tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Candinas D et al. | Efficacy of leflunomide in combination with current immunosuppressive agents in rat cardiac allotransplantation. | 1994 | Transplant. Proc. | pmid:7527959 |
| Tanabe K et al. | Japanese single-center experience of kidney transplantation under tacrolimus immunosuppression. | 2000 | Transplant. Proc. | pmid:11119897 |
| Alessiani M et al. | Adverse effects of FK 506 overdosage after liver transplantation. | 1993 | Transplant. Proc. | pmid:7679825 |
| Nishikawa K et al. | Experimental studies of vascularized joint allografts in rats. | 1994 | Transplant. Proc. | pmid:7513482 |
| Kobayashi M et al. | FK 506 assay past and present--characteristics of FK 506 ELISA. | 1991 | Transplant. Proc. | pmid:1721258 |
| Bechstein WO et al. | Tacrolimus (FK 506) therapy is associated with a significant reduction in immunosuppressive treatment failures following primary liver transplantation. | 1996 | Transplant. Proc. | pmid:8623211 |
| Mieles L et al. | Oral glucose tolerance test in liver recipients treated with FK 506. | 1990 | Transplant. Proc. | pmid:1689894 |
| Ben-Ari Z et al. | Comparison of tacrolimus with cyclosporin as primary immunosuppression in patients with hepatitis C virus infection after liver transplantation. | 2003 | Transplant. Proc. | pmid:12644067 |
| Gutiérrez Sánchez MJ et al. | Optimization of immunosuppression by switching from azathioprine to enteric-coated mycophenolate sodium in stable kidney transplant patients. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715907 |
| Rafecas A et al. | Immunosuppression with calcineurin inhibitors and polyclonal antibodies in liver transplantation. | 2002 | Transplant. Proc. | pmid:11959209 |
| Diez Ojea B et al. | Three-month experience with tacrolimus once-daily regimen in stable renal allografts. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715908 |
| Lladó L et al. | Prospective evaluation of a quadruple therapy based on tacrolimus after liver transplantation. | 2002 | Transplant. Proc. | pmid:11959210 |
| Aptaramanov B et al. | A comparison of mycophenolate mofetil with mycophenolate sodium in renal transplant recipients on tacrolimus-based treatment. | 2011 | Transplant. Proc. | pmid:21486609 |
| Ma A et al. | Immunological evaluation of combination therapy with tacrolimus and sirolimus on long-term allograft survival in nonhuman primates. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808578 |
| Dheir H et al. | Intensive polyoma virus nephropathy treatment as a preferable approach for graft surveillance. | 2011 | Transplant. Proc. | pmid:21486617 |
| Waller JR et al. | Mycophenolate mofetil inhibits intimal hyperplasia and attenuates the expression of genes favouring smooth muscle cell proliferation and migration. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808582 |
| Platz KP et al. | FK506 for primary and rescue therapy following liver transplantation. | 1998 | Transplant. Proc. | pmid:9636570 |
| Taibi A et al. | Rescue FK506 therapy for acute rejection and early chronic rejection after liver transplantation: report of 14 cases. | 1998 | Transplant. Proc. | pmid:9636571 |
| Oishi M et al. | A case of hyperkalemic distal renal tubular acidosis secondary to tacrolimus in living donor liver transplantation. | 2000 | Transplant. Proc. | pmid:11120143 |
| Soriano S et al. | Single-center experience with initial intravenous dosing of tacrolimus after kidney transplantation. | 1999 | Transplant. Proc. | pmid:10576045 |
| McCauley J et al. | Cyclosporine and FK 506 induced inhibition of renal epithelial cell proliferation. | 1991 | Transplant. Proc. | pmid:1721290 |
| McLachlan G et al. | Growth inhibition of the MOLT-4 human T-leukemia cell line. A comparison of cyclosporine and FK 506. | 1991 | Transplant. Proc. | pmid:1721291 |
| Serrano M et al. | Clinical value of a single determination of intracellular ATP levels in stimulated CD4+ T lymphocytes in pediatric patients with stable liver transplantation. | 2012 | Transplant. Proc. | pmid:23146475 |
| D'Silva M et al. | Immunosuppressive effect of brequinar on rat cardiac allograft survival in combination with leflunomide or FK 506. | 1996 | Transplant. Proc. | pmid:8623476 |
| Thomas FT et al. | Comparative efficacy of immunosuppressive drugs in xenografting. | 1990 | Transplant. Proc. | pmid:1693452 |
| Liu M et al. | C4d-positive acute humoral renal allograft rejection: rescue therapy by immunoadsorption in combination with tacrolimus and mycophenolate mofetil. | 2004 | Transplant. Proc. | pmid:15518760 |
| Stratta RJ | Late acute rejection episodes after vascularized pancreas transplantation. | 1998 | Transplant. Proc. | pmid:9636633 |
| Demirbas A et al. | FK 506 in simultaneous pancreas/kidney transplantation: the University of Miami experience. | 1997 | Transplant. Proc. | pmid:9365608 |
| Marente VC et al. | Modigraf administration through jejunostomy in liver transplant recipient: case report. | 2013 | Transplant. Proc. | pmid:24314992 |
| Murase N et al. | Small bowel transplantation in sensitized recipients: comparison with heart, kidney, and liver grafts. | 1994 | Transplant. Proc. | pmid:7518139 |
| Ziolkowski J et al. | Effect of immunosuppressive regimen on acute rejection and liver graft function. | 2003 | Transplant. Proc. | pmid:14529915 |
| Teisseyre J et al. | Elevated tacrolimus levels during diarrhea in children after liver transplantation. | 2003 | Transplant. Proc. | pmid:14529919 |
| Yu Y et al. | Mutagenicity of the new immunosuppressive drugs, FK 506, and spergualin. | 1993 | Transplant. Proc. | pmid:7682364 |
| Gaweco AS et al. | Common and sequential overexpression patterns of T-helper cytokines during acute (cellular) rejection, and correlation of proinflammatory cytokine expression with chronic (ductopenic) rejection of human liver allografts: a study under cyclosporine, FK 506, and quadruple BT 563 immunosuppression. | 1995 | Transplant. Proc. | pmid:7533370 |
| Takai K et al. | Delayed graft function after renal transplantation from a non-heart-beating donors. | 2003 | Transplant. Proc. | pmid:12591320 |
| Takaori K et al. | Effects of FK 506 on in vivo immunity in comparison to cyclosporine. | 1991 | Transplant. Proc. | pmid:1721322 |
| Bahra M et al. | Repeated steroid pulse therapies in HCV-positive liver recipients: significant risk factor for HCV-related graft loss. | 2005 | Transplant. Proc. | pmid:15919436 |
| Maes BD and Vanrenterghem YF | Cyclosporine: advantages versus disadvantages vis-Ã -vis tacrolimus. | 2004 | Transplant. Proc. | pmid:15041305 |
| Ã…berg F et al. | Asymptomatic De Novo Inflammatory Bowel Disease Late After Liver Transplantation for Primary Sclerosing Cholangitis: A Case Report. | 2015 | Transplant. Proc. | pmid:26680092 |
| Mayer AD | Chronic rejection and graft half-life: five-year follow-up of the European Tacrolimus Multicenter Renal Study. | 2002 | Transplant. Proc. | pmid:12176452 |
| Malireddy SR et al. | Altered first-pass effects in a liver transplant recipient explained intraindividual variation in calcineurin inhibitor concentrations: a case report. | 2008 | Transplant. Proc. | pmid:18589198 |
| Chiereghin A et al. | Monitoring cytomegalovirus T-cell immunity in small bowel/multivisceral transplant recipients. | 2010 Jan-Feb | Transplant. Proc. | pmid:20172283 |
| Funayama Y et al. | Changes in cell adhesion molecules after small bowel transplantation in rats. | 1995 | Transplant. Proc. | pmid:7533426 |
| Paul AA et al. | CMV retinitis and the use of FK 506. | 1991 | Transplant. Proc. | pmid:1721354 |
| Nanni G et al. | Lack of correlation between serum levels of mycophenolate mofetil and kidney transplant outcome in tacrolimus-based immunosupression. | 2002 | Transplant. Proc. | pmid:12270323 |
| Chmiel B et al. | Rheological properties of red blood cells in kidney transplant recipients: the role of lipid profile and type of immunosuppresion. | 2005 | Transplant. Proc. | pmid:15919493 |
| Miyagi M et al. | Comparison of the therapeutic effects between CsA and FK506 on chronic renal allograft injury and TGF-beta expression. | 2002 | Transplant. Proc. | pmid:12176497 |
| Malaise J et al. | Immunosuppressive drugs after simultaneous pancreas-kidney transplantation. | 2005 Jul-Aug | Transplant. Proc. | pmid:16182827 |
| Malaise J et al. | Tacrolimus compared with cyclosporine microemulsion in primary simultaneous pancreas-kidney transplantation: the EURO-SPK 3-year results. | 2005 Jul-Aug | Transplant. Proc. | pmid:16182828 |
| Takayama J et al. | Living related liver transplantation in patients with ABO incompatibility. | 1998 | Transplant. Proc. | pmid:9838537 |
| Zmonarski SC et al. | Lowering of Messenger Ribonucleic Acid Toll-Like Receptors 2-4,9 in Peripheral Blood Mononuclear Cells in Kidney Allograft Recipients, Relationships With Immunosuppressive Treatment, and Delayed Graft Function Occurrence. | 2016 | Transplant. Proc. | pmid:27496439 |
| Scott JS et al. | Tacrolimus: a cause of hypertrophic cardiomyopathy in pediatric heart transplant recipients? | 1999 Feb-Mar | Transplant. Proc. | pmid:10083017 |
| Rayes N et al. | Distribution of lymphocyte subtypes in liver transplant recipients. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123103 |
| Platz KP et al. | Impact of immunosuppression and acute rejection on hepatitis B recurrence. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123107 |
| Asfar S et al. | Small bowel transplantation. | 1996 | Transplant. Proc. | pmid:8908039 |
| Reyes J et al. | Intestinal transplantation in children: five-year experience. | 1996 | Transplant. Proc. | pmid:8908042 |
| Masaoka T | Problems of bone marrow transplantation in Japan. | 1994 | Transplant. Proc. | pmid:7520634 |
| Okano K et al. | Ameliorative effect of FK 506 on cold ischemia reperfusion injury of the rat liver. | 1994 | Transplant. Proc. | pmid:7520635 |
| Endoh M et al. | Nonmuscle myosin heavy chain and metalloproteinase-2 expression in concordant pulmonary xenografts. | 2000 | Transplant. Proc. | pmid:10936397 |
| Thomson AW et al. | Immunosuppressive activity, T-cell subset analysis, and acute toxicity of FK-506 in rats. | 1989 | Transplant. Proc. | pmid:2468203 |
| Hossein-Nia M et al. | Urinary proteins as a marker of drug-induced renal damage following treatment with cyclosporine or FK 506. | 1991 | Transplant. Proc. | pmid:1721388 |
| Citterio F et al. | Steroid withdrawal from tacrolimus-based therapy in renal transplant patients. | 2002 | Transplant. Proc. | pmid:12176545 |
| Han DJ et al. | A 39-month follow-up study to evaluate the safety and efficacy in kidney transplant recipients treated with modified-release tacrolimus (FK506E)-based immunosuppression regimen. | 2012 | Transplant. Proc. | pmid:22310592 |
| Chang HR et al. | Lack of hepatotoxicity upon sirolimus addition to a calcineurin inhibitor-based regimen in hepatitis virus-positive renal transplant recipients. | 2007 | Transplant. Proc. | pmid:17580178 |
| Steinmueller T et al. | The effect of cyclosporine vs FK 506 on glucose metabolism. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083504 |
| Iacona I et al. | Mycophenolic acid in combination with FK 506: a pharmacokinetic study in piglets after small-bowel transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123489 |
| Nakao A et al. | Cytokine mRNA expression on rat small bowel allograft treated with tacrolimus and simultaneous bone marrow transplantation via the portal vein. | 2000 | Transplant. Proc. | pmid:10995965 |
| Soltero L et al. | Coadministration of tacrolimus and ketoconazole in renal transplant recipients: cost analysis and review of metabolic effects. | 2003 | Transplant. Proc. | pmid:12826147 |
| Langer RM et al. | De novo tumors after kidney transplantation: the Budapest experience. | 2003 | Transplant. Proc. | pmid:12826170 |
| Masaoka T et al. | Phase II study of FK 506 for allogeneic bone marrow transplantation. | 1991 | Transplant. Proc. | pmid:1721417 |
| Tojimbara T et al. | Cyclosporine and tacrolimus both suppress activation of Kupffer cells in vitro. | 1996 | Transplant. Proc. | pmid:8658704 |
| Glanemann M et al. | Higher immunosuppressive efficacy of mycophenolate mofetil in combination with FK 506 than in combination with cyclosporine A. | 2000 | Transplant. Proc. | pmid:10812095 |
| White SA et al. | Randomized trial comparing neoral and tacrolimus immunousuppression for recipients of renal transplants procured from different donor groups. | 2000 | Transplant. Proc. | pmid:10812132 |
| Calne RY | The development of immunosuppression: the rapamycin milestone. | 2003 | Transplant. Proc. | pmid:12742463 |
| Fábrega E et al. | Effect of immunosuppressant blood levels on serum concentration of interleukin-17 and -23 in stable liver transplant recipients. | 2009 | Transplant. Proc. | pmid:19376417 |
| Sánchez Pérez B et al. | Adverse effects on the lipid profile of immunosuppressive regimens: tacrolimus versus cyclosporin measured using C2 levels. | 2009 | Transplant. Proc. | pmid:19376418 |
| Tahir W et al. | Diffuse Alveolar haemorrhage: a fatal complication after alemtuzumab induction therapy in renal transplantation. | Transplant. Proc. | pmid:25645795 | |
| Burke GW et al. | Steroid-resistant acute rejection following SPK: importance of maintaining therapeutic dosing in a triple-drug regimen. | 2002 | Transplant. Proc. | pmid:12176628 |
| Woeste G et al. | Tacrolimus/mycophenolate mofetil vs cyclosporine A/Azathioprine after simultaneous pancreas and kidney transplantation: five-year results of a randomized study. | 2002 | Transplant. Proc. | pmid:12176629 |
| Kishikawa H et al. | Low-dose steroid maintenance for renal transplant recipients. | 2010 | Transplant. Proc. | pmid:21168618 |
| Aguirrezabalaga J et al. | Lipid profiles in liver transplantation in patients receiving tacrolimus or cyclosporin. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267192 |
| Shishido S et al. | Pharmacokinetics of tacrolimus in pediatric renal transplant recipients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267193 |
| Kovarik JM et al. | Differential pharmacokinetic interaction of tacrolimus and cyclosporine on everolimus. | 2006 | Transplant. Proc. | pmid:17175302 |
| Moura Neto A et al. | Clinical Profile of Patients With Diabetes Mellitus and Liver Transplantation: Results After a Multidisciplinary Team Intervention. | 2018 | Transplant. Proc. | pmid:29661438 |
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| Quijano Y et al. | Tolerance: a study in long-term surviving animals after small bowel transplantation. | 1998 | Transplant. Proc. | pmid:9745494 |
| Duzova A et al. | Triple immunosuppression with or without basiliximab in pediatric renal transplantation: acute rejection rates at one year. | 2003 | Transplant. Proc. | pmid:14697926 |
| Reichenspurner H et al. | First experience with FK 506 for treatment of chronic pulmonary rejection. | 1995 | Transplant. Proc. | pmid:7540775 |
| Abu-Elmagd K et al. | FK 506: a new therapeutic agent for severe recalcitrant psoriasis. | 1991 | Transplant. Proc. | pmid:1721449 |
| Ueda D et al. | Influence of FK 506 on renal blood flow. | 1993 | Transplant. Proc. | pmid:7689280 |
| Chamienia A et al. | Open prospective study to evaluate cardiovascular risk factors and renal function in 2 dosage regimens of tacrolimus combined with mycophenolate mofetil and steroids in renal transplant patients: 5-year results. | 2014 | Transplant. Proc. | pmid:25380901 |
| Sigal NH et al. | Inhibition of human T-cell activation by FK 506, rapamycin, and cyclosporine A. | 1991 | Transplant. Proc. | pmid:1712132 |
| Kocak H et al. | Tacrolimus plus low-dose mycophenolate mofetil in renal transplant recipients: better 2-year graft and patient survival than with a higher mycophenolate mofetil dose. | 2005 | Transplant. Proc. | pmid:16213288 |
| Banerjee R et al. | Coadministration of itraconazole and tacrolimus after thoracic organ transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267435 |
| Abe T et al. | Risk factors for development of new-onset diabetes mellitus and progressive impairment of glucose metabolism after living-donor liver transplantation. | 2014 | Transplant. Proc. | pmid:24767367 |
| Fujimura T et al. | Cellular surface molecular and cytokine gene expression in rat heart allografts under optimal doses of cyclosporine and FK 506. | 1998 | Transplant. Proc. | pmid:9636413 |
| Fung JJ et al. | Conversion of liver allograft recipients from cyclosporine to FK 506-based immunosuppression: benefits and pitfalls. | 1991 | Transplant. Proc. | pmid:1703682 |
| Bresci S et al. | Case report: cystic fibrosis, lung transplantation, and the novel H1N1 flu. | 2010 Jul-Aug | Transplant. Proc. | pmid:20692461 |
| Ott R et al. | Conversion from tacrolimus to Neoral in liver and kidney transplant recipients. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750359 |
| Kliem V et al. | Tacrolimus for steroid- and OKT3-resistant rejection in kidney recipients. | 1998 | Transplant. Proc. | pmid:9636509 |