tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dury S et al. | Bronchiectasis diagnosed after renal transplantation: a retrospective multicenter study. | 2015 | BMC Pulm Med | pmid:26545860 |
| Obayashi N et al. | Management of tacrolimus-associated food allergy after liver transplantation. | 2015 | Pediatr Int | pmid:26541649 |
| Kwon M et al. | Bioequivalence of tacrolimus formulations with different dynamic solubility and in-vitro dissolution profiles. | 2015 | Arch. Pharm. Res. | pmid:24627339 |
| Tang T et al. | Roles of the tacrolimus-dependent transcription factor IRF4 in acute rejection after liver transplantation. | 2015 | Int. Immunopharmacol. | pmid:26093273 |
| Hu L et al. | Severe Tacrolimus-Induced Granulomatous Rosacea Recalcitrant to Oral Tetracyclines. | 2015 | J Drugs Dermatol | pmid:26091390 |
| Melilli E et al. | De novo use of a generic formulation of tacrolimus versus reference tacrolimus in kidney transplantation: evaluation of the clinical results, histology in protocol biopsies, and immunological monitoring. | 2015 | Transpl. Int. | pmid:26088437 |
| Traitanon O et al. | Differential Effects of Tacrolimus versus Sirolimus on the Proliferation, Activation and Differentiation of Human B Cells. | 2015 | PLoS ONE | pmid:26087255 |
| Boukoum H et al. | BK and JC polyomavirus infections in Tunisian renal transplant recipients. | 2015 | J. Med. Virol. | pmid:25952258 |
| Rahman S et al. | Nordihydroguiaretic acid attenuates skin tumorigenesis in Swiss albino mice with the condition of topical co-administration of an immunosuppressant. | 2015 | Chem. Biol. Interact. | pmid:25770929 |
| Miura M et al. | Tacrolimus reduction with everolimus addition for calcineurin inhibitor-induced arteriolopathy in kidney allografts. | 2015 | Nephrology (Carlton) | pmid:26031588 |
| Ma R et al. | FK506 ameliorates podocyte injury in type 2 diabetic nephropathy by down-regulating TRPC6 and NFAT expression. | 2015 | Int J Clin Exp Pathol | pmid:26823720 |
| Yagisawa T et al. | Arteriosclerosis in zero-time biopsy is a risk factor for tacrolimus-induced chronic nephrotoxicity. | 2015 | Nephrology (Carlton) | pmid:26031587 |
| Lee J et al. | A 12-month single arm pilot study to evaluate the efficacy and safety of sirolimus in combination with tacrolimus in kidney transplant recipients at high immunologic risk. | 2015 | J. Korean Med. Sci. | pmid:26028917 |
| Mabuchi M et al. | Improvement of solid material for affinity resins by application of long PEG spacers to capture the whole target complex of FK506. | 2015 | Bioorg. Med. Chem. Lett. | pmid:26025877 |
| Zhang D et al. | Multifunctional Poly(methyl vinyl ether-co-maleic anhydride)-graft-hydroxypropyl-β-cyclodextrin Amphiphilic Copolymer as an Oral High-Performance Delivery Carrier of Tacrolimus. | 2015 | Mol. Pharm. | pmid:26024817 |
| Huang G et al. | [Analysis on BK virus associated nephropathy related risk factors in renal transplant recipients]. | 2015 | Zhonghua Yi Xue Za Zhi | pmid:26814103 |
| Kaieda S et al. | Successful treatment of macrophage activation syndrome in a patient with dermatomyositis by combination with immunosuppressive therapy and plasmapheresis. | 2015 | Mod Rheumatol | pmid:24252010 |
| Ichimaru N et al. | Risk factors and incidence for lipid abnormalities in kidney transplant patients. | 2015 | Transplant. Proc. | pmid:25891708 |
| Lim EJ et al. | Effect of Immunosuppressive Agents on Hepatocyte Apoptosis Post-Liver Transplantation. | 2015 | PLoS ONE | pmid:26390404 |
| Shu WY et al. | Pharmacogenomics and personalized medicine: a review focused on their application in the Chinese population. | 2015 | Acta Pharmacol. Sin. | pmid:25891088 |
| Baird K et al. | Imatinib mesylate for the treatment of steroid-refractory sclerotic-type cutaneous chronic graft-versus-host disease. | 2015 | Biol. Blood Marrow Transplant. | pmid:25771402 |
| Kim D et al. | Hydrogen sulfide and hypoxia-induced changes in TASK (K2P3/9) activity and intracellular Ca(2+) concentration in rat carotid body glomus cells. | 2015 | Respir Physiol Neurobiol | pmid:25956223 |
| Shuker N et al. | Conversion from twice-daily to once-daily tacrolimus does not reduce intrapatient variability in tacrolimus exposure. | 2015 | Ther Drug Monit | pmid:25265255 |
| Soto GAC et al. | Dose increase needed in most cystic fibrosis lung transplantation patients when changing from twice- to once-daily tacrolimus oral administration. | 2015 | Eur. J. Clin. Pharmacol. | pmid:25953736 |
| Wang X et al. | Tacrolimus 0.03% ointment in labial discoid lupus erythematosus: A randomized, controlled clinical trial. | 2015 | J Clin Pharmacol | pmid:25951426 |
| Rojas L et al. | Effect of CYP3A5*3 on kidney transplant recipients treated with tacrolimus: a systematic review and meta-analysis of observational studies. | 2015 | Pharmacogenomics J. | pmid:25201288 |
| Ding L et al. | Clinical Immunosuppressants Inhibit Inflammatory, Proliferative, and Reprogramming Potential, But Not Angiogenesis of Human Pancreatic Duct Cells. | 2015 | Cell Transplant | pmid:25198311 |
| Chung YW et al. | Transcriptional activation of nuclear-related factor 2 by FK506 in Jurkat T cells. | 2015 | Transplant. Proc. | pmid:25891728 |
| Daunton A et al. | A cutaneous presentation of a common condition. | 2015 | BMJ | pmid:26681202 |
| Yang SS et al. | A single center, open-label, randomized pilot study to evaluate the safety and efficacy of tacrolimus modified release, Advagraf, versus tacrolimus twice daily, Prograf, in stable renal recipients (single). | 2015 | Transplant. Proc. | pmid:25891697 |
| Ã…berg F et al. | Asymptomatic De Novo Inflammatory Bowel Disease Late After Liver Transplantation for Primary Sclerosing Cholangitis: A Case Report. | 2015 | Transplant. Proc. | pmid:26680092 |
| Rojanathammanee L et al. | Attenuation of microglial activation in a mouse model of Alzheimer's disease via NFAT inhibition. | 2015 | J Neuroinflammation | pmid:25889879 |
| Størset E et al. | Improved Tacrolimus Target Concentration Achievement Using Computerized Dosing in Renal Transplant Recipients--A Prospective, Randomized Study. | 2015 | Transplantation | pmid:25886918 |
| Hempen CM et al. | Hematocrit-independent recovery of immunosuppressants from DBS using heated flow-through desorption. | 2015 | Bioanalysis | pmid:26327182 |
| Reig Mezquida JP et al. | Thrombotic microangiopathy associated with tacrolimus in lung transplantation. | 2015 | Arch. Bronconeumol. | pmid:25138798 |
| Rajaganapathy BR et al. | Intravesical Liposomal Tacrolimus Protects against Radiation Cystitis Induced by 3-Beam Targeted Bladder Radiation. | 2015 | J. Urol. | pmid:25839382 |
| Furlan SN et al. | Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention. | 2015 | Sci Transl Med | pmid:26606970 |
| Nagashima T and Minota S | Comment on: The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis. | 2015 | Rheumatology (Oxford) | pmid:25832615 |
| Vollmar J et al. | Efficacy and safety of a conversion from the original tacrolimus and mycophenolate mofetil to the generics Tacpan and Mowel after liver transplantation. | 2015 | Drug Des Devel Ther | pmid:26604701 |
| Yasuda S et al. | Comment on: The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis: reply. | 2015 | Rheumatology (Oxford) | pmid:25832614 |
| Eichenfield DZ and Eichenfield LF | Pimecrolimus is safe and effective in treating atopic dermatitis. | 2015 | J. Pediatr. | pmid:26603713 |
| Calabrese B and Halpain S | Differential targeting of dynamin-1 and dynamin-3 to nerve terminals during chronic suppression of neuronal activity. | 2015 | Mol. Cell. Neurosci. | pmid:25827095 |
| Li Z et al. | Tacrolimus Induces Insulin Resistance and Increases the Glucose Absorption in the Jejunum: A Potential Mechanism of the Diabetogenic Effects. | 2015 | PLoS ONE | pmid:26599323 |
| Madariaga ML et al. | Kidney-induced cardiac allograft tolerance in miniature swine is dependent on MHC-matching of donor cardiac and renal parenchyma. | 2015 | Am. J. Transplant. | pmid:25824550 |
| Fujibayashi T et al. | Comparison of efficacy and safety of tacrolimus and methotrexate in combination with abatacept in patients with rheumatoid arthritis; a retrospective observational study in the TBC Registry. | 2015 | Mod Rheumatol | pmid:25775147 |
| Wang YY et al. | Biochemical characterization of a malonyl-specific acyltransferase domain of FK506 biosynthetic polyketide synthase. | 2015 | Protein Pept. Lett. | pmid:25267255 |
| Adotama P et al. | Patient satisfaction with different treatment modalities for vitiligo. | 2015 | J. Am. Acad. Dermatol. | pmid:25773415 |
| Cendales L et al. | Tacrolimus to Belatacept Conversion Following Hand Transplantation: A Case Report. | 2015 | Am. J. Transplant. | pmid:25773260 |
| Soylu H et al. | Survival of renal transplant patients: data from a tertiary care center in Turkey. | 2015 | Transplant. Proc. | pmid:25769571 |
| Boloori A et al. | Characterization of Remitting and Relapsing Hyperglycemia in Post-Renal-Transplant Recipients. | 2015 | PLoS ONE | pmid:26551468 |
| Lightman S et al. | Pegylated interferon-α-2b reduces corticosteroid requirement in patients with Behçet's disease with upregulation of circulating regulatory T cells and reduction of Th17. | 2015 | Ann. Rheum. Dis. | pmid:25269831 |
| Singh N et al. | Extended release once a day tacrolimus. | 2015 | Curr Opin Organ Transplant | pmid:26536429 |
| Ohe M and Bohgaki T | A Case of Adult-Onset Still's Disease Treated with Monitoring of Serum Tacrolimus Levels. | 2015 | Bull Hosp Jt Dis (2013) | pmid:26535602 |
| Abdel-Azim H et al. | Unrelated donor hematopoietic stem cell transplantation for the treatment of non-malignant genetic diseases: An alemtuzumab based regimen is associated with cure of clinical disease; earlier clearance of alemtuzumab may be associated with graft rejection. | 2015 | Am. J. Hematol. | pmid:26242764 |
| Liu X et al. | Associations of HSD11B1 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients with prednisone combined therapy. | 2015 | Drug Metab. Dispos. | pmid:25587129 |
| Mahajan R et al. | Co-localization of agminated congenital melanocytic nevi with vitiligo vulgaris: an unusual presentation. | 2015 | Int. J. Dermatol. | pmid:25039486 |
| Zitelli K et al. | Eosinophilic folliculitis occurring after stem cell transplant for acute lymphoblastic leukemia: a case report and review. | 2015 | Int. J. Dermatol. | pmid:25039354 |
| Yokoyama Y et al. | Corticosteroid-sparing effect of tacrolimus in the initial treatment of dermatomyositis and polymyositis. | 2015 | Mod Rheumatol | pmid:25775144 |
| Asrani SK and O'Leary JG | Can one pill a day keep rejection away? | 2015 | Am. J. Transplant. | pmid:25703394 |
| Guethoff S et al. | De novo sirolimus with low-dose tacrolimus versus full-dose tacrolimus with mycophenolate mofetil after heart transplantation--8-year results. | 2015 | J. Heart Lung Transplant. | pmid:25701373 |
| Pensi D et al. | An UPLC-MS/MS method coupled with automated on-line SPE for quantification of tacrolimus in peripheral blood mononuclear cells. | 2015 | J Pharm Biomed Anal | pmid:25698619 |
| Kim M et al. | Nail lichen striatus: report of seven cases and review of the literature. | 2015 | Int. J. Dermatol. | pmid:26474189 |
| Roche NA et al. | Long-Term Multifunctional Outcome and Risks of Face Vascularized Composite Allotransplantation. | 2015 | J Craniofac Surg | pmid:26468783 |
| Peksa GD et al. | Dosing algorithm for concomitant administration of sirolimus, tacrolimus, and an azole after allogeneic hematopoietic stem cell transplantation. | 2015 | J Oncol Pharm Pract | pmid:24938293 |
| Cen J et al. | The new immunosuppressant, isogarcinol, binds directly to its target enzyme calcineurin, unlike cyclosporin A and tacrolimus. | 2015 | Biochimie | pmid:25701551 |
| Wang JY and Fan H | P70S6 kinase phosphorylation: a new site to assess pharmacodynamy of sirolimus. | 2015 | Chin. Med. J. | pmid:25698201 |
| Mizokami D et al. | Tacrolimus prevents laryngotracheal stenosis in an acute-injury rat model. | 2015 | Laryngoscope | pmid:25647147 |
| Ferjani H et al. | Tacrolimus and mycophenolate mofetil associations: Induction of oxidative stress or antioxidant effect? | 2015 | Hum Exp Toxicol | pmid:25645822 |
| RodrÃguez-Perálvarez M et al. | Everolimus is safe within the first month after liver transplantation. | 2015 | Transpl. Immunol. | pmid:26392195 |
| Ishida K et al. | Evaluation of the Safety and Effectiveness of Add-On Tacrolimus in Patients with Rheumatoid Arthritis Who Failed to Show an Adequate Response to Biological DMARDs: The Interim Results of a Specific Drug Use-Results Survey of Tacrolimus. | 2015 | Drugs R D | pmid:26386566 |
| Chow SP et al. | Long-Term Outcomes of High-Risk Keratoplasty in Patients Receiving Systemic Immunosuppression. | 2015 | Cornea | pmid:26382894 |
| Ogul H et al. | Severe toxic leukoencephalopathy associated with tacrolimus after living donor liver transplantation. | 2015 | Acta Neurol Belg | pmid:24854146 |
| Sato M et al. | Multifocal Fibrosclerosis with Hypertrophic Pachymeningitis and a Soft Tissue Mass around the Thoracic Vertebral Bodies: A Case Report with Review of the Literature. | 2015 | Intern. Med. | pmid:26328659 |
| Chittock J et al. | Comparing the Effect of a Twice-weekly Tacrolimus and Betamethasone Valerate Dose on the Subclinical Epidermal Barrier Defect in Atopic Dermatitis. | 2015 | Acta Derm. Venereol. | pmid:25594610 |
| Knops N et al. | The functional implications of common genetic variation in CYP3A5 and ABCB1 in human proximal tubule cells. | 2015 | Mol. Pharm. | pmid:25590378 |
| Pallet N et al. | Kidney transplant recipients carrying the CYP3A4*22 allelic variant have reduced tacrolimus clearance and often reach supratherapeutic tacrolimus concentrations. | 2015 | Am. J. Transplant. | pmid:25588704 |
| Ge Y et al. | The efficacy of tacrolimus in patients with refractory dermatomyositis/polymyositis: a systematic review. | 2015 | Clin. Rheumatol. | pmid:26328518 |
| Krystel-Whittemore M et al. | Polyomavirus nephropathy of the native kidney in a patient with rheumatoid arthritis and pulmonary fibrosis. | 2015 | BMJ Case Rep | pmid:26318171 |
| Velioglu A et al. | Association of BK Virus Titers With Lymphocyte Count in Renal Transplant Patients. | 2015 | Transplant. Proc. | pmid:26093733 |
| Demir T et al. | Cancer Screening of Renal Transplant Patients Undergoing Long-Term Immunosuppressive Therapy. | 2015 | Transplant. Proc. | pmid:26093731 |
| Schaap MM et al. | A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens. | 2015 | Arch. Toxicol. | pmid:25270620 |
| Yoo MC et al. | Steroid-free Liver Transplantation Using Rabbit Antithymocyte Globulin Induction in 500 Consecutive Patients. | 2015 | Transplantation | pmid:25539464 |
| Offer K et al. | Efficacy of tacrolimus/mycophenolate mofetil as acute graft-versus-host disease prophylaxis and the impact of subtherapeutic tacrolimus levels in children after matched sibling donor allogeneic hematopoietic cell transplantation. | 2015 | Biol. Blood Marrow Transplant. | pmid:25536217 |
| Ramachandran R et al. | Role of Tacrolimus only therapy in modified Ponticelli regimen resistant idiopathic membranous glomerulonephritis. | 2015 | Nephrology (Carlton) | pmid:25535867 |
| Wardhana EA and Datau | A patient with plaque type morphea mimicking systemic lupus erythematosus. | 2015 | Acta Med Indones | pmid:26260557 |
| Aikawa Y et al. | Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells. | 2015 | Cancer Sci. | pmid:25529853 |
| Kim SH et al. | Conversion of twice-daily to once-daily tacrolimus is safe in stable adult living donor liver transplant recipients. | 2015 | HBPD INT | pmid:26256081 |
| Ãœnal CM and Steinert M | FKBPs in bacterial infections. | 2015 | Biochim. Biophys. Acta | pmid:25529296 |
| Clift DE et al. | Effects of embryonic cyclosporine exposures on brain development and behavior. | 2015 | Behav. Brain Res. | pmid:25591474 |
| Joshi S et al. | Phosphatase inhibition prevents the activity-dependent trafficking of GABAA receptors during status epilepticus in the young animal. | 2015 | Epilepsia | pmid:26248944 |
| Duvoux C et al. | Sustained virological response to antiviral therapy in a randomized trial of cyclosporine versus tacrolimus in liver transplant patients with recurrent hepatitis C infection. | 2015 | Ann. Transplant. | pmid:25588713 |
| Hoerning A et al. | Pharmacodynamic monitoring of mammalian target of rapamycin inhibition by phosphoflow cytometric determination of p70S6 kinase activity. | 2015 | Transplantation | pmid:25099702 |
| Valke LL et al. | Soluble CD30 does not predict late acute rejection or safe tapering of immunosuppression in renal transplantation. | 2015 | Transpl. Immunol. | pmid:25446808 |
| Huang G et al. | Monitoring of polyomavirus BK replication and impact of preemptive immunosuppression reduction in renal-transplant recipients in China: a 5-year single-center analysis. | 2015 | Diagn. Microbiol. Infect. Dis. | pmid:25445121 |
| Spiekerkoetter E et al. | Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension. | 2015 | Am. J. Respir. Crit. Care Med. | pmid:26177174 |
| Mandelbrot DA et al. | Effect of Ramipril on Urinary Protein Excretion in Maintenance Renal Transplant Patients Converted to Sirolimus. | 2015 | Am. J. Transplant. | pmid:26176342 |
| Regelmann MO et al. | New-onset diabetes mellitus after pediatric liver transplantation. | 2015 | Pediatr Transplant | pmid:26032592 |
| Guo CL et al. | Efficacy of Topical Tacrolimus for Erosive Oral Lichen Planus: A Meta-analysis. | 2015 | Chin. Med. Sci. J. | pmid:26960301 |
| Apalla Z et al. | Psoriatic cheilitis: a report of 2 cases treated successfully with topical tacrolimus and a review of the literature. | 2015 | Actas Dermosifiliogr | pmid:26164836 |
| Vives R et al. | Safety and Activity of UR-1505 in Atopic Dermatitis: A Randomized, Double-blind Phase II Exploratory Trial. | 2015 | Clin Ther | pmid:26163200 |