Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Perego C et al. | Orthotopic liver-small bowel transplantation in pigs: study of immunologic parameters during therapy with FK 506-based immunosuppressive regimens. | 1996 | Transplant. Proc. | pmid:8907908 |
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Moreno JM et al. | Effectiveness and safety of mycophenolate mofetil as monotherapy in liver transplantation. | 2003 | Transplant. Proc. | pmid:12962831 |
Lieberman KV et al. | FK 506 is a direct glomeruloconstrictor, as determined by electrical resistance pulse sizing (ERPS). | 1991 | Transplant. Proc. | pmid:1721376 |
Shapiro R et al. | A pilot trial of tacrolimus, sirolimus, and steroids in renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176521 |
Demetris AJ et al. | Histopathology of human renal allograft rejection under FK 506: a comparison with cyclosporine. | 1991 | Transplant. Proc. | pmid:1703360 |
Nishimura Y et al. | A trial to obtain donor-specific immunotolerance using a vascularized thymus allograft. | 1998 | Transplant. Proc. | pmid:9838684 |
Damotte D et al. | Morphologic features of large bowel biopsies in combined small and large bowel transplantations could predict clinical rejection. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083252 |
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Kiuchi T et al. | Experience of tacrolimus-based immunosuppression in living-related liver transplantation complicated with graft tuberculosis: interaction with rifampicin and side effects. | 1996 | Transplant. Proc. | pmid:8962229 |
Ji SM et al. | Conversion from cyclosporine to tacrolimus for chronic allograft nephropathy. | 2007 | Transplant. Proc. | pmid:17580148 |
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Viebahn R et al. | Hypoxic and reoxygenation injury in human and rat hepatocytes--influence of FK 506 and cyclosporine. | 1991 | Transplant. Proc. | pmid:1721401 |
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Masaki Y et al. | Microchimerism and rat small bowel transplantation combined with donor-type bone marrow cells. | 1996 | Transplant. Proc. | pmid:8769154 |
Morrisett JD et al. | Effect of FK 506 and cyclosporine on plasma cholesterol levels in rabbits. | 1991 | Transplant. Proc. | pmid:1721402 |
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Sahara H et al. | Thymectomy does not abrogate long-term acceptance of MHC class I-disparate lung allografts in miniature Swine. | 2006 | Transplant. Proc. | pmid:17175240 |
El-Safa EA et al. | Paradoxical response to tacrolimus assessed by interleukin-2 gene expression. | 2006 | Transplant. Proc. | pmid:17175263 |
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Wu GD et al. | FK 506 inhibits the development of transplant arteriosclerosis. | 1991 | Transplant. Proc. | pmid:1721433 |
Makowka L et al. | The effect of FK-506 on hyperacute rejection in presensitized rats. | 1987 | Transplant. Proc. | pmid:2445082 |
Moreno M et al. | Clinical management of tacrolimus drug interactions in renal transplant patients. | 1999 | Transplant. Proc. | pmid:10500564 |
GarcÃa Meseguer C et al. | The effect of different immunosuppression on the outcome of pediatric renal transplants. | 1999 | Transplant. Proc. | pmid:10500577 |
Tur MD et al. | Apolipoprotein CIII is upregulated by anticalcineurins and rapamycin: implications in transplantation-induced dyslipidemia. | 2000 | Transplant. Proc. | pmid:11134804 |
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Demir T et al. | Cancer Screening of Renal Transplant Patients Undergoing Long-Term Immunosuppressive Therapy. | 2015 | Transplant. Proc. | pmid:26093731 |
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Braun F et al. | Living-related versus living-unrelated kidney transplantation using tacrolimus initial immunosuppression. | 2000 | Transplant. Proc. | pmid:10700989 |
Finni PE et al. | Is hepatitis C a risk factor to posttransplant diabetes mellitus after renal transplantation in patients using tacrolimus? | 2004 | Transplant. Proc. | pmid:15194303 |
Jiang H et al. | Effect of FK 506 on heart allograft survival in highly sensitized recipient rats in comparison with cyclosporine. | 1991 | Transplant. Proc. | pmid:1703702 |