Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Suetsugu K et al. | Analysis of the variable factors influencing tacrolimus blood concentration during the switch from continuous intravenous infusion to oral administration after allogeneic hematopoietic stem cell transplantation. | 2017 | Int. J. Hematol. | pmid:27822915 |
Kharfan-Dabaja MA et al. | Tacrolimus plus sirolimus with or without ATG as GVHD prophylaxis in HLA-mismatched unrelated donor allogeneic stem cell transplantation. | 2017 | Bone Marrow Transplant. | pmid:27819684 |
Trasi NS et al. | Non-Sink Dissolution Behavior and Solubility Limit of Commercial Tacrolimus Amorphous Formulations. | 2017 | J Pharm Sci | pmid:27816263 |
Wang C et al. | Combining metabolomics and network analysis to improve tacrolimus production in Streptomyces tsukubaensis using different exogenous feedings. | 2017 | J. Ind. Microbiol. Biotechnol. | pmid:28776273 |
Lim SW et al. | Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress. | 2017 | Cell Death Dis | pmid:28771227 |
Savaj S et al. | Irreversible Lesions of Tacrolimus-induced Posterior Reversible Leukoencephalopathy Syndrome. | 2017 | Iran J Kidney Dis | pmid:29190599 |
Shahid S et al. | Chronic hepatitis in the transplant patient. | 2017 | Br J Hosp Med (Lond) | pmid:28692371 |
Liao JH et al. | Gene Variations of Sixth Complement Component Affecting Tacrolimus Metabolism in Patients with Liver Transplantation for Hepatocellular Carcinoma. | 2017 | Chin. Med. J. | pmid:28685716 |
An Q et al. | High Colonization and Impaired Permeability Barrier in Facial Seborrheic Dermatitis. | 2017 | Chin. Med. J. | pmid:28685715 |
Gao L et al. | Synergistic Effects of Tacrolimus and Azoles against Exophiala dermatitidis. | 2017 | Antimicrob. Agents Chemother. | pmid:28923863 |
Ginocchio L et al. | Refractory Ulcerated Necrobiosis Lipoidica: Closure of a Difficult Wound with Topical Tacrolimus. | 2017 | Adv Skin Wound Care | pmid:28914682 |
Liang Q et al. | The efficacy and safety of tacrolimus monotherapy in adult-onset nephrotic syndrome caused by idiopathic membranous nephropathy. | 2017 | Ren Fail | pmid:28562168 |
Zhang J et al. | MicroRNA expression analysis during FK506-induced osteogenic differentiation in rat bone marrow stromal cells. | 2017 | Mol Med Rep | pmid:28560399 |
Asada A et al. | The effect of CYP3A5 genetic polymorphisms on adverse events in patients with ulcerative colitis treated with tacrolimus. | 2017 | Dig Liver Dis | pmid:27717793 |
Park SS et al. | Beneficial Role of Low-Dose Antithymocyte Globulin in Unrelated Stem Cell Transplantation for Adult Patients with Acquired Severe Aplastic Anemia: Reduction of Graft-versus-Host Disease and Improvement of Graft-versus-Host Disease-Free, Failure-Free Survival Rate. | 2017 | Biol. Blood Marrow Transplant. | pmid:28554856 |
Jin H et al. | Inappropriate amounts of topical tacrolimus applied on Korean patients with eczema. | 2017 | J Dermatolog Treat | pmid:27588441 |
Seo SR et al. | Disrupted Skin Barrier is Associated with Burning Sensation after Topical Tacrolimus Application in Atopic Dermatitis. | 2017 | Acta Derm. Venereol. | pmid:28512670 |
Shen CL et al. | Tacrolimus Blood Level Fluctuation Predisposes to Coexisting BK Virus Nephropathy and Acute Allograft Rejection. | 2017 | Sci Rep | pmid:28512328 |
Egeland EJ et al. | High Tacrolimus Clearance Is a Risk Factor for Acute Rejection in the Early Phase After Renal Transplantation. | 2017 | Transplantation | pmid:28452920 |
Kofod L et al. | Endometrial immune markers are potential predictors of normal fertility and pregnancy after in vitro fertilization. | 2017 | Am. J. Reprod. Immunol. | pmid:28440588 |
Banovic F et al. | Therapeutic effectiveness of calcineurin inhibitors in canine vesicular cutaneous lupus erythematosus. | 2017 | Vet. Dermatol. | pmid:28439997 |
Labroo P et al. | Effect Of combining FK506 and neurotrophins on neurite branching and elongation. | 2017 | Muscle Nerve | pmid:27503321 |
Zhang H et al. | Multitarget Therapy for Maintenance Treatment of Lupus Nephritis. | 2017 | J. Am. Soc. Nephrol. | pmid:28760751 |
Aktürk S et al. | Average Tacrolimus Trough Level in the First Month After Transplantation May Predict Acute Rejection. | 2017 | Transplant. Proc. | pmid:28340806 |
Calo S et al. | A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides. | 2017 | PLoS Genet. | pmid:28339467 |
Vanhove T et al. | Effect of ABCB1 diplotype on tacrolimus disposition in renal recipients depends on CYP3A5 and CYP3A4 genotype. | 2017 | Pharmacogenomics J. | pmid:27378609 |
Riva N et al. | Therapeutic monitoring of pediatric transplant patients with conversion to generic tacrolimus. | 2017 | Farm Hosp | pmid:28236795 |
Madsen MJ et al. | The Pharmacogenetics of Tacrolimus in Corticosteroid-Sparse Pediatric and Adult Kidney Transplant Recipients. | 2017 | Drugs R D | pmid:28229376 |
Vanhove T et al. | Determinants of the Magnitude of Interaction Between Tacrolimus and Voriconazole/Posaconazole in Solid Organ Recipients. | 2017 | Am. J. Transplant. | pmid:28224698 |
Sahutoglu T et al. | Tac-MMF Versus CsA-MMF/CsA-AZA-Based Regimens in Development of De Novo Complement-Binding Anti-HLA Antibodies After Kidney Transplantation. | 2017 | Transplant. Proc. | pmid:28340811 |
Størset E et al. | The CYP3A biomarker 4β-hydroxycholesterol does not improve tacrolimus dose predictions early after kidney transplantation. | 2017 | Br J Clin Pharmacol | pmid:28146606 |
Dai Y et al. | A case report of coup de sabre patient with hair transplantation. | 2017 | J Dermatolog Treat | pmid:28142293 |
Shihab F et al. | Association of Clinical Events With Everolimus Exposure in Kidney Transplant Patients Receiving Low Doses of Tacrolimus. | 2017 | Am. J. Transplant. | pmid:28141897 |
Chu CH et al. | Radiation recall dermatitis induced by topical tacrolimus for post-irradiation morphea. | 2017 | J Eur Acad Dermatol Venereol | pmid:27256845 |
Pensi D et al. | First UHPLC-MS/MS method coupled with automated online SPE for quantification both of tacrolimus and everolimus in peripheral blood mononuclear cells and its application on samples from co-treated pediatric patients. | 2017 | J Mass Spectrom | pmid:28098395 |
Lewis K et al. | Autoimmune enteropathy and hepatitis in pediatric heart transplant recipient. | 2017 | Pediatr Transplant | pmid:28097735 |
Sommer W et al. | Irradiation before and donor splenocyte infusion immediately after transplantation induce tolerance to lung, but not heart allografts in miniature swine. | 2017 | Transpl. Int. | pmid:28095640 |
Hayes W et al. | Hypomagnesemia and increased risk of new-onset diabetes mellitus after transplantation in pediatric renal transplant recipients. | 2017 | Pediatr. Nephrol. | pmid:28039534 |
Carnevale-Schianca F et al. | Post-Transplant Cyclophosphamide and Tacrolimus-Mycophenolate Mofetil Combination Prevents Graft-versus-Host Disease in Allogeneic Peripheral Blood Hematopoietic Cell Transplantation from HLA-Matched Donors. | 2017 | Biol. Blood Marrow Transplant. | pmid:28039079 |
Srivastava AK et al. | Serial in vivo imaging of transplanted allogeneic neural stem cell survival in a mouse model of amyotrophic lateral sclerosis. | 2017 | Exp. Neurol. | pmid:28038988 |
Wang L et al. | Efficacy and safety of tacrolimus for myasthenia gravis: a systematic review and meta-analysis. | 2017 | J. Neurol. | pmid:28921038 |
Hu Y et al. | FK506 suppresses hypoxia‑induced inflammation and protects tight junction function via the CaN‑NFATc1 signaling pathway in retinal microvascular epithelial cells. | 2017 | Mol Med Rep | pmid:28901449 |
Spiekerkoetter E et al. | Randomised placebo-controlled safety and tolerability trial of FK506 (tacrolimus) for pulmonary arterial hypertension. | 2017 | Eur. Respir. J. | pmid:28893866 |
Watanabe M et al. | Successful treatment of calcineurin inhibitor-induced pain syndrome with acute graft versus host disease by switching calcineurin inhibitors followed by pregabalin. | 2017 | Ann. Hematol. | pmid:28508935 |
Kalt DA | Tacrolimus: A Review of Laboratory Detection Methods and Indications for Use. | 2017 | Lab Med | pmid:29096030 |
Andrews LM et al. | Pharmacokinetic considerations related to therapeutic drug monitoring of tacrolimus in kidney transplant patients. | 2017 | Expert Opin Drug Metab Toxicol | pmid:29084469 |
Noceti O et al. | Activity of the Calcineurin Pathway in Patients on the Liver Transplantation Waiting List: Factors of Variability and Response to Tacrolimus Inhibition. | 2017 | Clin. Chem. | pmid:29054923 |
Vanhove T et al. | Pretransplant 4β-hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation. | 2017 | Br J Clin Pharmacol | pmid:28603840 |
Whitehouse G et al. | IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:28584086 |
Al-Kadhimi Z et al. | Low incidence of severe cGvHD and late NRM in a phase II trial of thymoglobulin, tacrolimus and sirolimus for GvHD prevention. | 2017 | Bone Marrow Transplant. | pmid:28581472 |