Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Mueller AR et al. | Severe neurotoxicity after liver transplantation: association between FK 506 therapy and hepatitis C virus disease. | 1994 | Transplant. Proc. | pmid:7527951 |
Kotowski M et al. | The Importance of New Generation Sequencing (NGS) HLA Typing in Renal Transplantation-Preliminary Report. | Transplant. Proc. | pmid:29937294 | |
Tai J et al. | In vivo function of pig islet xenografts in immunosuppressed diabetic mice. | 1995 | Transplant. Proc. | pmid:8539968 |
Jun H et al. | Experiences on conversion to once-daily Advagraf and sirolimus combination in stable kidney recipients. | 2014 | Transplant. Proc. | pmid:24655973 |
Schreier MH et al. | Inhibition of T-cell signaling pathways by immunophilin drug complexes: are side effects inherent to immunosuppressive properties? | 1993 | Transplant. Proc. | pmid:7679818 |
Tze WJ et al. | Immunohistochemical studies of pig islet xenograft in rats immunosuppressed with FK 506. | 1994 | Transplant. Proc. | pmid:7513470 |
Zheng B et al. | Effects of the new and highly active immunosuppressant, rapamycin, on lymphoid tissues and cells in vivo. | 1991 | Transplant. Proc. | pmid:1703717 |
Perrakis A et al. | Impact of the conversion of the immunosuppressive regimen from prograf to advagraf or to sirolimus in long-term stable liver transplant recipients: indications, safety, and outcome. | 2011 | Transplant. Proc. | pmid:22172830 |
Cherala G et al. | Tacrolimus pharmacokinetics in Hispanic children after kidney transplantation. | 2011 | Transplant. Proc. | pmid:22172831 |
Todo S et al. | Early trials with FK 506 as primary treatment in liver transplantation. | 1990 | Transplant. Proc. | pmid:1689886 |
Gupta S and Brennan DC | Pneumococcal 13-Valent Conjugate Vaccine (Prevnar 13)-Associated Immune Thrombocytopenic Purpura in a Renal Transplant Recipient: A Case Report. | Transplant. Proc. | pmid:26915880 | |
Stringa P et al. | Pretreatment Combination Reduces Remote Organ Damage Secondary to Intestinal Reperfusion Injury in Mice: Follow-up Study. | Transplant. Proc. | pmid:26915870 | |
Pascual J et al. | One-center comparison between primary immunosuppression based on neoral cyclosporine and tacrolimus for renal transplantation. | 2002 | Transplant. Proc. | pmid:11959200 |
Fougeray S et al. | Increased body mass index after kidney transplantation in activating transcription factor 6 single polymorphism gene carriers. | 2011 | Transplant. Proc. | pmid:22099811 |
Wachtman GS et al. | Biologics and donor bone marrow cells for targeted immunomodulation in vascularized composite allotransplantation: a translational trial in swine. | 2011 | Transplant. Proc. | pmid:22099837 |
Rossi G et al. | Three-year follow-up of low dose tacrolimus oral therapy after liver transplantation: a single-centre experience. | 1998 | Transplant. Proc. | pmid:9636562 |
Samuel D et al. | Tacrolimus (FK506)-based dual versus triple therapy following liver transplantation. | 1998 | Transplant. Proc. | pmid:9636563 |
Marcén R et al. | Evolution of rejection rates and kidney graft survival: a historical analysis. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715918 |
Vilalta R et al. | Delayed graft function is reduced with antithymocyte globulin induction in pediatric kidney transplantation. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715923 |
Todo S et al. | Intestinal transplantation in humans under FK 506. | 1993 | Transplant. Proc. | pmid:7680148 |
Nakao A et al. | Combined effect of donor-specific bone marrow transplantation via portal vein and FK506 on small bowel transplantation in the rat. | 2000 | Transplant. Proc. | pmid:11120044 |
Reyes J et al. | Nutritional management of intestinal transplant recipients. | 1993 | Transplant. Proc. | pmid:7680149 |
Rodrigo E et al. | Higher initial tacrolimus blood levels and concentration-dose ratios in kidney transplant recipients who develop diabetes mellitus. | 2005 | Transplant. Proc. | pmid:16386549 |
Favi E et al. | Prospective clinical trial comparing two immunosuppressive regimens, tacrolimus and mycophenolate mofetil versus everolimus and low-dose cyclosporine, in de novo renal transplant recipients: results at 6 months follow-up. | 2009 | Transplant. Proc. | pmid:19460503 |
Habucky K et al. | The pharmacodynamics of pentobarbital following FK 506 therapy. | 1991 | Transplant. Proc. | pmid:1721282 |
Undre NA et al. | Pharmacokinetics of tacrolimus: clinically relevant aspects. | 1999 | Transplant. Proc. | pmid:10576037 |
Farghali H et al. | Effect of FK 506 chronic administration on bromosulphthalein hepatic excretion in rats. | 1991 | Transplant. Proc. | pmid:1721283 |
Sung RS et al. | Survival of human islet xenografts irradiated with ultraviolet B in diabetic rats. | 1996 | Transplant. Proc. | pmid:8623427 |
Pirenne J et al. | Addition of the colon to small bowel grafts causes lethal graft-versus-host disease in FK 506-treated pigs. | 1996 | Transplant. Proc. | pmid:8623447 |
Mano A et al. | Reversible myocardial hypertrophy induced by tacrolimus in a pediatric heart transplant recipient: case report. | 2009 | Transplant. Proc. | pmid:19917396 |
Wiebe K et al. | FK506 rescue therapy in lung transplantation. | 1998 | Transplant. Proc. | pmid:9636613 |
Lampreabe I et al. | Toward personalized medicine in renal transplantation. | 2010 | Transplant. Proc. | pmid:20970553 |
Sato K et al. | Management of living donor liver transplant patients using twice-daily 4-hour intravenous cyclosporine therapy. | 2009 Jan-Feb | Transplant. Proc. | pmid:19249521 |
Miyazawa H et al. | Mechanisms of hamster kidney graft rejection in the rat. | 1994 | Transplant. Proc. | pmid:7518111 |
Tryphonopoulos P et al. | The impact of Campath 1H induction in adult liver allotransplantation. | 2005 | Transplant. Proc. | pmid:15848669 |
Jain A et al. | Tacrolimus for primary liver transplantation: 12 to 15 years actual follow-up with safety profile. | 2005 | Transplant. Proc. | pmid:15848671 |
Abouljoud MS et al. | Hyperlipidemia after liver transplantation: long-term results of the FK506/cyclosporine A US Multicenter Trial. US Multicenter Study Group. | 1995 | Transplant. Proc. | pmid:7533360 |
Morozumi K et al. | Diagnosis of chronic rejection using peritubular and glomerular capillary lesions. | 1996 | Transplant. Proc. | pmid:8644331 |
Azuma T et al. | Study of graft-infiltrating cells in the rat small bowel allograft using low-dose FK 506. | 1999 | Transplant. Proc. | pmid:10578293 |
McCarthy SA et al. | Effects of FK 506 and cyclosporine on T-cell tolerance: inhibition of a "protective" mechanism that regulates activation-induced apoptosis in developing thymocytes. | 1991 | Transplant. Proc. | pmid:1721314 |
Antoniou EA et al. | Effect of donor-specific transfusion in combination with FK 506 in rat cardiac allotransplantation. | 1999 | Transplant. Proc. | pmid:10578296 |
Savikko J et al. | Tacrolimus inhibits platelet-derived growth factor ligand and receptor induction as well as rejection changes in rat renal allografts during long-term follow-up. | 2002 | Transplant. Proc. | pmid:12176405 |
Erickson L et al. | Gene expression profiling of acute rejection and mixed lymphocyte reaction with tacrolimus immunosuppression. | 2002 | Transplant. Proc. | pmid:12176407 |
Pascual J et al. | Mycophenolate mofetil tolerability and dose changes in tacrolimus-treated renal allograft recipients. | 2006 | Transplant. Proc. | pmid:17097946 |
Krämer BK et al. | Steroid withdrawal or steroid avoidance in renal transplant recipients: focus on tacrolimus-based immunosuppressive regimens. | 2005 | Transplant. Proc. | pmid:15919467 |
Bismuth H | Comparison of FK 506- and cyclosporine-based immunosuppression: FK 506 therapy significantly reduces the incidence of acute, steroid-resistant, refractory, and chronic rejection whilst possessing a comparable safety profile. European FK 506 Multicenter Liver Study Group. | 1995 | Transplant. Proc. | pmid:7533415 |
Jain AB et al. | Correlation of rejection episodes with FK 506 dosage, FK 506 level, and steroids following primary orthotopic liver transplant. | 1991 | Transplant. Proc. | pmid:1721347 |
Charco R et al. | Low incidence of hypercholesterolemia among liver transplant patients under tacrolimus monotherapy immunosuppression. | 2002 | Transplant. Proc. | pmid:12176482 |
Parada MT et al. | Everolimus in lung transplantation in Chile. | 2010 Jan-Feb | Transplant. Proc. | pmid:20172343 |
Calia R et al. | Effects of switching from twice-daily to once-daily tacrolimus formulation on quality of life, anxiety, and transplant benefit perception after kidney transplantation. | 2011 | Transplant. Proc. | pmid:21620041 |
Meçule A et al. | Tacrolimus trough levels and level-to-dose ratio in stable renal transplant patients converted to a once-daily regimen. | 2011 | Transplant. Proc. | pmid:21620042 |
Bardella MT et al. | FK 506 and cyclosporine: effect on D-xylose absorption in pigs with orthotopic liver-small bowel allotransplants. | 1996 | Transplant. Proc. | pmid:8907937 |
Ota K | Living donor kidney transplantation in Japan. | 1994 | Transplant. Proc. | pmid:7520622 |
Watanabe T et al. | Effects of the endothelin-1 receptor antagonist TAK-044 on pulmonary injury in discordant xenotransplantation. | 2000 | Transplant. Proc. | pmid:10936270 |
Takayama K et al. | Hepatocyte growth factor and vascular endothelial growth factor expression in pig-to-primate xenotransplanted hearts. | 2000 | Transplant. Proc. | pmid:10936314 |
Perico N et al. | FK 506 does not affect the glomerular filtration rate and renal plasma flow in the rat. | 1991 | Transplant. Proc. | pmid:1721378 |
Veroux P et al. | Tacrolimus-induced neurotoxicity in kidney transplant recipients. | 2002 | Transplant. Proc. | pmid:12493415 |
Mieles L et al. | Glycemia and insulin need following FK 506 rescue therapy in liver transplant recipients. | 1991 | Transplant. Proc. | pmid:1703362 |
Wagner K et al. | Effect of FK 506 on excretion of urinary enzymes in rats. | 1991 | Transplant. Proc. | pmid:1721379 |
Izbicki G et al. | Improved survival after lung transplantation in patients treated with tacrolimus/mycophenolate mofetil as compared with cyclosporine/azathioprine. | 2002 | Transplant. Proc. | pmid:12493439 |
Warty V et al. | Distribution of FK 506 in plasma lipoproteins in transplant patients. | 1991 | Transplant. Proc. | pmid:1703363 |
Ushigome H et al. | Immunosuppression in cadaveric renal transplant recipients from non-heart-beating donors in a single center. | 2002 | Transplant. Proc. | pmid:12176533 |
Weir M | Impact of immunosuppressive regimes on posttransplant diabetes mellitus. | 2001 | Transplant. Proc. | pmid:11498201 |
Kaibori M et al. | Inhibition of iNOS induction by FK506, but not by cyclosporine, in rat hepatocytes. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083347 |
Asavakarn S et al. | Systematic Pharmaceutical Educational Approach to Enhance Drug Adherence in Liver Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27320587 |
Limsrichamrern S et al. | Correlation of Hematocrit and Tacrolimus Level in Liver Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27320581 |
el-Ghoroury M et al. | Efficacy and safety of tacrolimus versus cyclosporine in kidney and pancreas transplant recipients. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123461 |
Mueller AR et al. | Long-term follow-up in hepatitis C patients with respect to immunosuppression. | 1996 | Transplant. Proc. | pmid:8962255 |
Carbajal R et al. | Case report: boldo (Peumus boldus) and tacrolimus interaction in a renal transplant patient. | 2014 | Transplant. Proc. | pmid:24981811 |
Furtado A et al. | Local immunosuppression in clinical small bowel transplantation (report of two cases). | 2000 | Transplant. Proc. | pmid:10995910 |
Yessayan L et al. | Race, Calcineurin Inhibitor Exposure, and Renal Function After Solid Organ Transplantation. | 2015 | Transplant. Proc. | pmid:26707323 |
Tai J et al. | In vivo and in vitro effect of FK 506 on rat Leydig cell function. | 1991 | Transplant. Proc. | pmid:1721409 |
Sato Y et al. | FK 506 suppresses class II antigen expression in regenerating livers following partial hepatectomy in the rat. | 1992 | Transplant. Proc. | pmid:1379761 |
Chariat MN et al. | Basiliximab in the therapy of acute rejection after organ transplantation. | 2001 | Transplant. Proc. | pmid:11377567 |
Chan MC et al. | Conversion of cyclosporine to tacrolimus for refractory or persistent myocardial rejection. | 2002 | Transplant. Proc. | pmid:12176601 |
Molinaro M et al. | Pharmacokinetics of tacrolimus during the early phase after heart transplantation. | 2001 | Transplant. Proc. | pmid:11377570 |
van Riemsdijk IC et al. | Improvement of cardiovascular risk factors in heart transplant recipients after conversion from cyclosporine to tacrolimus: a role of the TGF-beta system. | 2002 | Transplant. Proc. | pmid:12176606 |
Ozkurt S et al. | Late effects of renal transplantation on endothelial functions and cardiac morphology. | 2011 | Transplant. Proc. | pmid:21911132 |
Pretagostini R et al. | Conversion from cyclosporin to tacrolimus in chronic allograft nephropathy. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267174 |
Dick TB et al. | Fludrocortisone is effective in the management of tacrolimus-induced hyperkalemia in liver transplant recipients. | 2011 | Transplant. Proc. | pmid:21911143 |
Abouljoud M et al. | Conversion to neoral provides effective rescue therapy for liver and kidney transplant patients intolerant of Prograf. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267175 |
Behr TM et al. | Incidence of humoral rejection in heart transplant recipients treated with tacrolimus or cyclosporine A. | 1998 | Transplant. Proc. | pmid:9723333 |
Berweck S et al. | Clinical use of the euglycemic hyperinsulinemic clamp for diagnosis of tacrolimus-induced insulin resistance after combined pancreas-kidney transplantation. | 1998 | Transplant. Proc. | pmid:9723345 |
Collin C et al. | Sublingual tacrolimus as an alternative to intravenous route in patients with thoracic transplant: a retrospective study. | 2010 | Transplant. Proc. | pmid:21168693 |
Slatinska J et al. | Long-term follow-up of stable kidney transplant recipients after conversion from tacrolimus twice daily immediate release to tacrolimus once-daily prolonged release: a large single-center experience. | 2013 | Transplant. Proc. | pmid:23726604 |
Dikow R et al. | Blood pressure profile and treatment quality in liver allograft recipients-benefit of tacrolimus versus cyclosporine. | 2004 | Transplant. Proc. | pmid:15251373 |
Katayama Y et al. | Immunosuppressive effects of FK 506 in rat lung transplantation. | 1991 | Transplant. Proc. | pmid:1721441 |
Yokomise H et al. | Immunosuppressive effects of FK 506 in canine lung transplantation. | 1991 | Transplant. Proc. | pmid:1721442 |
Odocha O et al. | Serum cholesterol levels in African Americans after renal transplantation under FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7689269 |
Nalesnik MA et al. | Toxicology of FK-506 in the Lewis rat. | 1987 | Transplant. Proc. | pmid:2445084 |
McCauley J et al. | Renal transplantation under FK 506 in African-Americans: early experience. | 1993 | Transplant. Proc. | pmid:7689270 |
Ochiai T et al. | Histopathologic studies in renal transplant recipient dogs receiving treatment with FK-506. | 1987 | Transplant. Proc. | pmid:2445085 |
Heffron TG et al. | Single-dose induction with daclizumab immediately after liver transplantation in pediatric patients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267368 |
Bárcena R et al. | Immunosuppression in liver transplantation: a European survey. | 1999 | Transplant. Proc. | pmid:10500654 |
Nicholson ML et al. | Is TGF-beta a profibrotic cytokine in human renal transplants? | 1998 | Transplant. Proc. | pmid:9636384 |
Fu Q et al. | Risk Factors for Acute Rejection After Deceased Donor Kidney Transplantation in China. | 2018 | Transplant. Proc. | pmid:30316380 |
Lautenschlager I et al. | Efficiency of FK 506 and CyA to prevent acute cellular rejection of pig liver allografts. | 1991 | Transplant. Proc. | pmid:1714650 |
Ikeda M et al. | Successful Second Allogeneic Stem Cell Transplantation From a Sibling Donor for Relapse of Myelodysplastic Syndrome in a Recipient of a Renal Transplant From His Mother: Case Report. | 2016 | Transplant. Proc. | pmid:27932152 |
Filler G | Optimization of immunosuppressive drug monitoring in children. | 2007 | Transplant. Proc. | pmid:17524944 |
Carl S et al. | Combining FK 506 and mycophenolate mofetil for the treatment of acute corticosteroid-resistant rejection following kidney transplantation: a new therapeutic concept. | 1998 | Transplant. Proc. | pmid:9636502 |