| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Perioral | D019557 | 4 associated lipids |
| Pouchitis | D019449 | 3 associated lipids |
| Endotoxemia | D019446 | 27 associated lipids |
| Oral Ulcer | D019226 | 1 associated lipids |
| Gingival Overgrowth | D019214 | 7 associated lipids |
| Fasciitis, Necrotizing | D019115 | 1 associated lipids |
| Postoperative Hemorrhage | D019106 | 7 associated lipids |
| Multiple Endocrine Neoplasia Type 2a | D018813 | 1 associated lipids |
| Anemia, Iron-Deficiency | D018798 | 6 associated lipids |
| Encephalitis, Viral | D018792 | 3 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sher LS et al. | Tacrolimus (FK 506) for rescue of chronic rejection following orthotopic liver transplantation. | 1996 | Transplant. Proc. | pmid:8623212 |
| Millis JM et al. | Treatment of steroid-resistant rejection with tacrolimus prior to OKT3 in liver transplant recipients. | 1996 | Transplant. Proc. | pmid:8623213 |
| Washburn WK et al. | Tacrolimus rescue therapy for renal allograft rejection refractory to cyclosporine-based immunosuppression. | 1996 | Transplant. Proc. | pmid:8623214 |
| Regazzi MB et al. | Interaction between FK 506 and diltiazem in an animal model. | 1996 | Transplant. Proc. | pmid:8623215 |
| Hashikura Y et al. | Immunosuppressant switching between cyclosporine and tacrolimus after liver transplantation. | 1996 | Transplant. Proc. | pmid:8623218 |
| Tomikawa S et al. | Immunosuppressive effects of bactobolamine in vitro and in vivo. | 1996 | Transplant. Proc. | pmid:8623223 |
| Nakajima H and Oka T | The inhibition of T-cell-receptor-induced Fas ligand upregulation by cyclosporine and FK 506. | 1996 | Transplant. Proc. | pmid:8623224 |
| Ko S et al. | Different immunosuppressive effects of liposomal FK506 in liver and kidney transplantation. | 1996 | Transplant. Proc. | pmid:8623229 |
| D'Silva M et al. | Immunosuppressive effect of brequinar on rat cardiac allograft survival in combination with leflunomide or FK 506. | 1996 | Transplant. Proc. | pmid:8623476 |
| Klintmalm GB | Clinical use of FK 506 in liver transplantation. | 1996 | Transplant. Proc. | pmid:8623484 |
| Butt TR et al. | Molecular basis of immunosuppressive drug action: regulation of steroid receptor-mediated transcription by FK 506. | 1996 | Transplant. Proc. | pmid:8623486 |
| Mori A et al. | Enhanced production and gene expression of IL-5 in bronchial asthma. Possible management of atopic diseases with IL-5 specific gene transcription inhibitor. | 1996 | Adv. Exp. Med. Biol. | pmid:9095279 |
| Millis JM et al. | Tacrolimus for primary treatment of steroid-resistant hepatic allograft rejection. | 1996 | Transplantation | pmid:8629298 |
| Systemic tacrolimus (FK 506) is effective for the treatment of psoriasis in a double-blind, placebo-controlled study. The European FK 506 Multicentre Psoriasis Study Group. | 1996 | Arch Dermatol | pmid:8629845 | |
| DiGiuseppe JA et al. | Tacrolimus-related posttransplant lymphoproliferative disorder presenting as autoimmune hemolytic anemia. | 1996 | Arch. Pathol. Lab. Med. | pmid:8629906 |
| Kinoshita I et al. | Myoblast transplantation in monkeys: control of immune response by FK506. | 1996 | J. Neuropathol. Exp. Neurol. | pmid:8642394 |
| Singh N et al. | Recurrent hepatitis C virus hepatitis in liver transplant recipients receiving tacrolimus: association with rejection and increased immunosuppression after transplantation. | 1996 | Surgery | pmid:8644012 |
| Morozumi K et al. | Diagnosis of chronic rejection using peritubular and glomerular capillary lesions. | 1996 | Transplant. Proc. | pmid:8644331 |
| Colombani PM et al. | Liver transplantation in infants younger than 1 year of age. | 1996 | Ann. Surg. | pmid:8645039 |
| Osowski CL et al. | Evaluation of the drug interaction between intravenous high-dose fluconazole and cyclosporine or tacrolimus in bone marrow transplant patients. | 1996 | Transplantation | pmid:8610430 |
| Tanida I et al. | Yeast Cls2p/Csg2p localized on the endoplasmic reticulum membrane regulates a non-exchangeable intracellular Ca2+ pool cooperatively with calcineurin. | 1996 | FEBS Lett. | pmid:8566225 |
| Buckle GJ et al. | HTLV-I-induced T-cell activation. | 1996 | J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. | pmid:8797712 |
| Wu J et al. | Reversal of multidrug resistance by tacrolimus hydrate. | 1996 | Methods Find Exp Clin Pharmacol | pmid:9121220 |
| Alessiani M et al. | Combined FK 506 and mycophenolate mofetil immunosuppression prolongs survival after small bowel transplantation in pigs. | 1996 | Transplant. Proc. | pmid:8907922 |
| Cohen DS et al. | Porcine small bowel transplantation with rapamycin-based induction immunosuppression and short-course cyclosporine or FK 506 therapy. | 1996 | Transplant. Proc. | pmid:8907923 |
| Toyama Y et al. | Prolonged small bowel graft survival using photochemotherapy and low-dose FK 506. | 1996 | Transplant. Proc. | pmid:8907924 |
| Yamada T et al. | Synergistic effect of FK 506 and trifluoperazine on the immunosuppression in rat small bowel transplantation. | 1996 | Transplant. Proc. | pmid:8907927 |
| Rossi G et al. | Results of orthotopic liver-small bowel transplantation in the pig using different immunosuppressive regimens. | 1996 | Transplant. Proc. | pmid:8907932 |
| Platz KP et al. | Immunosuppressive power and limitations of FK 506 for prevention and treatment of graft-vs-host disease after small bowel transplantation. | 1996 | Transplant. Proc. | pmid:8907933 |
| Velio P et al. | Rejection and survival after total orthotopic liver-small bowel allotransplantation in pigs immunosuppressed with FK 506. | 1996 | Transplant. Proc. | pmid:8907936 |
| Bardella MT et al. | FK 506 and cyclosporine: effect on D-xylose absorption in pigs with orthotopic liver-small bowel allotransplants. | 1996 | Transplant. Proc. | pmid:8907937 |
| Hayashi K et al. | Suppression of experimental crescentic-type anti-glomerular basement membrane (GBM) nephritis by FK506 (tacrolimus hydrate) in rats. | 1996 | Jpn. J. Pharmacol. | pmid:8822088 |
| Sasahara Y et al. | Okadaic acid suppresses neural differentiation-dependent expression of the neurofilament-L gene in P19 embryonal carcinoma cells by post-transcriptional modification. | 1996 | J. Biol. Chem. | pmid:8824230 |
| Lang T et al. | Production of IL-4 and IL-10 does not lead to immune quiescence in vascularized human organ grafts. | 1996 | Transplantation | pmid:8824477 |
| Matsuda H et al. | Interactions of FK506 (tacrolimus) with clinically important drugs. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8824931 |
| Moriwaki A et al. | Immunosuppressant FK506 prevents mossy fiber sprouting induced by kindling stimulation. | 1996 | Neurosci. Res. | pmid:8829156 |
| Ankarcrona M et al. | Calcineurin and mitochondrial function in glutamate-induced neuronal cell death. | 1996 | FEBS Lett. | pmid:8830666 |
| Braun F et al. | Clinical relevance of monitoring tacrolimus: comparison of microparticle enzyme immunoassay, enzyme-linked immunosorbent assay, and liquid chromatography mass spectrometry in renal transplant recipients converted from cyclosporine to tacrolimus. | 1996 | Transplant. Proc. | pmid:8962231 |
| Wilczek HE et al. | Renal transplant histopathologic changes during the first year in patients with tacrolimus (FK 506). | 1996 | Transplant. Proc. | pmid:8962232 |
| Yussim A et al. | Conversion from cyclosporine to tacrolimus in hepatic and renal transplantation. | 1996 | Transplant. Proc. | pmid:8962233 |
| Golling M et al. | Tacrolimus reduction improves glucose metabolism and insulin secretion after liver transplantation. | 1996 | Transplant. Proc. | pmid:8962234 |
| Platz KP et al. | Incidence and outcome of chronic rejection in CyA- and FK 506-treated patients. | 1996 | Transplant. Proc. | pmid:8962235 |
| Mollison KW et al. | Discovery of FK 506 analogues that are nontoxic to mouse pancreatic beta cells in vitro but show diabetogenic potential when administered to the rat. | 1996 | Transplant. Proc. | pmid:8962236 |
| Yokoyama I et al. | Decreased Fas antigen expression of cultured hepatocytes with FK 506. | 1996 | Transplant. Proc. | pmid:8962237 |
| Baruch Y et al. | Anasarca and hypertrophic cardiomyopathy in a liver transplant patient on FK506: relieved after a switch to Neoral. | 1996 | Transplant. Proc. | pmid:8769215 |
| Melter M et al. | Successful reconversion from tacrolimus to cyclosporine A Neoral in pediatric liver recipients. | 1996 | Transplant. Proc. | pmid:8769224 |
| Tanaka M et al. | Reduction of immunosuppressive agents after living related donor liver transplantation. | 1996 | Transplant. Proc. | pmid:8769268 |
| Randhawa PS et al. | Microvascular changes in renal allografts associated with FK506 (Tacrolimus) therapy. | 1996 | Am. J. Surg. Pathol. | pmid:8772784 |
| Johnson MW et al. | Hepatitis C viral infection in liver transplantation. | 1996 | Arch Surg | pmid:8611094 |
| Hisatomi A et al. | Effect of Prograf (FK506) on spermatogenesis in rats. | 1996 | Toxicology | pmid:8658548 |
| Mysliwiec J et al. | The effect of tacrolimus (FK506) and cyclosporin A (CyA) on peripheral serotonergic mechanisms in uremic rats. | 1996 | Thromb. Res. | pmid:8837316 |
| Devlin J and Williams R | Transplantation for fulminant hepatic failure: comparing tacrolimus versus cyclosporine for immunosuppression and the outcome in elective transplants. European FK506 Liver Study Group. | 1996 | Transplantation | pmid:8932266 |
| Lamb GD and Stephenson DG | Effects of FK506 and rapamycin on excitation-contraction coupling in skeletal muscle fibres of the rat. | 1996 | J. Physiol. (Lond.) | pmid:8842013 |
| Curran CF et al. | Acute overdoses of tacrolimus. | 1996 | Transplantation | pmid:8932293 |
| Tanaka K et al. | Effect of cyclosporin analogues and FK506 on transcellular transport of daunorubicin and vinblastine via P-glycoprotein. | 1996 | Pharm. Res. | pmid:8842048 |
| Bader A et al. | Tacrolimus (FK 506) biotransformation in primary rat hepatocytes depends on extracellular matrix geometry. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8935714 |
| Borvak J et al. | The use of cyclosporine, FK506, and SDZ NIM811 to prevent CD25- quiescent peripheral blood mononuclear cells from producing human immunodeficiency virus. | 1996 | J. Infect. Dis. | pmid:8843228 |
| Galat A | A large-scale processing of kinetic data files with derivation of the inhibitory constant Ki: an application to proline isomerases. | 1996 | Comput. Chem. | pmid:8936426 |
| Borg AJ et al. | 15-Deoxyspergualin inhibits interleukin 6 production in in vitro stimulated human lymphocytes. | 1996 | Transpl. Immunol. | pmid:8843590 |
| Chen BG et al. | Inhibition by CsA and FK506 of the in vitro proliferative response of gamma delta T cells on stimulation with anti-TCR delta monoclonal antibody. | 1996 | Transpl. Immunol. | pmid:8843593 |
| Andrews PA et al. | Racial variation in dosage requirements of tacrolimus. | 1996 | Lancet | pmid:8937292 |
| Toyota N et al. | Effects of FK506 and cyclosporin A on proliferation, histamine release and phenotype of murine mast cells. | 1996 | Arch. Dermatol. Res. | pmid:8844128 |
| Budde K et al. | Clinical pharmacokinetics of tacrolimus in rescue therapy after renal transplantation. | 1996 | Int J Clin Pharmacol Ther | pmid:8937932 |
| Owens-Grillo JK et al. | A model of protein targeting mediated by immunophilins and other proteins that bind to hsp90 via tetratricopeptide repeat domains. | 1996 | J. Biol. Chem. | pmid:8662874 |
| Kralli A and Yamamoto KR | An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones. | 1996 | J. Biol. Chem. | pmid:8663352 |
| Okada K et al. | Effect of FK 506 administered topically versus intramuscularly on suppression of the corneal immune reaction in rats. | 1996 | Ophthalmologica | pmid:8738464 |
| Wagner K et al. | Experimental and clinical experience with the use of tacrolimus (FK506) in kidney transplantation. | 1996 | Clin. Nephrol. | pmid:8738666 |
| Hohage H et al. | Influence of cyclosporine A and FK506 on 24 h blood pressure monitoring in kidney transplant recipients. | 1996 | Clin. Nephrol. | pmid:8738668 |
| Herget S et al. | Initial experience with tacrolimus rescue therapy in OKT3 resistant rejection. | 1996 | Clin. Nephrol. | pmid:8738671 |
| Alak AM and Lizak PP | Quality assurance procedure for monitoring tacrolimus (FK506) concentrations in whole blood by IMx assay. | 1996 | Ther Drug Monit | pmid:8738766 |
| Büttemeyer R et al. | Rejection of the component tissues of limb allografts in rats immunosuppressed with FK-506 and cyclosporine. | 1996 | Plast. Reconstr. Surg. | pmid:8532772 |
| Timmerman LA et al. | Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. | 1996 | Nature | pmid:8893011 |
| Inutsuka K et al. | Reconstruction of trachea and carina with immediate or cryopreserved allografts in dogs. | 1996 | Ann. Thorac. Surg. | pmid:8893587 |
| Ezeamuzie CI | Anti-allergic activity of cyclosporin-A metabolites and their interaction with the parent compound and FK 506. | 1996 | Int. J. Immunopharmacol. | pmid:8894806 |
| Ockenfels HM et al. | The effect of cyclosporin A and FK 506 on the cAMP content in psoriatic keratinocytes. | 1996 | Skin Pharmacol. | pmid:8896120 |
| Nash RA et al. | FK506 in combination with methotrexate for the prevention of graft-versus-host disease after marrow transplantation from matched unrelated donors. | 1996 | Blood | pmid:8896434 |
| Rozen TD et al. | Treatment-refractory cyclosporine-associated headache: relief with conversion to FK-506. | 1996 | Neurology | pmid:8909459 |
| Dawson S et al. | UCLA liver transplantation: analysis of immunological factors affecting outcome. | 1996 | Artif Organs | pmid:8896726 |
| Bell A et al. | The antiparasite effects of cyclosporin A: possible drug targets and clinical applications. | 1996 | Gen. Pharmacol. | pmid:8909976 |
| Kashu Y et al. | Prolongation of rat liver graft survival by splenectomy combined with low dose FK506 therapy. | 1996 | Artif Organs | pmid:8896731 |
| Weigao C | [Limb allograft in rats: studies on optimal maintenance dose of FK506 and development of graft-versus-host-disease (GVHD)]. | 1996 | Fukuoka Igaku Zasshi | pmid:8913057 |
| Shih M and Malbon CC | Protein kinase C deficiency blocks recovery from agonist-induced desensitization. | 1996 | J. Biol. Chem. | pmid:8702931 |
| Ohshima S et al. | Immunosuppressive treatment of primary cadaveric renal transplant patients receiving kidneys from non-heart beating donors. | 1996 | Artif Organs | pmid:8896734 |
| Yagita Y et al. | Effect of immunosuppressant FK506 on ischemia-induced degeneration of hippocampal neurons in gerbils. | 1996 | Life Sci. | pmid:8913329 |
| Okadome T et al. | Characterization of the interaction of FKBP12 with the transforming growth factor-beta type I receptor in vivo. | 1996 | J. Biol. Chem. | pmid:8702959 |
| Dawson TM | Immunosuppressants, immunophilins, and the nervous system. | 1996 | Ann. Neurol. | pmid:8871573 |
| Wang X et al. | Rapamycin inhibits aldolase A expression during human lymphocyte activation. | 1996 | J. Cell. Biochem. | pmid:8913875 |
| Rahfeld JU et al. | Isolation and amino acid sequence of a new 22-kDa FKBP-like peptidyl-prolyl cis/trans-isomerase of Escherichia coli. Similarity to Mip-like proteins of pathogenic bacteria. | 1996 | J. Biol. Chem. | pmid:8703024 |
| Pullicino P et al. | Posterior leucoencephalopathy syndrome. | 1996 | Lancet | pmid:8684128 |
| Pirenne J et al. | Combined transplantation of small and large bowel. FK506 versus cyclosporine A in a porcine model. | 1996 | Transplantation | pmid:8685944 |
| Tsugita M et al. | Tacrolimus pretreatment attenuates preexisting xenospecific immunity and abrogates hyperacute rejection in a presensitized hamster to rat liver transplant model. | 1996 | Transplantation | pmid:8685952 |
| Huntress JD and Papadakos PJ | The role of calcium-channel antagonists in solid organ transplantation. | 1996 | New Horiz | pmid:8689268 |
| Tokunaga Y and Alak AM | FK506 (tacrolimus) and its immunoreactive metabolites in whole blood of liver transplant patients and subjects with mild hepatic dysfunction. | 1996 | Pharm. Res. | pmid:8668663 |
| Rifai N et al. | The role of lipoproteins in the transport and uptake of cyclosporine and dihydro-tacrolimus into HepG2 and JURKAT cell lines. | 1996 | Clin. Biochem. | pmid:8601324 |
| Vilquin JT et al. | Partial laminin alpha2 chain restoration in alpha2 chain-deficient dy/dy mouse by primary muscle cell culture transplantation. | 1996 | J. Cell Biol. | pmid:8601607 |
| Schuetz EG et al. | Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. | 1996 | Mol. Pharmacol. | pmid:8632764 |
| Sun S et al. | Effect of tacrolimus on hemodynamics and absorption of experimental small intestinal transplants. | 1996 | Transplantation | pmid:8633368 |
| Kashu Y et al. | The effect of combination splenectomy and low-dose FK506 therapy on graft survival after liver allograft transplantation in rats. | 1996 | Transplantation | pmid:8633382 |
| Yoshimura N et al. | A case report of pregnancy in renal transplant recipient treated with FK506 (tacrolimus). | 1996 | Transplantation | pmid:8633388 |
| [Transplantation medicine. Tacrolimus increases survival chances after organ transplantation. XVI International Congress of the Transplantation Society. 25-30 August 1996 Barcelona]. | 1996 | Dtsch. Med. Wochenschr. | pmid:9447224 |