| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hand Injuries | D006230 | 1 associated lipids |
| Beckwith-Wiedemann Syndrome | D001506 | 1 associated lipids |
| IgG Deficiency | D017099 | 1 associated lipids |
| Deltaretrovirus Infections | D006800 | 1 associated lipids |
| Hepatopulmonary Syndrome | D020065 | 1 associated lipids |
| Herpes Labialis | D006560 | 1 associated lipids |
| End Stage Liver Disease | D058625 | 1 associated lipids |
| Nocturnal Myoclonus Syndrome | D020189 | 1 associated lipids |
| Uveomeningoencephalitic Syndrome | D014607 | 1 associated lipids |
| Myelitis | D009187 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ciancio G et al. | Current advantage of FK 506 in cadaveric kidney transplantation. | 1996 | Transplant. Proc. | pmid:8623207 |
| Pham SM et al. | Tacrolimus (FK 506) in clinical cardiac transplantation: a five-year experience. | 1996 | Transplant. Proc. | pmid:8623208 |
| Satomura K et al. | Pharmacokinetics of FK 506 in living-related liver transplantation. | 1996 | Transplant. Proc. | pmid:8623209 |
| Loss M et al. | Glucose and lipid metabolism in liver transplant patients under long-term tacrolimus (FK 506) monotherapy. | 1996 | Transplant. Proc. | pmid:8623210 |
| Bechstein WO et al. | Tacrolimus (FK 506) therapy is associated with a significant reduction in immunosuppressive treatment failures following primary liver transplantation. | 1996 | Transplant. Proc. | pmid:8623211 |
| Sher LS et al. | Tacrolimus (FK 506) for rescue of chronic rejection following orthotopic liver transplantation. | 1996 | Transplant. Proc. | pmid:8623212 |
| Millis JM et al. | Treatment of steroid-resistant rejection with tacrolimus prior to OKT3 in liver transplant recipients. | 1996 | Transplant. Proc. | pmid:8623213 |
| Ketel BL et al. | Tacrolimus-based vs cyclosporine-based immunotherapy in combined kidney-pancreas transplantation. | 1996 | Transplant. Proc. | pmid:8623453 |
| Kyo M et al. | Results with histological diagnosis in kidney transplant rejections treated with 15-deoxyspergualin. | 1996 | Transplant. Proc. | pmid:8623457 |
| D'Silva M et al. | Immunosuppressive effect of RS-61443 on rat cardiac allograft survival in combination with leflunomide or FK 506. | 1996 | Transplant. Proc. | pmid:8623467 |
| Pirenne J et al. | Bone marrow augmentation of kidney allografts can cause graft-versus-host disease in immunosuppressed recipients. | 1996 | Transplant. Proc. | pmid:8623472 |
| Ciancio G et al. | Human donor bone marrow cells can enhance hyporeactivity in renal transplantation using maintenance FK 506 and OKT3 induction therapy. | 1996 | Transplant. Proc. | pmid:8623473 |
| D'Silva M et al. | Immunosuppressive effect of brequinar on rat cardiac allograft survival in combination with leflunomide or FK 506. | 1996 | Transplant. Proc. | pmid:8623476 |
| Klintmalm GB | Clinical use of FK 506 in liver transplantation. | 1996 | Transplant. Proc. | pmid:8623484 |
| Butt TR et al. | Molecular basis of immunosuppressive drug action: regulation of steroid receptor-mediated transcription by FK 506. | 1996 | Transplant. Proc. | pmid:8623486 |
| Li W and Handschumacher RE | Regulation of the nuclear factor of activated T cells in stably transfected Jurkat cell clones. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8619834 |
| Kawashima M et al. | Tacrolimus concentrations in blood during topical treatment of atopic dermatitis. | 1996 | Lancet | pmid:8898050 |
| Drake M et al. | The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain. | 1996 | Acta Physiol. Scand. | pmid:8899062 |
| Zhang Q et al. | Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8799169 |
| Beauparlant P and Hiscott J | Biological and biochemical inhibitors of the NF-kappa B/Rel proteins and cytokine synthesis. | 1996 | Cytokine Growth Factor Rev. | pmid:8899295 |
| Spencer DM et al. | Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization. | 1996 | Curr. Biol. | pmid:8805308 |
| Kaplan B et al. | Frequency of hyperkalemia in recipients of simultaneous pancreas and kidney transplants with bladder drainage. | 1996 | Transplantation | pmid:8900321 |
| Franke EK and Luban J | Inhibition of HIV-1 replication by cyclosporine A or related compounds correlates with the ability to disrupt the Gag-cyclophilin A interaction. | 1996 | Virology | pmid:8806510 |
| Ichikawa Y et al. | Three-times-daily monotherapy with tacrolimus (FK 506) in kidney transplantation. | 1996 | Int. J. Urol. | pmid:8776613 |
| Mugiya S et al. | Renal blood flow and serotonin metabolism in tacrolimus treated rats. | 1996 | Int. J. Urol. | pmid:8776615 |
| Dmitrewski J et al. | Recurrence of primary biliary cirrhosis in the liver allograft: the effect of immunosuppression. | 1996 | J. Hepatol. | pmid:8778189 |
| Schwarz A | [Drug-induced kidney damage]. | 1996 | Z Arztl Fortbild (Jena) | pmid:8779233 |
| Newell KA et al. | Posttransplant lymphoproliferative disease in pediatric liver transplantation. Interplay between primary Epstein-Barr virus infection and immunosuppression. | 1996 | Transplantation | pmid:8779685 |
| Cicalese L et al. | Effect of FK506 on the mucosal perfusion of the rat intestinal allograft. | 1996 | Transplant. Proc. | pmid:8907959 |
| Reggiani P et al. | Oral administration of FK 506 in a swine model of liver-small bowel allotransplantation. | 1996 | Transplant. Proc. | pmid:8907965 |
| Spada M et al. | Bacterial translocation is enhanced in pig intestinal transplantation when the colon is included in the graft. | 1996 | Transplant. Proc. | pmid:8907997 |
| Alessiani M et al. | Intestinal transplantation with and without the colon in FK 506 immunosuppressed pigs. | 1996 | Transplant. Proc. | pmid:8908021 |
| Asfar S et al. | Small bowel transplantation. | 1996 | Transplant. Proc. | pmid:8908039 |
| Reyes J et al. | Intestinal transplantation in children: five-year experience. | 1996 | Transplant. Proc. | pmid:8908042 |
| Rao AS et al. | Augmentation of natural chimerism with donor bone marrow in orthotopic liver recipients. | 1996 | Transplant. Proc. | pmid:8908140 |
| Opelz G | Comparison of FK506 and cyclosporine. | 1996 | Transplantation | pmid:8830844 |
| Alper G and Small SL | Cerebrospinal fluid after organ transplantation. | 1996 | Transplant. Proc. | pmid:8908142 |
| Ho S et al. | The mechanism of action of cyclosporin A and FK506. | 1996 | Clin. Immunol. Immunopathol. | pmid:8811062 |
| Nishino H et al. | 3-Nitropropionic acid produces striatum selective lesions accompanied by iNOS expression. | 1996 | J. Chem. Neuroanat. | pmid:8811425 |
| Sonatore LM et al. | The utility of FK506-binding protein as a fusion partner in scintillation proximity assays: application to SH2 domains. | 1996 | Anal. Biochem. | pmid:8811923 |
| Jonas S et al. | Conversion to tacrolimus after liver transplantation. | 1996 | Transpl. Int. | pmid:8748407 |
| Cooley HM et al. | Resolution of pyoderma gangrenosum using tacolimus (FK-506) | 1996 | Aust N Z J Med | pmid:8744629 |
| Guérette B et al. | Increased interferon-gamma mRNA expression following alloincompatible myoblast transplantation is inhibited by FK506. | 1996 | Muscle Nerve | pmid:8965835 |
| Sharkey J et al. | Tacrolimus (FK506) ameliorates skilled motor deficits produced by middle cerebral artery occlusion in rats. | 1996 | Stroke | pmid:8969794 |
| Hedayat S et al. | Relationship of whole-blood FK506 concentrations to rejection and toxicity in liver and kidney transplants. | 1996 | J Biopharm Stat | pmid:8969977 |
| Taler SJ et al. | Role of steroid dose in hypertension early after liver transplantation with tacrolimus (FK506) and cyclosporine. | 1996 | Transplantation | pmid:8970613 |
| Tanabe K et al. | Diabetes mellitus after renal transplantation under FK 506 (tacrolimus) as primary immunosuppression. | 1996 | Transplant. Proc. | pmid:8658670 |
| Sugito K et al. | A comparative study of clinicopathologic characteristics of renal allografts under cyclosporine and FK506 immunosuppression. | 1996 | Transplant. Proc. | pmid:8658683 |
| Degawa H et al. | Blocking of ICAM-1 and LFA-1 in rat liver transplantation. | 1996 | Transplant. Proc. | pmid:8658695 |
| Watanabe K et al. | Immunosuppressive effect of bactobolamine in rat liver allotransplantation. | 1996 | Transplant. Proc. | pmid:8658697 |
| Tojimbara T et al. | Cyclosporine and tacrolimus both suppress activation of Kupffer cells in vitro. | 1996 | Transplant. Proc. | pmid:8658704 |
| Yuzawa K et al. | Topical immunosuppression in skin grafting with FK 506 ointment. | 1996 | Transplant. Proc. | pmid:8658707 |
| Yagura K et al. | Pharmacokinetic characteristics of two types of liposomal FK 506. | 1996 | Transplant. Proc. | pmid:8658708 |
| Ogawa N et al. | Suppressive effects of combination therapy with mizoribine and FK 506 on the development of accelerated coronary artery disease and myocardial rejection after heart transplantation. | 1996 | Transplant. Proc. | pmid:8658710 |
| Poon M et al. | Rapamycin inhibits vascular smooth muscle cell migration. | 1996 | J. Clin. Invest. | pmid:8941644 |
| Rokaw MD et al. | Rapamycin inhibits protein kinase C activity and stimulates Na+ transport in A6 cells. | 1996 | J. Biol. Chem. | pmid:8943313 |
| Matsui A et al. | Apparently increased trough levels of tacrolimus caused by acute infantile diarrhea in two infants with biliary atresia after liver transplantation. | 1996 | Acta Paediatr Jpn | pmid:9002314 |
| Adachi M et al. | Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain. | 1996 | Blood | pmid:8943845 |
| DeCenzo MT et al. | FK506-binding protein mutational analysis: defining the active-site residue contributions to catalysis and the stability of ligand complexes. | 1996 | Protein Eng. | pmid:9005438 |
| Przepiorka D et al. | Tacrolimus and minidose methotrexate for prevention of acute graft-versus-host disease after matched unrelated donor marrow transplantation. | 1996 | Blood | pmid:8943876 |
| Blecher O et al. | A novel plant peptidyl-prolyl-cis-trans-isomerase (PPIase): cDNA cloning, structural analysis, enzymatic activity and expression. | 1996 | Plant Mol. Biol. | pmid:8980498 |
| McCall E et al. | Effects of FK-506 on contraction and Ca2+ transients in rat cardiac myocytes. | 1996 | Circ. Res. | pmid:8943949 |
| Winkler M et al. | Evaluation of the Pro-Trac tacrolimus monoclonal whole-blood enzyme-linked immunosorbent assay for monitoring of tacrolimus levels in patients after kidney, heart, and liver transplantation. | 1996 | Ther Drug Monit | pmid:8946659 |
| Nichterlein T et al. | Effects of FK-506 on the course of murine salmonellosis. | 1996 | J Chemother | pmid:8981186 |
| MacFarlane G et al. | A simplified whole blood enzyme-linked immunosorbent assay (ProTrac II) for tacrolimus (FK506) using proteolytic extraction in place of organic solvents. | 1996 | Ther Drug Monit | pmid:8946668 |
| Redmon JB et al. | Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells. | 1996 | J. Clin. Invest. | pmid:8981925 |
| Brunet M et al. | Comparative analysis of tacrolimus (FK506) in whole blood liver transplant recipients by PRO-TRAC enzyme-linked immunosorbent assay and microparticle enzyme immunoassay IMX methods. | 1996 | Ther Drug Monit | pmid:8946669 |
| Sempuku T et al. | Osteogenic potential of allogeneic rat marrow cells in porous hydroxyapatite ceramics: a histological study. | 1996 | J. Orthop. Res. | pmid:8982133 |
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| Yu C et al. | Tacrolimus (FK506) and methotrexate regimens to prevent graft-versus-host disease after unrelated dog leukocyte antigen (DLA) nonidentical marrow transplantation. | 1996 | Bone Marrow Transplant. | pmid:8722370 |
| Fealy MJ and Press BH | Pinpointing the moment of allograft rejection. | 1996 | J Hand Surg Am | pmid:8724501 |
| Hall MN | The TOR signalling pathway and growth control in yeast. | 1996 | Biochem. Soc. Trans. | pmid:8674674 |
| Mattila PS | The actions of cyclosporin A and FK506 on T-lymphocyte activation. | 1996 | Biochem. Soc. Trans. | pmid:8674715 |
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| Jordan ML et al. | The use of tacrolimus in renal transplantation. | 1996 | World J Urol | pmid:8873438 |
| Wada Y et al. | BCX-34: a novel T-cell selective immunosuppressant: purine nucleoside phosphorylase (PNP) inhibitor. | 1996 | Artif Organs | pmid:8853794 |
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| DiMartini AF et al. | Prospective study of FK506 side effects: anxiety or akathisia? | 1996 | Biol. Psychiatry | pmid:8874843 |
| Horn F and Gross J | A role for calcineurin in Dictyostelium discoideum development. | 1996 | Differentiation | pmid:8855370 |
| Lu YF et al. | Calcineurin inhibitors, FK506 and cyclosporin A, suppress the NMDA receptor-mediated potentials and LTP, but not depotentiation in the rat hippocampus. | 1996 | Brain Res. | pmid:8874888 |
| Barkholt LM et al. | Epstein-Barr virus DNA in serum after liver transplantation--surveillance of viral activity during treatment with different immunosuppressive agents. | 1996 | Transpl. Int. | pmid:8875785 |
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| Morris-Stiff G et al. | Haemolytic uraemic syndrome associated with OKT3. | 1996 | Transpl. Int. | pmid:8875800 |
| Przepiorka D et al. | Allogeneic transplantation for advanced leukemia: improved short-term outcome with blood stem cell grafts and tacrolimus. | 1996 | Transplantation | pmid:8990368 |
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| Hartley AD et al. | cAMP inhibits bud growth in a yeast strain compromised for Ca2+ influx into the Golgi. | 1996 | Mol. Gen. Genet. | pmid:8709962 |
| Tokime T et al. | Neuroprotective effect of FK506, an immunosuppressant, on transient global ischemia in gerbil. | 1996 | Neurosci. Lett. | pmid:8710192 |
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| Lampen A et al. | Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber. | 1996 | Br. J. Pharmacol. | pmid:8732283 |
| Beretta L et al. | Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. | 1996 | EMBO J. | pmid:8599949 |
| Saada V et al. | Comparative evaluation of in vitro and in vivo immunosuppressive potential of cyclosporin G with cyclosporin A and FK-506. | 1996 | Int. J. Immunopharmacol. | pmid:8732436 |
| Inomata Y et al. | The evolution of immunosuppression with FK506 in pediatric living-related liver transplantation. | 1996 | Transplantation | pmid:8600632 |
| Asante-Korang A et al. | Experience of FK506 immune suppression in pediatric heart transplantation: a study of long-term adverse effects. | 1996 | J. Heart Lung Transplant. | pmid:8732602 |
| Gruessner RW et al. | A multicenter analysis of the first experience with FK506 for induction and rescue therapy after pancreas transplantation. | 1996 | Transplantation | pmid:8600635 |
| Rifai N et al. | The role of lipoproteins in the transport and uptake of cyclosporine and dihydro-tacrolimus into HepG2 and JURKAT cell lines. | 1996 | Clin. Biochem. | pmid:8601324 |