| MeSH term | MeSH ID | Detail |
|---|---|---|
| Infection | D007239 | 6 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Bone Diseases | D001847 | 4 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Ulcer | D014456 | 16 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Obesity | D009765 | 29 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Varshosaz J et al. | Physicochemical, Pharmacodynamic and Pharmacokinetic Characterization of Soluplus Stabilized Nanosuspension of Tacrolimus. | 2017 | Curr Drug Deliv | pmid:27697037 |
| Chiramel DM et al. | Topical tacrolimus causing gingival hyperplasia: A case report. | 2017 | Dermatol Ther | pmid:27572623 |
| Al Taii H et al. | The use of tacrolimus in refractory autoimmune hepatitis in children and adults: a single center experience. | 2017 | Scand. J. Gastroenterol. | pmid:27633047 |
| Choi Y et al. | A pharmacogenomic study on the pharmacokinetics of tacrolimus in healthy subjects using the DMET Plus platform. | 2017 | Pharmacogenomics J. | pmid:26882121 |
| Savaj S et al. | Irreversible Lesions of Tacrolimus-induced Posterior Reversible Leukoencephalopathy Syndrome. | 2017 | Iran J Kidney Dis | pmid:29190599 |
| Rhu J et al. | Clinical Implication of Mycophenolic Acid Trough Concentration Monitoring in Kidney Transplant Patients on a Tacrolimus Triple Maintenance Regimen: A Single-Center Experience. | 2017 | Ann. Transplant. | pmid:29180612 |
| Wei L et al. | Therapeutic Effects of FK506 on IgA Nephropathy Rat. | 2017 | Kidney Blood Press. Res. | pmid:29179182 |
| Cheung AY et al. | Probable Donor-Derived Cytomegalovirus Disease After Keratolimbal Allograft Transplantation. | 2017 | Cornea | pmid:28614157 |
| Krenzien F et al. | Age-Dependent Metabolic and Immunosuppressive Effects of Tacrolimus. | 2017 | Am. J. Transplant. | pmid:27754593 |
| Hurtgen BJ et al. | Impairment of early fracture healing by skeletal muscle trauma is restored by FK506. | 2017 | BMC Musculoskelet Disord | pmid:28606129 |
| Rummo OO et al. | ADHERE: randomized controlled trial comparing renal function in de novo kidney transplant recipients receiving prolonged-release tacrolimus plus mycophenolate mofetil or sirolimus. | 2017 | Transpl. Int. | pmid:27754567 |
| Hou X et al. | Overexpression of Fibulin-5 attenuates burn-induced inflammation via TRPV1/CGRP pathway. | 2017 | Exp. Cell Res. | pmid:28602628 |
| Tang JT et al. | The pharmacokinetics and pharmacodynamics of mycophenolate mofetil in younger and elderly renal transplant recipients. | 2017 | Br J Clin Pharmacol | pmid:27753146 |
| Zidan AS | Taste-masked tacrolimus-phospholipid nanodispersions: dissolution enhancement, taste masking and reduced gastric complications. | 2017 | Pharm Dev Technol | pmid:26811031 |
| Kita K and Mano Y | Application of volumetric absorptive microsampling device for quantification of tacrolimus in human blood as a model drug of high blood cell partition. | 2017 | J Pharm Biomed Anal | pmid:28601765 |
| Abongwa C et al. | Successful treatment of tacrolimus-related pure red cell aplasia and autoimmune hemolytic anemia with rituximab in a pediatric cardiac transplant patient. | 2017 | Pediatr Blood Cancer | pmid:28598573 |
| Weir MR et al. | Long-term Follow-up of Kidney Transplant Recipients in the Spare-the-Nephron-Trial. | 2017 | Transplantation | pmid:26950714 |
| Gao L et al. | Synergistic Effects of Tacrolimus and Azoles against Exophiala dermatitidis. | 2017 | Antimicrob. Agents Chemother. | pmid:28923863 |
| Ginocchio L et al. | Refractory Ulcerated Necrobiosis Lipoidica: Closure of a Difficult Wound with Topical Tacrolimus. | 2017 | Adv Skin Wound Care | pmid:28914682 |
| Ueno P et al. | Wound Healing Complications in Kidney Transplant Recipients Receiving Everolimus. | 2017 | Transplantation | pmid:27490418 |
| Weidinger S et al. | A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal. | 2017 | Br. J. Dermatol. | pmid:28868633 |
| Shahidi M | Thrombosis and von Willebrand Factor. | 2017 | Adv. Exp. Med. Biol. | pmid:27628010 |
| Jouve T et al. | New formulations of tacrolimus and prevention of acute and chronic rejections in adult kidney-transplant recipients. | 2017 | Expert Opin Drug Saf | pmid:28494654 |
| Koo K et al. | Beyond monotherapy: a systematic review on creative strategies in topical therapy of psoriasis. | 2017 | J Dermatolog Treat | pmid:28481664 |
| Miller AK et al. | Transmission of Donor-Derived Breast Carcinoma as a Recurrent Mass in a Keratolimbal Allograft. | 2017 | Cornea | pmid:28476053 |
| Nakagawa K et al. | Immunosuppressive treatment using tacrolimus promotes pregnancy outcome in infertile women with repeated implantation failures. | 2017 | Am. J. Reprod. Immunol. | pmid:28466977 |
| Shen CL et al. | Tacrolimus Blood Level Fluctuation Predisposes to Coexisting BK Virus Nephropathy and Acute Allograft Rejection. | 2017 | Sci Rep | pmid:28512328 |
| Eleftheriadis T et al. | In human cell cultures, everolimus is inferior to tacrolimus in inhibiting cellular alloimmunity, but equally effective as regards humoral alloimmunity. | 2017 | Int Urol Nephrol | pmid:28508247 |
| Henderson CN et al. | Continuous Abdominal Irrigation for Treatment of Tertiary Peritonitis in the Immunosuppressed Patient after Solid Organ Transplant: A Novel Approach. | 2017 | Am Surg | pmid:28424115 |
| Chen B et al. | Efficacy and safety of tacrolimus treatment for neuromyelitis optica spectrum disorder. | 2017 | Sci Rep | pmid:28400553 |
| Wolfshohl JA et al. | Improvement of erythema dyschromicum perstans using a combination of the 1,550-nm erbium-doped fractionated laser and topical tacrolimus ointment. | 2017 | Lasers Surg Med | pmid:27552666 |
| Mourad G et al. | Incidence of Posttransplantation Diabetes Mellitus in De Novo Kidney Transplant Recipients Receiving Prolonged-Release Tacrolimus-Based Immunosuppression With 2 Different Corticosteroid Minimization Strategies: ADVANCE, A Randomized Controlled Trial. | 2017 | Transplantation | pmid:27547871 |
| Sanghavi K et al. | Genotype-guided tacrolimus dosing in African-American kidney transplant recipients. | 2017 | Pharmacogenomics J. | pmid:26667830 |
| Størset E et al. | Response to: 'Response to: Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance'. | 2017 | Br J Clin Pharmacol | pmid:28374426 |
| Kizilbash SJ et al. | Infection rates in tacrolimus versus cyclosporine-treated pediatric kidney transplant recipients on a rapid discontinuation of prednisone protocol: 1-year analysis. | 2017 | Pediatr Transplant | pmid:28371243 |
| Khimani F et al. | Predictors of overall survival among patients treated with sirolimus/tacrolimus vs methotrexate/tacrolimus for GvHD prevention. | 2017 | Bone Marrow Transplant. | pmid:28368376 |
| Jin SE et al. | Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump. | 2017 | J Vis Exp | pmid:28362410 |
| Gard L et al. | A delicate balance between rejection and BK polyomavirus associated nephropathy; A retrospective cohort study in renal transplant recipients. | 2017 | PLoS ONE | pmid:28609473 |
| Zhang L et al. | Characterization of calcineurin from Cryptococcus humicola and the application of calcineurin in aluminum tolerance. | 2017 | BMC Biotechnol. | pmid:28356086 |
| Wang J et al. | Comparative proteomic and metabolomic analysis of Streptomyces tsukubaensis reveals the metabolic mechanism of FK506 overproduction by feeding soybean oil. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28175948 |
| Vanhove T et al. | Effect of ABCB1 diplotype on tacrolimus disposition in renal recipients depends on CYP3A5 and CYP3A4 genotype. | 2017 | Pharmacogenomics J. | pmid:27378609 |
| David-Neto E et al. | Longitudinal Pharmacokinetics of Tacrolimus in Elderly Compared With Younger Recipients in the First 6 Months After Renal Transplantation. | 2017 | Transplantation | pmid:27482958 |
| Varela-Veiga A et al. | Long-standing Papules on the Scrotum. | 2017 | Actas Dermosifiliogr | pmid:27328825 |
| Bellon H et al. | The Effect of Immunosuppression on Airway Integrity. | 2017 | Transplantation | pmid:28471870 |
| Marini BL et al. | Risk of graft-versus-host disease with rituximab-containing conditioning regimens in allogeneic hematopoietic stem cell transplant. | 2017 | J Oncol Pharm Pract | pmid:26970572 |
| Ferjani H et al. | Beneficial effects of mycophenolate mofetil on cardiotoxicity induced by tacrolimus in wistar rats. | 2017 | Exp. Biol. Med. (Maywood) | pmid:26582055 |
| Ikeda K et al. | Intestinal perforation due to hemorrhagic Cytomegalovirus enteritis in a patient with severe uncontrolled lupus nephritis: a case and review of the literature. | 2017 | Rheumatol. Int. | pmid:28283734 |
| Toyota H et al. | Process optimization by use of design of experiments: Application for liposomalization of FK506. | 2017 | Eur J Pharm Sci | pmid:28279762 |
| Eshraghian A et al. | Post-transplant lymphoproliferative disorder after liver transplantation: Incidence, long-term survival and impact of serum tacrolimus level. | 2017 | World J. Gastroenterol. | pmid:28275302 |
| Monaghan P et al. | The antimalarial action of FK506 and rapamycin: evidence for a direct effect on FK506-binding protein PfFKBP35. | 2017 | Parasitology | pmid:28274284 |
| Solari S et al. | Sublingual tacrolimus administration provides similar drug exposure to per-oral route employing lower doses in liver transplantation: a pilot study. | 2017 | Aliment. Pharmacol. Ther. | pmid:28261844 |
| RodrÃguez-Perálvarez M et al. | Maintenance immunosuppression for adults undergoing liver transplantation: a network meta-analysis. | 2017 | Cochrane Database Syst Rev | pmid:28362060 |
| Jackson MF et al. | Osteoclast precursors do not express CD68: results from CD68 promoter-driven RANK transgenic mice. | 2017 | FEBS Lett. | pmid:28173622 |
| Chakfe N | Commentary on "Tacrolimus Eluting Suture Inhibits Neointimal Hyperplasia: An Experimental In Vivo Study in Rats". | 2017 | Eur J Vasc Endovasc Surg | pmid:28169106 |
| Siponen M et al. | Topical tacrolimus, triamcinolone acetonide, and placebo in oral lichen planus: a pilot randomized controlled trial. | 2017 | Oral Dis | pmid:28168769 |
| Vanhove T et al. | Response to: 'Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance'. | 2017 | Br J Clin Pharmacol | pmid:28168728 |
| Gao L et al. | Low incidence of acute graft-versus-host disease with short-term tacrolimus in haploidentical hematopoietic stem cell transplantation. | 2017 | Leuk. Res. | pmid:28273549 |
| Ribero S and Borradori L | Re: risk of malignancy and systemic absorption after application of topical tacrolimus in oral lichen planus. | 2017 | J Eur Acad Dermatol Venereol | pmid:27291784 |
| Hamada T et al. | Phenotypic analysis of circulating T-cell subset and its association with burden of skin disease in patients with chronic actinic dermatitis: a hematologic and clinicopathologic study of 20 subjects. | 2017 | Int. J. Dermatol. | pmid:28176301 |
| Chung BH et al. | Suppressive Effect of 1α,25-Dihydroxyvitamin D3 on Th17-Immune Responses in Kidney Transplant Recipients With Tacrolimus-Based Immunosuppression. | 2017 | Transplantation | pmid:28107277 |
| Piotti G et al. | Once-daily prolonged-release tacrolimus formulations for kidney transplantation: what the nephrologist needs to know. | 2017 | J. Nephrol. | pmid:27206763 |
| Mekaj AY et al. | Effects of hyaluronic acid and tacrolimus on the prevention of perineural scar formation and on nerve regeneration after sciatic nerve repair in a rabbit model. | 2017 | Eur J Trauma Emerg Surg | pmid:27194249 |
| Jessop S et al. | Drugs for discoid lupus erythematosus. | 2017 | Cochrane Database Syst Rev | pmid:28476075 |
| Ma TK et al. | Therapeutic drug monitoring of once-daily tacrolimus (Advagraf) in a gastrectomized kidney transplant recipient. | 2017 | Nephrology (Carlton) | pmid:28064453 |
| Schifferer M et al. | Reversible Chemical Dimerization by rCD1. | 2017 | Meth. Enzymol. | pmid:28063490 |
| Kirresh T et al. | Development and validation of a liquid chromatography-mass spectrometric assay for simultaneous determination of tacrolimus and 13-O-desmethyl tacrolimus in rat kidney tissue. | 2017 | J Pharm Biomed Anal | pmid:28063333 |
| Qiao M et al. | The Natural Course of Atopic Dermatitis and the Association with Asthma. | 2017 | Inflammation | pmid:28063089 |
| Aschauer C et al. | Positioning of Tacrolimus for the Treatment of Diabetic Nephropathy Based on Computational Network Analysis. | 2017 | PLoS ONE | pmid:28060893 |
| Ivulich S et al. | Clinical Challenges of Tacrolimus for Maintenance Immunosuppression Post-Lung Transplantation. | 2017 | Transplant. Proc. | pmid:29149976 |
| Percy C et al. | Impact of Acute Infection Requiring Hospitalization on Tacrolimus Blood Levels in Kidney Transplant Recipients. | 2017 | Transplant. Proc. | pmid:29149962 |
| Dong Y et al. | Risk Factors, Clinical Features, and Treatment Outcomes of Recurrent Mooren Ulcers in China. | 2017 | Cornea | pmid:28060068 |
| Obaidat RM et al. | Using Supercritical Fluid Technology (SFT) in Preparation of Tacrolimus Solid Dispersions. | 2017 | AAPS PharmSciTech | pmid:27116202 |
| Krämer BK et al. | Efficacy of Prolonged- and Immediate-release Tacrolimus in Kidney Transplantation: A Pooled Analysis of Two Large, Randomized, Controlled Trials. | 2017 | Transplant. Proc. | pmid:29149958 |
| de Menezes AF et al. | Pharmacologic Treatment of Vitiligo in Children and Adolescents: A Systematic Review. | 2017 | Pediatr Dermatol | pmid:27878842 |
| Ianiri G et al. | FKBP12-Dependent Inhibition of Calcineurin Mediates Immunosuppressive Antifungal Drug Action in . | 2017 | MBio | pmid:29066552 |
| de Oliveira JTP et al. | Variability index of tacrolimus serum levels in pediatric liver transplant recipients younger than 12Â years: Non-adherence or risk of non-adherence? | 2017 | Pediatr Transplant | pmid:29034612 |
| Taber DJ et al. | A Comparative Effectiveness Analysis of Early Steroid Withdrawal in Black Kidney Transplant Recipients. | 2017 | Clin J Am Soc Nephrol | pmid:27979979 |
| Watanabe M et al. | Successful treatment of calcineurin inhibitor-induced pain syndrome with acute graft versus host disease by switching calcineurin inhibitors followed by pregabalin. | 2017 | Ann. Hematol. | pmid:28508935 |
| Flahault A et al. | Clinical impact of the CYP3A5 6986A>G allelic variant on kidney transplantation outcomes. | 2017 | Pharmacogenomics | pmid:27977332 |
| Knops N et al. | Tacrolimus dose requirements in paediatric renal allograft recipients are characterized by a biphasic course determined by age and bone maturation. | 2017 | Br J Clin Pharmacol | pmid:27966227 |
| Komaki Y et al. | Pharmacologic therapies for severe steroid refractory hospitalized ulcerative colitis: A network meta-analysis. | 2017 | J. Gastroenterol. Hepatol. | pmid:27957761 |
| Triñanes J et al. | Deciphering Tacrolimus-Induced Toxicity in Pancreatic β Cells. | 2017 | Am. J. Transplant. | pmid:28432716 |
| Khan SA et al. | Improvement in baroreflex control of renal sympathetic nerve activity in obese Sprague Dawley rats following immunosuppression. | 2017 | Acta Physiol (Oxf) | pmid:28456134 |
| Tron C et al. | Tacrolimus: Does direct glucuronidation matter? An analytical and pharmacological perspective. | 2017 | Pharmacol. Res. | pmid:28366836 |
| Suzuki Y et al. | Improved Open-Well Stability of Affinity Column-Mediated Immunoassay Reagent for Determining Blood Tacrolimus. | 2017 | Ther Drug Monit | pmid:28282367 |
| Wan T et al. | Dual roles of TPGS based microemulsion for tacrolimus: Enhancing the percutaneous delivery and anti-psoriatic efficacy. | 2017 | Int J Pharm | pmid:28629978 |
| Ganschow R et al. | Everolimus and reduced calcineurin inhibitor therapy in pediatric liver transplant recipients: Results from a multicenter, prospective study. | 2017 | Pediatr Transplant | pmid:28714558 |
| Perez LE et al. | Visilizumab with tacrolimus and methotrexate for GvHD prevention after allogeneic hematopoietic cell transplantation from mismatched unrelated donors. | 2017 | Bone Marrow Transplant. | pmid:27991896 |
| Bremer S et al. | NFAT-regulated cytokine gene expression during tacrolimus therapy early after renal transplantation. | 2017 | Br J Clin Pharmacol | pmid:28686294 |
| Rivosecchi RM et al. | Effects of Isavuconazole on the Plasma Concentrations of Tacrolimus among Solid-Organ Transplant Patients. | 2017 | Antimicrob. Agents Chemother. | pmid:28674051 |
| Hasegawa J et al. | Preemptive anti-cytomegalovirus therapy in high-risk (donor-positive, recipient-negative cytomegalovirus serostatus) kidney transplant recipients. | 2017 | Int. J. Infect. Dis. | pmid:28986314 |
| Lee SM et al. | Inhibition of acute lethal pulmonary inflammation by the IDO-AhR pathway. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:28673995 |
| Olariu R et al. | Intra-graft injection of tacrolimus promotes survival of vascularized composite allotransplantation. | 2017 | J. Surg. Res. | pmid:28985877 |
| Wang Y et al. | FK506 protects heart function via increasing autophagy after myocardial infarction in mice. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28965948 |
| Naicker D et al. | Nationwide conversion to generic tacrolimus in pediatric kidney transplant recipients. | 2017 | Pediatr. Nephrol. | pmid:28660366 |
| Wood LA et al. | New tools for "hot-wiring" clathrin-mediated endocytosis with temporal and spatial precision. | 2017 | J. Cell Biol. | pmid:28954824 |
| Sigurgeirsson B and Luger T | A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal - author response. | 2017 | Br. J. Dermatol. | pmid:28940181 |
| Tao X et al. | Long-term efficacy and side effects of low-dose tacrolimus for the treatment of Myasthenia Gravis. | 2017 | Neurol. Sci. | pmid:27873026 |
| Qi H et al. | Integration of parallel C-labeling experiments and in silico pathway analysis for enhanced production of ascomycin. | 2017 | Biotechnol. Bioeng. | pmid:27869289 |
| Gatault P et al. | Reduction of Extended-Release Tacrolimus Dose in Low-Immunological-Risk Kidney Transplant Recipients Increases Risk of Rejection and Appearance of Donor-Specific Antibodies: A Randomized Study. | 2017 | Am. J. Transplant. | pmid:27862923 |