tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Silber RE et al. | Comparison of the effect of FK 506 and alpha/beta-T-cell antibody R73 on transplant vascular sclerosis after heterotopic rat heart transplantation. | 1998 | Transplant. Proc. | pmid:9636398 |
| Müller V et al. | Effect of mycophenolate mofetil on the in vivo infiltration of lymphocytes in the rat remnant kidney. | 1998 | Transplant. Proc. | pmid:9636396 |
| Hutchinson IV et al. | Differences in the mode of action of cyclosporine and FK 506. | 1998 | Transplant. Proc. | pmid:9636388 |
| Ginevri F et al. | Expression of collagen by renal fibroblasts treated with FK 506 in vitro. | 1998 | Transplant. Proc. | pmid:9636387 |
| Nicholson ML et al. | Is TGF-beta a profibrotic cytokine in human renal transplants? | 1998 | Transplant. Proc. | pmid:9636384 |
| Tredger JM et al. | Therapeutic monitoring of tacrolimus (FK506) with the first- and second-generation microparticle enzyme immunoassays: performance and results in four patient populations. | 1998 | Ther Drug Monit | pmid:9631923 |
| Al-Awwa IA et al. | Importance of allograft biopsy in renal transplant recipients: correlation between clinical and histological diagnosis. | 1998 | Am. J. Kidney Dis. | pmid:9631859 |
| Starzl TE et al. | Tacrolimus (FK506) and the pharmaceutical/academic/regulatory gauntlet. | 1998 | Am. J. Kidney Dis. | pmid:9631858 |
| Ellouk-Achard S et al. | FK506 (Tacrolimus) decreases the cytotoxicity of cyclosporin A in rat hepatocytes in primary culture: implication of CYP3A induction. | 1998 | Arch. Toxicol. | pmid:9630010 |
| Takada Y et al. | Prolonged hepatic warm ischemia in non-heart-beating donors: protective effects of FK506 and a platelet activating factor antagonist in porcine liver transplantation. | 1998 | Surgery | pmid:9626320 |
| Pruvot FR and Noel C | Comment on "Pregnancy after liver transplantation under tacrolimus" by Jain et al. | 1998 | Transplantation | pmid:9625033 |
| Schulman SL et al. | Interaction between tacrolimus and chloramphenicol in a renal transplant recipient. | 1998 | Transplantation | pmid:9625026 |
| Lampen A et al. | Catalytic activities, protein- and mRNA-expression of cytochrome P450 isoenzymes in intestinal cell lines. | 1998 | Xenobiotica | pmid:9622846 |
| Kikuchi M et al. | Protective effects of FK506 against glutamate-induced neurotoxicity in retinal cell culture. | 1998 | Invest. Ophthalmol. Vis. Sci. | pmid:9620083 |
| Idilman R et al. | Immunosuppressive drug-induced leukoencephalopathy in patients with liver transplant. | 1998 | Eur J Gastroenterol Hepatol | pmid:9619393 |
| Tomás ML | [Immunosuppressive agents: side effects]. | 1997 | An R Acad Nac Med (Madr) | pmid:9616947 |
| Samsó M and Wagenknecht T | Contributions of electron microscopy and single-particle techniques to the determination of the ryanodine receptor three-dimensional structure. | 1998 | J. Struct. Biol. | pmid:9615436 |
| Kliem V and Brunkhorst R | Tacrolimus in kidney transplantation. A clinical review. | 1998 | Nephron | pmid:9609456 |
| Ito H et al. | Myoblast transplantation in non-dystrophic dog. | 1998 | Neuromuscul. Disord. | pmid:9608563 |
| Singer NG and McCune WJ | Update on immunosuppressive therapy. | 1998 | Curr Opin Rheumatol | pmid:9608317 |
| Tomono M et al. | Inhibitors of calcineurin block expression of cyclins A and E induced by fibroblast growth factor in Swiss 3T3 fibroblasts. | 1998 | Arch. Biochem. Biophys. | pmid:9606972 |
| Tomura N et al. | Transient neurotoxicity associated with FK506: MR findings. | 1998 May-Jun | J Comput Assist Tomogr | pmid:9606397 |
| Homey B et al. | Topical FK506 suppresses cytokine and costimulatory molecule expression in epidermal and local draining lymph node cells during primary skin immune responses. | 1998 | J. Immunol. | pmid:9605132 |
| Chang RK et al. | Marked left ventricular hypertrophy in children on tacrolimus (FK506) after orthotopic liver transplantation. | 1998 | Am. J. Cardiol. | pmid:9604971 |
| Capone D et al. | Therapeutic monitoring of tacrolimus in pediatric and adult transplanted patients. | 1998 | J Chemother | pmid:9603651 |
| Shapiro R et al. | Alopecia as a consequence of tacrolimus therapy. | 1998 | Transplantation | pmid:9603186 |
| Beatty PR et al. | Effect of cyclosporine and tacrolimus on the growth of Epstein-Barr virus-transformed B-cell lines. | 1998 | Transplantation | pmid:9603175 |
| Jurcevic S et al. | A new enzyme-linked immunosorbent assay to measure anti-endothelial antibodies after cardiac transplantation demonstrates greater inhibition of antibody formation by tacrolimus compared with cyclosporine. | 1998 | Transplantation | pmid:9603168 |
| Oyanagui Y | Immunosuppressants enhance superoxide radical/nitric oxide-dependent dexamethasone suppression of ischemic paw edema in mice. | 1998 | Eur. J. Pharmacol. | pmid:9600660 |
| Hueros G et al. | A maize FK506-sensitive immunophilin, mzFKBP-66, is a peptidylproline cis-trans-isomerase that interacts with calmodulin and a 36-kDa cytoplasmic protein. | 1998 | Planta | pmid:9599809 |
| Wagner R et al. | 32-Ascomycinyloxyacetic acid derived immunosuppressants. Independence of immunophilin binding and immunosuppressive potency. | 1998 | J. Med. Chem. | pmid:9599228 |
| Koyama T et al. | [Effects of various drugs on IL-8 production by eosinophils collected from patients with allergic inflammation]. | 1998 | Jpn J Antibiot | pmid:9597507 |
| Gregory CR | Immunosuppressive approaches to the prevention of graft vascular disease. | 1998 | Transplant. Proc. | pmid:9595134 |
| Weis M et al. | Impact of immunosuppression on coronary endothelial function after cardiac transplantation. | 1998 | Transplant. Proc. | pmid:9595131 |
| Marone G et al. | Immunopharmacology of human mast cells and basophils. | 1998 | Int. J. Clin. Lab. Res. | pmid:9594358 |
| Wakita H et al. | Dose-dependent, protective effect of FK506 against white matter changes in the rat brain after chronic cerebral ischemia. | 1998 | Brain Res. | pmid:9593846 |
| Hebebrand D et al. | Limb xenotransplantation using FK506 and RS61443 immunosuppression. | 1998 | J Reconstr Microsurg | pmid:9590615 |
| Chiba K et al. | FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. | 1998 | J. Immunol. | pmid:9590253 |
| Kadry Z et al. | Kaposi's sarcoma in liver transplant recipients on FK506. | 1998 | Transplantation | pmid:9583882 |
| Muraki T et al. | Effects of cyclosporine and FK506 on in vitro high shear-induced platelet reactivity in rat and human non-anticoagulated blood. | 1998 | Transplantation | pmid:9583878 |
| Zervos XA et al. | Comparison of tacrolimus with microemulsion cyclosporine as primary immunosuppression in hepatitis C patients after liver transplantation. | 1998 | Transplantation | pmid:9583863 |
| Abu-Elmagd K et al. | Clinical intestinal transplantation: new perspectives and immunologic considerations. | 1998 | J. Am. Coll. Surg. | pmid:9583691 |
| Cardoso CM et al. | Uncoupling of Ca2+ transport ATPase in muscle and blood platelets by diacylglycerol analogues and cyclosporin A antagonism. | 1997 | Biochem. J. | pmid:9581558 |
| Sugi-Ikai N et al. | Increased frequencies of interleukin-2- and interferon-gamma-producing T cells in patients with active Behçet's disease. | 1998 | Invest. Ophthalmol. Vis. Sci. | pmid:9579479 |
| Sakane T | [Physiopathology and therapy of Behcet's syndrome]. | 1998 | Nippon Naika Gakkai Zasshi | pmid:9577569 |
| Miyasaka N | [Recent findings on etiological mechanism of autoimmune diseases]. | 1998 | Nippon Naika Gakkai Zasshi | pmid:9577564 |
| Barinaga M | Signaling path may lead to better heart-failure therapies. | 1998 | Science | pmid:9575084 |
| Matsuda T et al. | Involvement of calcineurin in Ca2+ paradox-like injury of cultured rat astrocytes. | 1998 | J. Neurochem. | pmid:9572286 |
| Finney NS | Enantioselective epoxide hydrolysis: catalysis involving microbes, mammals and metals. | 1998 | Chem. Biol. | pmid:9571210 |
| Araki T et al. | Post-ischemic alterations in [3H]FK506 binding in the gerbil and rat brains. | 1998 | Metab Brain Dis | pmid:9570636 |