| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Graft Occlusion, Vascular | D006083 | 11 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee YH and Song GG | Relative efficacy and safety of tacrolimus, mycophenolate mofetil, and cyclophosphamide as induction therapy for lupus nephritis: a Bayesian network meta-analysis of randomized controlled trials. | 2015 | Lupus | pmid:26162684 |
| Liao R et al. | Tacrolimus Protects Podocytes from Injury in Lupus Nephritis Partly by Stabilizing the Cytoskeleton and Inhibiting Podocyte Apoptosis. | 2015 | PLoS ONE | pmid:26161538 |
| Kojima R et al. | Release mechanisms of tacrolimus-loaded PLGA and PLA microspheres and immunosuppressive effects of the microspheres in a rat heart transplantation model. | 2015 | Int J Pharm | pmid:26160668 |
| Kanchongkittiphon W et al. | Child with atopic dermatitis. | 2015 | Ann. Allergy Asthma Immunol. | pmid:25528736 |
| Shamsudin N et al. | Objective assessment of vitiligo with a computerised digital imaging analysis system. | 2015 | Australas. J. Dermatol. | pmid:25367709 |
| Velickovic-Radovanovic R et al. | Gender-dependent predictable pharmacokinetic method for tacrolimus exposure monitoring in kidney transplant patients. | 2015 | Eur J Drug Metab Pharmacokinet | pmid:24596067 |
| Traitanon O et al. | Differential Effects of Tacrolimus versus Sirolimus on the Proliferation, Activation and Differentiation of Human B Cells. | 2015 | PLoS ONE | pmid:26087255 |
| Kedzierska K et al. | The effect of immunosuppressive therapy on renal cell apoptosis in native rat kidneys. | 2015 | Histol. Histopathol. | pmid:25029518 |
| Seo YG et al. | Solid self-nanoemulsifying drug delivery system (SNEDDS) for enhanced oral bioavailability of poorly water-soluble tacrolimus: physicochemical characterisation and pharmacokinetics. | 2015 | J Microencapsul | pmid:26079598 |
| Menotta M et al. | Label-free quantification of Tacrolimus in biological samples by atomic force microscopy. | 2015 | Anal. Chim. Acta | pmid:26073814 |
| Hu WX et al. | Glucocorticoid with or without additional immunosuppressant therapy for patients with lupus podocytopathy: a retrospective single-center study. | 2015 | Lupus | pmid:25819933 |
| Mabuchi M et al. | Improvement of solid material for affinity resins by application of long PEG spacers to capture the whole target complex of FK506. | 2015 | Bioorg. Med. Chem. Lett. | pmid:26025877 |
| Zhang D et al. | Multifunctional Poly(methyl vinyl ether-co-maleic anhydride)-graft-hydroxypropyl-β-cyclodextrin Amphiphilic Copolymer as an Oral High-Performance Delivery Carrier of Tacrolimus. | 2015 | Mol. Pharm. | pmid:26024817 |
| Considine A et al. | Performance of modified-release tacrolimus after conversion in liver transplant patients indicates potentially favorable outcomes in selected cohorts. | 2015 | Liver Transpl. | pmid:25312292 |
| Taber DJ et al. | African-American race modifies the influence of tacrolimus concentrations on acute rejection and toxicity in kidney transplant recipients. | 2015 | Pharmacotherapy | pmid:26011276 |
| Parody R et al. | GVHD prophylaxis with sirolimus-tacrolimus may overcome the deleterious effect on survival of HLA mismatch after reduced-intensity conditioning allo-SCT. | 2015 | Bone Marrow Transplant. | pmid:25310306 |
| Hollis IB et al. | Medication management of cardiac allograft vasculopathy after heart transplantation. | 2015 | Pharmacotherapy | pmid:26011142 |
| Grammatikopoulos T et al. | Anti-CD20 Monoclonal Antibody Therapy in Functional Bile Salt Export Pump Deficiency After Liver Transplantation. | 2015 | J. Pediatr. Gastroenterol. Nutr. | pmid:24231640 |
| Leyking S et al. | Calcineurin inhibitors differentially alter the circadian rhythm of T-cell functionality in transplant recipients. | 2015 | J Transl Med | pmid:25885792 |
| Wang X et al. | Tacrolimus 0.03% ointment in labial discoid lupus erythematosus: A randomized, controlled clinical trial. | 2015 | J Clin Pharmacol | pmid:25951426 |
| Ozbek OY and Ozcay F | Long-term outcome of food allergy after liver transplantation in children. | 2015 | Pediatr Transplant | pmid:25882294 |
| Mistry NP et al. | Formulation and evaluation of tacrolimus-loaded galactosylated Poly(lactic-co-glycolic acid) nanoparticles for liver targeting. | 2015 | J. Pharm. Pharmacol. | pmid:25944126 |
| Banhara PB et al. | Tubular dysfunction in renal transplant patients using sirolimus or tacrolimus. | 2015 | Clin. Nephrol. | pmid:25943142 |
| Bonanni A et al. | Low-dose ofatumumab for rituximab-resistant nephrotic syndrome. | 2015 | BMJ Case Rep | pmid:26376698 |
| Zhou X et al. | Effect of immunosuppression on the human mesangial cell cycle. | 2015 | Mol Med Rep | pmid:25370945 |
| Peccerillo F et al. | Eosinophilic cellulitis. | 2015 | G Ital Dermatol Venereol | pmid:25946678 |
| Montero N and Pascual J | Immunosuppression and Post-transplant Hyperglycemia. | 2015 | Curr Diabetes Rev | pmid:25824238 |
| Seo YG et al. | Preparation and pharmaceutical evaluation of new tacrolimus-loaded solid self-emulsifying drug delivery system. | 2015 | Arch. Pharm. Res. | pmid:25134927 |
| Ott M et al. | Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway. | 2015 | Glia | pmid:25132599 |
| Abudou M et al. | Immunosuppressants for the prophylaxis of corneal graft rejection after penetrating keratoplasty. | 2015 | Cochrane Database Syst Rev | pmid:26313245 |
| Li Z et al. | Tacrolimus Induces Insulin Resistance and Increases the Glucose Absorption in the Jejunum: A Potential Mechanism of the Diabetogenic Effects. | 2015 | PLoS ONE | pmid:26599323 |
| Madariaga ML et al. | Kidney-induced cardiac allograft tolerance in miniature swine is dependent on MHC-matching of donor cardiac and renal parenchyma. | 2015 | Am. J. Transplant. | pmid:25824550 |
| Naito T et al. | ABCB1 genetic variant and its associated tacrolimus pharmacokinetics affect renal function in patients with rheumatoid arthritis. | 2015 | Clin. Chim. Acta | pmid:25817604 |
| Honda Y et al. | Disseminated Mycobacterium mantenii infection with multiple purulent cutaneous lesions. | 2015 | Acta Derm. Venereol. | pmid:25881714 |
| Chhatrala R et al. | Evolution of serum atherogenic risk in liver transplant recipients: Role of lipoproteins and metabolic and inflammatory markers. | 2015 | Liver Transpl. | pmid:25762084 |
| Soylu H et al. | Survival of renal transplant patients: data from a tertiary care center in Turkey. | 2015 | Transplant. Proc. | pmid:25769571 |
| Helmschrott M et al. | Advantageous effects of immunosuppression with tacrolimus in comparison with cyclosporine A regarding renal function in patients after heart transplantation. | 2015 | Drug Des Devel Ther | pmid:25759566 |
| Mlih M et al. | Na(+)/H (+) exchanger isoform 1 induced osteopontin expression in cardiomyocytes involves NFAT3/Gata4. | 2015 | Mol. Cell. Biochem. | pmid:25758355 |
| Ohe M and Bohgaki T | A Case of Adult-Onset Still's Disease Treated with Monitoring of Serum Tacrolimus Levels. | 2015 | Bull Hosp Jt Dis (2013) | pmid:26535602 |
| Xiao A et al. | H2S, a novel gasotransmitter, involves in gastric accommodation. | 2015 | Sci Rep | pmid:26531221 |
| Liu X et al. | Associations of HSD11B1 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients with prednisone combined therapy. | 2015 | Drug Metab. Dispos. | pmid:25587129 |
| Staatz CE et al. | Tacrolimus pharmacokinetics after kidney transplantation--Influence of changes in haematocrit and steroid dose. | 2015 | Br J Clin Pharmacol | pmid:26235203 |
| Ceulemans LJ et al. | Nonsteroidal anti-inflammatory drug-induced intestinal graft loss 12 years after transplantation. | 2015 | Transplantation | pmid:25695790 |
| Vardas PN et al. | Identification and management of atypical hemolytic uremic syndrome immediately post-heart transplantation. | 2015 | J Card Surg | pmid:25693626 |
| BlažiÄ M et al. | Roles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis. | 2015 | Microb. Cell Fact. | pmid:26466669 |
| Stevens RB et al. | A Randomized 2x2 Factorial Clinical Trial of Renal Transplantation: Steroid-Free Maintenance Immunosuppression with Calcineurin Inhibitor Withdrawal after Six Months Associates with Improved Renal Function and Reduced Chronic Histopathology. | 2015 | PLoS ONE | pmid:26465152 |
| Cai W et al. | Limited sampling strategy for predicting area under the concentration-time curve for mycophenolic Acid in Chinese adults receiving mycophenolate mofetil and tacrolimus early after renal transplantation. | 2015 | Ther Drug Monit | pmid:25525761 |
| Wang JY and Fan H | P70S6 kinase phosphorylation: a new site to assess pharmacodynamy of sirolimus. | 2015 | Chin. Med. J. | pmid:25698201 |
| Van Driest SL and Webber SA | Pharmacogenomics: personalizing pediatric heart transplantation. | 2015 | Circulation | pmid:25645611 |
| Detroyer D et al. | Resolution of diffuse skin and systemic Kaposi's sarcoma in a renal transplant recipient after introduction of everolimus: a case report. | 2015 | Transpl Infect Dis | pmid:25645490 |
| Chow SP et al. | Long-Term Outcomes of High-Risk Keratoplasty in Patients Receiving Systemic Immunosuppression. | 2015 | Cornea | pmid:26382894 |
| Lin NC et al. | Minimization or withdrawal of immunosuppressants in pediatric liver transplant recipients. | 2015 | J. Pediatr. Surg. | pmid:26377868 |
| Garcia MF et al. | Behavioral measures to reduce non-adherence in renal transplant recipients: a prospective randomized controlled trial. | 2015 | Int Urol Nephrol | pmid:26377496 |
| Tsujiwaki M et al. | Warty intralymphatic histiocytosis successfully treated with topical tacrolimus. | 2015 | J Eur Acad Dermatol Venereol | pmid:24851952 |
| Fukushima D et al. | Epstein-Barr virus--associated posttransplantation lymphoproliferative disorder with tacrolimus metabolism deterioration in infants after living-donor liver transplantation. | 2015 | Transplantation | pmid:24846306 |
| Elbadri A et al. | Factors affecting eGFR 5-year post-deceased donor renal transplant: analysis and predictive model. | 2015 | Ren Fail | pmid:25585951 |
| Tohme FA et al. | Conversion to a sirolimus-based regimen is associated with lower incidence of BK viremia in low-risk kidney transplant recipients. | 2015 | Transpl Infect Dis | pmid:25582442 |
| Krystel-Whittemore M et al. | Polyomavirus nephropathy of the native kidney in a patient with rheumatoid arthritis and pulmonary fibrosis. | 2015 | BMJ Case Rep | pmid:26318171 |
| Saint-Marcoux F et al. | How to handle missed or delayed doses of tacrolimus in renal transplant recipients? A pharmacokinetic investigation. | 2015 | Pharmacol. Res. | pmid:26316426 |
| Karam S and Wali RK | Current State of Immunosuppression: Past, Present, and Future. | 2015 | Crit. Rev. Eukaryot. Gene Expr. | pmid:26080606 |
| Ãœnal CM and Steinert M | FKBPs in bacterial infections. | 2015 | Biochim. Biophys. Acta | pmid:25529296 |
| Higa M et al. | Spatial control of calcineurin in response to heat shock in fission yeast. | 2015 | Genes Cells | pmid:25529221 |
| Lim SW et al. | Inhibition of dipeptidyl peptidase IV protects tacrolimus-induced kidney injury. | 2015 | Lab. Invest. | pmid:26237274 |
| Vaeth M et al. | Selective NFAT targeting in T cells ameliorates GvHD while maintaining antitumor activity. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25583478 |
| Wu B et al. | Triple immunosuppressive therapy in steroid-resistant nephrotic syndrome children with tacrolimus resistance or tacrolimus sensitivity but frequently relapsing. | 2015 | Nephrology (Carlton) | pmid:25312783 |
| Namvaran F et al. | The Effect of Tacrolimus on Reactive Oxygen Species and Total Antioxidant Status in Pancreatic Beta Cell Line. | 2015 | Exp Clin Transplant | pmid:25431882 |
| Vives R et al. | Safety and Activity of UR-1505 in Atopic Dermatitis: A Randomized, Double-blind Phase II Exploratory Trial. | 2015 | Clin Ther | pmid:26163200 |
| Kabrine M and Laraba-Djebari F | Immunomodulatory and protective properties of tacrolimus in experimental scorpion envenomation. | 2014 Jan-Mar | Int J Immunopathol Pharmacol | pmid:24674680 |
| Wang C and Lin A | Efficacy of topical calcineurin inhibitors in psoriasis. | 2014 Jan-Feb | J Cutan Med Surg | pmid:24377467 |
| Feito-RodrÃguez M et al. | Bacterial vaginosis in the context of lichen sclerosus in a prepubertal girl. | 2014 Jan-Feb | Pediatr Dermatol | pmid:24125016 |
| Veisa G et al. | The importance of renal biopsy in the management of renal transplantation. | 2014 Apr-Jun | Rev Med Chir Soc Med Nat Iasi | pmid:25076703 |
| Saito K et al. | Severe diffuse duodenitis successfully treated with intravenous tacrolimus after colectomy for ulcerative colitis. | 2014 | Intern. Med. | pmid:25366006 |
| Labrador J et al. | Risk factors for thrombotic microangiopathy in allogeneic hematopoietic stem cell recipients receiving GVHD prophylaxis with tacrolimus plus MTX or sirolimus. | 2014 | Bone Marrow Transplant. | pmid:24566710 |
| Liu Y et al. | Role of retrograde trafficking in stress response, host cell interactions, and virulence of Candida albicans. | 2014 | Eukaryotic Cell | pmid:24363364 |
| Kurzawski M et al. | CYP3A5 and CYP3A4, but not ABCB1 polymorphisms affect tacrolimus dose-adjusted trough concentrations in kidney transplant recipients. | 2014 | Pharmacogenomics | pmid:24444408 |
| Chen YK et al. | Personalized tacrolimus dose requirement by CYP3A5 but not ABCB1 or ACE genotyping in both recipient and donor after pediatric liver transplantation. | 2014 | PLoS ONE | pmid:25310192 |
| Steinebrunner N et al. | Pharmacodynamic monitoring of nuclear factor of activated T cell-regulated gene expression in liver allograft recipients on immunosuppressive therapy with calcineurin inhibitors in the course of time and correlation with acute rejection episodes--a prospective study. | 2014 | Ann. Transplant. | pmid:24457606 |
| Müller GG et al. | Topical tacrolimus 0.03% as sole therapy in vernal keratoconjunctivitis: a randomized double-masked study. | 2014 | Eye Contact Lens | pmid:24418865 |
| Hesselink DA et al. | The role of pharmacogenetics in the disposition of and response to tacrolimus in solid organ transplantation. | 2014 | Clin Pharmacokinet | pmid:24249597 |
| Zhu X et al. | Pilot study using tacrolimus rather than cyclosporine plus antithymocyte globulin as an immunosuppressive therapy regimen option for severe aplastic anemia in adults. | 2014 | Blood Cells Mol. Dis. | pmid:24931461 |
| Souza MC et al. | Tacrolimus-loaded PLGA implants: in vivo release and ocular toxicity. | 2014 | Curr. Eye Res. | pmid:24325382 |
| Talreja N et al. | Successful desensitization to agalsidase beta after anaphylaxis. | 2014 | Ann. Allergy Asthma Immunol. | pmid:24331397 |
| Musuamba FT et al. | Population pharmacokinetic analysis of tacrolimus early after pediatric liver transplantation. | 2014 | Ther Drug Monit | pmid:24081207 |
| Ricciardelli I et al. | Towards gene therapy for EBV-associated posttransplant lymphoma with genetically modified EBV-specific cytotoxic T cells. | 2014 | Blood | pmid:25185261 |
| Mujtaba MA et al. | Conversion from tacrolimus to belatacept to prevent the progression of chronic kidney disease in pancreas transplantation: case report of two patients. | 2014 | Am. J. Transplant. | pmid:25179306 |
| Takeuchi T et al. | Tacrolimus-induced left ventricular apical hypertrophy in a patient with post-allogeneic hematopoietic stem cell transplantation. | 2014 | Int. J. Cardiol. | pmid:25131917 |
| Huang H et al. | Effect and mechanism of tacrolimus on melanogenesis on A375 human melanoma cells. | 2014 | Chin. Med. J. | pmid:25131236 |
| Choi SW et al. | Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: a phase 1/2 trial. | 2014 | Lancet Oncol. | pmid:24295572 |
| Zwiech R | [The early C4d urinary excretion and long-term kidney graft survival in patients treated with tacrolimus and mycophenolate mophetil]. | 2014 | Pol. Merkur. Lekarski | pmid:24779215 |
| Boschetti G et al. | Tacrolimus induction followed by maintenance monotherapy is useful in selected patients with moderate-to-severe ulcerative colitis refractory to prior treatment. | 2014 | Dig Liver Dis | pmid:25023007 |
| Personett HA et al. | Impact of molecular adsorbent recirculating system therapy on tacrolimus elimination: a case report. | 2014 | Transplant. Proc. | pmid:25017243 |
| Feng S et al. | A rapidly reversible chemical dimerizer system to study lipid signaling in living cells. | 2014 | Angew. Chem. Int. Ed. Engl. | pmid:24841150 |
| Rotter D et al. | Calcineurin and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion. | 2014 | J. Mol. Cell. Cardiol. | pmid:24838101 |
| Fazal MA et al. | Dyslipidaemia among renal transplant recipients: cyclosporine versus tacrolimus. | 2014 | J Pak Med Assoc | pmid:25272531 |
| Muduma G et al. | A UK analysis of the cost of switching renal transplant patients from an immediate-release to a prolonged-release formulation of tacrolimus based on differences in trough concentration variability. | 2014 | J Med Econ | pmid:24754700 |
| Bloch J et al. | Donor ABCB1 genetic polymorphisms influence epithelial-to-mesenchyme transition in tacrolimus-treated kidney recipients. | 2014 | Pharmacogenomics | pmid:25521359 |
| Hodzic E et al. | Posterior reversible encephalopathy syndrome (PRES) as a complication of immunosuppressive therapy in renal transplantation in children. | 2014 | Med Arh | pmid:25195358 |
| Chen Y et al. | Comparison of long-term impact of immunosuppressants at therapeutic doses on hepatic function and histological changes in unilateral nephrectomized rats. | 2014 | Exp. Toxicol. Pathol. | pmid:25081300 |
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