tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Ye Q et al. | Functional analysis of hamster kidney xenografts in the rat: possible functional incompatibility and adaptation of hamster kidney grafts in a xenogenic rat environment. | 1996 | Transplant. Proc. | pmid:8623350 |
| Taibi A et al. | Rescue FK506 therapy for acute rejection and early chronic rejection after liver transplantation: report of 14 cases. | 1998 | Transplant. Proc. | pmid:9636571 |
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| Vela CG et al. | Prospective study of lipid disorders in FK506-versus cyclosporine-treated renal transplant patients. | 2000 | Transplant. Proc. | pmid:10715453 |
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| Schuller S et al. | Daclizumab induction therapy associated with tacrolimus-MMF has better outcome compared with tacrolimus-MMF alone in pediatric living donor liver transplantation. | 2005 | Transplant. Proc. | pmid:15848653 |
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| Mayer AD | Chronic rejection and graft half-life: five-year follow-up of the European Tacrolimus Multicenter Renal Study. | 2002 | Transplant. Proc. | pmid:12176452 |
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| Lewis WD et al. | FK 506 rescue therapy in liver transplant recipients with drug-resistant rejection. | 1991 | Transplant. Proc. | pmid:1721336 |
| Woodle ES et al. | FK 506: reversal of humorally mediated rejection following ABO-incompatible liver transplantation. | 1991 | Transplant. Proc. | pmid:1721337 |
| Weimer R et al. | sCD30 and neopterin as risk factors of chronic renal transplant rejection: impact of cyclosporine A, tacrolimus, and mycophenolate mofetil. | 2005 | Transplant. Proc. | pmid:15919463 |
| Heilman RL et al. | Steroid avoidance immunosuppression in low-risk kidney transplant recipients. | 2005 | Transplant. Proc. | pmid:15919466 |
| Allers C et al. | Tacrolimus, daclizumab, sirolimus, and budesonide after small bowel transplantation in order to reduce nephrotoxicity. | 2002 | Transplant. Proc. | pmid:12034251 |
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| Aktürk S et al. | Average Tacrolimus Trough Level in the First Month After Transplantation May Predict Acute Rejection. | 2017 | Transplant. Proc. | pmid:28340806 |
| Scantlebury VP et al. | Pediatric kidney transplantation at the University of Pittsburgh. | 1994 | Transplant. Proc. | pmid:7509095 |
| Hamano I et al. | Condyloma Acuminata of the Urethra in a Male Renal Transplant Recipient: A Case Report. | 2018 | Transplant. Proc. | pmid:30316397 |
| Wu MS et al. | Cyclosporine, but not FK 506 and rapamycin, enhances cell proliferation in mouse medullary thick ascending cultured cells. | 1998 | Transplant. Proc. | pmid:9838561 |
| Todo S et al. | Clinical small bowel or small bowel plus liver transplantation under FK 506. | 1991 | Transplant. Proc. | pmid:1721369 |
| Tzakis AG et al. | Use of FK 506 in pediatric patients. | 1991 | Transplant. Proc. | pmid:1703353 |
| Meiser BM et al. | The efficacy of the combination of tacrolimus and mycophenolate mofetil for prevention of acute myocardial rejection is dependent on routine monitoring of mycophenolic acid trough acid levels. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083018 |
| Crespo-Leiro MG | Tacrolimus in heart transplantation. | 2003 | Transplant. Proc. | pmid:12962869 |
| Platz KP et al. | Impact of immunosuppression and acute rejection on hepatitis B recurrence. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123107 |
| Reyes J et al. | Intestinal transplantation in children: five-year experience. | 1996 | Transplant. Proc. | pmid:8908042 |
| Dietl KH | Oral dosing of tacrolimus and cyclosporine microemulsion--results from a large multicenter study in renal transplantation. | 2002 | Transplant. Proc. | pmid:12176524 |
| San Miguel C et al. | Immunosuppression Strategies in the Treatment of Hepatocellular Carcinoma in Virgen de las Nieves University Hospital. | 2015 | Transplant. Proc. | pmid:26518930 |
| Miura K et al. | Development of the Intestinal Transplantation Model With Major Histocompatibility Complex Inbred CLAWN Miniature Swine. | 2016 | Transplant. Proc. | pmid:27320612 |
| Lee HK et al. | Expression of Endoplasmic Reticulum-Mediated Stress Proteins in FK506-Treated T-Lymphocytes. | 2016 | Transplant. Proc. | pmid:27320607 |
| Ito A et al. | Induction of tolerance in rat cardiac allograft model by intrathymic injection of donor bone marrow cells. | 1995 | Transplant. Proc. | pmid:7536974 |
| Büttemeyer R et al. | Peripheral nerve allotransplant immunosuppressed with FK 506: preliminary results. | 1995 | Transplant. Proc. | pmid:7536979 |
| Park JW et al. | Invasive pulmonary aspergillosis after living donor liver transplantation should be eradicated or not? A case report. | 2011 Jul-Aug | Transplant. Proc. | pmid:21839284 |
| DiMartini A et al. | Psychiatric morbidity in liver transplant patients. | 1991 | Transplant. Proc. | pmid:1721399 |
| Steinmueller T et al. | The effect of cyclosporine vs FK 506 on glucose metabolism. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083504 |
| Lopez OL et al. | Neuropathologic findings in liver transplantation: a comparative study of cyclosporine and FK 506. | 1991 | Transplant. Proc. | pmid:1721400 |
| Moutabarrik A et al. | Effect of FK 506 and cyclosporine on the expression of IL-6 and its receptor on stimulated monocytes. | 1993 | Transplant. Proc. | pmid:7685949 |
| Shapiro R et al. | A prospective, randomized trial of tacrolimus/prednisone vs tacrolimus/prednisone/mycophenolate mofetil in renal transplantation: 1-year actuarial follow-up. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083507 |
| Ochiai T et al. | Comparative studies on the immunosuppressive activity of FK506, 15-deoxyspergualin, and cyclosporine. | 1989 | Transplant. Proc. | pmid:2468228 |
| Takaya S et al. | Use of prostaglandin E1 in crossmatch-negative liver transplant recipients treated with FK 506. | 1993 | Transplant. Proc. | pmid:7685953 |
| Bhaloo S and Prasad GV | Severe reduction in tacrolimus levels with rifampin despite multiple cytochrome P450 inhibitors: a case report. | 2003 | Transplant. Proc. | pmid:14611983 |
| Yasunami Y et al. | Effects of a novel immunosuppressive agent, FK-506, on islet allograft survival in the rat. | 1989 | Transplant. Proc. | pmid:2468234 |
| Iacona I et al. | Mycophenolic acid in combination with FK 506: a pharmacokinetic study in piglets after small-bowel transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123489 |
| Batten P et al. | Effect of cyclosporine A and FK 506 on human T cell responses to xenogeneic and allogeneic endothelium: relative resistance of T cell/porcine endothelial interactions. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123582 |
| Migita K and Eguchi K | FK 506-mediated T-cell apoptosis induction. | 2001 | Transplant. Proc. | pmid:11377532 |
| Omoto K et al. | Adverse events in renal transplantation under tacrolimus/mycophnolate mofetil immunosuppression: a single-center experience. | 2002 | Transplant. Proc. | pmid:12176591 |
| Nakache R et al. | Management of massive proteinuria following renal transplantation with mycophenolate mofetil and blood pressure normalization. | 2001 | Transplant. Proc. | pmid:11377533 |
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| Canivet C et al. | T-cell function in maintenance renal transplant patients receiving mycophenolate mofetil and steroids with or without tacrolimus. | 2008 | Transplant. Proc. | pmid:19100403 |
| Shishido S et al. | Pharmacokinetics of tacrolimus in pediatric renal transplant recipients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267193 |
| Valdivia LA et al. | Differential survival of hamster-to-rat liver and cardiac xenografts under FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721432 |
| Kawano K et al. | FK506 reduces oxidative hepatic injury following cold ischemic preservation and transplantation. | 1996 | Transplant. Proc. | pmid:8658938 |
| Ochiai T et al. | Prolongation of canine renal allograft survival by treatment with FK-506. | 1987 | Transplant. Proc. | pmid:2445075 |
| Atillasoy E et al. | Cholesterol levels long-term after liver transplant. | 1998 | Transplant. Proc. | pmid:9723387 |
| Ju MK et al. | Mizoribine versus mycophenolate mofetil in combination therapy with tacrolimus for de novo kidney transplantation: evaluation of efficacy and safety. | 2013 | Transplant. Proc. | pmid:23726602 |
| Aktas S et al. | Comparison of basiliximab and daclizumab with triple immunosuppression in renal transplantation. | 2011 | Transplant. Proc. | pmid:21440732 |
| Ito T et al. | Therapeutic Effect of Sirolimus for Lymphangioleiomyomatosis Remaining in the Abdominopelvic Region After Lung Transplantation: A Case Report. | Transplant. Proc. | pmid:26915883 | |
| Lee KM and Eun SC | Experimental canine facial transplantation. | 2014 | Transplant. Proc. | pmid:24815162 |
| Shingaki S et al. | Graft-versus-host Disease-free, Relapse-free Survival After HLA-identical Sibling Peripheral Blood Stem Cell Transplantation With Tacrolimus-based Graft-versus-host Disease Prophylaxis in Japanese Patients. | Transplant. Proc. | pmid:29407317 | |
| Mehra MR et al. | A randomized comparison of an immunosuppressive strategy using tacrolimus and cyclosporine in black heart transplant recipients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267438 |
| Manzia TM et al. | Ab initio Everolimus-based Versus Standard Calcineurin Inhibitor Immunosuppression Regimen in Liver Transplant Recipients. | Transplant. Proc. | pmid:29407305 | |
| Nossal GJ | Summary of the First International FK 506 Congress: perspectives and prospects. | 1991 | Transplant. Proc. | pmid:1721464 |
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| Umbro I et al. | Long-term interleukin-2 assessment after conversion from a twice-daily to once-daily tacrolimus regimen in stable kidney recipients. | 2012 | Transplant. Proc. | pmid:22974867 |
| Tariciotti L et al. | Everolimus and Advagraf Ab Initio in Combined Liver and Kidney Transplant With Donor-Specific Antibodies: A Case Report. | 2016 | Transplant. Proc. | pmid:27932158 |
| Sevmis S et al. | Tacrolimus-related seizure in the early postoperative period after liver transplantation. | 2007 | Transplant. Proc. | pmid:17524935 |
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| Ott R et al. | Conversion from tacrolimus to Neoral in liver and kidney transplant recipients. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750359 |
| Badiou S et al. | Small dense low-density lipoprotein in renal transplant recipients: a potential target for prevention of cardiovascular complications? | 2006 | Transplant. Proc. | pmid:16980076 |
| Boggi U et al. | Use of basiliximab in conjunction with either Neora/MMF/steroids or Prograf/MMF/steroids in simultaneous pancreas-kidney transplantation. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750373 |
| Pillet A et al. | Monitoring HCMV infection with quantitative real-time PCR in HCMV-positive orthotopic liver transplant recipients, and predictive factors for treatment of the first episode of HCMV viremia. | 2006 | Transplant. Proc. | pmid:16980083 |
| Goto S et al. | Effect of FK 506 and cyclosporine on heart allograft survival in rats. | 1991 | Transplant. Proc. | pmid:1703700 |
| White SA et al. | Influence of delayed graft function in renal transplants from cadaveric or non-heart-beating donors. | 2000 | Transplant. Proc. | pmid:10701018 |
| Sens YA et al. | Posttransplant diabetes mellitus in renal transplant patients with hepatitis C virus. | 2004 | Transplant. Proc. | pmid:15194304 |
| Flavin T et al. | Initial experience with FK 506 as an immunosuppressant for nonhuman primate recipients of cardiac allografts. | 1991 | Transplant. Proc. | pmid:1703701 |
| Kliem V et al. | Tacrolimus for steroid- and OKT3-resistant rejection in kidney recipients. | 1998 | Transplant. Proc. | pmid:9636509 |
| Williams ST et al. | Preliminary analysis of a randomized trial comparing microemulsion cyclosporine and tacrolimus for recipients of renal transplants from non-heart-beating donors. | 2000 | Transplant. Proc. | pmid:10701022 |
| Boggi U et al. | Single-center, open, prospective, randomized pilot study comparing cyclosporine versus tacrolimus in simultaneous pancreas-kidney transplantation. | 2004 | Transplant. Proc. | pmid:15194369 |
| Anglicheau D et al. | Pharmacogenetics of tacrolimus and sirolimus in renal transplant patients: from retrospective analyses to prospective studies. | 2007 | Transplant. Proc. | pmid:17889118 |
| Copley JB et al. | Cyclosporine to tacrolimus: effect on hypertension and lipid profiles in renal allografts. | 1998 | Transplant. Proc. | pmid:9636510 |