin JM | A Reassuring Rejoinder Against Malignant Influences of Topical Calcineurin Use in Children. | 2015 | JAMA Dermatol | pmid:25692944 |
Margolis DJ et al. | Association Between Malignancy and Topical Use of Pimecrolimus. | 2015 | JAMA Dermatol | pmid:25692459 |
Fan DM et al. | Successful ABO-incompatible living-related intestinal transplantation: a 2-year follow-up. | 2015 | Am. J. Transplant. | pmid:25808777 |
Matsushima M et al. | [A case of anti-PL7 antibody positive myositis and a clinical and pathological review of the anti-synthetase syndrome]. | 2015 | Rinsho Shinkeigaku | pmid:26458569 |
Almeida-Corrêa S et al. | Calcineurin inhibition blocks within-, but not between-session fear extinction in mice. | 2015 | Learn. Mem. | pmid:25691516 |
Leneghan D and Bell A | Immunophilin-protein interactions in Plasmodium falciparum. | 2015 | Parasitology | pmid:26156578 |
Chen QJ et al. | Tacrolimus decreases insulin sensitivity without reducing fasting insulin concentration: a 2-year follow-up study in kidney transplant recipients. | 2015 | Ren Fail | pmid:25644968 |
Joneja U and Uppal G | Pseudo-Pelger-Huët anomaly in a patient on tacrolimus. | 2015 | Blood | pmid:26371350 |
Kawahara T et al. | Cyclosporine A and tacrolimus inhibit bladder cancer growth through down-regulation of NFATc1. | 2015 | Oncotarget | pmid:25638160 |
Dagher M et al. | Overweight, central obesity, and cardiometabolic risk factors in pediatric liver transplantation. | 2015 | Pediatr Transplant | pmid:25581506 |
Kita A et al. | Imp2, the PSTPIP homolog in fission yeast, affects sensitivity to the immunosuppressant FK506 and membrane trafficking in fission yeast. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25580011 |
Cortina G et al. | De novo tacrolimus-induced thrombotic microangiopathy in the early stage after renal transplantation successfully treated with conversion to everolimus. | 2015 | Pediatr. Nephrol. | pmid:25577332 |
Annunziato RA et al. | Can transition to adult care for transplant recipients be improved by intensified services while patients are still in pediatrics? | 2015 | Prog Transplant | pmid:26308783 |
Pape E et al. | Management of Tacrolimus-Telaprevir Drug-Drug Interaction in a Liver Transplant Patient With Hepatitis C Virus: Practical Considerations. | 2015 | Transplantation | pmid:26308424 |
Ruiz J et al. | Impact of Single Nucleotide Polymorphisms (SNPs) on Immunosuppressive Therapy in Lung Transplantation. | 2015 | Int J Mol Sci | pmid:26307985 |
Kurita T et al. | The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis. | 2015 | Rheumatology (Oxford) | pmid:24764266 |
Cavalié M et al. | Maintenance therapy of adult vitiligo with 0.1% tacrolimus ointment: a randomized, double blind, placebo-controlled study. | 2015 | J. Invest. Dermatol. | pmid:25521460 |
Reddy YN et al. | Is there a genetic predisposition to new-onset diabetes after kidney transplantation? | 2015 | Saudi J Kidney Dis Transpl | pmid:26586047 |
Yu Y et al. | Investigation into the interchangeability of generic formulations using immunosuppressants and a broad selection of medicines. | 2015 | Eur. J. Clin. Pharmacol. | pmid:26062932 |
Millner L et al. | A clinical approach to solving discrepancies in therapeutic drug monitoring results for patients on sirolimus or tacrolimus: Towards personalized medicine, immunosuppression and pharmacogenomics. | 2015 | Clin. Chim. Acta | pmid:26232156 |
Li JL et al. | Interactive effects of CYP3A4, CYP3A5, MDR1 and NR1I2 polymorphisms on tracrolimus trough concentrations in early postrenal transplant recipients. | 2015 | Pharmacogenomics | pmid:26228923 |
Li YX and Dijkers PF | Specific calcineurin isoforms are involved in Drosophila toll immune signaling. | 2015 | J. Immunol. | pmid:25429067 |
Allison SJ | Lupus nephritis: Multitarget induction therapy for LN. | 2015 | Nat Rev Nephrol | pmid:25421833 |
Tan ES et al. | Effective treatment of scrotal lichen simplex chronicus with 0.1% tacrolimus ointment: an observational study. | 2015 | J Eur Acad Dermatol Venereol | pmid:24666218 |
Takeuchi S et al. | Pruritus of patients with atopic dermatitis in daily life and their experience of therapeutic effects: results of a web-based questionnaire survey. | 2015 | Br. J. Dermatol. | pmid:25421804 |