| MeSH term | MeSH ID | Detail |
|---|---|---|
| Connective Tissue Diseases | D003240 | 2 associated lipids |
| Corneal Diseases | D003316 | 13 associated lipids |
| Cough | D003371 | 19 associated lipids |
| Crigler-Najjar Syndrome | D003414 | 1 associated lipids |
| Crohn Disease | D003424 | 12 associated lipids |
| Cryptococcosis | D003453 | 3 associated lipids |
| Cutis Laxa | D003483 | 1 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Phyllodes Tumor | D003557 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Alevizopoulos A et al. | Regulation of the transforming growth factor beta-responsive transcription factor CTF-1 by calcineurin and calcium/calmodulin-dependent protein kinase IV. | 1997 | J. Biol. Chem. | pmid:9295299 |
| Lal SM et al. | De novo membranous glomerulopathy in a renal transplant patient treated with FK 506. The first reported case. | 1997 | Int J Artif Organs | pmid:9298410 |
| Milićević NM and Milićević Z | Stereological study of splenic tissue compartments in FK506-treated rats. | 1997 | Histol. Histopathol. | pmid:9302561 |
| Wingard JR et al. | Lack of interaction between tacrolimus (FK506) and methotrexate in bone marrow transplant recipients. | 1997 | Bone Marrow Transplant. | pmid:9232256 |
| Yamagami S et al. | Mechanism of concordant corneal xenograft rejection in mice: synergistic effects of anti-leukocyte function-associated antigen-1 monoclonal antibody and FK506. | 1997 | Transplantation | pmid:9233699 |
| Wijnen RM and Ericzon BG | Update of tacrolimus in pancreas transplantation. | 1997 | Diabet. Med. | pmid:9400914 |
| Sawabe T et al. | Sinus arrest during tacrolimus (FK506) and digitalis treatment in a bone marrow transplant recipient. | 1997 | Transplantation | pmid:9233725 |
| Misao T et al. | Efficacy of combining donor-specific presensitization with a simultaneous single injection of tacrolimus on pulmonary allografts. | 1997 | J. Heart Lung Transplant. | pmid:9402508 |
| Suzuki J et al. | Inhibition of accelerated coronary atherosclerosis with short-term blockade of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 in a heterotopic murine model of heart transplantation. | 1997 | J. Heart Lung Transplant. | pmid:9402514 |
| Cohen SB et al. | Autocrine and paracrine regulation of human T cell IL-10 production. | 1997 | J. Immunol. | pmid:9190906 |
| Zucker K et al. | Unexpected augmentation of mycophenolic acid pharmacokinetics in renal transplant patients receiving tacrolimus and mycophenolate mofetil in combination therapy, and analogous in vitro findings. | 1997 | Transpl. Immunol. | pmid:9402690 |
| Miyata Y et al. | Phosphorylation of the immunosuppressant FK506-binding protein FKBP52 by casein kinase II: regulation of HSP90-binding activity of FKBP52. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9405642 |
| Taylor DO | The use of tacrolimus and mycophenolate mofetil after cardiac transplantation. | 1997 | Curr. Opin. Cardiol. | pmid:9192485 |
| Harihara Y and Makuuchi M | [Partial liver transplantation]. | 1997 | Nippon Naika Gakkai Zasshi | pmid:9340350 |
| Araki T et al. | Age-related changes of sodium-dependent D-[3H]aspartate and [3H]FK506 binding in rat brain. | 1997 | J Neural Transm | pmid:9203087 |
| Moroda T et al. | Self-reactive forbidden clones are confined to pathways of intermediate T-cell receptor cell differentiation even under immunosuppressive conditions. | 1997 | Immunology | pmid:9203970 |
| Spencer CM et al. | Tacrolimus. An update of its pharmacology and clinical efficacy in the management of organ transplantation. | 1997 | Drugs | pmid:9421697 |
| Mrvos R et al. | Tacrolimus (FK 506) overdose: a report of five cases. | 1997 | J. Toxicol. Clin. Toxicol. | pmid:9204100 |
| Stegall MD et al. | Mycophenolate mofetil decreases rejection in simultaneous pancreas-kidney transplantation when combined with tacrolimus or cyclosporine. | 1997 | Transplantation | pmid:9422404 |
| Sikorski R and Peters R | A cell growth switch. | 1997 | Science | pmid:9206844 |
| Shield CF et al. | Assessment of health-related quality of life in kidney transplant patients receiving tacrolimus (FK506)-based versus cyclosporine-based immunosuppression. FK506 Kidney Transplant Study Group. | 1997 | Transplantation | pmid:9422413 |
| Shafiee A et al. | Chemical and biological characterization of two FK506 analogs produced by targeted gene disruption in Streptomyces sp. MA6548. | 1997 | J. Antibiot. | pmid:9207912 |
| Stegall MD et al. | Prednisone withdrawal 14 days after liver transplantation with mycophenolate: a prospective trial of cyclosporine and tacrolimus. | 1997 | Transplantation | pmid:9422416 |
| Uberti JP et al. | Tacrolimus and methotrexate for the prophylaxis of acute graft-versus-host disease in allogeneic bone marrow transplantation in patients with hematologic malignancies. | 1997 | Bone Marrow Transplant. | pmid:9208118 |
| Shihab FS et al. | Mechanism of fibrosis in experimental tacrolimus nephrotoxicity. | 1997 | Transplantation | pmid:9422427 |
| Ohashi Y et al. | Successful treatment of steroid-resistant severe acute GVHD with 24-h continuous infusion of FK506. | 1997 | Bone Marrow Transplant. | pmid:9085743 |
| Vu MD et al. | Tacrolimus (FK506) and sirolimus (rapamycin) in combination are not antagonistic but produce extended graft survival in cardiac transplantation in the rat. | 1997 | Transplantation | pmid:9422432 |
| Oz HS and Hughes WT | Novel anti-Pneumocystis carinii effects of the immunosuppressant mycophenolate mofetil in contrast to provocative effects of tacrolimus, sirolimus, and dexamethasone. | 1997 | J. Infect. Dis. | pmid:9086147 |
| Wagner K et al. | New-onset diabetes mellitus in pediatric thoracic organ recipients receiving tacrolimus-based immunosuppression. | 1997 | J. Heart Lung Transplant. | pmid:9087870 |
| Kloke O et al. | Rapamycin antagonizes interleukin-6 mediated growth arrest and differentiation of myeloblastic M1 cells. | 1997 | Immunol. Lett. | pmid:9373220 |
| Eberlein-König B et al. | Modulation of histamine release in vitro by FK506 and interleukin-3 is determined by sequence of incubation. | 1997 | Arch. Dermatol. Res. | pmid:9373722 |
| Rudant E et al. | Study of the correlation between MEIA and ELISA methods for FK 506 determination in liver transplant recipients. | 1997 | J Clin Pharm Ther | pmid:9373812 |
| Sandborn WJ | Preliminary report on the use of oral tacrolimus (FK506) in the treatment of complicated proximal small bowel and fistulizing Crohn's disease. | 1997 | Am. J. Gastroenterol. | pmid:9149205 |
| Cetinkale O et al. | Involvement of neutrophils in ischemic injury. I. Biochemical and histopathological investigation of the effect of FK506 on dorsal skin flaps in rats. | 1997 | Ann Plast Surg | pmid:9374148 |
| Duddridge M and Powell RJ | Treatment of severe and difficult cases of systemic lupus erythematosus with tacrolimus. A report of three cases. | 1997 | Ann. Rheum. Dis. | pmid:9462174 |
| Katoh H et al. | Living related partial liver transplantation in biliary atresia: 11 cases of experience. | 1997 | Tohoku J. Exp. Med. | pmid:9149348 |
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| Muramatsu K et al. | Longer survival of rat limb allograft. Combined immunosuppression of FK-506 and 15-deoxyspergualin. | 1997 | Acta Orthop Scand | pmid:9462361 |
| Steffen R et al. | Autoimmune enteropathy in a pediatric patient: partial response to tacrolimus therapy. | 1997 | Clin Pediatr (Phila) | pmid:9152557 |
| Canzanello VJ et al. | Evolution of cardiovascular risk after liver transplantation: a comparison of cyclosporine A and tacrolimus (FK506). | 1997 | Liver Transpl Surg | pmid:9377752 |
| Chow FS et al. | Effect of hematocrit and albumin concentration on hepatic clearance of tacrolimus (FK506) during rabbit liver perfusion. | 1997 | Drug Metab. Dispos. | pmid:9152601 |
| De Gasperi A and Rohrer RJ | Scenario number two: sepsis and multiorgan failure after liver transplantation. | 1997 | Liver Transpl Surg | pmid:9377761 |
| Woo M et al. | Toxicities of tacrolimus and cyclosporin A after allogeneic blood stem cell transplantation. | 1997 | Bone Marrow Transplant. | pmid:9466284 |
| Araki T et al. | Effects of vinconate on age-related alterations in [3H]MK-801, [3H]glycine, sodium-dependent D-[3H]aspartate, [3H]FK-506 and [3H]PN200-110 binding in rats. | 1997 | Mech. Ageing Dev. | pmid:9152958 |
| Lang P and Baron C | Molecular mechanisms of immunosuppressive chemical agents recently introduced in clinical transplantation protocols. | 1997 | Nephrol. Dial. Transplant. | pmid:9351062 |
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| Waer M | New immunosuppressive agents for organ transplantation. | 1997 | Acta Clin Belg | pmid:9351290 |
| Delehanty LL et al. | Apoptosis in a Fas-resistant, T-cell receptor-sensitive human leukaemic T-cell clone. | 1997 | Immunology | pmid:9155645 |
| Newell KA et al. | Treatment with either anti-CD4 or anti-CD8 monoclonal antibodies blocks alphabeta T cell-mediated rejection of intestinal allografts in mice. | 1997 | Transplantation | pmid:9381541 |
| Iyengar AR et al. | Striking augmentation of hematopoietic cell chimerism in noncytoablated allogeneic bone marrow recipients by FLT3 ligand and tacrolimus. | 1997 | Transplantation | pmid:9158008 |
| van Hooff JP | Pneumocystis carinii pneumonia after renal transplantation. | 1997 | Transplantation | pmid:9158038 |
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| Velio P et al. | Combined orthotopic liver-small bowel transplantation or small bowel transplantation in pigs: relations between survival, rejection, and mucosal morphometry. | 1997 | Transplant. Proc. | pmid:9142295 |
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| Durham HD et al. | The immunosuppressant FK506 prolongs transgene expression in brain following adenovirus-mediated gene transfer. | 1997 | Neuroreport | pmid:9243594 |
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| Lang T et al. | Cholic acid synthesis is reduced in pediatric liver recipients during graft dysfunction due to ischemic injury and allograft rejection. | 1997 | Transplantation | pmid:9415561 |
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| Yagi M et al. | Effect of a glutamine-enriched diet on small bowel allograft during immunosuppressive therapy. | 1997 | Nutrition | pmid:9290090 |
| Ilan Y et al. | Transient immunosuppression with FK506 permits long-term expression of therapeutic genes introduced into the liver using recombinant adenoviruses in the rat. | 1997 | Hepatology | pmid:9328318 |
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| Hess DA et al. | The hydroxylamine of sulfamethoxazole synergizes with FK506 and cyclosporin A, inhibiting T-cell proliferation. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9103542 |
| Kawamura N et al. | Extremely high serum level of IgE during immunosuppressive therapy: paradoxical effect of cyclosporine A and tacrolimus. | 1997 | Int. Arch. Allergy Immunol. | pmid:9104801 |
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| Marks WH et al. | Asialoglycoprotein/asialoglycoprotein receptor (AGP-AGPr) interaction is an important mechanism for the uptake of FK506 by hepatocytes. | 1997 | Transplantation | pmid:9020333 |
| Aiko S et al. | Effects of cyclosporine or FK506 in chronic colitis. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9023326 |
| Budde K et al. | Differing proteinuria control with cyclosporin and tacrolimus. | 1997 | Lancet | pmid:9024386 |
| Testa G and Klintmalm GB | Cyclosporine and tacrolimus: the mainstay of immunosuppressive therapy for solid organ transplantation. | 1997 | Clin Liver Dis | pmid:15562576 |
| Alak AM et al. | A highly sensitive enzyme-linked immunosorbent assay for the determination of tacrolimus in atopic dermatitis patients. | 1997 | Ther Drug Monit | pmid:9029754 |
| Padhi ID et al. | Interaction between tacrolimus and erythromycin. | 1997 | Ther Drug Monit | pmid:9029762 |
| Tsuchida Y et al. | Limb allografts in rats treated with anti-ICAM-1 and anti-LFA-1 monoclonal antibodies. | 1997 | J Reconstr Microsurg | pmid:9044184 |
| Tsamandas AC et al. | Central venulitis in the allograft liver: a clinicopathologic study. | 1997 | Transplantation | pmid:9256183 |
| Sher LS et al. | Efficacy of tacrolimus as rescue therapy for chronic rejection in orthotopic liver transplantation: a report of the U.S. Multicenter Liver Study Group. | 1997 | Transplantation | pmid:9256184 |
| Tsamandas AC et al. | Adult heart transplantation under tacrolimus (FK506) immunosuppression: histopathologic observations and comparison to a cyclosporine-based regimen with lympholytic (ATG) induction. | 1997 | J. Heart Lung Transplant. | pmid:9257254 |
| Trede NS et al. | Tacrolimus (FK506) in allogeneic bone marrow transplantation for severe aplastic anemia following orthotopic liver transplantation. | 1997 | Bone Marrow Transplant. | pmid:9257897 |
| Freiberg RA et al. | Transcriptional control in keratinocytes and fibroblasts using synthetic ligands. | 1997 | J. Clin. Invest. | pmid:9169490 |
| Wang JH and Kelly PT | Postsynaptic calcineurin activity downregulates synaptic transmission by weakening intracellular Ca2+ signaling mechanisms in hippocampal CA1 neurons. | 1997 | J. Neurosci. | pmid:9169521 |
| Dodd DA | Rapid resolution of gingival hyperplasia after switching from cyclosporine A to tacrolimus. | 1997 | J. Heart Lung Transplant. | pmid:9171281 |
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