tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Garg V et al. | Topical tacrolimus nanoemulsion, a promising therapeutic approach for uveitis. | 2013 | Med. Hypotheses | pmid:24018283 |
| Gökceoğlu AU et al. | Circulating endothelial cells in pediatric renal transplant recipients. | 2013 | Pediatr. Nephrol. | pmid:24018796 |
| Kim YJ et al. | Impact of combined acute rejection on BK virus-associated nephropathy in kidney transplantation. | 2013 | J. Korean Med. Sci. | pmid:24339698 |
| Carcas-Sansuán AJ et al. | Conversion from Prograf to Advagraf in adolescents with stable liver transplants: comparative pharmacokinetics and 1-year follow-up. | 2013 | Liver Transpl. | pmid:23894093 |
| Howell J et al. | Cyclosporine and tacrolimus have inhibitory effects on toll-like receptor signaling after liver transplantation. | 2013 | Liver Transpl. | pmid:23894100 |
| Danielsen AA et al. | Splice cassette II of Na+,HCO3(-) cotransporter NBCn1 (slc4a7) interacts with calcineurin A: implications for transporter activity and intracellular pH control during rat artery contractions. | 2013 | J. Biol. Chem. | pmid:23382378 |
| Zhang CW et al. | [Establishment of a real-time PCR assay for simultaneously detecting human BKV and CMV DNA and its application in renal transplantation recipients]. | 2013 | Bing Du Xue Bao | pmid:23895006 |
| Cardona M et al. | [Association of everolimus with tacrolimus during the first year after heart transplantation: initial experience]. | 2013 | Med Clin (Barc) | pmid:23384432 |
| Yildirim R et al. | Treatment of pure red-cell aplasia with cyclosporine in a renal transplant patient. | 2013 | Exp Clin Transplant | pmid:22891934 |
| März AM et al. | Large FK506-binding proteins shape the pharmacology of rapamycin. | 2013 | Mol. Cell. Biol. | pmid:23358420 |
| Danby SG and Cork MJ | The effects of pimecrolimus on the innate immune response in atopic dermatitis. | 2013 | Br. J. Dermatol. | pmid:23362967 |
| Chen W et al. | Outcomes of tacrolimus therapy in adults with refractory membranous nephrotic syndrome: a prospective, multicenter clinical trial. | 2013 | Am. J. Med. Sci. | pmid:22627258 |
| Uesugi M et al. | Influence of cytochrome P450 (CYP) 3A4*1G polymorphism on the pharmacokinetics of tacrolimus, probability of acute cellular rejection, and mRNA expression level of CYP3A5 rather than CYP3A4 in living-donor liver transplant patients. | 2013 | Biol. Pharm. Bull. | pmid:24189425 |
| Nakase H | [Tacrolimus therapy for patients with ulcerative colitis]. | 2013 | Nihon Shokakibyo Gakkai Zasshi | pmid:24189819 |
| Abei M et al. | [Nonspecific reacting materials that interferes tacrolimus assay by ACMIA]. | 2013 | Rinsho Byori | pmid:24450102 |
| Yuda S et al. | [Sodium-losing nephropathy caused by tacrolimus after allogeneic hematopoietic stem cell transplantation]. | 2013 | Rinsho Ketsueki | pmid:24452151 |
| Nakane S | [Calcineurin inhibitors and IVIg in the treatment of myasthenia gravis]. | 2013 | Rinsho Shinkeigaku | pmid:24291970 |
| Nanaeva BA and Vardanian AV | [Tacrolimus in perianal manifestations of Crohn's disease]. | 2013 | Eksp Klin Gastroenterol | pmid:24294772 |
| Beckebaum S et al. | Calcineurin inhibitors in liver transplantation - still champions or threatened by serious competitors? | 2013 | Liver Int. | pmid:23442173 |
| Kovacs D et al. | Follow up of lung transplant recipients using an electronic nose. | 2013 | J Breath Res | pmid:23445553 |
| Gijsen VM et al. | Prevalence of renal dysfunction in tacrolimus-treated pediatric transplant recipients: a systematic review. | 2013 | Pediatr Transplant | pmid:23448292 |
| Okamoto M et al. | Successful treatment with tacrolimus in a case of lung-dominant connective tissue disease. | 2013 | Intern. Med. | pmid:23448773 |
| Muili KA et al. | Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin. | 2013 | J. Biol. Chem. | pmid:23148215 |
| Li H et al. | Immunosuppressant-related hip pain after orthotopic liver transplant. | 2013 | Exp Clin Transplant | pmid:22813534 |
| Brzezińska B et al. | Factors associated with glucose metabolism disorders after kidney transplantation. | 2013 | Endokrynol Pol | pmid:23450443 |
| Marente VC et al. | Modigraf administration through jejunostomy in liver transplant recipient: case report. | 2013 | Transplant. Proc. | pmid:24314992 |
| Telkes G et al. | Kidney transplantation in hereditary coproporphyria using tacrolimus and mycophenolate mofetil: a case report. | 2013 | Transplant. Proc. | pmid:24315002 |
| Azzi JR et al. | Calcineurin inhibitors: 40 years later, can't live without ... | 2013 | J. Immunol. | pmid:24319282 |
| Praehauser C et al. | Risk factors and outcome of expanded-criteria donor kidney transplants in patients with low immunological risk. | 2013 | Swiss Med Wkly | pmid:24222631 |
| Sun JY et al. | [Association of CYP3A5 and MDR1 genetic polymorphisms with the blood concentration of tacrolimus in Chinese liver and renal transplant recipients]. | 2013 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:24059111 |
| Kim CR and Lee DY | Combination of narrow-band ultraviolet B and topical tacrolimus is effective for segmental vitiligo. | 2013 | Int. J. Dermatol. | pmid:24073911 |
| Ali FR and Lyon CC | Tacrolimus toxicity following topical treatment of perianal Crohn's disease: an admonitory anecdote. | 2013 | J Crohns Colitis | pmid:24076430 |
| Orange DE et al. | Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo. | 2013 | Elife | pmid:23390586 |
| Tanaka T et al. | Evaluation of immune function under conversion from Prograf to Advagraf in living donor liver transplantation. | 2013 | Ann. Transplant. | pmid:23792533 |
| Pérez-López FR et al. | EMAS clinical guide: vulvar lichen sclerosus in peri and postmenopausal women. | 2013 | Maturitas | pmid:23291001 |
| Tsuchiya T et al. | Comparison of pharmacokinetics and pathology for low-dose tacrolimus once-daily and twice-daily in living kidney transplantation: prospective trial in once-daily versus twice-daily tacrolimus. | 2013 | Transplantation | pmid:23792649 |
| Ercan Z et al. | Kaposi's sarcoma in the early post-transplant period in a kidney transplant recipient. | 2013 | Nefrologia | pmid:24241380 |
| Skytte DM et al. | Some transformations of tacrolimus, an immunosuppressive drug. | 2013 | Eur J Pharm Sci | pmid:23238171 |
| Kosugi K et al. | A longitudinal study of the effect of experimental osteoporosis on bone trabecular structure in the rat mandibular condyle. | 2013 | Cranio | pmid:23795404 |
| Issa N et al. | Calcineurin inhibitor nephrotoxicity: a review and perspective of the evidence. | 2013 | Am. J. Nephrol. | pmid:23796509 |
| Durand P et al. | Tacrolimus dose requirement in pediatric liver transplantation: influence of CYP3A5 gene polymorphism. | 2013 | Pharmacogenomics | pmid:23837476 |
| Honda A et al. | Omission of day-11 MTX, in combination with tacrolimus, is not associated with increased risk of acute graft-versus-host disease after allo-BMT. | 2013 | Bone Marrow Transplant. | pmid:22751000 |
| Pitarch G and Giner F | Periorbital necrobiosis lipoidica. | 2013 | Actas Dermosifiliogr | pmid:23871211 |
| Piram M et al. | Short- and long-term outcome of linear morphoea in children. | 2013 | Br. J. Dermatol. | pmid:24032480 |
| Mouzaki M et al. | Basiliximab with delayed introduction of calcineurin inhibitors as a renal-sparing protocol following liver transplantation in children with renal impairment. | 2013 | Pediatr Transplant | pmid:24118898 |
| Vannaprasaht S et al. | Personalized tacrolimus doses determined by CYP3A5 genotype for induction and maintenance phases of kidney transplantation. | 2013 | Clin Ther | pmid:24120259 |
| Prud'homme GJ et al. | GABA protects human islet cells against the deleterious effects of immunosuppressive drugs and exerts immunoinhibitory effects alone. | 2013 | Transplantation | pmid:23851932 |
| Hilbrands R et al. | Predictive factors of allosensitization after immunosuppressant withdrawal in recipients of long-term cultured islet cell grafts. | 2013 | Transplantation | pmid:23857001 |
| Wang SE et al. | Hepatic veno-occlusive disease related to tacrolimus after pancreas transplantation. | 2013 | J Chin Med Assoc | pmid:23602212 |
| Fujii H et al. | Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineurin. | 2013 | Cell Rep | pmid:23602566 |
| Hodge G et al. | Up-regulation of alternate co-stimulatory molecules on proinflammatory CD28null T cells in bronchiolitis obliterans syndrome. | 2013 | Clin. Exp. Immunol. | pmid:23607447 |
| Ben Fredj N et al. | Tacrolimus therapeutic drug monitoring in Tunisian renal transplant recipients: effect of post-transplantation period. | 2013 | Transpl. Immunol. | pmid:23608723 |
| Yin ZQ et al. | Effects of topical tacrolimus 0.03% on long-term suberythemal ultraviolet B-irradiated epidermal Langerhans cells in mice. | 2013 | J Eur Acad Dermatol Venereol | pmid:22471949 |
| Hammerstrom AE et al. | Tacrolimus-associated posterior reversible encephalopathy syndrome in hematopoietic allogeneic stem cell transplantation. | 2013 | Am. J. Hematol. | pmid:23460378 |
| Sung J et al. | Alemtuzumab induction with tacrolimus monotherapy in 25 pediatric renal transplant recipients. | 2013 | Pediatr Transplant | pmid:24164824 |
| Briem-Richter A et al. | Peripheral blood biomarkers for the characterization of alloimmune reactivity after pediatric liver transplantation. | 2013 | Pediatr Transplant | pmid:24164827 |
| Shayani S et al. | Thrombotic microangiopathy associated with sirolimus level after allogeneic hematopoietic cell transplantation with tacrolimus/sirolimus-based graft-versus-host disease prophylaxis. | 2013 | Biol. Blood Marrow Transplant. | pmid:23078784 |
| Sheu JJ et al. | Innate immune response after acute myocardial infarction and pharmacomodulatory action of tacrolimus in reducing infarct size and preserving myocardial integrity. | 2013 | J. Biomed. Sci. | pmid:24165293 |
| McDiarmid SV | Adolescence: challenges and responses. | 2013 | Liver Transpl. | pmid:24166838 |
| Jensen JM et al. | Effects of pimecrolimus compared with triamcinolone acetonide cream on skin barrier structure in atopic dermatitis: a randomized, double-blind, right-left arm trial. | 2013 | Acta Derm. Venereol. | pmid:23571785 |
| Gorgan M et al. | Pulmonary hemorrhage with capillaritis secondary to mycophenolate mofetil in a heart-transplant patient. | 2013 | Arch. Pathol. Lab. Med. | pmid:24168511 |
| Lower DR et al. | Comparison of CEDIA FK506 assay with HPLC/MS/MS in a large cohort of pediatric patients. | 2013 | Am. J. Clin. Pathol. | pmid:23690122 |
| Vafadari R et al. | Tacrolimus inhibits NF-κB activation in peripheral human T cells. | 2013 | PLoS ONE | pmid:23573283 |
| Dai Y et al. | Liposomes containing bile salts as novel ocular delivery systems for tacrolimus (FK506): in vitro characterization and improved corneal permeation. | 2013 | Int J Nanomedicine | pmid:23690687 |
| Sinha R and Marks SD | Tacrolimus toxicity secondary to diarrhoea in nephrotic syndrome. | 2013 | Acta Paediatr. | pmid:23573873 |
| Takada Y et al. | Randomized, multicenter trial comparing tacrolimus plus mycophenolate mofetil to tacrolimus plus steroids in hepatitis C virus-positive recipients of living donor liver transplantation. | 2013 | Liver Transpl. | pmid:23696054 |
| Keating GM and Lyseng-Williamson KA | Everolimus: a guide to its use in liver transplantation. | 2013 | BioDrugs | pmid:23696253 |
| Trotter JF et al. | Early use of renal-sparing agents in liver transplantation: a closer look. | 2013 | Liver Transpl. | pmid:23696464 |
| Matsumoto A et al. | [A case of tacrolimus plus intensive LCAP therapy combination for refractory ulcerative colitis]. | 2013 | Nihon Shokakibyo Gakkai Zasshi | pmid:23558127 |
| Muramatsu H and Nagai K | Streptomyces tsukubensis sp. nov., a producer of the immunosuppressant tacrolimus. | 2013 | J. Antibiot. | pmid:23299187 |
| Yamaguchi K et al. | Limited sampling strategy for the estimation of mycophenolic acid area under the concentration-time curve treated in Japanese living-related renal transplant recipients with concomitant extended-release tacrolimus. | 2013 | Biol. Pharm. Bull. | pmid:23558676 |
| van Maarseveen E and van Zuilen AD | Pretransplantation pharmacokinetic assessments to predict posttransplantation dosing requirements in renal transplant recipients: what is known? | 2013 | Clin. Pharmacol. Ther. | pmid:23299646 |
| Zheng S et al. | Tacrolimus placental transfer at delivery and neonatal exposure through breast milk. | 2013 | Br J Clin Pharmacol | pmid:23528073 |
| Ishii T et al. | Treatment of cerebral ischemia-reperfusion injury with PEGylated liposomes encapsulating FK506. | 2013 | FASEB J. | pmid:23241312 |
| Nwaba A et al. | Tacrolimus-induced thrombotic microangiopathy in orthotopic liver transplant patients: case series of four patients. | 2013 | Intern Med J | pmid:23441660 |
| Hofmann M et al. | Validation of Dermaphot(®) for the assessment of steroid-induced skin atrophy. | 2013 | Arch. Dermatol. Res. | pmid:23242470 |
| Koop DR et al. | Analysis of tacrolimus and creatinine from a single dried blood spot using liquid chromatography tandem mass spectrometry. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23548676 |
| Kita J et al. | Significant improvement in MRI-proven bone edema is associated with protection from structural damage in very early RA patients managed using the tight control approach. | 2013 | Mod Rheumatol | pmid:22669596 |
| Lewis RE et al. | Tacrolimus enhances the potency of posaconazole against Rhizopus oryzae in vitro and in an experimental model of mucormycosis. | 2013 | J. Infect. Dis. | pmid:23242544 |
| Nakagawa Y et al. | Induction of rapid apoptosis for class I MHC molecule-restricted CD8(+) HIV-1 gp160-specific murine activated CTLs by free antigenic peptide in vivo. | 2013 | Int. Immunol. | pmid:22945875 |
| Schneeberger S et al. | Upper-extremity transplantation using a cell-based protocol to minimize immunosuppression. | 2013 | Ann. Surg. | pmid:23001085 |
| Pinelli NR et al. | Coadministration of liraglutide with tacrolimus in kidney transplant recipients: a case series. | 2013 | Diabetes Care | pmid:24065848 |
| McNeil C | Preventing graft-versus-host disease: transplanters glimpse hope beyond immunosuppressants. | 2013 | J. Natl. Cancer Inst. | pmid:23781000 |
| Ramser EM et al. | Amyloid-β oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons. | 2013 | Mol. Biol. Cell | pmid:23783030 |
| Bien CG et al. | Rasmussen encephalitis: incidence and course under randomized therapy with tacrolimus or intravenous immunoglobulins. | 2013 | Epilepsia | pmid:23216622 |
| Niioka T et al. | Pharmaceutical and genetic determinants for interindividual differences of tacrolimus bioavailability in renal transplant recipients. | 2013 | Eur. J. Clin. Pharmacol. | pmid:23733010 |
| Tanaka Y et al. | Prevention of joint destruction by tacrolimus in patients with early rheumatoid arthritis: a post hoc analysis of a double-blind, randomized, placebo-controlled study. | 2013 | Mod Rheumatol | pmid:23271170 |
| Murase S | Signal transducer and activator of transcription 3 (STAT3) degradation by proteasome controls a developmental switch in neurotrophin dependence. | 2013 | J. Biol. Chem. | pmid:23733189 |
| Min SI et al. | Conversion of twice-daily tacrolimus to once-daily tacrolimus formulation in stable pediatric kidney transplant recipients: pharmacokinetics and efficacy. | 2013 | Am. J. Transplant. | pmid:23734831 |
| Egli A et al. | Comparison of the effect of standard and novel immunosuppressive drugs on CMV-specific T-cell cytokine profiling. | 2013 | Transplantation | pmid:23274966 |
| Borrego-Utiel FJ et al. | Painful gynaecomastia secondary to cyclosporine A and tacrolimus in a patient with focal segmental glomerulosclerosis. | 2013 | Nefrologia | pmid:24241383 |
| Quigley MA et al. | Development of a reliable model of total abdominal wall transplantation. | 2013 | Plast. Reconstr. Surg. | pmid:24076687 |
| Sha T et al. | Establishment and validation of a new semi-chronic dextran sulfate sodium-induced model of colitis in mice. | 2013 | Int. Immunopharmacol. | pmid:23142502 |
| Boyer NL et al. | Tacrolimus-associated thrombotic microangiopathy in a lung transplant recipient. | 2013 | BMJ Case Rep | pmid:23396921 |
| Bramham K et al. | Breastfeeding and tacrolimus: serial monitoring in breast-fed and bottle-fed infants. | 2013 | Clin J Am Soc Nephrol | pmid:23349333 |
| Khaled SK et al. | A phase II study of sirolimus, tacrolimus and rabbit anti-thymocyte globulin as GVHD prophylaxis after unrelated-donor PBSC transplant. | 2013 | Bone Marrow Transplant. | pmid:23000644 |
| Mei Y et al. | Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107. | 2013 | PLoS ONE | pmid:23349825 |
| MartÃnez-Castro M et al. | Taxonomy and chemically semi-defined media for the analysis of the tacrolimus producer 'Streptomyces tsukubaensis'. | 2013 | Appl. Microbiol. Biotechnol. | pmid:22990582 |
| Gladstone DE et al. | Partially mismatched transplantation and human leukocyte antigen donor-specific antibodies. | 2013 | Biol. Blood Marrow Transplant. | pmid:23353119 |
| Nara M et al. | Effect of itraconazole on the concentrations of tacrolimus and cyclosporine in the blood of patients receiving allogeneic hematopoietic stem cell transplants. | 2013 | Eur. J. Clin. Pharmacol. | pmid:23354810 |