Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Sánchez-Pérez J | [Safety information for tacrolimus: present and future]. | 2008 | Actas Dermosifiliogr | pmid:18346426 |
Esteve-MartÃnez A et al. | [Treatment-resistant adult atopic dermatitis]. | 2011 | Actas Dermosifiliogr | pmid:21820642 |
Kageyama S et al. | Augmentation of natural killer cell activity induced by cytomegalovirus infection in mice treated with FK506. | 1997 | Acta Virol. | pmid:9391652 |
Radziejewski K et al. | Assessment of corneal and conjunctival metaplasia by impression cytology during the treatment of canine keratoconjunctivitis sicca. | 2018 | Acta Vet. Hung. | pmid:29958527 |
Radziejewski K and Balicki I | Comparative clinical evaluation of tacrolimus and cyclosporine eye drops for the treatment of canine keratoconjunctivitis sicca. | 2016 | Acta Vet. Hung. | pmid:27653428 |
Wartenberg KE et al. | Transient diffusion-weighted imaging changes in a patient with reversible leukoencephalopathy syndrome. | 2004 | Acta Radiol | pmid:15587428 |
Folwarczna J et al. | Effect of low-dose tacrolimus coadministered with raloxifene on the skeletal system in male rats. | 2009 Mar-Apr | Acta Pol Pharm | pmid:19719057 |
Turło J et al. | Submerged cultivation of Streptomyces tsukubaensis in media composed of waste products of food industry. | 2006 Sep-Oct | Acta Pol Pharm | pmid:17357618 |
Kaczmarczyk-Sedlak I et al. | Raloxifene does not affect the changes in bone histomorphometric parameters induced by low dose tacrolimus in male rats. | 2006 Jul-Aug | Acta Pol Pharm | pmid:17203868 |
Drake M et al. | The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain. | 1996 | Acta Physiol. Scand. | pmid:8899062 |
Ibarra FR et al. | Intracellular sodium modulates the state of protein kinase C phosphorylation of rat proximal tubule Na+,K+-ATPase. | 2002 | Acta Physiol. Scand. | pmid:12028137 |
Borda B et al. | Side effects of the calcineurin inhibitor, such as new-onset diabetes after kidney transplantation. | 2014 | Acta Physiol Hung | pmid:25183511 |
Khan SA et al. | Improvement in baroreflex control of renal sympathetic nerve activity in obese Sprague Dawley rats following immunosuppression. | 2017 | Acta Physiol (Oxf) | pmid:28456134 |
Chen YS et al. | Population pharmacokinetic analysis of tacrolimus in Chinese myasthenia gravis patients. | 2017 | Acta Pharmacol. Sin. | pmid:28552913 |
Zhang FM et al. | Effects of tacrolimus on infection of Friend murine leukemia virus to Fv-4 gene heterozygous mice. | 2004 | Acta Pharmacol. Sin. | pmid:14769211 |
Liu S et al. | The POR rs1057868-rs2868177 GC-GT diplotype is associated with high tacrolimus concentrations in early post-renal transplant recipients. | 2016 | Acta Pharmacol. Sin. | pmid:27498776 |
Luo X et al. | Prediction of tacrolimus metabolism and dosage requirements based on CYP3A4 phenotype and CYP3A5(*)3 genotype in Chinese renal transplant recipients. | 2016 | Acta Pharmacol. Sin. | pmid:26924289 |
Lu YX et al. | A population pharmacokinetic study of tacrolimus in healthy Chinese volunteers and liver transplant patients. | 2015 | Acta Pharmacol. Sin. | pmid:25500866 |
Chen JC and Ma P | Mechanism of FK506-induced renal hypoperfusion and its reversion in rats. | 2001 | Acta Pharmacol. Sin. | pmid:11749797 |
Yu Y et al. | Electrophysiological actions of cyclosporin A and tacrolimus on rat hippocampal CA1 pyramidal neurons. | 2007 | Acta Pharmacol. Sin. | pmid:18031601 |