tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Pseudomonas Infections D011552 25 associated lipids
Psoriasis D011565 47 associated lipids
Psychoses, Substance-Induced D011605 7 associated lipids
Pterygium D011625 3 associated lipids
Pulmonary Veno-Occlusive Disease D011668 1 associated lipids
Purpura, Thrombotic Thrombocytopenic D011697 6 associated lipids
Rectal Diseases D012002 1 associated lipids
Rectal Fistula D012003 2 associated lipids
Red-Cell Aplasia, Pure D012010 4 associated lipids
Reflex Sympathetic Dystrophy D012019 4 associated lipids
Respiration Disorders D012120 5 associated lipids
Respiratory Insufficiency D012131 10 associated lipids
Respiratory Tract Neoplasms D012142 2 associated lipids
Retinoblastoma D012175 12 associated lipids
Rhabdomyolysis D012206 9 associated lipids
Rheumatoid Nodule D012218 1 associated lipids
Rosacea D012393 13 associated lipids
Rotavirus Infections D012400 1 associated lipids
Rupture D012421 2 associated lipids
Sarcoidosis D012507 13 associated lipids
Sarcoma, Kaposi D012514 6 associated lipids
Osteosarcoma D012516 50 associated lipids
Scalp Dermatoses D012536 11 associated lipids
Sclerosis D012598 5 associated lipids
Dermatitis, Seborrheic D012628 10 associated lipids
Seizures D012640 87 associated lipids
Shock D012769 11 associated lipids
Shock, Septic D012772 11 associated lipids
Sinusitis D012852 9 associated lipids
Skin Diseases, Vesiculobullous D012872 5 associated lipids
Skin Neoplasms D012878 12 associated lipids
Sleep Wake Disorders D012893 7 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Stomach Ulcer D013276 75 associated lipids
Stomatitis D013280 14 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Surgical Wound Infection D013530 7 associated lipids
Tachycardia D013610 7 associated lipids
Telangiectasis D013684 2 associated lipids
Testicular Diseases D013733 15 associated lipids
Thinness D013851 11 associated lipids
Thrombocytopenia D013921 15 associated lipids
Thrombophlebitis D013924 6 associated lipids
Thrombosis D013927 49 associated lipids
Thymus Neoplasms D013953 15 associated lipids
Thyroid Diseases D013959 8 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Tinea D014005 5 associated lipids
Tinea Capitis D014006 1 associated lipids
Tongue Diseases D014060 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Abu Zaid M et al. Plasma biomarkers of risk for death in a multicenter phase 3 trial with uniform transplant characteristics post-allogeneic HCT. 2017 Blood pmid:27827824
Choi SW et al. Vorinostat plus tacrolimus/methotrexate to prevent GVHD after myeloablative conditioning, unrelated donor HCT. 2017 Blood pmid:28784598
Kurzawski M et al. Analysis of common polymorphisms within NR1I2 and NR1I3 genes and tacrolimus dose-adjusted concentration in stable kidney transplant recipients. 2017 Pharmacogenet. Genomics pmid:28777242
Wang C et al. Combining metabolomics and network analysis to improve tacrolimus production in Streptomyces tsukubaensis using different exogenous feedings. 2017 J. Ind. Microbiol. Biotechnol. pmid:28776273
Willerth SM Localized Tacrolimus Delivery Repairs the Damaged Central Nervous System. 2017 EBioMedicine pmid:29195745
Saito R et al. Two cases of eczematous drug eruption caused by oral tacrolimus administration. 2017 Contact Derm. pmid:28703346
Martial LC et al. Dried Blood Spot Sampling for Tacrolimus and Mycophenolic Acid in Children: Analytical and Clinical Validation. 2017 Ther Drug Monit pmid:28700522
Shahid S et al. Chronic hepatitis in the transplant patient. 2017 Br J Hosp Med (Lond) pmid:28692371
Liao JH et al. Gene Variations of Sixth Complement Component Affecting Tacrolimus Metabolism in Patients with Liver Transplantation for Hepatocellular Carcinoma. 2017 Chin. Med. J. pmid:28685716
Lee JE et al. A Case of Rheumatoid Vasculitis Involving Hepatic Artery in Early Rheumatoid Arthritis. 2017 J. Korean Med. Sci. pmid:28581281
Riva N et al. Pharmacoepidemiology of tacrolimus in pediatric liver transplantation. 2017 Pediatr Transplant pmid:28574195
Wu H et al. Novel self-assembled tacrolimus nanoparticles cross-linking thermosensitive hydrogels for local rheumatoid arthritis therapy. 2017 Colloids Surf B Biointerfaces pmid:27736727
Filipec Kanizaj T and Mijic M Inflammatory bowel disease in liver transplanted patients. 2017 World J. Gastroenterol. pmid:28566881
Damon C et al. Predictive Modeling of Tacrolimus Dose Requirement Based on High-Throughput Genetic Screening. 2017 Am. J. Transplant. pmid:27597269
Donati M et al. Resolution of Benign and Malignant Sebaceous Neoplasms, in a Renal Transplant Patient Treated With Everolimus. 2017 Exp Clin Transplant pmid:25924010
Zong YP et al. Effects of CYP3A5 polymorphisms on tacrolimus pharmacokinetics in pediatric kidney transplantation: a systematic review and meta-analysis of observational studies. 2017 World J Pediatr pmid:28540692
Seo SR et al. Disrupted Skin Barrier is Associated with Burning Sensation after Topical Tacrolimus Application in Atopic Dermatitis. 2017 Acta Derm. Venereol. pmid:28512670
Shen CL et al. Tacrolimus Blood Level Fluctuation Predisposes to Coexisting BK Virus Nephropathy and Acute Allograft Rejection. 2017 Sci Rep pmid:28512328
Egeland EJ et al. High Tacrolimus Clearance Is a Risk Factor for Acute Rejection in the Early Phase After Renal Transplantation. 2017 Transplantation pmid:28452920
Cakir U et al. Role of Everolimus on Cardiac Functions in Kidney Transplant Recipients. 2017 Transplant. Proc. pmid:28340820
Hettiarachchi PVKS et al. Comparison of topical tacrolimus and clobetasol in the management of symptomatic oral lichen planus: A double-blinded, randomized clinical trial in Sri Lanka. 2017 J Investig Clin Dent pmid:27633647
Ciftci HS et al. Influence of Proton Pump Inhibitors on Mycophenolic Acid Pharmacokinetics in Patients With Renal Transplantation and the Relationship With Cytochrome 2C19 Gene Polymorphism. 2017 Transplant. Proc. pmid:28340819
Rodrigues N et al. Serum Magnesium and Related Factors in Long-Term Renal Transplant Recipients: An Observational Study. 2017 Transplant. Proc. pmid:28457398
Mashayekhi S et al. The treatment of vulval lichen sclerosus in prepubertal girls: a critically appraised topic. 2017 Br. J. Dermatol. pmid:28244087
Guttman-Yassky E et al. Molecular signatures order the potency of topically applied anti-inflammatory drugs in patients with atopic dermatitis. 2017 J. Allergy Clin. Immunol. pmid:28238742
Takagi K et al. Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Liver Transplantation. 2017 Acta Med. Okayama pmid:28238015
Sahutoglu T et al. Tac-MMF Versus CsA-MMF/CsA-AZA-Based Regimens in Development of De Novo Complement-Binding Anti-HLA Antibodies After Kidney Transplantation. 2017 Transplant. Proc. pmid:28340811
Rebora A Tacrolimus and oral lichen planus: the question remains. 2017 J Eur Acad Dermatol Venereol pmid:27324047
Kanai T et al. Adequate tacrolimus concentration for myasthenia gravis treatment. 2017 Eur. J. Neurol. pmid:28102047
Sarier M et al. HPV type 45-positive condyloma acuminata of the bladder in a renal transplant recipient. 2017 Transpl Infect Dis pmid:28100036
Fan B et al. Prograf produces more benefits for CYP3A5 low expression patients in early stage after kidney transplantation. 2017 Biomed. Pharmacother. pmid:28157649
Hanchanale P et al. Nocardia liver abscess post liver transplantation-A rare presentation. 2017 Transpl Infect Dis pmid:28150374
Størset E et al. The CYP3A biomarker 4β-hydroxycholesterol does not improve tacrolimus dose predictions early after kidney transplantation. 2017 Br J Clin Pharmacol pmid:28146606
Dai Y et al. A case report of coup de sabre patient with hair transplantation. 2017 J Dermatolog Treat pmid:28142293
Hashemizadeh Z et al. Observational Study of Associations between Voriconazole Therapeutic Drug Monitoring, Toxicity, and Outcome in Liver Transplant Patients. 2017 Antimicrob. Agents Chemother. pmid:28923870
Pensi D et al. First UHPLC-MS/MS method coupled with automated online SPE for quantification both of tacrolimus and everolimus in peripheral blood mononuclear cells and its application on samples from co-treated pediatric patients. 2017 J Mass Spectrom pmid:28098395
Cukor D et al. A Pilot Randomized Controlled Trial to Promote Immunosuppressant Adherence in Adult Kidney Transplant Recipients. 2017 Nephron pmid:28049201
Calvo PL et al. Donor CYP3A5 genotype influences tacrolimus disposition on the first day after paediatric liver transplantation. 2017 Br J Clin Pharmacol pmid:28044353
Hayes W et al. Hypomagnesemia and increased risk of new-onset diabetes mellitus after transplantation in pediatric renal transplant recipients. 2017 Pediatr. Nephrol. pmid:28039534
Baskiran A et al. Pregnancy After Liver Transplantation: Risks and Outcomes. 2017 Transplant. Proc. pmid:28923640
Shi G et al. Variation of CD4CD25Foxp3 Regulatory T Cells and Th17 Cells in the Peripheral Blood of Human Liver Allograft Patients With Long-term Survival. 2017 Transplant. Proc. pmid:28923634
Wang L et al. Efficacy and safety of tacrolimus for myasthenia gravis: a systematic review and meta-analysis. 2017 J. Neurol. pmid:28921038
Weininger U et al. Dynamics of Aromatic Side Chains in the Active Site of FKBP12. 2017 Biochemistry pmid:27936610
Hosoi K et al. Prolonged tacrolimus for pediatric gastrointestinal disorder: Double-edged sword? 2017 Pediatr Int pmid:27935231
Alloway RR et al. Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial. 2017 PLoS Med. pmid:29135993
Parrow NL and Fleming RE Releasing the FKBP12 brake on hepcidin. 2017 Blood pmid:29122771
Kalt DA Tacrolimus: A Review of Laboratory Detection Methods and Indications for Use. 2017 Lab Med pmid:29096030
Andrews LM et al. Pharmacokinetic considerations related to therapeutic drug monitoring of tacrolimus in kidney transplant patients. 2017 Expert Opin Drug Metab Toxicol pmid:29084469
Esquirol A et al. Single-agent GvHD prophylaxis with tacrolimus after post-transplant high-dose cyclophosphamide is a valid option for haploidentical transplantation in adults with hematological malignancies. 2017 Bone Marrow Transplant. pmid:28604667
Vanhove T et al. Pretransplant 4β-hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation. 2017 Br J Clin Pharmacol pmid:28603840