| MeSH term | MeSH ID | Detail |
|---|---|---|
| Brain Diseases | D001927 | 27 associated lipids |
| Endotoxemia | D019446 | 27 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
| Pseudomonas Infections | D011552 | 25 associated lipids |
| Cerebrovascular Disorders | D002561 | 25 associated lipids |
| Ascites | D001201 | 25 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Meiser BM and Reichart B | New trends in clinical immunosuppression. | 1994 | Transplant. Proc. | pmid:7527954 |
| Nakajima K et al. | Effects of triple therapy of cyclosporine, FK 506, and RS-61443 on allogeneic small bowel transplantation in dogs. | 1993 | Transplant. Proc. | pmid:7679821 |
| Ohtsuka S et al. | Hamster-to-rat xenotransplantation of whole pancreas by FK 506 combined with splenectomy. | 1994 | Transplant. Proc. | pmid:7513473 |
| Risaliti A et al. | Cardiovascular and metabolic complications after liver transplantation: Neoral- versus tacrolimus-based immunosuppression. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750569 |
| Tanabe K et al. | Prospective analysis and successful treatment of thrombotic microangiopathy in renal allografts under tacrolimus immunosuppression. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750571 |
| Goto T et al. | FK 506: historical perspectives. | 1991 | Transplant. Proc. | pmid:1721254 |
| Ochiai T et al. | Effective and safe use of FK 506: combination treatment with rapamycin or RS-61443 in experimental organ transplantation. | 1991 | Transplant. Proc. | pmid:1721255 |
| Ciancio G et al. | Current advantage of FK 506 in cadaveric kidney transplantation. | 1996 | Transplant. Proc. | pmid:8623207 |
| Vanrenterghem Y et al. | Co-administration of tacrolimus and mycophenolate mofetil in cadaveric renal transplant recipients. | 1998 | Transplant. Proc. | pmid:9636523 |
| Tanabe K et al. | Japanese single-center experience of kidney transplantation under tacrolimus immunosuppression. | 2000 | Transplant. Proc. | pmid:11119897 |
| Claesson K et al. | Lipoprotein patterns in renal transplant patients: a comparison between FK 506 and cyclosporine A patients. | 1998 | Transplant. Proc. | pmid:9636524 |
| Lye WC | Primary tacrolimus-based immunosuppression in renal allograft recipients: a single center experience. | 2000 | Transplant. Proc. | pmid:11119898 |
| Bruce DS et al. | Effects of tacrolimus, mycophenolate mofetil, and cyclosporine microemulsion on rejection incidence in synchronous pancreas-kidney transplantation. | 1998 | Transplant. Proc. | pmid:9532150 |
| Peddi VR et al. | Tacrolimus eliminates acute rejection as a major complication following simultaneous kidney and pancreas transplantation. | 1998 | Transplant. Proc. | pmid:9532151 |
| Ben-Ari Z et al. | Comparison of tacrolimus with cyclosporin as primary immunosuppression in patients with hepatitis C virus infection after liver transplantation. | 2003 | Transplant. Proc. | pmid:12644067 |
| Gutiérrez Sánchez MJ et al. | Optimization of immunosuppression by switching from azathioprine to enteric-coated mycophenolate sodium in stable kidney transplant patients. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715907 |
| Staschak S et al. | A cost comparison of liver transplantation with FK 506 or CyA as the primary immunosuppressive agent. | 1990 | Transplant. Proc. | pmid:1689896 |
| Lladó L et al. | Prospective evaluation of a quadruple therapy based on tacrolimus after liver transplantation. | 2002 | Transplant. Proc. | pmid:11959210 |
| Aptaramanov B et al. | A comparison of mycophenolate mofetil with mycophenolate sodium in renal transplant recipients on tacrolimus-based treatment. | 2011 | Transplant. Proc. | pmid:21486609 |
| Ma A et al. | Immunological evaluation of combination therapy with tacrolimus and sirolimus on long-term allograft survival in nonhuman primates. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808578 |
| Osako M et al. | Alloimmune response may be involved in neointimal hyperplasia in cryopreserved aortic allografts. | 2001 | Transplant. Proc. | pmid:11406250 |
| Mañez R et al. | Association between donor-recipient HLA-DR compatibility and cytomegalovirus hepatitis and chronic rejection in liver transplantation. | 1993 | Transplant. Proc. | pmid:7680170 |
| Müller MK et al. | Inhibition of insulin release by FK 506 and its prevention by rioprostil, a stable prostaglandin E1 analogue. | 1991 | Transplant. Proc. | pmid:1721286 |
| Ketel BL et al. | Tacrolimus-based vs cyclosporine-based immunotherapy in combined kidney-pancreas transplantation. | 1996 | Transplant. Proc. | pmid:8623453 |
| Mueller AR et al. | Does initial graft function influence the outcome after liver transplantation? | 1998 | Transplant. Proc. | pmid:9636594 |
| Oishi M et al. | A case of hyperkalemic distal renal tubular acidosis secondary to tacrolimus in living donor liver transplantation. | 2000 | Transplant. Proc. | pmid:11120143 |
| Soriano S et al. | Single-center experience with initial intravenous dosing of tacrolimus after kidney transplantation. | 1999 | Transplant. Proc. | pmid:10576045 |
| Serrano M et al. | Clinical value of a single determination of intracellular ATP levels in stimulated CD4+ T lymphocytes in pediatric patients with stable liver transplantation. | 2012 | Transplant. Proc. | pmid:23146475 |
| Takeuchi H et al. | Lymphocyte sensitivity to cyclosporine and tacrolimus in chronic renal failure patients and clinical significance in renal transplantation. | 1998 | Transplant. Proc. | pmid:9474950 |
| DÃaz-Molina B et al. | Effect of CYP3A5, CYP3A4, and ABCB1 genotypes as determinants of tacrolimus dose and clinical outcomes after heart transplantation. | 2012 | Transplant. Proc. | pmid:23146479 |
| Liu M et al. | C4d-positive acute humoral renal allograft rejection: rescue therapy by immunoadsorption in combination with tacrolimus and mycophenolate mofetil. | 2004 | Transplant. Proc. | pmid:15518760 |
| Deardon DJ et al. | Small bowel tonometry: a possible technique for detecting early small bowel allograft dysfunction. | 1993 | Transplant. Proc. | pmid:7505502 |
| Hayashi S et al. | Synergistic effect of donor pretreatment using FK 506 in hamster-to-rat cardiac xenotransplantation. | 1994 | Transplant. Proc. | pmid:7518126 |
| Ohtsuka S et al. | Mechanism of antibody production in guinea pig to rat discordant xenotransplant: establishment of a simple model by intravenous injection of discordant splenocytes. | 1994 | Transplant. Proc. | pmid:7518130 |
| Marente VC et al. | Modigraf administration through jejunostomy in liver transplant recipient: case report. | 2013 | Transplant. Proc. | pmid:24314992 |
| Woodle ES et al. | FK 506 rescue therapy: early conversion improves efficacy. | 1993 | Transplant. Proc. | pmid:7682359 |
| Loss M et al. | Influence of long-term cyclosporine or FK 506 therapy on glucose and lipid metabolism in stable liver graft recipients. | 1995 | Transplant. Proc. | pmid:7533365 |
| Yagihashi A et al. | The effect of FK 506 on peripheral blood T-lymphocyte subsets in orthotopic liver transplant patients. | 1991 | Transplant. Proc. | pmid:1721318 |
| Ziolkowski J et al. | Effect of immunosuppressive regimen on acute rejection and liver graft function. | 2003 | Transplant. Proc. | pmid:14529915 |
| Kato T et al. | FK506 may suppress liver injury during the early period following living-related liver transplantation. | 2003 | Transplant. Proc. | pmid:12591316 |
| Bahra M et al. | Repeated steroid pulse therapies in HCV-positive liver recipients: significant risk factor for HCV-related graft loss. | 2005 | Transplant. Proc. | pmid:15919436 |
| Maes BD and Vanrenterghem YF | Cyclosporine: advantages versus disadvantages vis-Ã -vis tacrolimus. | 2004 | Transplant. Proc. | pmid:15041305 |
| Ã…berg F et al. | Asymptomatic De Novo Inflammatory Bowel Disease Late After Liver Transplantation for Primary Sclerosing Cholangitis: A Case Report. | 2015 | Transplant. Proc. | pmid:26680092 |
| Malireddy SR et al. | Altered first-pass effects in a liver transplant recipient explained intraindividual variation in calcineurin inhibitor concentrations: a case report. | 2008 | Transplant. Proc. | pmid:18589198 |
| Braun F et al. | Therapeutic drug monitoring of tacrolimus early after liver transplantation. | 2002 | Transplant. Proc. | pmid:12176473 |
| Tashiro H et al. | Monitoring for engraftment of rat orthotopic liver transplantation by semiquantitative PCR. | 1995 | Transplant. Proc. | pmid:7533421 |
| Schorlemmer HU et al. | Long-term allograft survival and tolerance induction by the synergistic activity of malononitrilamides and tacrolimus. | 1998 | Transplant. Proc. | pmid:9865312 |
| Felser I et al. | Changes in quality of life following conversion from CyA to FK 506 in orthotopic liver transplant patients. | 1991 | Transplant. Proc. | pmid:1721350 |
| Chiereghin A et al. | Monitoring cytomegalovirus T-cell immunity in small bowel/multivisceral transplant recipients. | 2010 Jan-Feb | Transplant. Proc. | pmid:20172283 |
| Dierickx D et al. | Thrombotic microangiopathy following intestinal transplantation: a single center experience. | 2010 Jan-Feb | Transplant. Proc. | pmid:20172285 |
| Nanni G et al. | Lack of correlation between serum levels of mycophenolate mofetil and kidney transplant outcome in tacrolimus-based immunosupression. | 2002 | Transplant. Proc. | pmid:12270323 |
| Pape L et al. | Long-term stable glomerular filtration rate achieved with tacrolimus in pediatric renal transplantation. | 2002 | Transplant. Proc. | pmid:12270367 |
| Prasad GV et al. | Role of dietary salt intake in posttransplant hypertension with tacrolimus-based immunosuppression. | 2005 | Transplant. Proc. | pmid:15919496 |
| Walgenbach KJ et al. | Increased presence of mast cells and interleukin-4 during chronic rejection of rat intestinal allografts. | 1996 | Transplant. Proc. | pmid:8907896 |
| Miyagi M et al. | Comparison of the therapeutic effects between CsA and FK506 on chronic renal allograft injury and TGF-beta expression. | 2002 | Transplant. Proc. | pmid:12176497 |
| Nüssler NC et al. | CD8+ host cells infiltrate the intestinal mucosa after allogeneic small bowel transplantation even in the absence of acute rejection. | 1996 | Transplant. Proc. | pmid:8907898 |
| van Hooff JP et al. | Benelux experience with a combination of tacrolimus and mycophenolate mofetil: 4-year results. | 2002 | Transplant. Proc. | pmid:12176498 |
| Malaise J et al. | Immunosuppressive drugs after simultaneous pancreas-kidney transplantation. | 2005 Jul-Aug | Transplant. Proc. | pmid:16182827 |
| Zmonarski SC et al. | Lowering of Messenger Ribonucleic Acid Toll-Like Receptors 2-4,9 in Peripheral Blood Mononuclear Cells in Kidney Allograft Recipients, Relationships With Immunosuppressive Treatment, and Delayed Graft Function Occurrence. | 2016 | Transplant. Proc. | pmid:27496439 |
| Oishi M et al. | Successful swine small bowel transplantation using FK506: effect on endotoxin translocation. | 1994 | Transplant. Proc. | pmid:7520629 |
| Moutabarrik A et al. | FK 506 mechanism of nephrotoxicity: stimulatory effect on endothelin secretion by cultured kidney cells and tubular cell toxicity in vitro. | 1991 | Transplant. Proc. | pmid:1721382 |
| Takeda M et al. | Immunologic factors contributing to acute rejection in lungs xenotransplanted between primates. | 1998 | Transplant. Proc. | pmid:9838670 |
| Murase N et al. | Immunomodulation of intestinal transplant with allograft irradiation and simultaneous donor bone marrow infusion. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083238 |
| Endoh M et al. | Nonmuscle myosin heavy chain and metalloproteinase-2 expression in concordant pulmonary xenografts. | 2000 | Transplant. Proc. | pmid:10936397 |
| Gassel HJ et al. | Selective immunosuppression induces tolerance after liver transplantation: an immunohistochemical and cytofluorographic analysis of the graft and recipient immune system. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123253 |
| Kliem V et al. | FK 506 in the treatment of steroid- and OKT3-resistant rejection in renal transplant recipients: reduced dosage and anti-infective prophylaxis. | 1996 | Transplant. Proc. | pmid:8962227 |
| Citterio F et al. | Steroid withdrawal from tacrolimus-based therapy in renal transplant patients. | 2002 | Transplant. Proc. | pmid:12176545 |
| Han DJ et al. | A 39-month follow-up study to evaluate the safety and efficacy in kidney transplant recipients treated with modified-release tacrolimus (FK506E)-based immunosuppression regimen. | 2012 | Transplant. Proc. | pmid:22310592 |
| Chang HR et al. | Lack of hepatotoxicity upon sirolimus addition to a calcineurin inhibitor-based regimen in hepatitis virus-positive renal transplant recipients. | 2007 | Transplant. Proc. | pmid:17580178 |
| Jiang H et al. | IL-10: a tacrolimus-specific cytotoxic mediator in ongoing allograft rejection. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266931 |
| Orsenigo R et al. | FK506 and SMS 201-995: effect on heterotopic heart transplantation in rats. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266956 |
| Ohtsuka S et al. | The effect of short-term FK 506 therapy on pancreas transplantation in rats. | 1991 | Transplant. Proc. | pmid:1721413 |
| Tanabe K et al. | Diabetes mellitus after renal transplantation under FK 506 (tacrolimus) as primary immunosuppression. | 1996 | Transplant. Proc. | pmid:8658670 |
| Nakao A et al. | Cytokine mRNA expression on rat small bowel allograft treated with tacrolimus and simultaneous bone marrow transplantation via the portal vein. | 2000 | Transplant. Proc. | pmid:10995965 |
| Yamashita T et al. | Prolongation of pancreaticoduodenal allograft survival in rats by treatment with FK 506. | 1991 | Transplant. Proc. | pmid:1721414 |
| Sugito K et al. | A comparative study of clinicopathologic characteristics of renal allografts under cyclosporine and FK506 immunosuppression. | 1996 | Transplant. Proc. | pmid:8658683 |
| Soltero L et al. | Coadministration of tacrolimus and ketoconazole in renal transplant recipients: cost analysis and review of metabolic effects. | 2003 | Transplant. Proc. | pmid:12826147 |
| Langer RM et al. | De novo tumors after kidney transplantation: the Budapest experience. | 2003 | Transplant. Proc. | pmid:12826170 |
| Glanemann M et al. | Higher immunosuppressive efficacy of mycophenolate mofetil in combination with FK 506 than in combination with cyclosporine A. | 2000 | Transplant. Proc. | pmid:10812095 |
| McMaster P et al. | Liver transplantation: changing goals in immunosuppression. | 1998 | Transplant. Proc. | pmid:9723295 |
| Fábrega E et al. | Effect of immunosuppressant blood levels on serum concentration of interleukin-17 and -23 in stable liver transplant recipients. | 2009 | Transplant. Proc. | pmid:19376417 |
| Tahir W et al. | Diffuse Alveolar haemorrhage: a fatal complication after alemtuzumab induction therapy in renal transplantation. | Transplant. Proc. | pmid:25645795 | |
| Burke GW et al. | Steroid-resistant acute rejection following SPK: importance of maintaining therapeutic dosing in a triple-drug regimen. | 2002 | Transplant. Proc. | pmid:12176628 |
| Kovarik JM et al. | Differential pharmacokinetic interaction of tacrolimus and cyclosporine on everolimus. | 2006 | Transplant. Proc. | pmid:17175302 |
| Moura Neto A et al. | Clinical Profile of Patients With Diabetes Mellitus and Liver Transplantation: Results After a Multidisciplinary Team Intervention. | 2018 | Transplant. Proc. | pmid:29661438 |
| Mühlbacher F | Tacrolimus versus cyclosporin microemulsion in liver transplantation: results of a 3-month study. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267317 |
| Duzova A et al. | Triple immunosuppression with or without basiliximab in pediatric renal transplantation: acute rejection rates at one year. | 2003 | Transplant. Proc. | pmid:14697926 |
| Lin CY et al. | Effects of FK 506 on the biochemical markers in canine lung allograft rejection. | 1991 | Transplant. Proc. | pmid:1721445 |
| Morales E et al. | Conversion from cyclosporine to FK 506 as rescue therapy in renal transplantation with poorly steroid-responsive acute rejection. | 1999 | Transplant. Proc. | pmid:10500562 |
| Jost U et al. | FK 506 treatment of intractable rejection after liver transplantation. | 1993 | Transplant. Proc. | pmid:7689276 |
| Nardo B et al. | Evidence of microchimerism after pretransplant blood transfusion and FK 506 in liver xenograft. | 2000 | Transplant. Proc. | pmid:11134771 |
| Miyata Y et al. | Development of xenogeneic microchimerism correlated with graft outcome in hamster-to-rat heart xenotransplantation. | 1998 | Transplant. Proc. | pmid:9723548 |
| Chamienia A et al. | Open prospective study to evaluate cardiovascular risk factors and renal function in 2 dosage regimens of tacrolimus combined with mycophenolate mofetil and steroids in renal transplant patients: 5-year results. | 2014 | Transplant. Proc. | pmid:25380901 |
| Kocak H et al. | Tacrolimus plus low-dose mycophenolate mofetil in renal transplant recipients: better 2-year graft and patient survival than with a higher mycophenolate mofetil dose. | 2005 | Transplant. Proc. | pmid:16213288 |
| Abou-Jaoude MM et al. | Tacrolimus (FK506) versus cyclosporine microemulsion (neoral) as maintenance immunosuppression therapy in kidney transplant recipients. | 2005 | Transplant. Proc. | pmid:16213293 |
| Abe T et al. | Risk factors for development of new-onset diabetes mellitus and progressive impairment of glucose metabolism after living-donor liver transplantation. | 2014 | Transplant. Proc. | pmid:24767367 |
| Reimer J et al. | Quality of life after kidney transplantation--the impact of tacrolimus. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267573 |
| McLaughlin GE et al. | Effect of aminophylline on urine flow in children with tacrolimus-induced renal insufficiency. | 2000 | Transplant. Proc. | pmid:10856596 |
| Fritsche L et al. | Conversion to mycophenolate mofetil for chronic progressive deterioration of renal allograft function: first clinical experiences in 44 patients. | 1998 | Transplant. Proc. | pmid:9636481 |
| Bresci S et al. | Case report: cystic fibrosis, lung transplantation, and the novel H1N1 flu. | 2010 Jul-Aug | Transplant. Proc. | pmid:20692461 |