tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Abnormalities, Multiple D000015 13 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Acne Vulgaris D000152 35 associated lipids
Adenocarcinoma D000230 166 associated lipids
Adrenal Insufficiency D000309 3 associated lipids
Akinetic Mutism D000405 1 associated lipids
Albuminuria D000419 18 associated lipids
Alopecia D000505 14 associated lipids
Alopecia Areata D000506 6 associated lipids
Alzheimer Disease D000544 76 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Yanada M et al. Tacrolimus instead of cyclosporine used for prophylaxis against graft-versus-host disease improves outcome after hematopoietic stem cell transplantation from unrelated donors, but not from HLA-identical sibling donors: a nationwide survey conducted in Japan. 2004 Bone Marrow Transplant. pmid:15220958
Okano A et al. Subcutaneous infection with Mycobacterium fortuitum after allogeneic bone marrow transplantation. 2001 Bone Marrow Transplant. pmid:11704796
Takahata M et al. Cyclosporin A-induced encephalopathy after allogeneic bone marrow transplantation with prevention of graft-versus-host disease by tacrolimus. 2001 Bone Marrow Transplant. pmid:11704797
Espino G et al. Assessment of myocardial hypertrophy by echocardiography in adult patients receiving tacrolimus or cyclosporine therapy for prevention of acute GVHD. 2001 Bone Marrow Transplant. pmid:11803349
Watanabe N et al. Relationship between tacrolimus blood concentrations and clinical outcome during the first 4 weeks after SCT in children. 2010 Bone Marrow Transplant. pmid:19915626
Uberti JP et al. Tacrolimus and methotrexate for the prophylaxis of acute graft-versus-host disease in allogeneic bone marrow transplantation in patients with hematologic malignancies. 1997 Bone Marrow Transplant. pmid:9208118
Ohashi Y et al. Successful treatment of steroid-resistant severe acute GVHD with 24-h continuous infusion of FK506. 1997 Bone Marrow Transplant. pmid:9085743
Mehta P et al. Increased clearance of tacrolimus in children: need for higher doses and earlier initiation prior to bone marrow transplantation. 1999 Bone Marrow Transplant. pmid:10627642
Messina C et al. Prevention and treatment of acute GvHD. 2008 Bone Marrow Transplant. pmid:18545247
Hiraoka A et al. Phase III study comparing tacrolimus (FK506) with cyclosporine for graft-versus-host disease prophylaxis after allogeneic bone marrow transplantation. 2001 Bone Marrow Transplant. pmid:11509936
Yu C et al. Glucocorticoids fail to enhance the effect of FK506 and methotrexate in prevention of graft-versus-host disease after DLA-nonidentical, unrelated marrow transplantation. 1997 Bone Marrow Transplant. pmid:9244417
Fujino M et al. Intestinal thrombotic microangiopathy induced by FK506 in rats. 2007 Bone Marrow Transplant. pmid:17277791
Mori T et al. Drug interaction between voriconazole and tacrolimus in allogeneic hematopoietic SCT recipients. 2011 Bone Marrow Transplant. pmid:20453893
Kanamaru A et al. FK506 treatment of graft-versus-host disease developing or exacerbating during prophylaxis and therapy with cyclosporin and/or other immunosuppressants. Japanese FK506 BMT Study Group. 1995 Bone Marrow Transplant. pmid:7581086
Riley L et al. Cross-sensitivity reaction between tacrolimus and macrolide antibiotics. 2000 Bone Marrow Transplant. pmid:10808214
Ochiai N et al. Successful non-T cell-depleted HLA haplo-identical three-loci mismatched hematopoietic stem cell transplantation from mother to son based on the feto-maternal microchimerism in chronic myelogenous leukemia. 2002 Bone Marrow Transplant. pmid:12439703
Yumura-Yagi K et al. Unrelated donor bone marrow transplantation for 100 pediatric patients: a single institute's experience. 2005 Bone Marrow Transplant. pmid:15968285
Gondo H et al. Acquired Pelger-Huët anomaly in association with concomitant tacrolimus and fluconazole therapy following allogeneic bone marrow transplantation. 2000 Bone Marrow Transplant. pmid:11149744
Suehiro A et al. Enhancement by cyclosporine A and tacrolimus of serotonin-induced formation of small platelet aggregation. 2002 Bone Marrow Transplant. pmid:11850703
Nelson R et al. Sirolimus, tacrolimus and antithymocyte globulin as GVHD prophylaxis in HLA-mismatched unrelated donor hematopoietic cell transplantation: a single institution experience. 2015 Bone Marrow Transplant. pmid:26301969
Han CW et al. Differential effects of the immunosuppressants cyclosporin A, FK506 and KM2210 on cytokine gene expression. 1995 Bone Marrow Transplant. pmid:7545487
Terakura S et al. Exploratory research for optimal GvHD prophylaxis after single unit CBT in adults: short-term methotrexate reduced the incidence of severe GvHD more than mycophenolate mofetil. 2017 Bone Marrow Transplant. pmid:27941766
Zohren F et al. Tacrolimus and mycofenolate mofetil as GvHD prophylaxis following nonmyeloablative conditioning and unrelated hematopoietic SCT for adult patients with advanced hematologic diseases. 2011 Bone Marrow Transplant. pmid:20661230
Esquirol A et al. Single-agent GvHD prophylaxis with tacrolimus after post-transplant high-dose cyclophosphamide is a valid option for haploidentical transplantation in adults with hematological malignancies. 2017 Bone Marrow Transplant. pmid:28604667
Kanda J et al. Pre-engraftment syndrome after myeloablative dual umbilical cord blood transplantation: risk factors and response to treatment. 2013 Bone Marrow Transplant. pmid:23334274
Cooper MH et al. Short-term myeloid reconstitution following TBI is not adversely affected by doses of FK506 that abrogate lethal GVHD. 1994 Bone Marrow Transplant. pmid:7527689
Boughton O et al. A published pharmacogenetic algorithm was poorly predictive of tacrolimus clearance in an independent cohort of renal transplant recipients. 2013 Br J Clin Pharmacol pmid:23305195
Antignac M et al. Population pharmacokinetics and bioavailability of tacrolimus in kidney transplant patients. 2007 Br J Clin Pharmacol pmid:17425625
Nishimoto M et al. Drug interactions and safety profiles with concomitant use of caspofungin and calcineurin inhibitors in allogeneic haematopoietic cell transplantation. 2017 Br J Clin Pharmacol pmid:28407449
Böttiger Y et al. Tacrolimus whole blood concentrations correlate closely to side-effects in renal transplant recipients. 1999 Br J Clin Pharmacol pmid:10510159
Cusinato DA et al. Relationship of CYP3A5 genotype and ABCB1 diplotype to tacrolimus disposition in Brazilian kidney transplant patients. 2014 Br J Clin Pharmacol pmid:24528196
Mai I et al. MDR1 haplotypes derived from exons 21 and 26 do not affect the steady-state pharmacokinetics of tacrolimus in renal transplant patients. 2004 Br J Clin Pharmacol pmid:15521904
Woillard JB et al. Risk of diarrhoea in a long-term cohort of renal transplant patients given mycophenolate mofetil: the significant role of the UGT1A8 2 variant allele. 2010 Br J Clin Pharmacol pmid:20565459
Tang JT et al. The pharmacokinetics and pharmacodynamics of mycophenolate mofetil in younger and elderly renal transplant recipients. 2017 Br J Clin Pharmacol pmid:27753146
Hawwa AF et al. Influence of ABCB1 polymorphisms and haplotypes on tacrolimus nephrotoxicity and dosage requirements in children with liver transplant. 2009 Br J Clin Pharmacol pmid:19740399
Zahir H et al. Factors affecting variability in distribution of tacrolimus in liver transplant recipients. 2004 Br J Clin Pharmacol pmid:14998426
Atcheson BA et al. Mycophenolic acid pharmacokinetics and related outcomes early after renal transplant. 2005 Br J Clin Pharmacol pmid:15752372
Jalil MH et al. Population pharmacokinetic and pharmacogenetic analysis of tacrolimus in paediatric liver transplant patients. 2014 Br J Clin Pharmacol pmid:23738951
Johnston A and Holt DW Therapeutic drug monitoring of immunosuppressant drugs. 1999 Br J Clin Pharmacol pmid:10233195
Billaud EM et al. Evidence for a pharmacokinetic interaction between itraconazole and tacrolimus in organ transplant patients. 1998 Br J Clin Pharmacol pmid:9764970
Horigome A et al. Lymphocyte-sensitivity to glucocorticoid correlates with the sensitivity to cyclosporin A and tacrolimus in chronic renal failure patients. 1999 Br J Clin Pharmacol pmid:10583028
Øzbay LA et al. Calcineurin inhibitors acutely improve insulin sensitivity without affecting insulin secretion in healthy human volunteers. 2012 Br J Clin Pharmacol pmid:21988494
Størset E et al. Response to: 'Response to: Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance'. 2017 Br J Clin Pharmacol pmid:28374426
Jacobo-Cabral CO et al. Population pharmacokinetic analysis of tacrolimus in Mexican paediatric renal transplant patients: role of CYP3A5 genotype and formulation. 2015 Br J Clin Pharmacol pmid:25846845
Størset E et al. Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling. 2014 Br J Clin Pharmacol pmid:25279405
Suzuki Y et al. Impact of CYP3A5 genetic polymorphism on pharmacokinetics of tacrolimus in healthy Japanese subjects. 2008 Br J Clin Pharmacol pmid:18341670
Pham VV et al. Graft rejection: pharmacogenetic analysis or drug anamnesis? 2008 Br J Clin Pharmacol pmid:18341681
Gonschior AK et al. Measurement of blood concentrations of FK506 (tacrolimus) and its metabolites in seven liver graft patients after the first dose by h.p.l.c.-MS and microparticle enzyme immunoassay (MEIA). 1994 Br J Clin Pharmacol pmid:7534100
Zhao CY et al. External evaluation of published population pharmacokinetic models of tacrolimus in adult renal transplant recipients. 2016 Br J Clin Pharmacol pmid:26574188
Barraclough KA et al. Evaluation of limited sampling methods for estimation of tacrolimus exposure in adult kidney transplant recipients. 2011 Br J Clin Pharmacol pmid:21219401
Cremers S et al. Characterizing the role of enterohepatic recycling in the interactions between mycophenolate mofetil and calcineurin inhibitors in renal transplant patients by pharmacokinetic modelling. 2005 Br J Clin Pharmacol pmid:16120063
Barau C et al. Population pharmacokinetics of mycophenolic acid and dose optimization with limited sampling strategy in liver transplant children. 2012 Br J Clin Pharmacol pmid:22329639
Choi JH et al. Influence of the CYP3A5 and MDR1 genetic polymorphisms on the pharmacokinetics of tacrolimus in healthy Korean subjects. 2007 Br J Clin Pharmacol pmid:17391324
Musuamba FT et al. Statistical tools for dose individualization of mycophenolic acid and tacrolimus co-administered during the first month after renal transplantation. 2013 Br J Clin Pharmacol pmid:23072565
Vanhove T et al. Comparative performance of oral midazolam clearance and plasma 4β-hydroxycholesterol to explain interindividual variability in tacrolimus clearance. 2016 Br J Clin Pharmacol pmid:27501475
Woillard JB et al. Population pharmacokinetic model and Bayesian estimator for two tacrolimus formulations--twice daily Prograf and once daily Advagraf. 2011 Br J Clin Pharmacol pmid:21284698
Staatz CE et al. Tacrolimus pharmacokinetics after kidney transplantation--Influence of changes in haematocrit and steroid dose. 2015 Br J Clin Pharmacol pmid:26235203
Vanhove T et al. Response to 'Tacrolimus pharmacokinetics after kidney transplantation--Influence of changes in haematocrit and steroid dose'. 2015 Br J Clin Pharmacol pmid:26235051
Vanhove T et al. Response to: 'Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance'. 2017 Br J Clin Pharmacol pmid:28168728
Størset E et al. The CYP3A biomarker 4β-hydroxycholesterol does not improve tacrolimus dose predictions early after kidney transplantation. 2017 Br J Clin Pharmacol pmid:28146606
Mück W et al. Tacrolimus/cerivastatin interaction study in liver transplant recipients. 2001 Br J Clin Pharmacol pmid:11488782
Kassir N et al. Population pharmacokinetics and Bayesian estimation of tacrolimus exposure in paediatric liver transplant recipients. 2014 Br J Clin Pharmacol pmid:24977292
Passey C et al. Dosing equation for tacrolimus using genetic variants and clinical factors. 2011 Br J Clin Pharmacol pmid:21671989
Zheng S et al. Tacrolimus placental transfer at delivery and neonatal exposure through breast milk. 2013 Br J Clin Pharmacol pmid:23528073
Satoh S et al. Lack of tacrolimus circadian pharmacokinetics and CYP3A5 pharmacogenetics in the early and maintenance stages in Japanese renal transplant recipients. 2008 Br J Clin Pharmacol pmid:18429967
de Jonge H et al. Progressive decline in tacrolimus clearance after renal transplantation is partially explained by decreasing CYP3A4 activity and increasing haematocrit. 2015 Br J Clin Pharmacol pmid:26114223
Xin HW et al. Effects of Schisandra sphenanthera extract on the pharmacokinetics of tacrolimus in healthy volunteers. 2007 Br J Clin Pharmacol pmid:17506780
Mathew BS et al. A limited sampling strategy for tacrolimus in renal transplant patients. 2008 Br J Clin Pharmacol pmid:18662286
Christians U et al. Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes. 1996 Br J Clin Pharmacol pmid:8866917
Sam WJ et al. Population pharmacokinetics of tacrolimus in Asian paediatric liver transplant patients. 2000 Br J Clin Pharmacol pmid:11136292
Calvo PL et al. Donor CYP3A5 genotype influences tacrolimus disposition on the first day after paediatric liver transplantation. 2017 Br J Clin Pharmacol pmid:28044353
Stifft F et al. Rectal and sublingual administration of tacrolimus: a single-dose pharmacokinetic study in healthy volunteers. 2014 Br J Clin Pharmacol pmid:24809233
Størset E et al. Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance. 2017 Br J Clin Pharmacol pmid:28008657
Renders L et al. Tacrolimus and cerivastatin pharmacokinetics and adverse effects after single and multiple dosing with cerivastatin in renal transplant recipients. 2003 Br J Clin Pharmacol pmid:12895195
Knops N et al. Tacrolimus dose requirements in paediatric renal allograft recipients are characterized by a biphasic course determined by age and bone maturation. 2017 Br J Clin Pharmacol pmid:27966227
Elens L et al. The CYP3A4*22 allele affects the predictive value of a pharmacogenetic algorithm predicting tacrolimus predose concentrations. 2013 Br J Clin Pharmacol pmid:23163400
Bremer S et al. NFAT-regulated cytokine gene expression during tacrolimus therapy early after renal transplantation. 2017 Br J Clin Pharmacol pmid:28686294
Elens L et al. Clinical implementation of pharmacogenetics in kidney transplantation: calcineurin inhibitors in the starting blocks. 2014 Br J Clin Pharmacol pmid:24118098
Hesselink DA et al. Tacrolimus dose requirement in renal transplant recipients is significantly higher when used in combination with corticosteroids. 2003 Br J Clin Pharmacol pmid:12919182
Vanhove T et al. Pretransplant 4β-hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation. 2017 Br J Clin Pharmacol pmid:28603840
James DG Which immunomodulator? 1991 Br J Clin Pract pmid:1718384
Bowman H and Lennard TW Immunosuppressive drugs. 1992 Nov 4-17 Br J Hosp Med pmid:1282440
Shahid S et al. Chronic hepatitis in the transplant patient. 2017 Br J Hosp Med (Lond) pmid:28692371
Murphy CC et al. Validity of using vision-related quality of life as a treatment end point in intermediate and posterior uveitis. 2007 Br J Ophthalmol pmid:16973657
Oh-i K et al. Intravitreal injection of Tacrolimus (FK506) suppresses ongoing experimental autoimmune uveoretinitis in Rats. 2007 Br J Ophthalmol pmid:16987901
Tam PM et al. Topical tacrolimus 0.03% monotherapy for vernal keratoconjunctivitis--case series. 2010 Br J Ophthalmol pmid:20558422
Young AL et al. Allo-limbal transplantation in patients with limbal stem cell deficiency. 1999 Br J Ophthalmol pmid:10574823
Rao SK et al. Limbal allografting using FK-506. 1999 Br J Ophthalmol pmid:10574824
Oh-i K et al. Upregulation of neurotrophic factor-related gene expression in retina with experimental autoimmune uveoretinitis by intravitreal injection of tacrolimus (FK506). 2007 Br J Ophthalmol pmid:17940132
Fukushima A et al. Therapeutic effects of 0.1% tacrolimus eye drops for refractory allergic ocular diseases with proliferative lesion or corneal involvement. 2014 Br J Ophthalmol pmid:24695688
Joseph A et al. Tacrolimus immunosuppression in high-risk corneal grafts. 2007 Br J Ophthalmol pmid:16956911
Hogan A et al. Outcomes after combination photodynamic therapy and immunosuppression for inflammatory subfoveal choroidal neovascularisation. 2005 Br J Ophthalmol pmid:16113360
Lake DB and Poole TR Tacrolimus. 2003 Br J Ophthalmol pmid:12488279
Magalhaes OA et al. Topical 0.03% tacrolimus preventing rejection in high-risk corneal transplantation: a cohort study. 2013 Br J Ophthalmol pmid:24008822
Shoughy SS and Tabbara KF Topical tacrolimus solution in autoimmune polyglandular syndrome-1-associated keratitis. 2017 Br J Ophthalmol pmid:28137823
Leder HA et al. Disappearance of classic birdshot spots after immunosuppression with tacrolimus and mycophenolate mofetil. 2008 Br J Ophthalmol pmid:18227210
Aoki S et al. Systemic FK506 improved tear secretion in dry eye associated with chronic graft versus host disease. 2005 Br J Ophthalmol pmid:15665364
Ortega KL et al. Oral ulcers after a transplant. 2010 Br J Oral Maxillofac Surg pmid:19231045
Cetinkale O et al. The use of FK506 and skin allografting for the treatment of severe burns in an animal model. 1993 Br J Plast Surg pmid:7690295
Ahn KJ et al. Diffusion-weighted MRI and ADC mapping in FK506 neurotoxicity. 2003 Br J Radiol pmid:14711782