tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Prescott TA et al. | A yeast chemical genetics approach identifies the compound 3,4,5-trimethoxybenzyl isothiocyanate as a calcineurin inhibitor. | 2014 | FEBS Lett. | pmid:24374339 |
| Wu Y et al. | Increased macrophage activation inhibited by tacrolimus in the kidney of diabetic rats. | 2014 | Nephron Exp. Nephrol. | pmid:25376933 |
| Catalano G et al. | Everolimus-based immunosuppression in a case of ABO-incompatible liver transplantation with calcineurin inhibitor-related posterior occipital syndrome. | 2014 | Transpl. Int. | pmid:24606320 |
| Saito K et al. | Severe diffuse duodenitis successfully treated with intravenous tacrolimus after colectomy for ulcerative colitis. | 2014 | Intern. Med. | pmid:25366006 |
| Siddiqui A et al. | Chemometric methods for the quantification of crystalline tacrolimus in solid dispersion by powder X-ray diffractrometry. | 2014 | J Pharm Sci | pmid:24585357 |
| Uesugi S et al. | Calcineurin inhibitors suppress the high-temperature stress sensitivity of the yeast ubiquitin ligase Rsp5 mutant: a new method of screening for calcineurin inhibitors. | 2014 | FEMS Yeast Res. | pmid:25035868 |
| Labrador J et al. | Risk factors for thrombotic microangiopathy in allogeneic hematopoietic stem cell recipients receiving GVHD prophylaxis with tacrolimus plus MTX or sirolimus. | 2014 | Bone Marrow Transplant. | pmid:24566710 |
| Goldberg NR et al. | Success with single-agent immunosuppression for multifocal choroidopathies. | 2014 | Am. J. Ophthalmol. | pmid:25194229 |
| Verma M et al. | Impact of single immunosuppressive drug withdrawal on lymphocyte immunoreactivity. | 2014 | J. Surg. Res. | pmid:24485875 |
| El-Sheikh AA et al. | Renal glucuronidation and multidrug resistance protein 2-/ multidrug resistance protein 4-mediated efflux of mycophenolic acid: interaction with cyclosporine and tacrolimus. | 2014 | Transl Res | pmid:24486136 |
| Carr L et al. | Calcineurin activity assay measurement by liquid chromatography-tandem mass spectrometry in the multiple reaction monitoring mode. | 2014 | Clin. Chem. | pmid:24281780 |
| Rehman S et al. | Effect of different tacrolimus levels on early outcomes after kidney transplantation. | 2014 | Ann. Transplant. | pmid:24509826 |
| Xie M et al. | Tacrolimus-related seizure after pediatric liver transplantation--a single-center experience. | 2014 | Pediatr Transplant | pmid:24283660 |
| Balato A et al. | Tacrolimus does not alter the production of several cytokines and antimicrobial peptide in Malassezia furfur-infected-keratinocytes. | 2014 | Mycoses | pmid:24512536 |
| Qin XL et al. | In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) on the CYP3A/P-glycoprotein-mediated absorption and metabolism of tacrolimus. | 2014 | Drug Metab. Dispos. | pmid:24195812 |
| Li CJ et al. | Impact of the CYP3A5, CYP3A4, COMT, IL-10 and POR genetic polymorphisms on tacrolimus metabolism in Chinese renal transplant recipients. | 2014 | PLoS ONE | pmid:24465960 |
| Silva-Cunha A et al. | Evaluation of the pharmacokinetics and ocular tolerance of a microemulsion containing tacrolimus. | 2014 | J Ocul Pharmacol Ther | pmid:24199740 |
| Diémé B et al. | Assessing the metabolic effects of calcineurin inhibitors in renal transplant recipients by urine metabolic profiling. | 2014 | Transplantation | pmid:24598938 |
| Oellerich M et al. | Use of graft-derived cell-free DNA as an organ integrity biomarker to reexamine effective tacrolimus trough concentrations after liver transplantation. | 2014 | Ther Drug Monit | pmid:24452066 |
| Suarez-Kurtz G et al. | Pharmacogenomic implications of population admixture: Brazil as a model case. | 2014 | Pharmacogenomics | pmid:24444410 |
| Kurzawski M et al. | CYP3A5 and CYP3A4, but not ABCB1 polymorphisms affect tacrolimus dose-adjusted trough concentrations in kidney transplant recipients. | 2014 | Pharmacogenomics | pmid:24444408 |
| Ducroux E et al. | Hidradenitis suppurativa after renal transplantation: complete remission after switching from oral cyclosporine to oral tacrolimus. | 2014 | J. Am. Acad. Dermatol. | pmid:25437996 |
| Xue F et al. | CYP3A5 genotypes affect tacrolimus pharmacokinetics and infectious complications in Chinese pediatric liver transplant patients. | 2014 | Pediatr Transplant | pmid:24438215 |
| Chen YK et al. | Personalized tacrolimus dose requirement by CYP3A5 but not ABCB1 or ACE genotyping in both recipient and donor after pediatric liver transplantation. | 2014 | PLoS ONE | pmid:25310192 |
| Fuchs U et al. | Clinical outcome in heart transplant recipients receiving everolimus in combination with dosage reduction of the calcineurin inhibitor cyclosporine A or tacrolimus. | 2014 | Transpl. Immunol. | pmid:24932812 |
| Zhu X et al. | Pilot study using tacrolimus rather than cyclosporine plus antithymocyte globulin as an immunosuppressive therapy regimen option for severe aplastic anemia in adults. | 2014 | Blood Cells Mol. Dis. | pmid:24931461 |
| Han N et al. | Population pharmacokinetic-pharmacogenetic model of tacrolimus in the early period after kidney transplantation. | 2014 | Basic Clin. Pharmacol. Toxicol. | pmid:24238261 |
| Taguchi K et al. | False tacrolimus concentrations measured by antibody-conjugated magnetic immunoassay in liver transplant patient: 2 case reports and literature review. | 2014 | Exp Clin Transplant | pmid:24206050 |
| Cho A et al. | Calcineurin signaling regulates neural induction through antagonizing the BMP pathway. | 2014 | Neuron | pmid:24698271 |
| Teraki Y | [Atopic dermatitis in pregnancy]. | 2014 | Arerugi | pmid:24714179 |
| Rangel EB | Tacrolimus in pancreas transplant: a focus on toxicity, diabetogenic effect and drug-drug interactions. | 2014 | Expert Opin Drug Metab Toxicol | pmid:25255841 |
| Casey MJ et al. | Prolonged immunosuppression preserves nonsensitization status after kidney transplant failure. | 2014 | Transplantation | pmid:24717218 |
| Trotter JF and Lizardo-Sanchez L | Everolimus in liver transplantation. | 2014 | Curr Opin Organ Transplant | pmid:25254569 |
| Stifft F et al. | Lower variability in 24-hour exposure during once-daily compared to twice-daily tacrolimus formulation in kidney transplantation. | 2014 | Transplantation | pmid:24686426 |
| Hirai F et al. | Impact of CYP3A5 genetic polymorphisms on the pharmacokinetics and short-term remission in patients with ulcerative colitis treated with tacrolimus. | 2014 | J. Gastroenterol. Hepatol. | pmid:24033383 |
| Funaro D et al. | A double-blind, randomized prospective study evaluating topical clobetasol propionate 0.05% versus topical tacrolimus 0.1% in patients with vulvar lichen sclerosus. | 2014 | J. Am. Acad. Dermatol. | pmid:24704090 |
| Doligalski CT et al. | Sublingual administration of tacrolimus: current trends and available evidence. | 2014 | Pharmacotherapy | pmid:25251980 |
| Burroughs LM et al. | Treosulfan-based conditioning and hematopoietic cell transplantation for nonmalignant diseases: a prospective multicenter trial. | 2014 | Biol. Blood Marrow Transplant. | pmid:25196857 |
| Ghanem RC et al. | Tacrolimus for the treatment of subepithelial infiltrates resistant to topical steroids after adenoviral keratoconjunctivitis. | 2014 | Cornea | pmid:25188789 |
| Ricciardelli I et al. | Towards gene therapy for EBV-associated posttransplant lymphoma with genetically modified EBV-specific cytotoxic T cells. | 2014 | Blood | pmid:25185261 |
| Mujtaba MA et al. | Conversion from tacrolimus to belatacept to prevent the progression of chronic kidney disease in pancreas transplantation: case report of two patients. | 2014 | Am. J. Transplant. | pmid:25179306 |
| Werk AN et al. | Identification and characterization of a defective CYP3A4 genotype in a kidney transplant patient with severely diminished tacrolimus clearance. | 2014 | Clin. Pharmacol. Ther. | pmid:24126681 |
| Chatterjea A et al. | Suppression of the immune system as a critical step for bone formation from allogeneic osteoprogenitors implanted in rats. | 2014 | J. Cell. Mol. Med. | pmid:24237965 |
| Mabe S et al. | Detecting protein-protein interactions based on kinase-mediated growth induction of mammalian cells. | 2014 | Sci Rep | pmid:25135216 |
| Sol Fustiñana M et al. | Protein degradation by ubiquitin-proteasome system in formation and labilization of contextual conditioning memory. | 2014 | Learn. Mem. | pmid:25135196 |
| Takeuchi T et al. | Tacrolimus-induced left ventricular apical hypertrophy in a patient with post-allogeneic hematopoietic stem cell transplantation. | 2014 | Int. J. Cardiol. | pmid:25131917 |
| Huang H et al. | Effect and mechanism of tacrolimus on melanogenesis on A375 human melanoma cells. | 2014 | Chin. Med. J. | pmid:25131236 |
| ZivÄić-Ćosić S et al. | Immune reactivity of renal transplant recipients receiving interleukin-2 receptor antagonists during the early posttransplant period. | 2014 | Int Urol Nephrol | pmid:23515930 |
| Wang B et al. | Multifaceted interaction of the traditional Chinese medicinal herb Schisandra chinensis with cytochrome P450-mediated drug metabolism in rats. | 2014 | J Ethnopharmacol | pmid:25091466 |
| Hadjipanagi D et al. | Genetic polymorphisms in warfarin and tacrolimus-related genes VKORC1, CYP2C9 and CYP3A5 in the Greek-Cypriot population. | 2014 | BMC Res Notes | pmid:24593903 |
| Bao J and Liang H | Tacrolimus-induced permanent asymptomatic pontine myelinolysis after liver transplantation. | 2014 | Intern. Med. | pmid:25088893 |
| Yan YH et al. | Role of FK506 binding protein 12 in morphine-induced μ-opioid receptor internalization and desensitization. | 2014 | Neurosci. Lett. | pmid:24607931 |
| Purani JM and Purani HJ | Treatment of geographic tongue with topical tacrolimus. | 2014 | BMJ Case Rep | pmid:25085945 |
| Kornblit B et al. | A randomized phase II trial of tacrolimus, mycophenolate mofetil and sirolimus after non-myeloablative unrelated donor transplantation. | 2014 | Haematologica | pmid:25085357 |
| Sethna CB and Gipson DS | Treatment of FSGS in Children. | 2014 | Adv Chronic Kidney Dis | pmid:24602468 |
| Bercaw-Pratt JL et al. | Clinical recommendation: pediatric lichen sclerosus. | 2014 | J Pediatr Adolesc Gynecol | pmid:24602304 |
| Demmers MW et al. | Substantial proliferation of human renal tubular epithelial cell-reactive CD4+CD28null memory T cells, which is resistant to tacrolimus and everolimus. | 2014 | Transplantation | pmid:24157471 |
| Kraus TS et al. | Angioimmunoblastic T cell lymphoma: an unusual presentation of posttransplant lymphoproliferative disorder in a pediatric patient. | 2014 | Acta Haematol. | pmid:24157860 |
| Hostettler KE et al. | Calcineurin inhibitors in bronchiolitis obliterans syndrome following stem cell transplantation. | 2014 | Eur. Respir. J. | pmid:23645405 |
| Thapa RK and Yoo BK | Evaluation of the effect of tacrolimus-loaded liquid crystalline nanoparticles on psoriasis-like skin inflammation. | 2014 | J Dermatolog Treat | pmid:23210668 |
| Viecelli A et al. | Diagnostic and management dilemma of a pancreas-kidney transplant recipient with aplastic anaemia. | 2014 | BMJ Case Rep | pmid:25257886 |
| Yamazoe K et al. | Efficacy and safety of systemic tacrolimus in high-risk penetrating keratoplasty after graft failure with systemic cyclosporine. | 2014 | Cornea | pmid:25255133 |
| Segarra-Medrano A et al. | Evolution of antibody titre against the M-type phospholipase A2 receptor and clinical response in idiopathic membranous nephropathy patients treated with tacrolimus. | 2014 | Nefrologia | pmid:25036063 |
| Boschetti G et al. | Tacrolimus induction followed by maintenance monotherapy is useful in selected patients with moderate-to-severe ulcerative colitis refractory to prior treatment. | 2014 | Dig Liver Dis | pmid:25023007 |
| John K et al. | Role of dendritic cells in the context of acute cellular rejection: comparison between tacrolimus- or cyclosporine A-treated heart transplanted recipients. | 2014 | Cytometry B Clin Cytom | pmid:24668729 |
| Okamoto T et al. | Clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with febrile urinary tract infection. | 2014 | Eur. J. Pediatr. | pmid:24221606 |
| Personett HA et al. | Impact of molecular adsorbent recirculating system therapy on tacrolimus elimination: a case report. | 2014 | Transplant. Proc. | pmid:25017243 |
| Steinebrunner N et al. | Reduced residual gene expression of nuclear factor of activated T cells-regulated genes correlates with the risk of cytomegalovirus infection after liver transplantation. | 2014 | Transpl Infect Dis | pmid:24666466 |
| Levinger E et al. | Topical 0.03% tacrolimus for subepithelial infiltrates secondary to adenoviral keratoconjunctivitis. | 2014 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:24696044 |
| GoriaÄnov VA et al. | [Effect of tacrolimus on the results of living related kidney donor transplantation]. | 2014 | Ter. Arkh. | pmid:25095659 |
| Shilpa PS et al. | Topical tacrolimus in the management of oral lichen planus: literature review. | 2014 | J Calif Dent Assoc | pmid:25080722 |
| Kuramitsu S et al. | [Case report of introducing MMF and steroids as an immunosuppressive therapy after living-donor liver transplantation for a patient with the diabetic nephropathy]. | 2014 | Fukuoka Igaku Zasshi | pmid:25000660 |
| Kluk J et al. | Follicular mucinosis treated with topical 0.1% tacrolimus ointment. | 2014 | Clin. Exp. Dermatol. | pmid:24252117 |
| Matsumoto K et al. | [Perioperative agranulocytosis induced by immunosuppressants in a renal graft recipient : a case report]. | 2014 | Hinyokika Kiyo | pmid:25001642 |
| Friedrich RB et al. | Nanoencapsulation of tacrolimus in lipid-core nanocapsules showed similar immunosuppressive activity after oral and intraperitoneal administrations. | 2014 | J Biomed Nanotechnol | pmid:25016659 |
| Rostaing L et al. | The pharmacokinetics of everolimus in de novo kidney transplant patients receiving tacrolimus: an analysis from the randomized ASSET study. | 2014 | Ann. Transplant. | pmid:25017487 |
| Nomura H et al. | A patient with lupus miliaris disseminatus faciei treated successfully with a combination of oral metronidazole and topical tacrolimus. | 2014 | J. Dermatol. | pmid:24931738 |
| Rahman Z et al. | Near-infrared and fourier transform infrared chemometric methods for the quantification of crystalline tacrolimus from sustained-release amorphous solid dispersion. | 2014 | J Pharm Sci | pmid:24931728 |
| Kim SH et al. | Expression, purification and characterization of soluble recombinant peptidyl-prolyl cis/trans isomerase from Vibrio anguillarum. | 2014 | Protein Expr. Purif. | pmid:24931498 |
| Enderby CY et al. | Tacrolimus dosage requirements in lung transplant recipients receiving antifungal prophylaxis with voriconazole followed by itraconazole: a preliminary prospective study. | 2014 | Clin Transplant | pmid:24931421 |
| Liu Z et al. | Tacrolimus-based versus cyclosporine-based immunosuppression in hepatitis C virus-infected patients after liver transplantation: a meta-analysis and systematic review. | 2014 | PLoS ONE | pmid:25198195 |
| Tran D et al. | Conversion from twice-daily to once-daily extended-release tacrolimus in renal transplant recipients: 2-year results and review of the literature. | 2014 | Exp Clin Transplant | pmid:24844288 |
| Feng S et al. | A rapidly reversible chemical dimerizer system to study lipid signaling in living cells. | 2014 | Angew. Chem. Int. Ed. Engl. | pmid:24841150 |
| Kahvecioglu S et al. | Effects of calcineurin inhibitors on paraoxonase and arylesterase activity after a kidney transplant. | 2014 | Exp Clin Transplant | pmid:24447269 |
| Doren EL and Aya-ay ML | Pyoderma gangrenosum following breast reduction: treatment with topical tacrolimus and steroids. | 2014 | Aesthet Surg J | pmid:24448967 |
| Lin YH and Pratt MR | A dual small-molecule rheostat for precise control of protein concentration in Mammalian cells. | 2014 | Chembiochem | pmid:24615791 |
| Hashi S et al. | Assessment of four methodologies (microparticle enzyme immunoassay, chemiluminescent enzyme immunoassay, affinity column-mediated immunoassay, and flow injection assay-tandem mass spectrometry) for measuring tacrolimus blood concentration in Japanese liver transplant recipients. | 2014 | Transplant. Proc. | pmid:24767342 |
| Uemoto S et al. | Safety and efficacy of once-daily modified-release tacrolimus in liver transplant recipients: a multicenter postmarketing surveillance in Japan. | 2014 | Transplant. Proc. | pmid:24767340 |
| Yamanaka M et al. | Development and evaluation of a tacrolimus cream formulation using a binary solvent system. | 2014 | Int J Pharm | pmid:24456671 |
| Levy G et al. | REFINE: a randomized trial comparing cyclosporine A and tacrolimus on fibrosis after liver transplantation for hepatitis C. | 2014 | Am. J. Transplant. | pmid:24456049 |
| Muduma G et al. | A UK analysis of the cost of switching renal transplant patients from an immediate-release to a prolonged-release formulation of tacrolimus based on differences in trough concentration variability. | 2014 | J Med Econ | pmid:24754700 |
| Parashos SA et al. | Measuring disease progression in early Parkinson disease: the National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) experience. | 2014 | JAMA Neurol | pmid:24711047 |
| Bloch J et al. | Donor ABCB1 genetic polymorphisms influence epithelial-to-mesenchyme transition in tacrolimus-treated kidney recipients. | 2014 | Pharmacogenomics | pmid:25521359 |
| Chen Y et al. | Comparison of long-term impact of immunosuppressants at therapeutic doses on hepatic function and histological changes in unilateral nephrectomized rats. | 2014 | Exp. Toxicol. Pathol. | pmid:25081300 |
| DÃaz-GarcÃa C et al. | Pregnancy after allogeneic uterus transplantation in the rat: perinatal outcome and growth trajectory. | 2014 | Fertil. Steril. | pmid:25439799 |
| Ibrahim O et al. | The role of infliximab in the treatment of superficial granulomatous pyoderma of the head and neck. | 2014 | J. Am. Acad. Dermatol. | pmid:25438004 |
| Kraaij MD et al. | Human monocytes produce interferon-gamma upon stimulation with LPS. | 2014 | Cytokine | pmid:24680476 |
| Sawamoto K et al. | Mechanisms of lower maintenance dose of tacrolimus in obese patients. | 2014 | Drug Metab. Pharmacokinet. | pmid:24670405 |
| Xie M et al. | Brucellosis infection in an adult liver transplant recipient. | 2014 | Transpl Infect Dis | pmid:24666385 |
| Takazono T et al. | Paradoxical response to disseminated non-tuberculosis mycobacteriosis treatment in a patient receiving tumor necrosis factor-α inhibitor: a case report. | 2014 | BMC Infect. Dis. | pmid:24576098 |