tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li H et al. | Resistance reversal induced by a combination of fluconazole and tacrolimus (FK506) in Candida glabrata. | 2015 | J. Med. Microbiol. | pmid:25355935 |
| Gallon L et al. | Cellular and molecular immune profiles in renal transplant recipients after conversion from tacrolimus to sirolimus. | 2015 | Kidney Int. | pmid:25354238 |
| Pamuk F et al. | Evaluation of gingival alterations in rats medicated with cyclosporine A, tacrolimus and sirolimus: a stereological study. | 2015 | J. Periodont. Res. | pmid:25399832 |
| Koreth J et al. | A Bortezomib-Based Regimen Offers Promising Survival and Graft-versus-Host Disease Prophylaxis in Myeloablative HLA-Mismatched and Unrelated Donor Transplantation: A Phase II Trial. | 2015 | Biol. Blood Marrow Transplant. | pmid:26055298 |
| Sikma MA et al. | Pharmacokinetics and Toxicity of Tacrolimus Early After Heart and Lung Transplantation. | 2015 | Am. J. Transplant. | pmid:26053114 |
| Rozman Peterka T et al. | Solid state compatibility study and characterization of a novel degradation product of tacrolimus in formulation. | 2015 | J Pharm Biomed Anal | pmid:25804434 |
| Revollo J | Update on the clinical utility of once-daily tacrolimus in the management of transplantation. | 2015 | Drug Des Devel Ther | pmid:26005334 |
| Cortes X et al. | Successful use of infliximab and tacrolimus in a patient with Crohn's disease. | 2015 | Int J Clin Pharmacol Ther | pmid:25997551 |
| Takahashi N et al. | Concomitant methotrexate and tacrolimus augment the clinical response to abatacept in patients with rheumatoid arthritis with a prior history of biological DMARD use. | 2015 | Rheumatol. Int. | pmid:25991396 |
| Brännström M et al. | Livebirth after uterus transplantation. | 2015 | Lancet | pmid:25301505 |
| de Weerd AE et al. | ABO-incompatible kidney transplant recipients have a higher bleeding risk after antigen-specific immunoadsorption. | 2015 | Transpl. Int. | pmid:25070762 |
| Yahng SA et al. | A well-tolerated regimen of 800 cGy TBI-fludarabine-busulfan-ATG for reliable engraftment after unmanipulated haploidentical peripheral blood stem cell transplantation in adult patients with acute myeloid leukemia. | 2015 | Biol. Blood Marrow Transplant. | pmid:25300871 |
| Cheng S and Rodier F | Manipulating senescence in health and disease: emerging tools. | 2015 | Cell Cycle | pmid:25928330 |
| Hricik DE et al. | Adverse Outcomes of Tacrolimus Withdrawal in Immune-Quiescent Kidney Transplant Recipients. | 2015 | J. Am. Soc. Nephrol. | pmid:25925687 |
| Matas AJ and Gaston RS | Moving Beyond Minimization Trials in Kidney Transplantation. | 2015 | J. Am. Soc. Nephrol. | pmid:25925686 |
| Bogéa TH et al. | Light Induces Ultrastructural Changes in Rod Outer and Inner Segments, Including Autophagy, in a Transgenic Xenopus laevis P23H Rhodopsin Model of Retinitis Pigmentosa. | 2015 | Invest. Ophthalmol. Vis. Sci. | pmid:26720441 |
| Hiraoka S et al. | The earliest trough concentration predicts the dose of tacrolimus required for remission induction therapy in ulcerative colitis patients. | 2015 | BMC Gastroenterol | pmid:25925267 |
| Falloon K et al. | Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus. | 2015 | PLoS ONE | pmid:26366742 |
| Chapron B et al. | Reversible, time-dependent inhibition of CYP3A-mediated metabolism of midazolam and tacrolimus by telaprevir in human liver microsomes. | 2015 | J Pharm Pharm Sci | pmid:25877445 |
| Nashan B et al. | Evaluating the efficacy, safety and evolution of renal function with early initiation of everolimus-facilitated tacrolimus reduction in de novo liver transplant recipients: Study protocol for a randomized controlled trial. | 2015 | Trials | pmid:25873064 |
| Ramachandran R et al. | Chronic nephrotoxicity limits successful use of Tacrolimus in the management of adult steroid-dependent minimal change disease. | 2015 | Nephrology (Carlton) | pmid:25872662 |
| Shahraki M et al. | Influence of Tacrolimus (FK506) on Nerve Regeneration Using Allografts: A Rat Sciatic Nerve Model. | 2015 | J. Oral Maxillofac. Surg. | pmid:25869987 |
| Zhu L et al. | Effects of CYP3A5 genotypes, ABCB1 C3435T and G2677T/A polymorphism on pharmacokinetics of Tacrolimus in Chinese adult liver transplant patients. | 2015 | Xenobiotica | pmid:25869250 |
| Dastgheib L et al. | Assessment of the adjuvant effect of tacrolimus in the management of pemphigus vulgaris: A randomized controlled trial. | 2015 | J Dermatolog Treat | pmid:24552352 |
| RodrÃguez-RodrÃguez AE et al. | Glucose homeostasis changes and pancreatic β-cell proliferation after switching to cyclosporin in tacrolimus-induced diabetes mellitus. | 2015 | Nefrologia | pmid:26299169 |
| Hlavaty KA et al. | Cellular and molecular targeting for nanotherapeutics in transplantation tolerance. | 2015 | Clin. Immunol. | pmid:25805659 |
| Halvorsen JA and Aasebø W | Oral tacrolimus treatment of pruritus in prurigo nodularis. | 2015 | Acta Derm. Venereol. | pmid:25804254 |
| Sigurgeirsson B et al. | Safety and efficacy of pimecrolimus in atopic dermatitis: a 5-year randomized trial. | 2015 | Pediatrics | pmid:25802354 |
| Garritsen FM et al. | Ten years experience with oral immunosuppressive treatment in adult patients with atopic dermatitis in two academic centres. | 2015 | J Eur Acad Dermatol Venereol | pmid:25752497 |
| Wu D et al. | BK Virus-Associated Nephropathy with Plasma Cell-Rich Infiltrates Treated by Bortezomib-Based Regimen. | 2015 | Exp Clin Transplant | pmid:25748726 |
| Jo GA et al. | Isolation and characterization of a 17-kDa FKBP-type peptidyl-prolyl cis/trans isomerase from Vibrio anguillarum. | 2015 | Protein Expr. Purif. | pmid:25747528 |
| Tachibana T et al. | Successful Engraftment and Durable Graft-versus-host Disease Control with Haploidentical Peripheral Blood and a Short-term Conditioning Regimen for Primary Graft Failure. | 2015 | Intern. Med. | pmid:26521905 |
| Liu J et al. | Adherence to Immunosuppressive Medication in Renal Transplant Recipients From Follow-up Outpatient in China: Association of 2 Different Measurement Methods. | 2015 | Clin Ther | pmid:26519232 |
| Guerra Júnior AA et al. | Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil. | 2015 | Rev Saude Publica | pmid:25741648 |
| Shuker N et al. | Intra-patient variability in tacrolimus exposure: causes, consequences for clinical management. | 2015 | Transplant Rev (Orlando) | pmid:25687818 |
| Kawakami K et al. | Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis. | 2015 | World J. Gastroenterol. | pmid:25684955 |
| Al Gain M et al. | [Sirolimus-induced lymphedema in a kidney-transplant recipient: Partial recovery after changeover to tacrolimus]. | 2015 | Ann Dermatol Venereol | pmid:25683011 |
| Ikeya K et al. | Tacrolimus for remission induction in ulcerative colitis: Mayo endoscopic subscore 0 and 1 predict long-term prognosis. | 2015 | Dig Liver Dis | pmid:25682993 |
| Zhao L et al. | Bovine serum albumin nanoparticles for delivery of tacrolimus to reduce its kidney uptake and functional nephrotoxicity. | 2015 | Int J Pharm | pmid:25681723 |
| Matsushima M et al. | [A case of anti-PL7 antibody positive myositis and a clinical and pathological review of the anti-synthetase syndrome]. | 2015 | Rinsho Shinkeigaku | pmid:26458569 |
| Kim S et al. | Reduction of increased calcineurin activity rescues impaired homeostatic synaptic plasticity in presenilin 1 M146V mutant. | 2015 | Neurobiol. Aging | pmid:26455952 |
| Fukuta T et al. | Treatment of stroke with liposomal neuroprotective agents under cerebral ischemia conditions. | 2015 | Eur J Pharm Biopharm | pmid:26455340 |
| BuendÃa JA et al. | Combinational Effect of CYP3A5 and MDR-1 Polymorphisms on Tacrolimus Pharmacokinetics in Liver Transplant Patients. | 2015 | Exp Clin Transplant | pmid:26450467 |
| Cuellar-Rodriguez J et al. | Matched related and unrelated donor hematopoietic stem cell transplantation for DOCK8 deficiency. | 2015 | Biol. Blood Marrow Transplant. | pmid:25636378 |
| Schoettler M et al. | Treatment and outcomes of immune cytopenias following solid organ transplant in children. | 2015 | Pediatr Blood Cancer | pmid:25308853 |
| Chung H et al. | Renal transplantation: better fat than thin. | 2015 | J. Surg. Res. | pmid:25634827 |
| Pennington CA and Park JM | Sublingual tacrolimus as an alternative to oral administration for solid organ transplant recipients. | 2015 | Am J Health Syst Pharm | pmid:25631834 |
| Mok CC | Mycophenolate mofetil for lupus nephritis: an update. | 2015 | Expert Rev Clin Immunol | pmid:26364748 |
| Satake K et al. | Olopatadine hydrochloride suppresses hot flashes induced by topical treatment with tacrolimus ointment in rats. | 2015 | Eur. J. Pharmacol. | pmid:26362749 |
| Gao L and Sun Y | In vitro interactions of antifungal agents and tacrolimus against Aspergillus biofilms. | 2015 | Antimicrob. Agents Chemother. | pmid:26303797 |
| Iwamoto T et al. | Effect of Genetic Polymorphism of CYP3A5 and CYP2C19 and Concomitant Use of Voriconazole on Blood Tacrolimus Concentration in Patients Receiving Hematopoietic Stem Cell Transplantation. | 2015 | Ther Drug Monit | pmid:25565672 |
| Yao X et al. | Limited Sampling Strategy for Mycophenolic Acid in Chinese Kidney Transplant Recipients Receiving Enteric-Coated Mycophenolate Sodium and Tacrolimus During the Early Posttransplantation Phase. | 2015 | Ther Drug Monit | pmid:25565669 |
| Nelson R et al. | Sirolimus, tacrolimus and antithymocyte globulin as GVHD prophylaxis in HLA-mismatched unrelated donor hematopoietic cell transplantation: a single institution experience. | 2015 | Bone Marrow Transplant. | pmid:26301969 |
| Lemaitre F et al. | Pharmacokinetics and pharmacodynamics of tacrolimus in liver transplant recipients: inside the white blood cells. | 2015 | Clin. Biochem. | pmid:25562187 |
| Tedesco-Silva H et al. | Reduced Incidence of Cytomegalovirus Infection in Kidney Transplant Recipients Receiving Everolimus and Reduced Tacrolimus Doses. | 2015 | Am. J. Transplant. | pmid:25988935 |
| Bauters T et al. | Practical considerations in the use of intravenous tacrolimus in hematopoietic stem cell transplantation patients. | 2015 | J Oncol Pharm Pract | pmid:24748582 |
| Tornatore KM et al. | Influence of sex and race on mycophenolic acid pharmacokinetics in stable African American and Caucasian renal transplant recipients. | 2015 | Clin Pharmacokinet | pmid:25511793 |
| Li JL et al. | Interactive effects of CYP3A4, CYP3A5, MDR1 and NR1I2 polymorphisms on tracrolimus trough concentrations in early postrenal transplant recipients. | 2015 | Pharmacogenomics | pmid:26228923 |
| Zhu LQ et al. | Posterior reversible encephalopathy syndrome and graft-versus-host disease after liver transplantation: a case report and review of the literature. | 2015 | Int J Clin Pharmacol Ther | pmid:26227100 |
| Lu YX et al. | A population pharmacokinetic study of tacrolimus in healthy Chinese volunteers and liver transplant patients. | 2015 | Acta Pharmacol. Sin. | pmid:25500866 |
| Zhang JJ et al. | The genetic polymorphisms of POR*28 and CYP3A5*3 significantly influence the pharmacokinetics of tacrolimus in Chinese renal transplant recipients. | 2015 | Int J Clin Pharmacol Ther | pmid:26227094 |
| Jung JW et al. | Long-term result of maintenance treatment with tacrolimus ointment in chronic ocular graft-versus-host disease. | 2015 | Am. J. Ophthalmol. | pmid:25498356 |
| Roberts WK et al. | A destructive feedback loop mediated by CXCL10 in central nervous system inflammatory disease. | 2015 | Ann. Neurol. | pmid:26224283 |
| Kloster-Jensen K et al. | Intracellular sirolimus concentration is reduced by tacrolimus in human pancreatic islets in vitro. | 2015 | Transpl. Int. | pmid:26046470 |
| Peake RW et al. | Multicenter evaluation of the thermo scientific prelude for measurement of immunosuppressant drugs using sample preparation liquid chromatography-tandem mass spectrometry. | 2015 | Ther Drug Monit | pmid:25072947 |
| Mettang T and Kremer AE | Uremic pruritus. | 2015 | Kidney Int. | pmid:24402092 |
| Lancia P et al. | Choosing the right dose of tacrolimus. | 2015 | Arch. Dis. Child. | pmid:25416736 |
| Kabrine M and Laraba-Djebari F | Immunomodulatory and protective properties of tacrolimus in experimental scorpion envenomation. | 2014 Jan-Mar | Int J Immunopathol Pharmacol | pmid:24674680 |
| Wang C and Lin A | Efficacy of topical calcineurin inhibitors in psoriasis. | 2014 Jan-Feb | J Cutan Med Surg | pmid:24377467 |
| Feito-RodrÃguez M et al. | Bacterial vaginosis in the context of lichen sclerosus in a prepubertal girl. | 2014 Jan-Feb | Pediatr Dermatol | pmid:24125016 |
| Veisa G et al. | The importance of renal biopsy in the management of renal transplantation. | 2014 Apr-Jun | Rev Med Chir Soc Med Nat Iasi | pmid:25076703 |
| Chen CH et al. | Comparison of tuberculosis infection rates in a national database of renal transplant patients with data from a single center in Taiwan. | 2014 | Transplant. Proc. | pmid:24656019 |
| Furian L et al. | Everolimus associated with low-dose calcineurin inhibitors, an option in kidney transplant recipients of very old donors. | 2014 | Transplant. Proc. | pmid:25498057 |
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| Pedroso JA et al. | Elderly kidney transplant recipient with intermittent fever: a case report of leishmaniasis with acute kidney injury during liposomal amphotericin B therapy. | 2014 | Transplant. Proc. | pmid:25242789 |
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| Guitard J et al. | An unexpected diagnosis in a renal-transplant patient with proteinuria treated with everolimus: AL amyloidosis. | 2014 | Clin. Nephrol. | pmid:24040781 |
| Baldo A et al. | Vitiligo, NB-UVB and tacrolimus: our experience in Naples. | 2014 | G Ital Dermatol Venereol | pmid:24566573 |
| Favennec C et al. | Consideration of the switch from twice-daily to once-daily tacrolimus in pediatric kidney transplant in daily clinical practice: pharmacokinetic parameters, patient satisfaction and medical practices. | 2014 | Pediatr Transplant | pmid:25164065 |
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| Murota H et al. | Olopatadine hydrochloride decreases tissue interleukin-31 levels in an atopic dermatitis mouse model. | 2014 | Acta Derm. Venereol. | pmid:23817562 |
| Gupta AK et al. | Efficient neutrophil extracellular trap induction requires mobilization of both intracellular and extracellular calcium pools and is modulated by cyclosporine A. | 2014 | PLoS ONE | pmid:24819773 |
| Amanova A et al. | Colchicine levels in chronic kidney diseases and kidney transplant recipients using tacrolimus. | 2014 | Clin Transplant | pmid:25125128 |
| Schmid S et al. | Volatility of serum creatinine relative to tacrolimus levels predicts kidney transplant rejection. | 2014 | Ann. Transplant. | pmid:25123847 |
| Guillén-Gómez E et al. | Monocyte implication in renal allograft dysfunction. | 2014 | Clin. Exp. Immunol. | pmid:24134783 |
| Farkas K et al. | Ability of different rescue therapies to save the bowel in acute, severe, steroid-refractory ulcerative colitis. | 2014 | Expert Rev Gastroenterol Hepatol | pmid:24738535 |
| Li T et al. | Effect of FK506 nanospheres on regeneration of allogeneic nerve after transplant. | 2014 | Asian Pac J Trop Med | pmid:25066398 |
| Miyauchi T et al. | Evidence for the therapeutic efficacy of either mild hypothermia or oxygen radical scavengers after repetitive mild traumatic brain injury. | 2014 | J. Neurotrauma | pmid:24341607 |
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| Inaba A et al. | Cerebral toxoplasmosis after umbilical cord blood transplantation diagnosed by the detection of anti-toxoplasma specific IgM antibody in cerebrospinal fluid. | 2014 | Rinsho Ketsueki | pmid:24850458 |
| Kurzawski M et al. | Impact of PPARA and POR polymorphisms on tacrolimus pharmacokinetics and new-onset diabetes in kidney transplant recipients. | 2014 | Pharmacogenet. Genomics | pmid:24921414 |
| Parvizi Z et al. | Association between E23K variant in KCNJ11 gene and new-onset diabetes after liver transplantation. | 2014 | Mol. Biol. Rep. | pmid:24996284 |
| Ji SM et al. | Retrospective evaluation of the effect of mycophenolate mofetil dosage on survival of kidney grafts based on biopsy results. | 2014 | Transplant. Proc. | pmid:25498056 |
| Hebral AL et al. | Pregnancy after kidney transplantation: outcome and anti-human leucocyte antigen alloimmunization risk. | 2014 | Nephrol. Dial. Transplant. | pmid:24914091 |
| Hayes D et al. | Alternative tacrolimus and sirolimus regimen associated with rapid resolution of posterior reversible encephalopathy syndrome after lung transplantation. | 2014 | Pediatr. Neurol. | pmid:24405697 |
| Bergmann TK et al. | Comparison of the influence of cyclosporine and tacrolimus on the pharmacokinetics of prednisolone in adult male kidney transplant recipients. | 2014 | Clin Drug Investig | pmid:24385281 |
| Lesche D et al. | CYP3A5*3 and POR*28 genetic variants influence the required dose of tacrolimus in heart transplant recipients. | 2014 | Ther Drug Monit | pmid:24739669 |
| van der Vusse ML et al. | Helicobacter canis bacteremia in a renal transplant patient. | 2014 | Transpl Infect Dis | pmid:24372779 |
| Földes G et al. | Immunosuppressive agents modulate function, growth, and survival of cardiomyocytes and endothelial cells derived from human embryonic stem cells. | 2014 | Stem Cells Dev. | pmid:24192059 |