Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Miyazawa H et al. | Mechanisms of hamster kidney graft rejection in the rat. | 1994 | Transplant. Proc. | pmid:7518111 |
Li D et al. | Tacrolimus dosing in Chinese renal transplant patients is related to MDR1 gene C3435T polymorphisms. | 2006 | Transplant. Proc. | pmid:17112846 |
Abouljoud MS et al. | Hyperlipidemia after liver transplantation: long-term results of the FK506/cyclosporine A US Multicenter Trial. US Multicenter Study Group. | 1995 | Transplant. Proc. | pmid:7533360 |
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Azuma T et al. | Study of graft-infiltrating cells in the rat small bowel allograft using low-dose FK 506. | 1999 | Transplant. Proc. | pmid:10578293 |
McCarthy SA et al. | Effects of FK 506 and cyclosporine on T-cell tolerance: inhibition of a "protective" mechanism that regulates activation-induced apoptosis in developing thymocytes. | 1991 | Transplant. Proc. | pmid:1721314 |
Antoniou EA et al. | Effect of donor-specific transfusion in combination with FK 506 in rat cardiac allotransplantation. | 1999 | Transplant. Proc. | pmid:10578296 |
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Zeevi A et al. | Comparative in vitro studies on the immunosuppressive activities of mycophenolic acid, bredinin, FK 506, cyclosporine, and rapamycin. | 1991 | Transplant. Proc. | pmid:1721315 |
Savikko J et al. | Tacrolimus inhibits platelet-derived growth factor ligand and receptor induction as well as rejection changes in rat renal allografts during long-term follow-up. | 2002 | Transplant. Proc. | pmid:12176405 |
Erickson L et al. | Gene expression profiling of acute rejection and mixed lymphocyte reaction with tacrolimus immunosuppression. | 2002 | Transplant. Proc. | pmid:12176407 |
Abecassis MM et al. | Patient outcomes and economics of once-daily tacrolimus in renal transplant patients: results of a modeling analysis. | 2008 | Transplant. Proc. | pmid:18589126 |
Rintala JM et al. | The effect of FK778 on acute rat renal allograft rejection and expression of platelet-derived growth factor and transforming growth factor-beta. | 2006 | Transplant. Proc. | pmid:17098049 |
Bismuth H | Comparison of FK 506- and cyclosporine-based immunosuppression: FK 506 therapy significantly reduces the incidence of acute, steroid-resistant, refractory, and chronic rejection whilst possessing a comparable safety profile. European FK 506 Multicenter Liver Study Group. | 1995 | Transplant. Proc. | pmid:7533415 |
Zhou W et al. | Calcineurin inhibitors block B-1 cell differentiation: the relevance to immunosuppressive treatment in ABO-incompatible transplantation. | 2005 | Transplant. Proc. | pmid:15919474 |
Jain AB et al. | Correlation of rejection episodes with FK 506 dosage, FK 506 level, and steroids following primary orthotopic liver transplant. | 1991 | Transplant. Proc. | pmid:1721347 |
Niel OR et al. | Long-term glomerular filtration rate in liver allograft recipients according to the type of calcineurin inhibitors. | 2009 | Transplant. Proc. | pmid:19857743 |
Marin M et al. | Factors influencing the onset of diabetes mellitus after kidney transplantation: a single French center experience. | 2005 | Transplant. Proc. | pmid:15919484 |
Charco R et al. | Low incidence of hypercholesterolemia among liver transplant patients under tacrolimus monotherapy immunosuppression. | 2002 | Transplant. Proc. | pmid:12176482 |
Lyne JC et al. | Cadaveric renal transplantation against a positive historic crossmatch under tacrolimus immunosuppression: long-term follow-up. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123015 |
Cheng CY et al. | Intervention of Online Percent Coefficient of Variation Reporting System Reduces the Variability of Tacrolimus Trough Concentration in Kidney Transplant Recipients. | 2018 | Transplant. Proc. | pmid:30316366 |
Bardella MT et al. | FK 506 and cyclosporine: effect on D-xylose absorption in pigs with orthotopic liver-small bowel allotransplants. | 1996 | Transplant. Proc. | pmid:8907937 |
Liu Y et al. | Delayed Initiation of Tacrolimus Is Safe and Effective in Renal Transplant Recipients With Delayed and Slow Graft Function. | 2018 | Transplant. Proc. | pmid:30316359 |
Sugitani A et al. | Intestinal neurons in acute and chronic rejection after small bowel transplantation in dogs. | 1996 | Transplant. Proc. | pmid:8907941 |
Ota K | Living donor kidney transplantation in Japan. | 1994 | Transplant. Proc. | pmid:7520622 |
Takahara S et al. | Monitoring of FK 506 blood levels in kidney transplant recipients. | 1994 | Transplant. Proc. | pmid:7520623 |
Watanabe T et al. | Effects of the endothelin-1 receptor antagonist TAK-044 on pulmonary injury in discordant xenotransplantation. | 2000 | Transplant. Proc. | pmid:10936270 |
Takayama K et al. | Hepatocyte growth factor and vascular endothelial growth factor expression in pig-to-primate xenotransplanted hearts. | 2000 | Transplant. Proc. | pmid:10936314 |
Perico N et al. | FK 506 does not affect the glomerular filtration rate and renal plasma flow in the rat. | 1991 | Transplant. Proc. | pmid:1721378 |
Veroux P et al. | Tacrolimus-induced neurotoxicity in kidney transplant recipients. | 2002 | Transplant. Proc. | pmid:12493415 |
Mieles L et al. | Glycemia and insulin need following FK 506 rescue therapy in liver transplant recipients. | 1991 | Transplant. Proc. | pmid:1703362 |
Wagner K et al. | Effect of FK 506 on excretion of urinary enzymes in rats. | 1991 | Transplant. Proc. | pmid:1721379 |
Izbicki G et al. | Improved survival after lung transplantation in patients treated with tacrolimus/mycophenolate mofetil as compared with cyclosporine/azathioprine. | 2002 | Transplant. Proc. | pmid:12493439 |
Warty V et al. | Distribution of FK 506 in plasma lipoproteins in transplant patients. | 1991 | Transplant. Proc. | pmid:1703363 |
Shimizu T et al. | Clinical and histological analysis of chronic tacrolimus nephrotoxicity in renal allografts. | 2008 | Transplant. Proc. | pmid:18790237 |
Ushigome H et al. | Immunosuppression in cadaveric renal transplant recipients from non-heart-beating donors in a single center. | 2002 | Transplant. Proc. | pmid:12176533 |
Weir M | Impact of immunosuppressive regimes on posttransplant diabetes mellitus. | 2001 | Transplant. Proc. | pmid:11498201 |
Kaibori M et al. | Inhibition of iNOS induction by FK506, but not by cyclosporine, in rat hepatocytes. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083347 |
el-Ghoroury M et al. | Efficacy and safety of tacrolimus versus cyclosporine in kidney and pancreas transplant recipients. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123461 |
Mueller AR et al. | Long-term follow-up in hepatitis C patients with respect to immunosuppression. | 1996 | Transplant. Proc. | pmid:8962255 |
Furtado A et al. | Local immunosuppression in clinical small bowel transplantation (report of two cases). | 2000 | Transplant. Proc. | pmid:10995910 |
Alessiani M et al. | Pharmacokinetic study of intraarterial local intestinal infusion of tacrolimus. | 2000 | Transplant. Proc. | pmid:10995915 |
Ayar Y et al. | Risk Factors Affecting Graft and Patient Survivals After Transplantation From Deceased Donors in a Developing Country: A Single-Center Experience. | 2017 | Transplant. Proc. | pmid:28219583 |
Tai J et al. | In vivo and in vitro effect of FK 506 on rat Leydig cell function. | 1991 | Transplant. Proc. | pmid:1721409 |
Sato Y et al. | FK 506 suppresses class II antigen expression in regenerating livers following partial hepatectomy in the rat. | 1992 | Transplant. Proc. | pmid:1379761 |
Sheng H et al. | Ocular complications of heart transplantation in a Chinese population. | 2008 | Transplant. Proc. | pmid:19100445 |
Chariat MN et al. | Basiliximab in the therapy of acute rejection after organ transplantation. | 2001 | Transplant. Proc. | pmid:11377567 |
Yoshimura N et al. | Effectiveness of the Combination of Everolimus and Tacrolimus With High Dosage of Mizoribine for Living Donor-Related Kidney Transplantation. | 2016 | Transplant. Proc. | pmid:27234736 |
Yamada MF et al. | Myeloablative cord blood transplantation for adults with hematological malignancies using tacrolimus and short-term methotrexate for graft-versus-host disease prophylaxis: single-institution analysis. | 2008 | Transplant. Proc. | pmid:19100456 |
Chan MC et al. | Conversion of cyclosporine to tacrolimus for refractory or persistent myocardial rejection. | 2002 | Transplant. Proc. | pmid:12176601 |
Molinaro M et al. | Pharmacokinetics of tacrolimus during the early phase after heart transplantation. | 2001 | Transplant. Proc. | pmid:11377570 |
van Riemsdijk IC et al. | Improvement of cardiovascular risk factors in heart transplant recipients after conversion from cyclosporine to tacrolimus: a role of the TGF-beta system. | 2002 | Transplant. Proc. | pmid:12176606 |
Pretagostini R et al. | Conversion from cyclosporin to tacrolimus in chronic allograft nephropathy. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267174 |
Abouljoud M et al. | Conversion to neoral provides effective rescue therapy for liver and kidney transplant patients intolerant of Prograf. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267175 |
Akbas SH et al. | The effect of MDR1 (ABCB1) polymorphism on the pharmacokinetic of tacrolimus in Turkish renal transplant recipients. | 2006 | Transplant. Proc. | pmid:16797284 |
Franke GH et al. | Switching from cyclosporine to tacrolimus leads to improved disease-specific quality of life in patients after kidney transplantation. | 2006 | Transplant. Proc. | pmid:16797285 |
Behr TM et al. | Incidence of humoral rejection in heart transplant recipients treated with tacrolimus or cyclosporine A. | 1998 | Transplant. Proc. | pmid:9723333 |
Berweck S et al. | Clinical use of the euglycemic hyperinsulinemic clamp for diagnosis of tacrolimus-induced insulin resistance after combined pancreas-kidney transplantation. | 1998 | Transplant. Proc. | pmid:9723345 |
Dikow R et al. | Blood pressure profile and treatment quality in liver allograft recipients-benefit of tacrolimus versus cyclosporine. | 2004 | Transplant. Proc. | pmid:15251373 |
Katayama Y et al. | Immunosuppressive effects of FK 506 in rat lung transplantation. | 1991 | Transplant. Proc. | pmid:1721441 |
Yokomise H et al. | Immunosuppressive effects of FK 506 in canine lung transplantation. | 1991 | Transplant. Proc. | pmid:1721442 |
Odocha O et al. | Serum cholesterol levels in African Americans after renal transplantation under FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7689269 |
Nalesnik MA et al. | Toxicology of FK-506 in the Lewis rat. | 1987 | Transplant. Proc. | pmid:2445084 |
McCauley J et al. | Renal transplantation under FK 506 in African-Americans: early experience. | 1993 | Transplant. Proc. | pmid:7689270 |
Ochiai T et al. | Histopathologic studies in renal transplant recipient dogs receiving treatment with FK-506. | 1987 | Transplant. Proc. | pmid:2445085 |
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Heffron TG et al. | Single-dose induction with daclizumab immediately after liver transplantation in pediatric patients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267368 |
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Nicholson ML et al. | Is TGF-beta a profibrotic cytokine in human renal transplants? | 1998 | Transplant. Proc. | pmid:9636384 |
Lautenschlager I et al. | Efficiency of FK 506 and CyA to prevent acute cellular rejection of pig liver allografts. | 1991 | Transplant. Proc. | pmid:1714650 |
Carl S et al. | Combining FK 506 and mycophenolate mofetil for the treatment of acute corticosteroid-resistant rejection following kidney transplantation: a new therapeutic concept. | 1998 | Transplant. Proc. | pmid:9636502 |