tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Infection D007239 6 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Bone Diseases D001847 4 associated lipids
Leukemia P388 D007941 43 associated lipids
Ulcer D014456 16 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Obesity D009765 29 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

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Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Bunnapradist S et al. LCPT once-daily extended-release tacrolimus tablets versus twice-daily capsules: a pooled analysis of two phase 3 trials in important de novo and stable kidney transplant recipient subgroups. 2016 Transpl. Int. pmid:26953629
van der Schaft J et al. First experience with extended release tacrolimus in the treatment of adult patients with severe, difficult to treat atopic dermatitis: Clinical efficacy, safety and dose finding. 2016 J. Dermatol. Sci. pmid:26547110
Gokhale NS Systematic approach to managing vernal keratoconjunctivitis in clinical practice: Severity grading system and a treatment algorithm. 2016 Indian J Ophthalmol pmid:27050351
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Nakamura H et al. Usefulness of tacrolimus for refractory adult-onset still's disease: Report of six cases. 2016 Mod Rheumatol pmid:25036233
Khan S et al. Tacrolimus-loaded nanostructured lipid carriers for oral delivery-in vivo bioavailability enhancement. 2016 Eur J Pharm Biopharm pmid:27793753
Wen Y et al. Tacrolimus restores podocyte injury and stabilizes the expression of Cabin1 in 5/6 nephrectomized rats. 2016 Ren Fail pmid:26905810
Högerle BA et al. Challenging immunosuppression treatment in lung transplant recipients with kidney failure. 2016 Transpl. Immunol. pmid:26892232
Kimura H et al. Has widespread use of biologic and immunosuppressant therapy for ulcerative colitis affected surgical trends? Results of a questionnaire survey of surgical institutions in Japan. 2016 Surg. Today pmid:26467558
Törlén J et al. A prospective randomized trial comparing cyclosporine/methotrexate and tacrolimus/sirolimus as graft-versus-host disease prophylaxis after allogeneic hematopoietic stem cell transplantation. 2016 Haematologica pmid:27662016
Zhang XS et al. FkbN and Tcs7 are pathway-specific regulators of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis L19. 2016 J. Ind. Microbiol. Biotechnol. pmid:27757551
Martial LC et al. A preliminary study searching for the right dose of tacrolimus in very young (≤4 years) renal transplant patients. 2016 J. Pharm. Pharmacol. pmid:27669677
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Chang KT et al. Tacrolimus suppresses atopic dermatitis-associated cytokines and chemokines in monocytes. 2016 J Microbiol Immunol Infect pmid:25315214
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Zeng W et al. Hyaluronic acid-coated niosomes facilitate tacrolimus ocular delivery: Mucoadhesion, precorneal retention, aqueous humor pharmacokinetics, and transcorneal permeability. 2016 Colloids Surf B Biointerfaces pmid:26820107
Rebora A Tacrolimus and oral lichen planus. Possible absorption after mucosal application? 2016 J Eur Acad Dermatol Venereol pmid:26372839
Nuki Y et al. Comparison of the therapeutic efficacy and safety between tacrolimus and infliximab for moderate-to-severe ulcerative colitis: a single center experience. 2016 Scand. J. Gastroenterol. pmid:26818468
Jin H et al. Clinical study of double dose of valsartan combined with tacrolimus in treatment of diabetic nephropathy. 2016 Eur Rev Med Pharmacol Sci pmid:26813471
Joko T et al. Therapeutic Effect of 0.1% Topical Tacrolimus for Childhood Interstitial Keratitis Refractory to Cyclosporine. 2016 J Nippon Med Sch pmid:26960587
Wang N et al. Paclitaxel and Tacrolimus Coencapsulated Polymeric Micelles That Enhance the Therapeutic Effect of Drug-Resistant Ovarian Cancer. 2016 ACS Appl Mater Interfaces pmid:26809267
Malachowski SJ et al. Annular Lichenoid Dermatitis of Youth: A Chronic Case Managed Using Pimecrolimus. 2016 Pediatr Dermatol pmid:27653808
Sawada T et al. Experimental Studies on Protective Effects of FK506 Against Hepatic Ischemia-Reperfusion Injury. 2016 J. Med. Invest. pmid:27644569
Hu X et al. Chimeric Allografts Induced by Short-Term Treatment With Stem Cell-Mobilizing Agents Result in Long-Term Kidney Transplant Survival Without Immunosuppression: A Study in Rats. 2016 Am. J. Transplant. pmid:26749344
Gabriel D et al. Improved topical delivery of tacrolimus: A novel composite hydrogel formulation for the treatment of psoriasis. 2016 J Control Release pmid:27639683
Cameron AM et al. Chimeric Allografts Induced by Short-Term Treatment With Stem Cell Mobilizing Agents Result in Long-Term Kidney Transplant Survival Without Immunosuppression: II, Study in Miniature Swine. 2016 Am. J. Transplant. pmid:26748958
Chen CA et al. Quantitative analysis of tissue inflammation and responses to treatment in immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome, and review of literature. 2016 J Microbiol Immunol Infect pmid:26748735
Karagüzel G et al. Vitamin D status and the effects of oral vitamin D treatment in children with vitiligo: A prospective study. 2016 Clin Nutr ESPEN pmid:28531780
Yoshida T et al. Oral tacrolimus oil formulations for enhanced lymphatic delivery and efficient inhibition of T-cell's interleukin-2 production. 2016 Eur J Pharm Biopharm pmid:26748381
Muñoz Gómez MM et al. [Tacrolimus-induced gynecomastia in a patient with polymyositis]. 2016 Med Clin (Barc) pmid:26678165
Ferjani H et al. Protective effect of mycophenolate mofetil against nephrotoxicity and hepatotoxicity induced by tacrolimus in Wistar rats. 2016 J. Physiol. Biochem. pmid:26746208
Vasu S et al. Granulocyte Colony-Stimulating Factor-Mobilized Allografts Contain Activated Immune Cell Subsets Associated with Risk of Acute and Chronic Graft-versus-Host Disease. 2016 Biol. Blood Marrow Transplant. pmid:26743340
Yoo EC et al. Developmental changes of MPA exposure in children. 2016 Pediatr. Nephrol. pmid:26743220
Pouché L et al. A candidate gene approach of the calcineurin pathway to identify variants associated with clinical outcomes in renal transplantation. 2016 Pharmacogenomics pmid:26894651
Abdel-Kahaar E et al. Analytical Validation and Cross-Validation of an NFAT-Regulated Gene Expression Assay for Pharmacodynamic Monitoring of Therapy With Calcineurin Inhibitors. 2016 Ther Drug Monit pmid:27661400
Radziejewski K and Balicki I Comparative clinical evaluation of tacrolimus and cyclosporine eye drops for the treatment of canine keratoconjunctivitis sicca. 2016 Acta Vet. Hung. pmid:27653428
Sommerer C et al. Design and rationale of the ATHENA study--A 12-month, multicentre, prospective study evaluating the outcomes of a de novo everolimus-based regimen in combination with reduced cyclosporine or tacrolimus versus a standard regimen in kidney transplant patients: study protocol for a randomised controlled trial. 2016 Trials pmid:26888217
Kannegieter NM et al. Conversion to Once-Daily Tacrolimus Results in Increased p38MAPK Phosphorylation in T Lymphocytes of Kidney Transplant Recipients. 2016 Ther Drug Monit pmid:26606072
Wang Z et al. Nanocomposite microparticles (nCmP) for the delivery of tacrolimus in the treatment of pulmonary arterial hypertension. 2016 Int J Pharm pmid:27568494
Rahnama-Moghadam S et al. Vesicular eruption in a 2-year-old boy. 2016 J Fam Pract pmid:27565104
Yang EM et al. Tacrolimus for children with refractory nephrotic syndrome: a one-year prospective, multicenter, and open-label study of Tacrobell®, a generic formula. 2016 World J Pediatr pmid:26684309
Haasova M et al. Immunosuppressive therapy for kidney transplantation in children and adolescents: systematic review and economic evaluation. 2016 Health Technol Assess pmid:27557331
Tsuji T et al. Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 ointment (fingolimod) in NC/Nga mice. 2016 Allergol Int pmid:26666476
Ishiwata Y et al. Effects of Miconazole Oral Gel on Blood Concentrations of Tacrolimus and Cyclosporine: A Retrospective Observational Study. 2016 Ther Drug Monit pmid:27559841
Lee C et al. Treatment of bleomycin-induced pulmonary fibrosis by inhaled tacrolimus-loaded chitosan-coated poly(lactic-co-glycolic acid) nanoparticles. 2016 Biomed. Pharmacother. pmid:26898446
Zegarska J et al. Tacrolimus Metabolite M-III May Have Nephrotoxic and Myelotoxic Effects and Increase the Incidence of Infections in Kidney Transplant Recipients. 2016 Transplant. Proc. pmid:27496443
Bargnoux AS et al. Evaluation of the New Siemens Tacrolimus Assay on the Dimension EXL Integrated Chemistry System Analyzer: Comparison With an Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Method. 2016 Ther Drug Monit pmid:27494947
Arai K et al. A Case Report of Drug-Induced Thrombocytopenia after Living Donor Liver Transplantation. 2016 Kobe J Med Sci pmid:27492209
Ren H et al. Phosphatase inhibition increases AQP2 accumulation in the rat IMCD apical plasma membrane. 2016 Am. J. Physiol. Renal Physiol. pmid:27488997
Woolner K and Sauder M Periorbital erythema following alcohol ingestion during treatment with topical tacrolimus. 2016 CMAJ pmid:26598374
Yoshida S et al. Treatment with DHA/EPA ameliorates atopic dermatitis-like skin disease by blocking LTB4 production. 2016 J. Med. Invest. pmid:27644556
Kociszewska-Najman B et al. Congenital Infections in Neonates of Women With Liver or Kidney Transplants. 2016 Transplant. Proc. pmid:27496446
Zmonarski SC et al. Lowering of Messenger Ribonucleic Acid Toll-Like Receptors 2-4,9 in Peripheral Blood Mononuclear Cells in Kidney Allograft Recipients, Relationships With Immunosuppressive Treatment, and Delayed Graft Function Occurrence. 2016 Transplant. Proc. pmid:27496439
Ashizuka S et al. Adrenomedullin Therapy in Patients with Refractory Ulcerative Colitis: A Case Series. 2016 Dig. Dis. Sci. pmid:26470867
Saito B et al. Umbilical cord blood transplantation for adults using tacrolimus with two-day very-short-term methotrexate for graft-versus-host disease prophylaxis. 2016 Leuk. Res. pmid:27376545
Matsui K et al. Betamethasone, but Not Tacrolimus, Suppresses the Development of Th2 Cells Mediated by Langerhans Cell-Like Dendritic Cells. 2016 Biol. Pharm. Bull. pmid:27374298
Kimsa M et al. Transforming growth factor β-related genes in human retinal pigment epithelial cells after tacrolimus treatment. 2016 Pharmacol Rep pmid:27372923
García-Delgado R et al. Systemic Absorption of Topical Tacrolimus in Metastatic Crohn Disease With Skin Ulcers. 2016 Actas Dermosifiliogr pmid:27372545
Gray JM and Ameduri RK Tacrolimus-associated hemolytic uremic syndrome in a pediatric heart transplant recipient. 2016 Pediatr Transplant pmid:27371345
Tanriover B et al. Acute Rejection Rates and Graft Outcomes According to Induction Regimen among Recipients of Kidneys from Deceased Donors Treated with Tacrolimus and Mycophenolate. 2016 Clin J Am Soc Nephrol pmid:27364616
Watanabe R et al. Successful multi-target therapy using corticosteroid, tacrolimus, cyclophosphamide, and rituximab for rapidly progressive interstitial lung disease in a patient with clinically amyopathic dermatomyositis. 2016 Mod Rheumatol pmid:25698368
Vignali D et al. IL-7 Mediated Homeostatic Expansion of Human CD4+CD25+FOXP3+ Regulatory T Cells After Depletion With Anti-CD25 Monoclonal Antibody. 2016 Transplantation pmid:27306531
Tsuji H et al. Efficacy and Safety of Grapefruit Juice Intake Accompanying Tacrolimus Treatment in Connective Tissue Disease Patients. 2016 Intern. Med. pmid:27301503
Berryhill A et al. Cysteamine in renal transplantation: A report of two patients with nephropathic cystinosis and the successful re-initiation of cysteamine therapy during the immediate post-transplant period. 2016 Pediatr Transplant pmid:26477696
Saitman A et al. Evaluation of the Waters MassTrak LC-MS/MS Assay for Tacrolimus and a Comparison to the Abbott Architect Immunoassay. 2016 Ther Drug Monit pmid:26473523
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Tremblay S et al. Absence of the Effect of Pretransplant Body Mass Index on Post Kidney Transplant Outcomes. 2016 Prog Transplant pmid:27207408
Wen Y et al. Effect of the knockdown of Cabin1 on p53 in glomerular podocyte. 2016 J. Recept. Signal Transduct. Res. pmid:26400065
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Emoto C et al. Risk Assessment of Drug-Drug Interactions of Calcineurin Inhibitors Affecting Sirolimus Pharmacokinetics in Renal Transplant Patients. 2016 Ther Drug Monit pmid:27310200
Menninga NJ et al. Restless Legs Syndrome Following Lung Transplantation: Prevalence and Relationship With Tacrolimus Exposure. 2016 Prog Transplant pmid:27207403
Badri PS et al. Pharmacokinetics of Tacrolimus and Cyclosporine in Liver Transplant Recipients Receiving 3 Direct-Acting Antivirals as Treatment for Hepatitis C Infection. 2016 Ther Drug Monit pmid:27310199
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Rodríguez-Ausín P et al. Topical tacrolimus 0.03% for the treatment of ocular psoriasis. 2016 Arch Soc Esp Oftalmol pmid:27130870
Stifft F et al. Effect of Breakfast on the Exposure of the Once-Daily Tacrolimus Formulation in Stable Kidney Transplant Recipients. 2016 Ther Drug Monit pmid:27128604
Pirmez R et al. Acne keloidalis nuchae in renal transplant patients receiving tacrolimus and sirolimus. 2016 Australas. J. Dermatol. pmid:27124649
Khaled SK et al. Influence of Absorption, Distribution, Metabolism, and Excretion Genomic Variants on Tacrolimus/Sirolimus Blood Levels and Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation. 2016 Biol. Blood Marrow Transplant. pmid:26325438
Matsukawa T et al. Reduced-dose methotrexate in combination with tacrolimus was associated with rapid engraftment and recovery from oral mucositis without affecting the incidence of GVHD. 2016 Int. J. Hematol. pmid:27119977
Peng L et al. Comparison of different therapies in high-risk patients with idiopathic membranous nephropathy. 2016 J. Formos. Med. Assoc. pmid:26315481
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Ruangkanchanasetr P et al. Beta Cell Function and Insulin Resistance After Conversion from Tacrolimus Twice-Daily to Extended-Release Tacrolimus Once-Daily in Stable Renal Transplant Recipients. 2016 Ann. Transplant. pmid:27980321
Castagna L et al. Tacrolimus compared with cyclosporine A after haploidentical T-cell replete transplantation with post-infusion cyclophosphamide. 2016 Bone Marrow Transplant. pmid:26595078
Wang YY et al. Characterization of Discrete Phosphopantetheinyl Transferases in Streptomyces tsukubaensis L19 Unveils a Complicate Phosphopantetheinylation Network. 2016 Sci Rep pmid:27052100
Lee DR et al. Enhanced dissolution and oral absorption of tacrolimus by supersaturable self-emulsifying drug delivery system. 2016 Int J Nanomedicine pmid:27051286
Cai SC et al. Topical calcineurin inhibitors in eczema and cancer association: A cohort study. 2016 J Dermatolog Treat pmid:27049893
Aldoss I et al. Cytogenetics Does Not Impact Outcomes in Adult Patients with Acute Lymphoblastic Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation. 2016 Biol. Blood Marrow Transplant. pmid:27044907
Yamamoto T et al. Editorial: tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis--authors' reply. 2016 Aliment. Pharmacol. Ther. pmid:27040167
Taylor KM and Sparrow MP Editorial: tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis. 2016 Aliment. Pharmacol. Ther. pmid:27040166
Imamura CK et al. Impact of cytochrome P450 2C19 polymorphisms on the pharmacokinetics of tacrolimus when coadministered with voriconazole. 2016 J Clin Pharmacol pmid:26239045
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Gu C et al. Triptolide Reduces the Required Dose of Tacrolimus by Attenuating Inflammation, Enhancing Immunosuppression, and Increasing Donor Chimerism in a Heterotopic Hindlimb Transplantation Model. 2016 Plast. Reconstr. Surg. pmid:27879593
Lee WS et al. Efficacy and safety of low-dose tacrolimus for active rheumatoid arthritis with an inadequate response to methotrexate. 2016 Korean J. Intern. Med. pmid:26961485