Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Tata PN et al. | Species-dependent hepatic metabolism of immunosuppressive agent tacrolimus (FK-506). | 2009 | Xenobiotica | pmid:19604035 |
Chitnis SD et al. | Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism. | 2013 | Xenobiotica | pmid:23278282 |
Gupta AS et al. | Pyoderma Gangrenosum of the Scalp: A Rare Clinical Variant. | 2018 | Wounds | pmid:29481333 |
Kiyama T et al. | Tacrolimus enhances colon anastomotic healing in rats. | 2002 Sep-Oct | Wound Repair Regen | pmid:12406167 |
Yang J et al. | Zinc finger protein A20 protects rats against chronic liver allograft dysfunction. | 2012 | World J. Gastroenterol. | pmid:22826618 |
Zhou J et al. | Conversion to sirolimus immunosuppression in liver transplantation recipients with hepatocellular carcinoma: Report of an initial experience. | 2006 | World J. Gastroenterol. | pmid:16718799 |
Filipec Kanizaj T and Mijic M | Inflammatory bowel disease in liver transplanted patients. | 2017 | World J. Gastroenterol. | pmid:28566881 |
Kang YZ et al. | Autoimmune hepatitis-primary biliary cirrhosis concurrent with biliary stricture after liver transplantation. | 2015 | World J. Gastroenterol. | pmid:25717264 |
Schott E et al. | Development of ulcerative colitis in a patient with multiple sclerosis following treatment with interferon beta 1a. | 2007 | World J. Gastroenterol. | pmid:17659718 |
Schumacher G et al. | Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth. | 2005 | World J. Gastroenterol. | pmid:15770715 |
Hao JC et al. | Effect of low-dose tacrolimus with mycophenolate mofetil on renal function following liver transplantation. | 2014 | World J. Gastroenterol. | pmid:25170222 |
Lan X et al. | Efficacy of immunosuppression monotherapy after liver transplantation: a meta-analysis. | 2014 | World J. Gastroenterol. | pmid:25232269 |
Del Bello A et al. | High tacrolimus intra-patient variability is associated with graft rejection, and donor-specific antibodies occurrence after liver transplantation. | 2018 | World J. Gastroenterol. | pmid:29713132 |
Meier J and Sturm A | Current treatment of ulcerative colitis. | 2011 | World J. Gastroenterol. | pmid:21912469 |
Akamatsu N et al. | Late-onset acute rejection after living donor liver transplantation. | 2006 | World J. Gastroenterol. | pmid:17075982 |
Wietzke-Braun P et al. | Initial steroid-free immunosuppression after liver transplantation in recipients with hepatitis C virus related cirrhosis. | 2004 | World J. Gastroenterol. | pmid:15259068 |
Higashi H et al. | First successful perinatal management of pregnancy after ABO-incompatible liver transplantation. | 2017 | World J. Gastroenterol. | pmid:28210092 |
Shao ZY et al. | Prophylaxis of chronic kidney disease after liver transplantation--experience from west China. | 2012 | World J. Gastroenterol. | pmid:22408361 |
Indriolo A and Ravelli P | Clinical management of inflammatory bowel disease in the organ recipient. | 2014 | World J. Gastroenterol. | pmid:24707135 |
Shen T et al. | Reversible sinusoidal obstruction syndrome associated with tacrolimus following liver transplantation. | 2015 | World J. Gastroenterol. | pmid:26034381 |